Format

Send to:

Choose Destination

PLA2G4C phospholipase A2 group IVC [ Homo sapiens (human) ]

Gene ID: 8605, updated on 8-Jul-2021

Summary

Official Symbol
PLA2G4Cprovided by HGNC
Official Full Name
phospholipase A2 group IVCprovided by HGNC
Primary source
HGNC:HGNC:9037
See related
Ensembl:ENSG00000105499 MIM:603602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPLA2-gamma
Summary
This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in brain (RPKM 6.1), heart (RPKM 5.7) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PLA2G4C in Genome Data Viewer
Location:
19q13.33
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48047846..48111383, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48551103..48614074, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene binder of sperm protein homolog 1 Neighboring gene epididymal sperm binding protein 1 Neighboring gene calcium binding protein 5 Neighboring gene PLA2G4C antisense RNA 1 Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene zinc finger SWIM-type containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
Tat tat HIV-1 Tat upregulates phospholipase A2, group IVC (PLA2G4C) expression in Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42247, FLJ44164, DKFZp586C0423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysophospholipase activity TAS
Traceable Author Statement
more info
 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity TAS
Traceable Author Statement
more info
 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytosolic phospholipase A2 gamma
Names
cytosolic lysophospholipase
cytosolic lysophospholipid O-acyltransferase
phospholipase A2, group IVC (cytosolic, calcium-independent)
NP_001152794.1
NP_001152795.1
NP_003697.2
XP_011525733.1
XP_011525734.1
XP_011525735.1
XP_016882900.1
XP_016882901.1
XP_016882902.1
XP_016882903.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016021.1 RefSeqGene

    Range
    5036..68007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159322.2NP_001152794.1  cytosolic phospholipase A2 gamma isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC010458, AC011466, AK295400
    Consensus CDS
    CCDS59403.1
    UniProtKB/Swiss-Prot
    Q9UP65
    Related
    ENSP00000472546.1, ENST00000599111.5
    Conserved Domains (1) summary
    cd07202
    Location:19539
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
  2. NM_001159323.2NP_001152795.1  cytosolic phospholipase A2 gamma isoform 3

    See identical proteins and their annotated locations for NP_001152795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC010458, AC011466, AK022440
    Consensus CDS
    CCDS54286.1
    UniProtKB/Swiss-Prot
    Q9UP65
    Related
    ENSP00000346228.2, ENST00000354276.7
    Conserved Domains (1) summary
    cd07202
    Location:4527
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
  3. NM_003706.3NP_003697.2  cytosolic phospholipase A2 gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_003697.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AC010458, AC011466, BC063416
    Consensus CDS
    CCDS12710.1
    UniProtKB/Swiss-Prot
    Q9UP65
    UniProtKB/TrEMBL
    A0A024QZH0
    Related
    ENSP00000469473.1, ENST00000599921.6
    Conserved Domains (1) summary
    cd07202
    Location:4529
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48047846..48111383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527431.3XP_011525733.1  cytosolic phospholipase A2 gamma isoform X1

    Conserved Domains (1) summary
    cd07202
    Location:4511
    cPLA2_Grp-IVC; Group IVC cytoplasmic phospholipase A2; catalytic domain; Ca-independent
  2. XM_017027411.2XP_016882900.1  cytosolic phospholipase A2 gamma isoform X2

  3. XM_017027412.2XP_016882901.1  cytosolic phospholipase A2 gamma isoform X5

    Conserved Domains (1) summary
    cl11396
    Location:10350
    Patatin_and_cPLA2; Patatins and Phospholipases
  4. XM_017027413.2XP_016882902.1  cytosolic phospholipase A2 gamma isoform X6

  5. XM_011527432.3XP_011525734.1  cytosolic phospholipase A2 gamma isoform X3

    Conserved Domains (1) summary
    cl11396
    Location:4425
    Patatin_and_cPLA2; Patatins and Phospholipases
  6. XM_011527433.3XP_011525735.1  cytosolic phospholipase A2 gamma isoform X4

    See identical proteins and their annotated locations for XP_011525735.1

    Conserved Domains (1) summary
    cl11396
    Location:4253
    Patatin_and_cPLA2; Patatins and Phospholipases
  7. XM_017027414.2XP_016882903.1  cytosolic phospholipase A2 gamma isoform X7

Support Center