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MAPK10 mitogen-activated protein kinase 10 [ Homo sapiens (human) ]

Gene ID: 5602, updated on 7-Jun-2020

Summary

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Official Symbol
MAPK10provided by HGNC
Official Full Name
mitogen-activated protein kinase 10provided by HGNC
Primary source
HGNC:HGNC:6872
See related
Ensembl:ENSG00000109339 MIM:602897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Biased expression in brain (RPKM 15.3), fat (RPKM 4.4) and 11 other tissues See more
Orthologs
mouse all

Genomic context

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See MAPK10 in Genome Data Viewer
Location:
4q21.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (86010405..86594625, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (86933452..87374283, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 24 Neighboring gene uncharacterized LOC105377319 Neighboring gene microRNA 4451 Neighboring gene MAPK10 antisense RNA 1 Neighboring gene RN7SK pseudogene 96 Neighboring gene microRNA 4452 Neighboring gene protein tyrosine phosphatase non-receptor type 13 Neighboring gene uncharacterized LOC107986189 Neighboring gene solute carrier family 10 member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dysregulated miR-27a-3p promotes nasopharyngeal carcinoma cell proliferation and migration by targeting Mapk10. Li L, et al. Oncol Rep, 2017 May. PMID 28393229, Free PMC Article
  2. Peptide mini-scaffold facilitates JNK3 activation in cells. Zhan X, et al. Sci Rep, 2016 Feb 12. PMID 26868142, Free PMC Article
  3. Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline. Gourmaud S, et al. J Psychiatry Neurosci, 2015 May. PMID 25455349, Free PMC Article
  4. Phosphorylation- and nucleotide-binding-induced changes to the stability and hydrogen exchange patterns of JNK1β1 provide insight into its mechanisms of activation. Owen GR, et al. J Mol Biol, 2014 Oct 23. PMID 25178256
  5. JNK3 is required for the cytoprotective effect of exendin 4. Ezanno H, et al. J Diabetes Res, 2014. PMID 25025079, Free PMC Article

See all (112) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural mechanisms of the arrestin-3/JNK3 interactions have been reported.
    Title: Structural Mechanism of the Arrestin-3/JNK3 Interaction.
  2. the present study identified a novel significant association between the increased expression levels of MAPK10, TUBB2B and RASL11B, and neuroblastoma cells.
    Title: Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma.
  3. phosphorylation rate of JNK3 at Thr-221 by MKK7 is two orders of magnitude faster than the corresponding phosphorylation of Tyr-223 by MKK4 with or without arrestin-3
    Title: Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification.
  4. Mapk10 expression was regulated by miR27a-3p in nasopharyngeal carcinoma.Mapk10 gene was down-regulated in the nasopharyngeal carcinoma cells.
    Title: Dysregulated miR-27a-3p promotes nasopharyngeal carcinoma cell proliferation and migration by targeting Mapk10.
  5. Peptide mini-scaffold facilitates JNK3 activation in cells.
    Title: Peptide mini-scaffold facilitates JNK3 activation in cells.
  6. Study found that JNK3 levels are increased in brain tissue and CSF from patients with Alzheimer disease and CSF levels could reflect the rate of cognitive decline
    Title: Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline.
  7. Data indicate that tetra-substituted pyridinylimidazoles were designed as dual inhibitors of c-Jun N-terminal kinase (JNK) 3 and p38alpha mitogen-activated protein (MAP) kinase, and both kinases may be involved in the progression of Huntington's disease.
    Title: Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c-Jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases.
  8. JNK3 is required for the antiapoptotic effects of exendin 4
    Title: JNK3 is required for the cytoprotective effect of exendin 4.
  9. analysis of the unique mechanisms by which JNK1beta1 is regulated
    Title: Phosphorylation- and nucleotide-binding-induced changes to the stability and hydrogen exchange patterns of JNK1β1 provide insight into its mechanisms of activation.
  10. Mitogen-activated protein kinase 10 JNK3 alpha (JNK3apha2)binds to both domains of arrestin-3.
    Title: Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
NHGRI GWA Catalog
Genome wide association study identifies a novel putative mammographic density locus at 1q12-q21.
NHGRI GWA Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
env Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK PubMed
env HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in primary human central nervous system (CNS) cells with an early peak of activation at 2 to 5 minutes PubMed
Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
env Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12099, FLJ33785, MGC50974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
  
JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
MAP kinase kinase activity TAS
Traceable Author Statement
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
  
JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
JNK cascade TAS
Traceable Author Statement
more info
  
JUN phosphorylation IEA
Inferred from Electronic Annotation
more info
  
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
  
cellular hyperosmotic response IEA
Inferred from Electronic Annotation
more info
  
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
neurotransmitter receptor transport to postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
regulation of DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
  
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
response to light stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
response to water deprivation IEA
Inferred from Electronic Annotation
more info
  
rhythmic process IEA
Inferred from Electronic Annotation
more info
  
signal transduction TAS
Traceable Author Statement
more info
 PubMed 
vesicle-mediated transport in synapse IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
cytosol TAS
Traceable Author Statement
more info
  
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
neuron projection IEA
Inferred from Electronic Annotation
more info
  
nucleoplasm TAS
Traceable Author Statement
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
  
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 10
Names
JNK3 alpha protein kinase
MAP kinase 10
MAP kinase p49 3F12
c-Jun N-terminal kinase 3
stress activated protein kinase beta
stress-activated protein kinase 1b
stress-activated protein kinase JNK3
NP_001304996.1
NP_001304997.1
NP_001304998.1
NP_001338553.1
NP_001338554.1
NP_001350586.1
NP_002744.1
NP_620446.1
NP_620448.1
XP_005263186.1
XP_005263187.1
XP_005263188.1
XP_005263192.1
XP_006714331.1
XP_006714332.1
XP_011530419.1
XP_011530420.1
XP_011530422.1
XP_011530423.1
XP_016863909.1
XP_016863911.1
XP_016863912.1
XP_016863916.1
XP_016863917.1
XP_016863918.1
XP_016863919.1
XP_016863921.1
XP_016863922.1
XP_016863923.1
XP_016863924.1
XP_016863925.1
XP_016863926.1
XP_016863930.1
XP_016863934.1
XP_016863936.1
XP_016863937.1
XP_016863938.1
XP_016863939.1
XP_016863940.1
XP_016863941.1
XP_016863942.1
XP_016863943.1
XP_024309907.1
XP_024309908.1
XP_024309909.1
XP_024309910.1
XP_024309911.1
XP_024309912.1
XP_024309913.1
XP_024309914.1
XP_024309915.1
XP_024309916.1
XP_024309917.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013325.2 RefSeqGene

    Range
    4936..447697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318067.1 → NP_001304996.1  mitogen-activated protein kinase 10 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate in-frame coding exon compared to variant 1. The resulting isoform (5) is the same length; however, contains a different 23 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC104059, AF052141, AK225974, BC035057
    Consensus CDS
    CCDS87243.1
    UniProtKB/Swiss-Prot
    P53779
    UniProtKB/TrEMBL
    A0A286YF97
    Related
    ENSP00000493344.1, ENST00000641718.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. NM_001318068.1 → NP_001304997.1  mitogen-activated protein kinase 10 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon, lacks an internal exon and contains an alternate in-frame coding exon compared to variant 1. These differences result in translation initiation from an in-frame, downstream start codon, and an isoform (6) with a shorter N-terminus and containing a different 23 aa protein segment compared to isoform 1.
    Source sequence(s)
    AC104059, AF052141, AK057723, BC035057, BC051731
    UniProtKB/Swiss-Prot
    P53779
    UniProtKB/TrEMBL
    Q499Y8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001318069.2 → NP_001304998.1  mitogen-activated protein kinase 10 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AC104059, AF052141, AK057723, BC022492, BC035057
    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (2) summary
    smart00220
    Location:64 → 359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. NM_001351624.2 → NP_001338553.1  mitogen-activated protein kinase 10 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC104059, AF052141, AK307129, BC022492, BC035057
    Consensus CDS
    CCDS3612.1
    Related
    ENSP00000493040.1, ENST00000642015.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. NM_001351625.2 → NP_001338554.1  mitogen-activated protein kinase 10 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC104059, AF052141, AK307129, BC022492, BC035057, CB069160
    Consensus CDS
    CCDS87242.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. NM_001363657.2 → NP_001350586.1  mitogen-activated protein kinase 10 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC096953, AC104059, AC104827, AC108054
    Consensus CDS
    CCDS87241.1
    Related
    ENSP00000492922.1, ENST00000641208.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  7. NM_002753.5 → NP_002744.1  mitogen-activated protein kinase 10 isoform 2

