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    IL18R1 interleukin 18 receptor 1 [ Homo sapiens (human) ]

    Gene ID: 8809, updated on 5-Mar-2024

    Summary

    Official Symbol
    IL18R1provided by HGNC
    Official Full Name
    interleukin 18 receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:5988
    See related
    Ensembl:ENSG00000115604 MIM:604494; AllianceGenome:HGNC:5988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp; IL-18Ralpha; IL18Ralpha2; IL-18R-alpha
    Summary
    The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in appendix (RPKM 4.6), gall bladder (RPKM 3.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL18R1 in Genome Data Viewer
    Location:
    2q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (102355796..102398776)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102814660..102857641)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102972256..103015236)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102867123-102867716 Neighboring gene CFAP144 pseudogene 2 Neighboring gene interleukin 1 receptor like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102972025-102972526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16307 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 pseudogene 5 Neighboring gene interleukin 18 receptor accessory protein Neighboring gene microRNA 4772

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A large-scale, consortium-based genomewide association study of asthma.
    EBI GWAS Catalog
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    EBI GWAS Catalog
    Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
    EBI GWAS Catalog
    Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
    EBI GWAS Catalog
    Genome-wide association study to identify genetic determinants of severe asthma.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog
    Newly identified genetic risk variants for celiac disease related to the immune response.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of interleukin 18 receptor 1 (IL18R1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show downregulation of interleukin 18 receptor 1 (IL18R1) expression as compared to untreated control PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-1 receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-18 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-18 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables interleukin-18 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-18 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of interleukin-18 receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-18 receptor 1
    Names
    CD218 antigen-like family member A
    IL1 receptor-related protein
    cytokine receptor
    interleukin-18 receptor alpha
    NP_001269328.1
    NP_001358347.1
    NP_001358348.1
    NP_001358349.1
    NP_001358350.1
    NP_001358351.1
    NP_001358352.1
    NP_001358353.1
    NP_003846.1
    XP_024308970.1
    XP_024308972.1
    XP_024308973.1
    XP_047302123.1
    XP_047302124.1
    XP_047302125.1
    XP_054200332.1
    XP_054200333.1
    XP_054200334.1
    XP_054200335.1
    XP_054200336.1
    XP_054200337.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282399.2NP_001269328.1  interleukin-18 receptor 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC007248
      UniProtKB/Swiss-Prot
      Q13478
      Conserved Domains (4) summary
      cd00096
      Location:78156
      Ig; Immunoglobulin domain
      smart00410
      Location:69158
      IG_like; Immunoglobulin like
      pfam01582
      Location:222364
      TIR; TIR domain
      cl11960
      Location:253
      Ig; Immunoglobulin domain
    2. NM_001371418.1NP_001358347.1  interleukin-18 receptor 1 isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007248
      UniProtKB/TrEMBL
      B7ZKV7
      Conserved Domains (4) summary
      PHA02785
      Location:171312
      PHA02785; IL-beta-binding protein; Provisional
      pfam01582
      Location:376540
      TIR; TIR domain
      pfam18452
      Location:72119
      Ig_6; Immunoglobulin domain
      cl11960
      Location:129208
      Ig; Immunoglobulin domain
    3. NM_001371419.1NP_001358348.1  interleukin-18 receptor 1 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007248
      Conserved Domains (3) summary
      PHA02785
      Location:171312
      PHA02785; IL-beta-binding protein; Provisional
      pfam18452
      Location:72119
      Ig_6; Immunoglobulin domain
      cl11960
      Location:129208
      Ig; Immunoglobulin domain
    4. NM_001371420.1NP_001358349.1  interleukin-18 receptor 1 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007248
      Conserved Domains (3) summary
      PHA02785
      Location:171312
      PHA02785; IL-beta-binding protein; Provisional
      pfam18452
      Location:72119
      Ig_6; Immunoglobulin domain
      cl11960
      Location:129208
      Ig; Immunoglobulin domain
    5. NM_001371421.1NP_001358350.1  interleukin-18 receptor 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC007248
      Conserved Domains (3) summary
      PHA02785
      Location:16157
      PHA02785; IL-beta-binding protein; Provisional
      pfam01582
      Location:222386
      TIR; TIR domain
      cl11960
      Location:253
      Ig; Immunoglobulin domain
    6. NM_001371422.1NP_001358351.1  interleukin-18 receptor 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC007248
      Conserved Domains (1) summary
      pfam01582
      Location:128292
      TIR; TIR domain
    7. NM_001371423.1NP_001358352.1  interleukin-18 receptor 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC007248
      Conserved Domains (1) summary
      pfam01582
      Location:127291
      TIR; TIR domain
    8. NM_001371424.1NP_001358353.1  interleukin-18 receptor 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC007248
      Conserved Domains (1) summary
      pfam01582
      Location:127291
      TIR; TIR domain
    9. NM_003855.5NP_003846.1  interleukin-18 receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_003846.1

