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Il18r1 interleukin 18 receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 16182, updated on 24-Sep-2025
Official Symbol
Il18r1provided by MGI
Official Full Name
interleukin 18 receptor 1provided by MGI
Primary source
MGI:MGI:105383
See related
Ensembl:ENSMUSG00000026070 AllianceGenome:MGI:105383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il1rrp; Il18ralpha
Summary
Enables interleukin-18 receptor activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including T-helper 1 cell differentiation; interleukin-18-mediated signaling pathway; and positive regulation of type II interferon production. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Is expressed in aorta-gonad-mesonephros and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL18R1 (interleukin 18 receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in lung adult (RPKM 4.7), bladder adult (RPKM 0.7) and 3 other tissues See more
Orthologs
human all
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See Il18r1 in Genome Data Viewer
Location:
1 B; 1 19.27 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40504712..40540014)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40465552..40500854)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 1 receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_00741 Neighboring gene interleukin 18 receptor accessory protein Neighboring gene predicted gene, 35801 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. IL-18Rα-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness. Holmkvist P, et al. Eur J Immunol, 2016 Jun. PMID 27062602
  2. Deletion of IL-18 receptor ameliorates renal injury in bovine serum albumin-induced glomerulonephritis. Sugiyama M, et al. Clin Immunol, 2008 Jul. PMID 18462998
  3. IL-18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection. da Mota JB, et al. J Leukoc Biol, 2020 Oct. PMID 32450614
  4. Inhibition of the IL-18 Receptor Signaling Pathway Ameliorates Disease in a Murine Model of Rheumatoid Arthritis. Nozaki Y, et al. Cells, 2019 Dec 18. PMID 31861496, Free PMC Article
  5. The Basophil IL-18 Receptor Precisely Regulates the Host Immune Response and Malaria-Induced Intestinal Permeability and Alters Parasite Transmission to Mosquitoes without Effect on Gametocytemia. Donnelly EL, et al. Immunohorizons, 2022 Aug 19. PMID 35985797, Free PMC Article

See all (161) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL18 Receptor Signaling Inhibits Intratumoral CD8[+] T-Cell Migration in a Murine Pancreatic Cancer Model.
    Title: IL18 Receptor Signaling Inhibits Intratumoral CD8(+) T-Cell Migration in a Murine Pancreatic Cancer Model.
  2. Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.
    Title: Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.
  3. The Basophil IL-18 Receptor Precisely Regulates the Host Immune Response and Malaria-Induced Intestinal Permeability and Alters Parasite Transmission to Mosquitoes without Effect on Gametocytemia.
    Title: The Basophil IL-18 Receptor Precisely Regulates the Host Immune Response and Malaria-Induced Intestinal Permeability and Alters Parasite Transmission to Mosquitoes without Effect on Gametocytemia.
  4. IL-18/IL-18R Signaling Is Dispensable for ILC Development But Constrains the Growth of ILCP/ILCs.
    Title: IL-18/IL-18R Signaling Is Dispensable for ILC Development But Constrains the Growth of ILCP/ILCs.
  5. IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock.
    Title: IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock.
  6. Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Ralpha(hi) CD8(+) T cells.
    Title: Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rα(hi) CD8(+) T cells.
  7. IL-18R signaling is required for gammadelta T cell response and confers resistance to Trypanosoma cruzi infection.
    Title: IL-18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection.
  8. Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice.
    Title: Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice.
  9. Inhibition of the IL-18 Receptor Signaling Pathway Ameliorates Disease in a Murine Model of Rheumatoid Arthritis.
    Title: Inhibition of the IL-18 Receptor Signaling Pathway Ameliorates Disease in a Murine Model of Rheumatoid Arthritis.
  10. asthma is very likely to be determined by balance of IL-18/IL-18BP/IL-18R expression in inflammatory cells.
    Title: Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (2)  1 citation

