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    PPARG peroxisome proliferator activated receptor gamma [ Homo sapiens (human) ]

    Gene ID: 5468, updated on 26-Jul-2021

    Summary

    Official Symbol
    PPARGprovided by HGNC
    Official Full Name
    peroxisome proliferator activated receptor gammaprovided by HGNC
    Primary source
    HGNC:HGNC:9236
    See related
    Ensembl:ENSG00000132170 MIM:601487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma
    Summary
    This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in fat (RPKM 44.7), urinary bladder (RPKM 10.3) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PPARG in Genome Data Viewer
    Location:
    3p25.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (12287368..12434344)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12328867..12475843)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene synapsin II Neighboring gene MT-CO1 pseudogene 5 Neighboring gene glutathione S-transferase mu 5 pseudogene 1 Neighboring gene PPARG eExon liver enhancer Neighboring gene RNA, 5S ribosomal pseudogene 123 Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene RNA, U6 small nuclear 377, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    GeneReviews: Not available
    A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
    GeneReviews: Not available
    Carotid intimal medial thickness 1
    MedGen: C1836302 OMIM: 609338 GeneReviews: Not available
    Compare labs
    Familial partial lipodystrophy 3
    MedGen: C1720861 OMIM: 604367 GeneReviews: Not available
    Compare labs
    Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
    GeneReviews: Not available
    Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
    GeneReviews: Not available
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    GeneReviews: Not available
    Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.
    GeneReviews: Not available
    Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
    GeneReviews: Not available
    Obesity
    MedGen: C0028754 OMIM: 601665 GeneReviews: Not available
    Compare labs
    Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
    GeneReviews: Not available
    Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
    GeneReviews: Not available
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    GeneReviews: Not available
    Type 2 diabetes mellitus
    MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates PPARgamma expression in human mesenchymal stem cells PubMed
    env In human osteoblast (hOB) cell lines, HIV-1 Gag and gp120 reduce RUNX-2 and PPAR-gamma mRNA expression and activity PubMed
    Nef nef HIV-1 Nef suppresses PPAR-gamma expression in human T and macrophage cell lines, and the effects of PPAR-gamma on viral replication is reduced by co-expression of Nef in MT4 T cells PubMed
    Pr55(Gag) gag In human osteoblast (hOB) cell lines, HIV-1 Gag and gp120 reduce RUNX-2 and PPAR-gamma mRNA expression and activity PubMed
    Tat tat HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells PubMed
    tat Sera from high viral load HIV-1-infected individuals induce a clear proadipogenic phenotype with increased expression of adipogenic markers including LPL and PPARgamma by HIV-1 Tat-mediated inhibition of COUP TF-1 PubMed
    tat HIV-1 Tat enhances the differentiation of mesenchymal stem cells (MSC) toward adipogenesis by the transcription and activity upregulation of PPARgamma PubMed
    tat The endogenous PPARgamma ligand 15d-PGJ2 inhibits HIV-1 Tat-induced MCP-1 production in human microglia-like cells PubMed
    tat PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB PubMed
    tat Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin PubMed
    Vif vif HIV-1 Vif downregulates the expression of peroxisome proliferator-activated receptor gamma (PPARG) in Vif-expression T cells PubMed
    matrix gag HIV-1 MA downregulates PPARG gene expression in HepG2 cells PubMed
    gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA binding domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables E-box binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables LBD domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables STAT family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables alpha-actinin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables arachidonic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables prostaglandin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein C-terminus binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables retinoid X receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables retinoid X receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to low-density lipoprotein particle stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lipid homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lipoprotein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macrophage derived foam cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of SMAD protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cellular response to transforming growth factor beta stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of cholesterol storage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of interferon-gamma-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of macrophage derived foam cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of pathway-restricted SMAD protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of pri-miRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of receptor signaling pathway via STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of sequestering of triglyceride IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of smooth muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peroxisome proliferator activated receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peroxisome proliferator activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in placenta development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of positive regulation of low-density lipoprotein receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cholesterol transporter activity IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to lipid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to lipid ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to nutrient TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in retinoic acid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in white fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in white fat cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisome proliferator-activated receptor gamma
    Names
    PPAR-gamma
    nuclear receptor subfamily 1 group C member 3
    peroxisome proliferator-activated nuclear receptor gamma variant 1
    peroxisome proliferator-activated receptor-gamma 5
    peroxisome proliferator-activated receptor-gamma splicing

