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Pparg peroxisome proliferator activated receptor gamma [ Mus musculus (house mouse) ]

Gene ID: 19016, updated on 27-Feb-2024

Summary

Official Symbol
Ppargprovided by MGI
Official Full Name
peroxisome proliferator activated receptor gammaprovided by MGI
Primary source
MGI:MGI:97747
See related
Ensembl:ENSMUSG00000000440 AllianceGenome:MGI:97747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nr1c3; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2
Summary
This gene encodes a nuclear receptor protein belonging to the peroxisome proliferator-activated receptor (Ppar) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to DNA motifs termed "peroxisome proliferator response elements" to either activate or inhibit gene expression. Mice lacking the encoded protein die at an embryonic stage due to severe defects in placental vascularization. When the embryos lacking this gene are supplemented with healthy placentas, the mutants survive to term, but succumb to lipodystrophy and multiple hemorrhages. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 32.5), mammary gland adult (RPKM 26.1) and 13 other tissues See more
Orthologs
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Genomic context

See Pparg in Genome Data Viewer
Location:
6 E3; 6 53.41 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115337828..115467365)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115360879..115490404)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38877 Neighboring gene predicted gene, 38878 Neighboring gene predicted gene, 36301 Neighboring gene predicted gene, 36355

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (36)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding domain binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables LBD domain binding ISO
Inferred from Sequence Orthology
more info
 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lithium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within diet induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in lipoprotein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of connective tissue replacement involved in inflammatory response wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microglial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuroinflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pancreatic stellate cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptide hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome proliferator activated receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of SMAD protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of adiponectin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of adipose tissue development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of low-density lipoprotein receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to insulin stimulus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to dietary excess IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to food IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to light stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within white fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within_negative_effect wound healing involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of SUMO ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisome proliferator-activated receptor gamma
Names
nuclear receptor subfamily 1 group C member 3
peroxisome proliferator activated receptor gamma 2
peroxisome proliferator activated receptor gamma 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127330.3NP_001120802.1  peroxisome proliferator-activated receptor gamma isoform 1

    See identical proteins and their annotated locations for NP_001120802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 2. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC153828, AC171970
    Consensus CDS
    CCDS51876.1
    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, M1VPI1, Q4FJR2
    Related
    ENSMUSP00000131962.2, ENSMUST00000171644.8
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  2. NM_001308352.2NP_001295281.1  peroxisome proliferator-activated receptor gamma isoform 1

    See identical proteins and their annotated locations for NP_001295281.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 2. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC153828, AC171970
    Consensus CDS
    CCDS51876.1
    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, M1VPI1, Q4FJR2
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  3. NM_001308354.2NP_001295283.1  peroxisome proliferator-activated receptor gamma isoform 1

    See identical proteins and their annotated locations for NP_001295283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 2. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC153828, AC171970
    Consensus CDS
    CCDS51876.1
    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, M1VPI1, Q4FJR2
    Related
    ENSMUSP00000145525.2, ENSMUST00000203732.3
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  4. NM_001410262.1NP_001397191.1  peroxisome proliferator-activated receptor gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC153828, AC171970
    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, M1VPI1, Q4FJR2
  5. NM_011146.4NP_035276.2  peroxisome proliferator-activated receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_035276.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AC153828, AC171970
    Consensus CDS
    CCDS20439.1
    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, Q4FJR2, Q6GU14
    Related
    ENSMUSP00000000450.4, ENSMUST00000000450.5
    Conserved Domains (3) summary
    cd06932
    Location:237504
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:138221
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:31108
    PPARgamma_N; PPAR gamma N-terminal region

RNA

  1. NR_176969.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153828, AC171970
  2. NR_176970.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153828, AC171970
  3. NR_176971.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153828, AC171970

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    115337828..115467365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505743.4XP_006505806.1  peroxisome proliferator-activated receptor gamma isoform X2

    See identical proteins and their annotated locations for XP_006505806.1

    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, M1VPI1, Q4FJR2
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  2. XM_006505739.4XP_006505802.1  peroxisome proliferator-activated receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_006505802.1

    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, Q4FJR2
    Conserved Domains (3) summary
    cd06932
    Location:232499
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:133216
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:26103
    PPARgamma_N; PPAR gamma N-terminal region
  3. XM_017321455.3XP_017176944.1  peroxisome proliferator-activated receptor gamma isoform X2

    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, M1VPI1, Q4FJR2
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  4. XM_006505738.5XP_006505801.1  peroxisome proliferator-activated receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_006505801.1

    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, Q4FJR2
    Conserved Domains (3) summary
    cd06932
    Location:232499
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:133216
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:26103
    PPARgamma_N; PPAR gamma N-terminal region
  5. XM_011241252.1XP_011239554.1  peroxisome proliferator-activated receptor gamma isoform X2

    See identical proteins and their annotated locations for XP_011239554.1

    UniProtKB/Swiss-Prot
    P37238
    UniProtKB/TrEMBL
    A0N0C8, M1VPI1, Q4FJR2
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region

RNA

  1. XR_001785108.2 RNA Sequence