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    EPB41 erythrocyte membrane protein band 4.1 [ Homo sapiens (human) ]

    Gene ID: 2035, updated on 4-Jul-2021

    Summary

    Official Symbol
    EPB41provided by HGNC
    Official Full Name
    erythrocyte membrane protein band 4.1provided by HGNC
    Primary source
    HGNC:HGNC:3377
    See related
    Ensembl:ENSG00000159023 MIM:130500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HE; EL1; 4.1R
    Summary
    The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.2), lymph node (RPKM 8.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EPB41 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28887100..29120041)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (29213612..29446553)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 282 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4082 Neighboring gene ribosomal protein L27 pseudogene 4 Neighboring gene transmembrane protein 200B Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Elliptocytosis 1
    MedGen: C2678497 OMIM: 611804 GeneReviews: Not available
    Compare labs
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) (EPB41) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated erythrocyte membrane protein band 4.1 (EPB41) protein is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein C-terminus binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein N-terminus binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables spectrin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of intestinal absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell cortex region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in spectrin-associated cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    protein 4.1
    Names
    EPB4.1
    P4.1
    band 4.1
    elliptocytosis 1, RH-linked
    erythrocyte surface protein band 4.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013344.1 RefSeqGene

      Range
      5001..237956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001166005.2NP_001159477.1  protein 4.1 isoform 1

      See identical proteins and their annotated locations for NP_001159477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL009181, AL138785, AL357500
      Consensus CDS
      CCDS53288.1
      UniProtKB/Swiss-Prot
      P11171
      UniProtKB/TrEMBL
      Q1WWM3, Q59F12
      Related
      ENSP00000362904.1, ENST00000373798.5
      Conserved Domains (5) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668715
      SAB; SAB domain
      pfam05902
      Location:754860
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    2. NM_001166006.2NP_001159478.1  protein 4.1 isoform 3

      See identical proteins and their annotated locations for NP_001159478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs at the 5' and 3' ends, and is missing an internal, in-frame coding exon compared to variant 1, resulting in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL009181, BC039079, DA480006
      Consensus CDS
      CCDS53289.1
      UniProtKB/Swiss-Prot
      P11171
      Related
      ENSP00000362903.1, ENST00000373797.2
      Conserved Domains (6) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:653699
      SAB; SAB domain
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    3. NM_001166007.2NP_001159479.1  protein 4.1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate acceptor splice site at an exon at the 5' end, and is missing three short, internal, in-frame coding exons compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (5) compared to isoform 1.
      Source sequence(s)
      AB209649, AI076831, BC113841
      Consensus CDS
      CCDS85947.1
      UniProtKB/TrEMBL
      Q29RX4, Q59F12
      Related
      ENSP00000496326.1, ENST00000647103.1
      Conserved Domains (7) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:87192
      FERM_M; FERM central domain
      pfam04382
      Location:406450
      SAB; SAB domain
      pfam05902
      Location:491597
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
      pfam09379
      Location:565
      FERM_N; FERM N-terminal domain
    4. NM_001376013.1NP_001362942.1  protein 4.1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000345259.4, ENST00000343067.9
      Conserved Domains (5) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668715
      SAB; SAB domain
      pfam05902
      Location:754860
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    5. NM_001376014.1NP_001362943.1  protein 4.1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000317597.8, ENST00000349460.9
      Conserved Domains (5) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:633680
      SAB; SAB domain
      pfam05902
      Location:731837
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    6. NM_001376015.1NP_001362944.1  protein 4.1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Conserved Domains (5) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:633680
      SAB; SAB domain
      pfam05902
      Location:719825
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    7. NM_001376016.1NP_001362945.1  protein 4.1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000498003.1, ENST00000650265.1
      Conserved Domains (4) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668715
      SAB; SAB domain
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    8. NM_001376017.1NP_001362946.1  protein 4.1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000494945.1, ENST00000644600.1
      Conserved Domains (4) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668715
      SAB; SAB domain
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    9. NM_001376018.1NP_001362947.1  protein 4.1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Conserved Domains (4) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:667714
      SAB; SAB domain
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    10. NM_001376019.1NP_001362948.1  protein 4.1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000494435.1, ENST00000643604.1
      Conserved Domains (4) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:668715
      SAB; SAB domain
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    11. NM_001376020.1NP_001362949.1  protein 4.1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Conserved Domains (4) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:667714
      SAB; SAB domain
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    12. NM_001376021.1NP_001362950.1  protein 4.1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Conserved Domains (4) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:615661
      SAB; SAB domain
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
    13. NM_001376022.1NP_001362951.1  protein 4.1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000494212.1, ENST00000642937.2
      Conserved Domains (5) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:459506
      SAB; SAB domain
      pfam05902
      Location:545651
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
    14. NM_001376023.1NP_001362952.1  protein 4.1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000496138.1, ENST00000646189.1
      Conserved Domains (4) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:459506
      SAB; SAB domain
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
    15. NM_001376024.1NP_001362953.1  protein 4.1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Conserved Domains (4) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:459506
      SAB; SAB domain
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
    16. NM_001376025.1NP_001362954.1  protein 4.1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000493575.1, ENST00000646800.1
      Conserved Domains (4) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:459506
      SAB; SAB domain
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
    17. NM_001376026.1NP_001362955.1  protein 4.1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Related
      ENSP00000495138.1, ENST00000644342.1
      Conserved Domains (4) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:423470
      SAB; SAB domain
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
    18. NM_001376027.1NP_001362956.1  protein 4.1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Conserved Domains (4) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:406452
      SAB; SAB domain
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
    19. NM_001376028.1NP_001362957.1  protein 4.1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL009181, AL138785, AL357500
      Conserved Domains (4) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:405451
      SAB; SAB domain
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
    20. NM_004437.4NP_004428.1  protein 4.1 isoform 6

