Conserved Protein Domain Family
TIR

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pfam01582: TIR 
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TIR domain
The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Statistics
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PSSM-Id: 307630
View PSSM: pfam01582
Aligned: 24 rows
Threshold Bit Score: 122.074
Threshold Setting Gi: 20140413
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam01582 is a member of the superfamily cl23801.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4C6R_A          9 HQVFI-------NFRGADLRRRFVSHLVTAL--KLNNINVFIDDYE-DRGQPL-D-VLLKRIEESKIVLAIFSGNYTESV 76
gi 90110768   386 YVLYPkp----hKESQRHAVDALVLNILPEVleRQCGYKLFIFGRDeFPGQAVaN-VIDENVKLCRRLIVIVVPESLGFG 460
gi 20140413   677 FVIYS-----------SQDEDWVRNELVKNLeeGVPPFQLCLHYRDfIPGVAIaAnIIHEGFHKSRKVIVVVSQHFIQSR 745
gi 26454633   385 YIIYPrvf--rgSAAGTHSVEYFVHHTLPDVleNKCGYKLCIYGRDlLPGQDAaT-VVESSIQNSRRQVFVLAPHMMHSK 461
gi 74762124   411 FVSYAkwssfpsEATSSLSEEHLALSLFPDVleNKYGYSLCLLERDvAPGGVYaE-DIVSIIKRSRRGIFILSPNYVNGP 489
gi 76363210   410 FVSYSnwsspetDAVGSLSEEHLALNLFPEVleDTYGYRLCLLDRDvTPGGVYaD-DIVSIIKKSRRGIFILSPSYLNGP 488
gi 26395370   378 FVSYLk-----eCRPENGEEHTFAVEILPRVleKHFGYKLCIFERDvVPGGAVvD-EIHSLIEKSRRLIIVLSKSYMSNE 451
gi 34222652   408 YVSYA----------RNAEEEEFVLLTLRGVleNEFGYKLCIFDRDsLPGGIVtD-ETLSFIQKSRRLLVVLSPNYVLQG 476
gi 297839159    9 YDVFL-------SFRGLDTRRNFISFLYKEL--VRRNIRTFKDDKElENGRRIsP-ELKRAIEESKFAVVVVSVNYAASP 78
gi 947107122   21 YDVFV-------SFRGEDTRNSFTAFLFEAL--KKQGIEAFKDDKDiRKGESIaP-ELIRAIEGSHVFLVVFSKDYASST 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4C6R_A         77 --WCVRELEKIKDCTD-EGTLVAIPIFYKLEPSTVrdlkgKFGDRFRSMAKGDe----RKKKWKEAFNLipnimgiiiDK 149
gi 90110768   461 llKNLSEEQIAVYSALiQDGMKVILIELEKIEDYT-----VMPESIQYIKQKH-----GAIRWHGDFTE---------QS 521
gi 20140413   746 --WCIFEYEIAQTWQFlSSRAGIIFIVLQKVEK-------TLLRQQVELYRLLsr--nTYLEWE--------------DS 800
gi 26454633   462 --EFAYEQEIALHSALiQNNSKVILIEMEPLGEASrlqvgDLQDSLQHLVKIQ-----GTIKWREDHVA---------DK 525
gi 74762124   490 ---SIFELQAAVNLALdDQTLKLILIKFCYFQEPE-----SLPHLVKKALRVL-----PTVTWRGL------------KS 544
gi 76363210   489 ---RVFELQAAVNLALvDQTLKLILIKFCSFQEPE-----SLPYLVKKALRVL-----PTVTWKGL------------KS 543
gi 26395370   452 ---VRYELESGLHEALvERKIKIILIEFTPVTDFT-----FLPQSLKLLKSH------RVLKWKAD------------KS 505
gi 34222652   477 t-QALLELKAGLENMAsRGNINVILVQYKAVKE-------TKVKELKRAKTVL-----TVIKWKGE------------KS 531
gi 297839159   79 --WCLDELVKIMDFEN-KGSITVMPIFYGVDPCHLrrqsgDVAEQFKKHEAREed-ldKVASWRRALTSlasisgdcsLK 154
gi 947107122   91 --WCLRELAHIWNCFQ-PSTRHLLPIFYDVDPSQVrklsgDYEKAFAQHQQSSrfqekEITTWREVLERvasl-sgwdIR 166
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
4C6R_A        150 KSVESEKVNEIVKAV-------------------KTALTGI 171
gi 90110768   522 QCMKTKFWKTVRYHMpprrcrpfppvqllqhtpcYRTAGPE 562
gi 20140413   801 VLGRHIFWRRLRKALld---------------gkSWNPEGT 826
gi 26454633   526 QSLSSKFWKHVRYQMpvpe------------rasKTASVAA 554
gi 74762124   545 VPPNSRFWAKMRYHMpvknsqgftwnqlritsriFQWKGLS 585
gi 76363210   544 VHASSRFWTQIRYHMpvknsnrfmfnglriflkgFSPEKDL 584
gi 26395370   506 LSYNSRFWKNLLYLMp------------------AKTVKPG 528
gi 34222652   532 KYPQGRFWKQLQVAMpv---------------kkSPRRSSS 557
gi 297839159  155 CEDESKLVDEIADKI-------------------SKKLMVV 176
gi 947107122  167 NKEQPTVIDEIVQKI-------------------KKIVGCK 188
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