    See identical proteins and their annotated locations for NP_002744.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate acceptor splice site at the 3' terminal exon, which causes a frameshift compared to variant 1. The resulting isoform (2, also know as JNK3 alpha1) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC096953, AC104059, AF052141, AK057723, U07620
    Consensus CDS
    CCDS43247.1
    UniProtKB/Swiss-Prot
    P53779
    UniProtKB/TrEMBL
    A8MWW6
    Related
    ENSP00000493237.1, ENST00000641170.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. NM_138980.4 → NP_620446.1  mitogen-activated protein kinase 10 isoform 3

    See identical proteins and their annotated locations for NP_620446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC104059, AF052141, AK057723, BC022492, BC035057, DA192997
    Consensus CDS
    CCDS3612.1
    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000491866.1, ENST00000638225.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  9. NM_138982.4 → NP_620448.1  mitogen-activated protein kinase 10 isoform 1

    See identical proteins and their annotated locations for NP_620448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    AC104059, AF052141, AK057723, BC022492, BC035057
    Consensus CDS
    CCDS34026.1
    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000493435.1, ENST00000641462.2
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    86010405..86594625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454141.1 → XP_024309909.1  mitogen-activated protein kinase 10 isoform X1

    Related
    ENSP00000493275.1, ENST00000641051.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. XM_017008428.2 → XP_016863917.1  mitogen-activated protein kinase 10 isoform X5

    UniProtKB/TrEMBL
    A0A286YFD7
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  3. XM_011532120.3 → XP_011530422.1  mitogen-activated protein kinase 10 isoform X4

    See identical proteins and their annotated locations for XP_011530422.1

    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000493177.1, ENST00000641737.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  4. XM_024454142.1 → XP_024309910.1  mitogen-activated protein kinase 10 isoform X1

    Related
    ENSP00000493363.1, ENST00000641157.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_024454145.1 → XP_024309913.1  mitogen-activated protein kinase 10 isoform X6

    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_011532117.3 → XP_011530419.1  mitogen-activated protein kinase 10 isoform X1

    See identical proteins and their annotated locations for XP_011530419.1

    UniProtKB/Swiss-Prot
    P53779
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  7. XM_024454144.1 → XP_024309912.1  mitogen-activated protein kinase 10 isoform X6

    Related
    ENSP00000493270.1, ENST00000641050.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. XM_024454140.1 → XP_024309908.1  mitogen-activated protein kinase 10 isoform X1

    Related
    ENSP00000493013.1, ENST00000641952.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  9. XM_024454148.1 → XP_024309916.1  mitogen-activated protein kinase 10 isoform X14

    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  10. XM_024454139.1 → XP_024309907.1  mitogen-activated protein kinase 10 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  11. XM_017008448.2 → XP_016863937.1  mitogen-activated protein kinase 10 isoform X13

    UniProtKB/TrEMBL
    I6L9F3
    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  12. XM_005263131.3 → XP_005263188.1  mitogen-activated protein kinase 10 isoform X2