      See identical proteins and their annotated locations for NP_004428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate acceptor splice site at an exon at the 5' end, and is missing several short, internal, in-frame coding exons compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (6) compared to isoform 1.
      Source sequence(s)
      AB209649, AI076831, AL138785, BC039079, M14993
      Consensus CDS
      CCDS331.1
      UniProtKB/Swiss-Prot
      P11171
      UniProtKB/TrEMBL
      Q59F12
      Related
      ENSP00000362906.3, ENST00000373800.7
      Conserved Domains (7) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:87192
      FERM_M; FERM central domain
      pfam04382
      Location:425471
      SAB; SAB domain
      pfam05902
      Location:512584
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
      pfam09379
      Location:565
      FERM_N; FERM N-terminal domain
    21. NM_203342.3NP_976217.1  protein 4.1 isoform 4

      See identical proteins and their annotated locations for NP_976217.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional exon at the 5' end, and is missing an internal, in-frame coding exon compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (4) compared to isoform 1.
      Source sequence(s)
      AB209649, AI076831, AL138785, BC039079, J03796
      Consensus CDS
      CCDS332.1
      UniProtKB/Swiss-Prot
      P11171
      UniProtKB/TrEMBL
      Q59F12
      Conserved Domains (7) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:87192
      FERM_M; FERM central domain
      pfam04382
      Location:444490
      SAB; SAB domain
      pfam05902
      Location:531637
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
      pfam09379
      Location:565
      FERM_N; FERM N-terminal domain
    22. NM_203343.3NP_976218.1  protein 4.1 isoform 2

      See identical proteins and their annotated locations for NP_976218.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing several short, internal, in-frame coding exons compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1.
      Source sequence(s)
      AB209649, AI076831, J03796
      Consensus CDS
      CCDS330.1
      UniProtKB/TrEMBL
      Q59F12
      Related
      ENSP00000290100.6, ENST00000347529.7
      Conserved Domains (6) summary
      smart00295
      Location:211366
      B41; Band 4.1 homologues
      cd13184
      Location:361454
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:261366
      FERM_M; FERM central domain
      pfam04382
      Location:580624
      SAB; SAB domain
      pfam05902
      Location:665771
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:464506
      FA; FERM adjacent (FA)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      28887100..29120041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540964.1XP_011539266.1  protein 4.1 isoform X35

      Conserved Domains (7) summary
      smart00295
      Location:2192
      B41; Band 4.1 homologues
      cd13184
      Location:187280
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:87192
      FERM_M; FERM central domain
      pfam04382
      Location:458504
      SAB; SAB domain
      pfam05902
      Location:712818
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:290332
      FA; FERM adjacent (FA)
      pfam09379
      Location:565
      FERM_N; FERM N-terminal domain
    2. XM_017000595.1XP_016856084.1  protein 4.1 isoform X38

    3. XM_017000594.1XP_016856083.1  protein 4.1 isoform X37

    4. XM_017000596.1XP_016856085.1  protein 4.1 isoform X40

    5. XM_017000593.1XP_016856082.1  protein 4.1 isoform X36

    6. XM_017000597.1XP_016856086.1  protein 4.1 isoform X41

    7. XM_024453880.1XP_024309648.1  protein 4.1 isoform X39

      Conserved Domains (5) summary
      smart00295
      Location:2157
      B41; Band 4.1 homologues
      cd13184
      Location:152245
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:423469
      SAB; SAB domain
      pfam05902
      Location:677783
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:255297
      FA; FERM adjacent (FA)
    8. XM_017000584.2XP_016856073.1  protein 4.1 isoform X1