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleosidase activity, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-18 binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-18 binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-18 binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables interleukin-18 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-18 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-18 receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables interleukin-18 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-18 receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T-helper 1 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-18-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-18-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within interleukin-18-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interleukin-18-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-18-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of T-helper 1 cell cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T-helper 1 cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T-helper 1 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type II interferon production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of interleukin-18 receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of interleukin-18 receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
interleukin-18 receptor 1
Names
CD218 antigen-like family member A
IL-18R-1
IL-18R-alpha
IL-18R1
IL-18Ralpha
IL-1Rrp
IL1 receptor-related protein
IL1R-rp
interleukin 1 receptor related protein
interleukin-18 receptor alpha
NP_001155314.1
NP_001155315.1
NP_032391.1
XP_006495790.1
XP_006495791.1
XP_006495792.1
XP_006495793.1
XP_006495795.1
XP_006495797.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161842.1 → NP_001155314.1  interleukin-18 receptor 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001155314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC167126
    Consensus CDS
    CCDS48247.1
    UniProtKB/TrEMBL
    Q8C257
    Related
    ENSMUSP00000128277.2, ENSMUST00000167723.8
    Conserved Domains (3) summary
    cd00096
    Location:46 → 113
    Ig; Immunoglobulin domain
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain

  2. NM_001161843.1 → NP_001155315.1  interleukin-18 receptor 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001155315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice pattern in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC167126
    Consensus CDS
    CCDS48247.1
    UniProtKB/TrEMBL
    Q8C257
    Related
    ENSMUSP00000141695.2, ENSMUST00000193391.6
    Conserved Domains (3) summary
    cd00096
    Location:46 → 113
    Ig; Immunoglobulin domain
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain

  3. NM_008365.2 → NP_032391.1  interleukin-18 receptor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_032391.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC167126
    Consensus CDS
    CCDS35549.1
    UniProtKB/Swiss-Prot
    Q61098
    Related
    ENSMUSP00000103679.3, ENSMUST00000108044.4
    Conserved Domains (4) summary
    PHA02785
    Location:157 → 257
    PHA02785; IL-beta-binding protein; Provisional
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    pfam01582
    Location:374 → 534
    TIR; TIR domain
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    40504712..40540014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495727.3 → XP_006495790.1  interleukin-18 receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006495790.1

    UniProtKB/Swiss-Prot
    Q61098
    Conserved Domains (4) summary
    PHA02785
    Location:157 → 257
    PHA02785; IL-beta-binding protein; Provisional
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    pfam01582
    Location:374 → 534
    TIR; TIR domain
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain

  2. XM_006495729.5 → XP_006495792.1  interleukin-18 receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006495792.1

    UniProtKB/Swiss-Prot
    Q61098
    Conserved Domains (4) summary
    PHA02785
    Location:157 → 257
    PHA02785; IL-beta-binding protein; Provisional
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    pfam01582
    Location:374 → 534
    TIR; TIR domain
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain

  3. XM_006495734.5 → XP_006495797.1  interleukin-18 receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006495797.1

    UniProtKB/Swiss-Prot
    Q61098
    Conserved Domains (4) summary
    PHA02785
    Location:157 → 257
    PHA02785; IL-beta-binding protein; Provisional
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    pfam01582
    Location:374 → 534
    TIR; TIR domain
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain

  4. XM_006495730.3 → XP_006495793.1  interleukin-18 receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006495793.1

    UniProtKB/Swiss-Prot
    Q61098
    Conserved Domains (4) summary
    PHA02785
    Location:157 → 257
    PHA02785; IL-beta-binding protein; Provisional
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    pfam01582
    Location:374 → 534
    TIR; TIR domain
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain

  5. XM_006495732.3 → XP_006495795.1  interleukin-18 receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006495795.1

    UniProtKB/Swiss-Prot
    Q61098
    Conserved Domains (4) summary
    PHA02785
    Location:157 → 257
    PHA02785; IL-beta-binding protein; Provisional
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    pfam01582
    Location:374 → 534
    TIR; TIR domain
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain

  6. XM_006495728.3 → XP_006495791.1  interleukin-18 receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006495791.1

    UniProtKB/Swiss-Prot
    Q61098
    Conserved Domains (4) summary
    PHA02785
    Location:157 → 257
    PHA02785; IL-beta-binding protein; Provisional
    smart00410
    Location:26 → 112
    IG_like; Immunoglobulin like
    pfam01582
    Location:374 → 534
    TIR; TIR domain
    cl11960
    Location:131 → 205
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61098.1 GenPept UniProtKB/Swiss-Prot:Q61098

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