    See identical proteins and their annotated locations for XP_005263188.1

    UniProtKB/TrEMBL
    A0A286YF97
    Related
    ENSP00000492913.1, ENST00000641553.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  13. XM_006714269.3 → XP_006714332.1  mitogen-activated protein kinase 10 isoform X7

    See identical proteins and their annotated locations for XP_006714332.1

    UniProtKB/TrEMBL
    A0A1P0B7D2
    Related
    ENSP00000378598.5, ENST00000395169.9
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  14. XM_005263135.4 → XP_005263192.1  mitogen-activated protein kinase 10 isoform X6

    See identical proteins and their annotated locations for XP_005263192.1

    UniProtKB/Swiss-Prot
    P53779
    UniProtKB/TrEMBL
    A8MWW6
    Related
    ENSP00000378586.4, ENST00000395157.9
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  15. XM_017008434.2 → XP_016863923.1  mitogen-activated protein kinase 10 isoform X9

    UniProtKB/TrEMBL
    D6RJF9
    Related
    ENSP00000352157.4, ENST00000359221.8
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  16. XM_017008450.2 → XP_016863939.1  mitogen-activated protein kinase 10 isoform X14

    UniProtKB/TrEMBL
    Q499Y8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  17. XM_017008433.2 → XP_016863922.1  mitogen-activated protein kinase 10 isoform X8

    UniProtKB/TrEMBL
    A0A286YEQ7
    Related
    ENSP00000492898.1, ENST00000641384.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 336
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  18. XM_017008441.2 → XP_016863930.1  mitogen-activated protein kinase 10 isoform X11

    UniProtKB/TrEMBL
    A0A286YFN2
    Related
    ENSP00000493447.1, ENST00000642023.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 336
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  19. XM_017008427.2 → XP_016863916.1  mitogen-activated protein kinase 10 isoform X5

    UniProtKB/TrEMBL
    A0A286YFD7
    Related
    ENSP00000493350.1, ENST00000641166.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  20. XM_017008445.2 → XP_016863934.1  mitogen-activated protein kinase 10 isoform X12

    UniProtKB/TrEMBL
    A0A286YES0
    Related
    ENSP00000492920.1, ENST00000641607.1
    Conserved Domains (1) summary
    cd07850
    Location:1 → 284
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  21. XM_017008451.2 → XP_016863940.1  mitogen-activated protein kinase 10 isoform X15

    UniProtKB/TrEMBL
    A0A286YF02
    Related
    ENSP00000493455.1, ENST00000641047.1
    Conserved Domains (1) summary
    cd07850
    Location:1 → 284
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  22. XM_017008449.2 → XP_016863938.1  mitogen-activated protein kinase 10 isoform X14

    UniProtKB/TrEMBL
    Q499Y8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  23. XM_017008447.2 → XP_016863936.1  mitogen-activated protein kinase 10 isoform X13

    UniProtKB/TrEMBL
    I6L9F3
    Conserved Domains (1) summary
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  24. XM_017008452.2 → XP_016863941.1  mitogen-activated protein kinase 10 isoform X16

    Related
    ENSP00000492912.1, ENST00000641881.1
    Conserved Domains (2) summary
    smart00220
    Location:1 → 214
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 253
    PKc_like; Protein Kinases, catalytic domain

  25. XM_017008420.2 → XP_016863909.1  mitogen-activated protein kinase 10 isoform X1

    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000493045.1, ENST00000641983.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  26. XM_006714268.3 → XP_006714331.1  mitogen-activated protein kinase 10 isoform X4

    See identical proteins and their annotated locations for XP_006714331.1

    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000493049.1, ENST00000641803.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  27. XM_017008435.2 → XP_016863924.1  mitogen-activated protein kinase 10 isoform X9