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011749.1 RefSeqGene

      Range
      5001..151507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330615.4NP_001317544.2  peroxisome proliferator-activated receptor gamma isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and lacks an alternate exon in the 3' coding region, resulting in a frameshift and different 3' UTR, compared to variant 2. It encodes isoform 3, which is shorter and contains distinct N- and C-termini, compared to isoform 2. Variants 5, 11, and 12 all encode the same isoform (3).
      Source sequence(s)
      AC090947, AC091492, AC093174
      Consensus CDS
      CCDS87046.1
      Related
      ENSP00000380196.2, ENST00000397000.6
      Conserved Domains (3) summary
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
      cl11397
      Location:207243
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. NM_001354666.3NP_001341595.2  peroxisome proliferator-activated receptor gamma isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 3, 4, 7, 13, and 14, encodes isoform 1.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Consensus CDS
      CCDS2610.2
      Related
      ENSP00000380205.3, ENST00000397010.7
      Conserved Domains (3) summary
      cd06932
      Location:207474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
    3. NM_001354667.3NP_001341596.2  peroxisome proliferator-activated receptor gamma isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 3, 4, 6, 13, and 14, encodes isoform 1.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Consensus CDS
      CCDS2610.2
      Conserved Domains (3) summary
      cd06932
      Location:207474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
    4. NM_001354668.2NP_001341597.1  peroxisome proliferator-activated receptor gamma isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC090947, AC093174, AJ563369
      Conserved Domains (3) summary
      cd06965
      Location:138221
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:31108
      PPARgamma_N; PPAR gamma N-terminal region
      cl11397
      Location:237274
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    5. NM_001354669.2NP_001341598.1  peroxisome proliferator-activated receptor gamma isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC090947, AC091492, AC093174
      Conserved Domains (1) summary
      cd06932
      Location:34265
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    6. NM_001354670.2NP_001341599.1  peroxisome proliferator-activated receptor gamma isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC090947, AC091492, AJ563370
      Conserved Domains (3) summary
      cd06965
      Location:110193
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:380
      PPARgamma_N; PPAR gamma N-terminal region
      cl11397
      Location:209246
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    7. NM_001374261.3NP_001361190.2  peroxisome proliferator-activated receptor gamma isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 5 and 12, encodes isoform 3.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Conserved Domains (3) summary
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
      cl11397
      Location:207243
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    8. NM_001374262.3NP_001361191.2  peroxisome proliferator-activated receptor gamma isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 5 and 11, encodes isoform 3.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Conserved Domains (3) summary
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
      cl11397
      Location:207243
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    9. NM_001374263.2NP_001361192.2  peroxisome proliferator-activated receptor gamma isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1, 3, 4, 6, 7, and 14, encodes isoform 1.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Related
      ENSP00000507893.1, ENST00000683586.1
      Conserved Domains (3) summary
      cd06932
      Location:207474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
    10. NM_001374264.2NP_001361193.2  peroxisome proliferator-activated receptor gamma isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 1, 3, 4, 6, 7, and 13, encodes isoform 1.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Conserved Domains (3) summary
      cd06932
      Location:207474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
    11. NM_001374265.1NP_001361194.1  peroxisome proliferator-activated receptor gamma isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090947, AC093174
      Related
      ENSP00000507823.1, ENST00000683699.1
      Conserved Domains (3) summary
      cd06965
      Location:138221
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:31108
      PPARgamma_N; PPAR gamma N-terminal region
      cl11397
      Location:237273
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    12. NM_001374266.1NP_001361195.1  peroxisome proliferator-activated receptor gamma isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC090947, AC091492, AC093174
      Conserved Domains (2) summary
      cd06965
      Location:110193
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:380
      PPARgamma_N; PPAR gamma N-terminal region
    13. NM_005037.7NP_005028.5  peroxisome proliferator-activated receptor gamma isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Consensus CDS
      CCDS2610.2
      Related
      ENSP00000380210.3, ENST00000397015.7
      Conserved Domains (3) summary
      cd06932
      Location:207474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
    14. NM_015869.5NP_056953.2  peroxisome proliferator-activated receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_056953.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AC090947, AC093174
      Consensus CDS
      CCDS2609.1
      UniProtKB/Swiss-Prot
      P37231
      Related
      ENSP00000287820.6, ENST00000287820.10
      Conserved Domains (3) summary
      cd06932
      Location:237504
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:138221
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:31108
      PPARgamma_N; PPAR gamma N-terminal region
    15. NM_138711.6NP_619725.3  peroxisome proliferator-activated receptor gamma isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Consensus CDS
      CCDS2610.2
      Related
      ENSP00000498313.1, ENST00000651735.1
      Conserved Domains (3) summary
      cd06932
      Location:207474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region
    16. NM_138712.5NP_619726.3  peroxisome proliferator-activated receptor gamma isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AC090947, AC091492, AC093174
      Consensus CDS
      CCDS2610.2
      Related
      ENSP00000312472.7, ENST00000309576.11
      Conserved Domains (3) summary
      cd06932
      Location:207474
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      pfam12577
      Location:178
      PPARgamma_N; PPAR gamma N-terminal region

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      12287368..12434344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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