3QIJ,3IVF,1H4R,2I1J,3PVL,2J0M,3PZD


Conserved Protein Domain Family
B41

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smart00295: B41 
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Band 4.1 homologues
Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.
Statistics
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PSSM-Id: 214604
View PSSM: smart00295
Aligned: 62 rows
Threshold Bit Score: 68.4758
Threshold Setting Gi: 201861823
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QIJ_A         19 HCKVSLLDDT--VYECVVEKHAKGQDLLKRVCEHLNL-------LEE-DYFGLAIWD-NATs-------------K---- 70
gi 75098088   280 TTIVFFLDET--FEEITYDMATTVADAIEEVAGIIKL-------SAH-ASFSLFECRkVVTgskspd---pgneeY---- 342
gi 122108290 2242 RQAFYISKDH--NVSQTLRPITVAEEMIQELCNLLNVrs----lHEQ-QEFSLCYTVgKDKh-------------L---- 2297
gi 74765115   282 TCKIRFIDQS--TKLAKINTYTTIREITDTVCRQYGIs-----qQSI-KMFGISAVNeTAGis----------kvV---- 339
gi 77432385   421 KVRIYRMDGSyrSVELKHGNNTTVQQIMEGMRLSQETqqyftiwICS-ENLSLQLKPyHKPlq----------hvR---- 485
gi 297268811 1311 MLPVTFMDGT--TKTLLTDSATTAKELCNALADKISL-------KDR-FGFSLYIALfDKVsslgsgsdhvmdaiS---- 1376
gi 17568553  1174 VLAVTFMDGS--VKTLCADSATTAAELCKQLAEKVGL-------TNS-FGFSLYIALfDKVsslgsgtdhvmdaiS---- 1239
gi 194380708  580 TSTVYCHGGG--SCKITINSHTTAGEVVEKLIRGLAMe------DSR-NMFALFEYNgHVDk-------------Aiesr 637
3PVL_A        265 MLPVTFMDGT--TKTLLTDSATTARELCNALADKISL-------KDR-FGFSLYIALfDKVsslgsgsdhvmdaiS---- 330
3PZD_A        201 TSTVYCHGGG--SCKITINSHTTAGEVVEKLIRGLAM-------EDSrNMFALFEYNgHVDkaiesrt-vvadvlA---- 266
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QIJ_A         71 --------TWLDSAKEIKKQ-VRg-----------VPWNFTFNVKFYPPD--------PAQLTEDITRY--YLCLQLRQD 120
gi 75098088   343 --------ICLDENKYIGDLlEDfkalkdrskgeiLHCKLSFKKKLFRES--------DEAVTEPMFVQ--LSYVQLQHD 404
gi 122108290 2298 --------NYCKNDNYLMDIiTEseh-------kkLPFQFYLKRTVWVHP-----------LRYDNAAYidSMFDQVIDD 2351
gi 74765115   340 --------SETDMIYDVLARwEQse--------ekGEFYFQVRRRFFLDDvnkildqeHLWTDDDICFE--LTYCQIRDE 401
gi 77432385   486 --------DWPEILAELTNLdPQr-----------ETPQLFLRRDVRLPLe-------VEKQIEDPLAIl-ILFDEARYN 538
gi 297268811 1377 --------QCEQYAKEQGAQeRN------------APWRLFFRKEVFTPW--------HS-PSEDNVATn-LIYQQVVRG 1426
gi 17568553  1240 --------QCEQYAKEQGRQeRN------------APWRLFFRKEIFSPW---------HDPRDDPVSTn-LIYQQVIRG 1289
gi 194380708  638 tvvadvlaKFEKLAATSEVGd--------------LPWKFYFKLYCFLDT--------DNVPK-DSVEFa-FMFEQAHEA 693
3PVL_A        331 --------QCEQYAKEQGAQeRN------------APWRLFFRKEVFTPW--------HN-PSEDNVATn-LIYQQVVRG 380
3PZD_A        267 --------KFEKLAATSEVGd--------------LPWKFYFKLYCFLDT--------DNVPK-DSVEFa-FMFEQAHEA 314
