2BNH,1A4Y,1YRG


Conserved Protein Domain Family
LRR_RI

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cd00116: LRR_RI 
Click on image for an interactive view with Cn3D
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Statistics
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PSSM-Id: 238064
View PSSM: cd00116
Aligned: 16 rows
Threshold Bit Score: 155.206
Threshold Setting Gi: 2498405
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
SubstrateLeucine-rich
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:Substrate binding site [chemical binding site]
Evidence:
  • Citation:PMID 9311977
  • Comment:Contacts in the human ribonuclease inhibitor-angiogenin complex structure.
  • Structure:1A4Y; hRI with bound angiogenin
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            ##                                        
2BNH         2 MNLDIHCEQLs-----dARWTELLPLLQQ---YEVVRLDDCGLte--eHCKDIGSALRANpsLTELCLRTNELg------ 65   pig
1A4Y_A       5 QSLDIQCEELs-----dARWAELLPLLQQ---CQVVRLDDCGLte--aRCKDISSALRVNpaLAELNLRSNELg------ 68   human
1YRG_A       1 ARFSIEGKSLkldaittEDEKSVFAVLLEddsVKEIVLSGNTIgt--eAARWLSENIASKkdLEIAEFSDIFTgrvk-de 77   fission yeast
1172922     21 GQLSFKGKSLkln--taEDAKDVIKEIEDfdsLEALRLEGNTVgv--eAARVIAKALEKKseLKRCHWSDMFTgrlr-te 95   human
3914621     21 GELSFKGKTLkln--taQDAEEVIREIEEyegLQALRLEGNTVgv--eAAKAIAEVLQRKpdLKRCHWSDMFTgrlr-pe 95   African clawed frog
4757728    168 FVVRFLFGLVn-----qERTSYLEKKLSC---MISQQIRLELLkw--iEVKAKAKKLHDQpsQLELFYCLYEMqe----- 232  human
465669      12 KQLKLDTEEEi------SKVIDQIRKHLN---LEVLDFRGNTLsv--lAGKLIAESLKTRreLKECIWSDMFTgrlk-de 79   Caenorhabditis e...
7500043    172 LNLSFNKQIDm------RGWTTIFRSIRHavsLQMLNLRYTNLnd--rSIPALCKMARAQpsASLTCLHLENTqm----- 238  Caenorhabditis e...
416732     789 LARYLKRLQPg-----tLRARQLLELLHCaheAEEAGIWQHVVqelpgRLSFLGTRLTPP--DAHVLGKALEAagqdfsl 861  human
7305567    176 DLLPLCRNYVr-----rIHVDQFLPPVRM---PTPLQGEEQSDsg--sEGEGSEPEKDHYq-LQTLVGGLKHLeel---d 241  house mouse
Feature 1                                #                                                     
2BNH        66 -dAGVHLVLQGLqsp-tcKIQKLSLQNCSLte-aGCGVLPSTLrsl--ptLRELHLSDNPLGd--AGLRLLCEGLLDp-- 136  pig
1A4Y_A      69 -dVGVHCVLQGLqtp-scKIQKLSLQNCCLtg-aGCGVLSSTLrtl--ptLQELHLSDNLLGd--AGLQLLCEGLLDp-- 139  human
1YRG_A      78 ipEALRLLLQALlk--cpKLHTVRLSDNAFgp-tAQEPLIDFLskh--tpLEHLYLHNNGLGp--QAGAKIARALQElav 150  fission yeast
1172922     96 ipPALISLGEGLita-gaQLVELDLSDNAFgp-dGVQGFEALLkssacftLQELKLNNCGMGi--GGGKILAAALTEchr 171  human
3914621     96 ipTALRSLGDALita-gaQLTELDLSDNAFgp-dGVRGFEALLksptcftLQELKLNNCGMGi--GGGKILAAALTEchk 171  African clawed frog
4757728    233 -eDFVQRAMDYFpkieinLSTRMDHMVSSFci-eNCHRVESLSlg----fLHNMPKEEEEEEkegRHLDMVQCVLPSs-- 304  human
465669      80 ipLVLDALGEALtas-gcRLTTLDLSDNAFga-gLSTSLYNFLqspalysLENLILNNNGLG---LAGKTVGKALCSlid 154  Caenorhabditis e...
7500043    239 sgKNLLVLICALkn--ntGLRELYLGDNGLqptdGSHIYQLITsn---ssLQLLDLRNNSIGd--SGVRHICDGLRHrea 311  Caenorhabditis e...
416732     862 dlRSTGICPSGLgs--lvGLSCVTRFRAALs--dTVALWESLRq------HGETKLLQAAEEk-fTIEPFKAKSLKDv-- 928  human
7305567    242 lvYGVKDCGMNFe----wNLFLFTYRDCYS----LAATIKACHt------LKIFKLTRSKVDd--DKARILIRSLLDh-- 303  house mouse
Feature 1                       #                           #                                  
2BNH       137 -------qCHLEKLQLEYCRLTaaSCEPLASVLratrALKELTVSNNDIGe-AGARVLGQGLadsacqLETLRLENCGLT 208  pig
1A4Y_A     140 -------qCRLEKLQLEYCSLSaaSCEPLASVLrakpDFKELTVSNNDINe-AGVRVLCQGLkdspcqLEALKLESCGVT 211  human
1YRG_A     151 nk-kaknaPPLRSIICGRNRLEngSMKEWAKTFqshrLLHTVKMVQNGIRp-EGIEHLLLEGlaycqeLKVLDLQDNTFT 228  fission yeast
1172922    172 kssaqgkpLALKVFVAGRNRLEndGATALAEAFrvigTLEEVHMPQNGINh-PGITALAQAFavn-plLRVINLNDNTFT 249  human
3914621    172 kssahgkpLALKVFIAGRNRLEndGATALSEAFrligTLEEVHMPQNGINh-AGITALAESFkan-slLKVINLNDNTFT 249  African clawed frog
4757728    305 -------sHAACSHGLGRCGLSheCCFDISLVLssnqKLVELDLSDNALGd-FGIRLLCVGLkhllcnLKKLWLVNSALR 376  human
465669     155 askkagtpLKLKKFVCGRNRLEveSTIALSDAFiklgTLEEIRLPQNGIRd-DGIIALAEAFrmn-kkLRIIDINDNFCC 232  Caenorhabditis e...
7500043    312 -----vekSSLSAMVLWNNNVTgaSMDSLAEALientKIETLNIGNNNLGv-EGIARLKPALasn-shLHRLGLQNTGIN 384  Caenorhabditis e...
416732     929 --------EDLGKLVQTQRTRS--SSEDTAGELpavrDLKKLEFALGPVSgpQAFPKLVRILtaf-ssLQHLDLDALSEN 997  human
7305567    304 --------PALEELDLSHNLIGdrGARAAAKLLsh-sRLRVLNLANNQLQa-PGAQSLAHALahn-tnLVFLNLRLNCIE 372  house mouse
Feature 1                                                         #                            
2BNH       209 ---------------------------PANCKDLCGIVasq-asLRELDLGSNGLGd----aGIAELCPglls-pasrLK 255  pig
1A4Y_A     212 ---------------------------SDNCRDLCGIVask-asLRELALGSNKLGd----vGMAELCPgllh-pssrLR 258  human
1YRG_A     229 ---------------------------HLGSSALAIALksw-pnLRELGLNDCLLSa----rGAAAVVDafsklenigLQ 276  fission yeast
1172922    250 ---------------------------EKGAVAMAETLktl-rqVEVINFGDCLVRs----kGAVAIADairg-glpkLK 296  human
3914621    250 ---------------------------EKGGVAMAEALktl-rqVEVINFGDCLVRs----kGAQAIASalke-glhkLK 296  African clawed frog
4757728    377 qsvvqlcprysalirisrtftarqhsrRQGIKLLCEGLlhpdckLQVLELDNCNLTshc-cwDLSTLLTss-----qsLR 450  human
465669     233 ---------------------------PEGAIQISEVLsdl-qfIEVLDLGDCVCDdpgvlaIIAELDKinr----dcLK 280  Caenorhabditis e...
7500043    385 ---------------------------CEGAIILAECIadn-iaLLRVDIRDNPIAl----aGLLALHSamkmntsitLL 432  Caenorhabditis e...
416732     998 ki------------------------gDEGVSQLSATFpql-ksLETLNLSQNNITd----lGAYKLAEalps-laasLL 1047 human
7305567    373 ---------------------------DEGGQAIAHALetn-kcLSVLHLGGNKLSe-----PTATLLSqmlt-vnttLV 418  house mouse
Feature 1        # #                              #                                  #      
2BNH       256 TLWLWECDItasGCRDLCRVLQAk-----eTLKELSLAGNKLgdeg----arllCESLLQPg--CQLESLWVKSCSL 321  pig
1A4Y_A     259 TLWIWECGItakGCGDLCRVLRAk-----eSLKELSLAGNELgdeg----arllCETLLEPg--CQLESLWVKSCSF 324  human
1YRG_A     277 TLRLQYNEIeldAVRTLKTVIDEkm----pDLLFLELNGNRFseed-----dvvDEIREVFs-tRGRGELDELDDME 343  fission yeast
1172922    297 ELNLSFCEIkrdAALAVAEAMADk-----aELEKLDLNGNTLgeeg----ceqlQEVLEGF---NMAKVLASLSDDE 361  human
3914621    297 DLNLSYCEIkadAAVSLAESVEDk-----sDLEKLDLNGNCLgeeg----ceqvQEILESI---NMANILGSLSDDE 361  African clawed frog
4757728    451 KLSLGNNDLgdlGVMMFCEVLKQqs----cLLQNLGLSEMYFnye------tksALETLQE---EKPELTVVFEPSW 514  human
465669     281 KVVLSGNNIt-sDVIDEIGACFNsp---kmCHVKVDISVNMFgkd------fdsAKARHGK---GNIDFGRRGDDEL 344  Caenorhabditis elegans
7500043    433 NIDASCVKL---SSEKVREYQDEferyfreIQTYCDRNKDDVlkrltvtfddeeGDSGVEKkdgNECEGEDNKDRQD 506  Caenorhabditis elegans
416732    1048 RLSLYNNCIcdvGAESLARVLPDm-----vSLRVMDVQYNKFtaaga---qqlaASLRRCPh--VETLAMWTPTIPF 1114 human
7305567    419 SLNLSCNHIgqdGGKQLLEGISDn-----kTILEFDLRLSDVsqes----eyliGQVLHANreaARQRTLNPGHFSS 486  house mouse

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