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Nat Genet. 2010 Dec;42(12):1118-25. doi: 10.1038/ng.717.

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

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1
Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

Abstract

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.

PMID:
21102463
PMCID:
PMC3299551
DOI:
10.1038/ng.717
[Indexed for MEDLINE]
Free PMC Article

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