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QIJ_A        121 IVAGRLPCS----------FA-TLALLGSYTIQSELGDYDPElh---gvDYVSD-------------FKLAP-------- 165
gi 75098088   405 YIMGNYPVG----------KD-DAAQMSALQILVDIGYVDGPesc--tdWTSLL-------------ERFLP-------- 450
gi 122108290 2352 YLRGSLISTnslgqltaatTE-EIIKLAAYLFLLL-PDNPKGl------NAKTL-------------PQIVP-------- 2402
gi 74765115   402 WMKGLYTNVn---------EK-DSSIIAAILIQLLYPNQSKLv-----lTKEVV-------------RQVLP-------- 445
gi 77432385   539 LLKGFYTAP----------DA-KLITLASLLLQIVYGNYESKkhkqgflNEENL-------------KSIVP-------- 586
gi 297268811 1427 VKFGEYRCE----------KEdDLAELASQQYFVDYGSEMILe-----rLLNLV-------------PTYIP-------- 1470
gi 17568553  1290 IKYGEYRCDk---------DE-ELAAICAQQYYIDEGTMDVNk------lENNL-------------PSYLP-------- 1332
gi 194380708  694 VIHGHHPAP----------EE-NLQVLAALRLQYLQGDYTLHaai--ppLEEVYslqrlkarisqstKTFTPcerlekrr 760
3PVL_A        381 VKFGEYRCE----------KEdDLAELASQQYFVDYG---SEmil--erLLSLV-------------PTYIP-------- 424
3PZD_A        315 VIHGHHPAP----------EE-NLQVLAALRLQYLQGDYTLHaai--ppLEEVY-------------SLQRL-------- 360
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QIJ_A        166 ----NQT--------KEL-----------EEK---------------------VMELHK-SY-----RS-M--TPAQA-D 191
gi 75098088   451 ----RQIamt--rakREW-----------ELD---------------------ILSRYK-LM-----EN-L--TKDDA-K 482
gi 122108290 2403 ----KSViepkhrhqEEM-----------VTR---------------------ISRQLK-MFg----GR-M--RPAEA-K 2437
gi 74765115   446 ----DQIlns--qniKVW-----------ISM---------------------IESQIF-EL-----VS-Q--TPEYL-K 477
gi 77432385   587 ----VTKlks---kaPHW-----------TNR---------------------ILHEYK-NLstsegVS-K--EMHHL-Q 622
gi 297268811 1471 ----DREitpl-ktlEKW-----------AQL---------------------AIAAHK-KG-----IYaQ--RRTDA-Q 1504
gi 17568553  1333 ----DFEmsgkemalEKW-----------TQT---------------------IMHQYRkKF-----TG-RlpSQIEV-K 1369
gi 194380708  761 tsflEGTlrrsfrtgSVV-----------RQKveeeqmldmwikeevssarasIIDKWR-KF-----QG-M--NQEQA-M 819
3PVL_A        425 ----DREitpl-knlEKW-----------AQL---------------------AIAAHK-KG-----IYaQ--RRTDSqK 459
3PZD_A        361 ----KARisqs-tktQMLdmwikeevssaRAS---------------------IIDKWR-KF-----QG-M--NQEQA-M 404
                         330       340
                  ....*....|....*....|..
3QIJ_A        192 LE--FLENAK-KLS-MYGVDLH 209
gi 75098088   483 QQ--FLRILR-TLP--YGNSVF 499
gi 122108290 2438 SH--FLELLS-TWP-TFGVLHY 2455
gi 74765115   478 LM--FINLIG-SKSpLFGCTLF 496
gi 77432385   623 RM--FLQNCW-EIP-TYGAAFF 640
gi 297268811 1505 -K--VKEDVV-NYA-RFKWPLl 1521
gi 17568553  1370 EN--VVSVAKtKWP-LLFSRFY 1388
gi 194380708  820 AK--YMALIK-EWP-GYGSTLF 837
3PVL_A        460 VKedVVNYARfKWP-LLFSRFY 480
3PZD_A        405 AK--YMALIK-EWP-GYGSTLF 422
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