      Status: REVIEWED

      Source sequence(s)
      AC007248
      Consensus CDS
      CCDS2060.1
      UniProtKB/Swiss-Prot
      B2R9Y5, Q13478, Q52LC9
      Related
      ENSP00000233957.1, ENST00000233957.7
      Conserved Domains (3) summary
      pfam01582
      Location:378520
      TIR; TIR domain
      cl11960
      Location:129208
      Ig; Immunoglobulin domain
      cl28655
      Location:171312
      PHA02785; IL-beta-binding protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      102355796..102398776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453204.2XP_024308972.1  interleukin-18 receptor 1 isoform X3

      Conserved Domains (3) summary
      pfam01582
      Location:351467
      TIR; TIR domain
      cl11960
      Location:129208
      Ig; Immunoglobulin domain
      cl28655
      Location:171312
      PHA02785; IL-beta-binding protein; Provisional
    2. XM_024453205.2XP_024308973.1  interleukin-18 receptor 1 isoform X4

      Conserved Domains (3) summary
      pfam01582
      Location:324466
      TIR; TIR domain
      cl11960
      Location:129208
      Ig; Immunoglobulin domain
      cl28655
      Location:171312
      PHA02785; IL-beta-binding protein; Provisional
    3. XM_024453202.2XP_024308970.1  interleukin-18 receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R9Y5, Q13478, Q52LC9
      Related
      ENSP00000387211.1, ENST00000409599.5
      Conserved Domains (3) summary
      pfam01582
      Location:378520
      TIR; TIR domain
      cl11960
      Location:129208
      Ig; Immunoglobulin domain
      cl28655
      Location:171312
      PHA02785; IL-beta-binding protein; Provisional
    4. XM_047446167.1XP_047302123.1  interleukin-18 receptor 1 isoform X2

      UniProtKB/TrEMBL
      B7ZKV7
    5. XM_047446169.1XP_047302125.1  interleukin-18 receptor 1 isoform X6

    6. XM_047446168.1XP_047302124.1  interleukin-18 receptor 1 isoform X5

    RNA

    1. XR_923054.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      102814660..102857641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344359.1XP_054200334.1  interleukin-18 receptor 1 isoform X3

    2. XM_054344360.1XP_054200335.1  interleukin-18 receptor 1 isoform X4

    3. XM_054344357.1XP_054200332.1  interleukin-18 receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R9Y5, Q13478, Q52LC9
    4. XM_054344358.1XP_054200333.1  interleukin-18 receptor 1 isoform X2

      UniProtKB/TrEMBL
      B7ZKV7
    5. XM_054344362.1XP_054200337.1  interleukin-18 receptor 1 isoform X6

    6. XM_054344361.1XP_054200336.1  interleukin-18 receptor 1 isoform X5

    RNA

    1. XR_008486579.1 RNA Sequence