    UniProtKB/TrEMBL
    D6RJF9
    Related
    ENSP00000425654.2, ENST00000512689.6
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  28. XM_017008429.2 → XP_016863918.1  mitogen-activated protein kinase 10 isoform X6

    UniProtKB/Swiss-Prot
    P53779
    UniProtKB/TrEMBL
    A8MWW6
    Related
    ENSP00000491122.1, ENST00000640858.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  29. XM_005263129.3 → XP_005263186.1  mitogen-activated protein kinase 10 isoform X1

    See identical proteins and their annotated locations for XP_005263186.1

    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000493072.1, ENST00000641066.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  30. XM_017008430.2 → XP_016863919.1  mitogen-activated protein kinase 10 isoform X6

    UniProtKB/Swiss-Prot
    P53779
    UniProtKB/TrEMBL
    A8MWW6
    Related
    ENSP00000492231.1, ENST00000640970.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  31. XM_017008423.2 → XP_016863912.1  mitogen-activated protein kinase 10 isoform X4

    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000378595.1, ENST00000395166.6
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  32. XM_017008436.2 → XP_016863925.1  mitogen-activated protein kinase 10 isoform X9

    UniProtKB/TrEMBL
    D6RJF9
    Related
    ENSP00000493206.1, ENST00000641989.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  33. XM_011532118.3 → XP_011530420.1  mitogen-activated protein kinase 10 isoform X1

    See identical proteins and their annotated locations for XP_011530420.1

    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000492292.1, ENST00000638313.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  34. XM_024454146.1 → XP_024309914.1  mitogen-activated protein kinase 10 isoform X6

    Related
    ENSP00000492942.1, ENST00000642038.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  35. XM_011532121.3 → XP_011530423.1  mitogen-activated protein kinase 10 isoform X4

    See identical proteins and their annotated locations for XP_011530423.1

    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000491089.1, ENST00000639242.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  36. XM_017008437.2 → XP_016863926.1  mitogen-activated protein kinase 10 isoform X9

    UniProtKB/TrEMBL
    D6RJF9
    Related
    ENSP00000493309.1, ENST00000641767.1
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  37. XM_005263130.3 → XP_005263187.1  mitogen-activated protein kinase 10 isoform X1

    See identical proteins and their annotated locations for XP_005263187.1

    UniProtKB/Swiss-Prot
    P53779
    Related
    ENSP00000414469.4, ENST00000449047.8
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  38. XM_017008432.2 → XP_016863921.1  mitogen-activated protein kinase 10 isoform X6

    UniProtKB/Swiss-Prot
    P53779
    UniProtKB/TrEMBL
    A8MWW6
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  39. XM_024454143.1 → XP_024309911.1  mitogen-activated protein kinase 10 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  40. XM_024454147.1 → XP_024309915.1  mitogen-activated protein kinase 10 isoform X6

    Related
    ENSP00000493396.1, ENST00000641862.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  41. XM_017008422.2 → XP_016863911.1  mitogen-activated protein kinase 10 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:64 → 335
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63 → 374
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  42. XM_017008454.2 → XP_016863943.1  mitogen-activated protein kinase 10 isoform X18

    UniProtKB/TrEMBL
    D6RCB1
    Related
    ENSP00000422277.2, ENST00000511167.6
    Conserved Domains (1) summary
    cl21453
    Location:63 → 243
    PKc_like; Protein Kinases, catalytic domain

  43. XM_024454149.1 → XP_024309917.1  mitogen-activated protein kinase 10 isoform X18

    Conserved Domains (1) summary
    cl21453
    Location:63 → 243
    PKc_like; Protein Kinases, catalytic domain

  44. XM_017008453.2 → XP_016863942.1  mitogen-activated protein kinase 10 isoform X17

    Conserved Domains (2) summary
    smart00220
    Location:64 → 240
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:63 → 243
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001741289.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138981.2: Suppressed sequence

    Description
    NM_138981.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53779.2 GenPept UniProtKB/Swiss-Prot:P53779

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