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam05902
      Location:9211027
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    9. XM_017000585.2XP_016856074.1  protein 4.1 isoform X12

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:615659
      SAB; SAB domain
      pfam05902
      Location:867973
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    10. XM_011540956.1XP_011539258.1  protein 4.1 isoform X1

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam05902
      Location:9211027
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    11. XM_011540958.1XP_011539260.1  protein 4.1 isoform X4

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam05902
      Location:9081014
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    12. XM_005245760.1XP_005245817.1  protein 4.1 isoform X14

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam05902
      Location:771877
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    13. XM_006710434.1XP_006710497.1  protein 4.1 isoform X3

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam05902
      Location:9161022
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    14. XM_006710439.1XP_006710502.1  protein 4.1 isoform X15

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam05902
      Location:766872
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    15. XM_005245753.1XP_005245810.1  protein 4.1 isoform X6

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam05902
      Location:9041010
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    16. XM_005245768.1XP_005245825.1  protein 4.1 isoform X22

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam05902
      Location:731817
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    17. XM_011540959.1XP_011539261.1  protein 4.1 isoform X5

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:653699
      SAB; SAB domain
      pfam05902
      Location:9071013
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    18. XM_005245763.1XP_005245820.1  protein 4.1 isoform X17

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:653699
      SAB; SAB domain
      pfam05902
      Location:740846
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    19. XM_011540961.1XP_011539263.1  protein 4.1 isoform X8

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:633678
      SAB; SAB domain
      pfam05902
      Location:886992
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    20. XM_005245757.1XP_005245814.1  protein 4.1 isoform X11

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:633678
      SAB; SAB domain
      pfam05902
      Location:869975
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    21. XM_011540960.1XP_011539262.1  protein 4.1 isoform X7

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:634680
      SAB; SAB domain
      pfam05902
      Location:888994
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    22. XM_005245764.1XP_005245821.1  protein 4.1 isoform X19

      See identical proteins and their annotated locations for XP_005245821.1

      UniProtKB/Swiss-Prot
      P11171
      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:634680
      SAB; SAB domain
      pfam05902
      Location:721827
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    23. XM_011540962.1XP_011539264.1  protein 4.1 isoform X12

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:615659
      SAB; SAB domain
      pfam05902
      Location:867973
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    24. XM_005245769.1XP_005245826.1  protein 4.1 isoform X23

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:615659
      SAB; SAB domain
      pfam05902
      Location:700806
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    25. XM_005245774.1XP_005245831.1  protein 4.1 isoform X32

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:615659
      SAB; SAB domain
      pfam05902
      Location:677763
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    26. XM_011540957.1XP_011539259.1  protein 4.1 isoform X2

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:666712
      SAB; SAB domain
      pfam05902
      Location:9201026
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    27. XM_017000583.1XP_016856072.1  protein 4.1 isoform X13

    28. XM_005245770.1XP_005245827.1  protein 4.1 isoform X24

      Conserved Domains (7) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:614658
      SAB; SAB domain
      pfam05902
      Location:699805
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    29. XM_017000581.1XP_016856070.1  protein 4.1 isoform X9

    30. XM_017000589.1XP_016856078.1  protein 4.1 isoform X29

      UniProtKB/Swiss-Prot
      P11171
      Conserved Domains (6) summary
      smart00295
      Location:211366
      B41; Band 4.1 homologues
      cd13184
      Location:361454
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:261366
      FERM_M; FERM central domain
      pfam04382
      Location:580624
      SAB; SAB domain
      pfam05902
      Location:665771
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:464506
      FA; FERM adjacent (FA)
    31. XM_017000582.1XP_016856071.1  protein 4.1 isoform X10

    32. XM_017000590.1XP_016856079.1  protein 4.1 isoform X30

    33. XM_011540965.3XP_011539267.1  protein 4.1 isoform X31

      Conserved Domains (6) summary
      smart00295
      Location:211401
      B41; Band 4.1 homologues
      cd13184
      Location:396489
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:296401
      FERM_M; FERM central domain
      pfam04382
      Location:667713
      SAB; SAB domain
      pfam08736
      Location:499541
      FA; FERM adjacent (FA)
      pfam09379
      Location:214274
      FERM_N; FERM N-terminal domain
    34. XM_017000592.1XP_016856081.1  protein 4.1 isoform X34

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