Conserved Protein Domain Family
NR_DBD_Ppar

?
cd06965: NR_DBD_Ppar 
Click on image for an interactive view with Cn3D
DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. PPAR interacts with specific DNA sites upstream of the target gene and modulates the rate of transcriptional initiation. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily of ligand-activated transcription factors. PPARs play important roles in regulating cellular differentiation, development and lipid metabolism. Activated PPAR forms a heterodimer with the retinoid X receptor (RXR) that binds to the hormone response elements, which are composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pair located upstream of the peroxisome proliferator responsive genes, and interacts with co-activators. Several essential fatty acids, oxidized lipids and prostaglandin J derivatives can bind and activate PPAR. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, PPAR has a central well conserved DNA binding domain (DBD), a variable N-terminal regulatory domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
BioAssay Targets and Results
?
CID: 3238389
AID: 504934
GI: 29171750
more
Late stage assay provider results from the probe development effort to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors
Chemical Name: AC1MMGHU
CID: 449459
AID: 2277
GI: 29171750
more
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors.
Chemical Name: 4-Hydroxytamoxifen
CID: 9821465
AID: 2277
GI: 29171750
more
Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors.
Chemical Name: cholecalciferol
Statistics
?
PSSM-Id: 143523
View PSSM: cd06965
Aligned: 8 rows
Threshold Bit Score: 165.338
Threshold Setting Gi: 72164991
Created: 24-Nov-2008
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
Hierarchy
?
Display:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:zinc binding site [ion binding site]
Evidence:
  • Structure:3DZU_d; Zn binding site of human Rxr Alpha Nuclear Receptor Complex DNA binding domain, contacts determined at 3.5A
    View structure with Cn3D
  • Comment:Zinc finger, C4-type: The domain contains two groups of four Cys residues. Each group is involved in the co-ordination of a single zinc atom.

cd06965 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd06965 is a member of the superfamily cl02596.
cd06916:NR_DBD_likecd06955:NR_DBD_VDRcd06956:NR_DBD_RXRcd06957:NR_DBD_PNR_like_2cd06958:NR_DBD_COUP_TFcd06959:NR_DBD_EcR_likecd06960:NR_DBD_HNF4Acd06961:NR_DBD_TRcd06962:NR_DBD_FXRcd06963:NR_DBD_GR_likecd06964:NR_DBD_RARcd06965:NR_DBD_Pparcd06966:NR_DBD_CARcd06967:NR_DBD_TR2_likecd06968:NR_DBD_RORcd06969:NR_DBD_NGFI-Bcd06970:NR_DBD_PNRcd07154:NR_DBD_PNR_likecd07155:NR_DBD_ER_likecd07156:NR_DBD_VDR_likecd07157:2DBD_NR_DBD1cd07158:NR_DBD_Ppar_likecd07160:NR_DBD_LXRcd07161:NR_DBD_EcRcd07162:NR_DBD_PXRcd07163:NR_DBD_TLXcd07164:NR_DBD_PNR_like_1cd07165:NR_DBD_DmE78_likecd07166:NR_DBD_REV_ERBcd07167:NR_DBD_Lrh-1_likecd07168:NR_DBD_DHR4_likecd07169:NR_DBD_GCNF_likecd07170:NR_DBD_ERRcd07171:NR_DBD_ERcd07172:NR_DBD_GR_PRcd07173:NR_DBD_ARcd07179:2DBD_NR_DBD2115899356721649911183439623DZU D47825369198282033585719219413322115899356721649911183439623DZU D47825369198282033585719219413322
cd06965 Sequence Cluster
cd06965 Sequence Cluster
Sub-family Hierarchy
Click to see CD Hierarchy help
 cd06965 Branch
 Whole Hierarchy
 [Download CDTree]
CD Hierarchy
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  #             #  #               #         #         #  #                   
3DZU_D        52 ECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLN-----CRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGR 126
gi 219413322  47 PCKICNDKASGFHYGVHSCEGCKGFFRRTIRKSLTYKPCDGS-----CTVHRRSRNKCQYCRFQKCLNAGMSHDSVRFGR 121
gi 118343962  48 LCKVCGDKASGFHYGVHACEGCKGFFRRTIRLKIEYETCVQS-----CKVDLKSRNKCQFCRFKKCVGLGMSRDAIRFGR 122
gi 198282033 154 ECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLVYDHCDLH-----CRIHKKSRNKCQYCRFQKCLMVGMSHNAIRFGR 228
gi 47825369  108 ECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLN-----CRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGR 182
gi 585719    108 ECRVCSDKASGFHYGVHACEGCKGFFRRTIRLKLVYDRCERM-----CKIQKKNRNKCQYCRFEKCLNVGMSHNAIRFGR 182
gi 115899356 107 RCQICGDKASGMHYGVYSCEGCKGFFRRTQRLKIDYKPCPYWgqpdgCIVNIGTRNKCQYCRYQKCIILGMSSTAVRMGR 186
gi 72164991   23 KCRVCGDKASGFHYGVHSCEGCKGFFRRTHRMKLVYKPCPFVkt-epCKINIATRNKCQYCRFQKCMQVGMSHDASRFGR 101

                 ....*....
Feature 1                 
3DZU_D       127 MPQAEKEKL 135
gi 219413322 122 MPKVEREKI 130
gi 118343962 123 MPRHEKQQI 131
gi 198282033 229 MPQAEKEKL 237
gi 47825369  183 MPQAEKEKL 191
gi 585719    183 MPRSEKAKL 191
gi 115899356 187 VPKVEVLKL 195
gi 72164991  102 MPREERLRL 110

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap