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LRRIQ1 leucine rich repeats and IQ motif containing 1 [ Homo sapiens (human) ]

Gene ID: 84125, updated on 23-Nov-2021

Summary

Official Symbol
LRRIQ1provided by HGNC
Official Full Name
leucine rich repeats and IQ motif containing 1provided by HGNC
Primary source
HGNC:HGNC:25708
See related
Ensembl:ENSG00000133640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 3.9), lung (RPKM 0.9) and 4 other tissues See more
Orthologs
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Genomic context

See LRRIQ1 in Genome Data Viewer
Location:
12q21.31
Exon count:
37
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (85036351..85273060)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (85430129..85638883)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724680 Neighboring gene Sharpr-MPRA regulatory region 14945 Neighboring gene tetraspanin 19 Neighboring gene Sharpr-MPRA regulatory region 9199 Neighboring gene long intergenic non-protein coding RNA 2820 Neighboring gene ALX homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of leucine-rich repeats and IQ motif containing 1 (LRRIQ1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12303

General protein information

Preferred Names
leucine-rich repeat and IQ domain-containing protein 1
Names
testicular tissue protein Li 111

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079910.2NP_001073379.1  leucine-rich repeat and IQ domain-containing protein 1

    See identical proteins and their annotated locations for NP_001073379.1

    Status: VALIDATED

    Source sequence(s)
    AB058704, AC079631, AU122206, BU608190, BU677204, CA502842, DB447399, DN831755
    Consensus CDS
    CCDS41816.1
    UniProtKB/Swiss-Prot
    Q96JM4
    UniProtKB/TrEMBL
    A0A140VJN5
    Related
    ENSP00000376910.2, ENST00000393217.7
    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    cd00116
    Location:9631095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    85036351..85273060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538819.3XP_011537121.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X3

    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    cd00116
    Location:9631095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
  2. XM_024449222.1XP_024304990.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X7

    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
    cl26018
    Location:9711108
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26511
    Location:162644
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_011538817.2XP_011537119.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    cd00116
    Location:9631095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
    pfam14988
    Location:164343
    DUF4515; Domain of unknown function (DUF4515)
  4. XM_024449221.1XP_024304989.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X6

    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
    cl26018
    Location:9711108
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26511
    Location:162644
    Neuromodulin_N; Gap junction protein N-terminal region
  5. XM_011538818.2XP_011537120.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X2

    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    cd00116
    Location:9631095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
  6. XM_024449220.1XP_024304988.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X5

    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
    cl26018
    Location:9711108
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26511
    Location:162644
    Neuromodulin_N; Gap junction protein N-terminal region
  7. XM_017020019.1XP_016875508.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q96JM4
    UniProtKB/TrEMBL
    A0A140VJN5
    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    cd00116
    Location:9631095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
  8. XM_024449223.1XP_024304991.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X8

    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
    cl26018
    Location:9711108
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26511
    Location:162644
    Neuromodulin_N; Gap junction protein N-terminal region
  9. XM_011538823.2XP_011537125.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X9

    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    cd00116
    Location:9631095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
  10. XM_011538824.2XP_011537126.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X10

    Related
    ENST00000525971.6
    Conserved Domains (5) summary
    smart00015
    Location:13381354
    IQ; Calmodulin-binding motif
    cd00116
    Location:9631095
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:10371091
    LRR_8; Leucine rich repeat
  11. XM_011538825.2XP_011537127.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X11

    Conserved Domains (3) summary
    sd00033
    Location:820841
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:818856
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:10151070
    LRR_8; Leucine rich repeat

RNA

  1. XR_944764.2 RNA Sequence

  2. XR_944765.2 RNA Sequence

  3. XR_944766.2 RNA Sequence

  4. XR_001748890.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032165.3: Suppressed sequence

    Description
    NM_032165.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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