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Lrriq1 leucine-rich repeats and IQ motif containing 1 [ Mus musculus (house mouse) ]

Gene ID: 74978, updated on 5-Mar-2024

Summary

Official Symbol
Lrriq1provided by MGI
Official Full Name
leucine-rich repeats and IQ motif containing 1provided by MGI
Primary source
MGI:MGI:1922228
See related
Ensembl:ENSMUSG00000019892 AllianceGenome:MGI:1922228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1557; 4930503E15Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be active in cytoplasm. Orthologous to human LRRIQ1 (leucine rich repeats and IQ motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.6), whole brain E14.5 (RPKM 0.3) and 6 other tissues See more
Orthologs
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Genomic context

Location:
10 D1; 10 53.65 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (102880238..103072236, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (103044377..103236375, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5175 Neighboring gene ALX homeobox 1 Neighboring gene predicted gene, 34298 Neighboring gene predicted gene, 25376 Neighboring gene STARR-seq mESC enhancer starr_27747 Neighboring gene STARR-seq mESC enhancer starr_27748 Neighboring gene STARR-seq mESC enhancer starr_27749 Neighboring gene STARR-seq mESC enhancer starr_27750 Neighboring gene STARR-seq mESC enhancer starr_27751 Neighboring gene RIKEN cDNA 6430590A10 gene Neighboring gene STARR-seq mESC enhancer starr_27752 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 15 Neighboring gene ribosomal protein L7A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
leucine-rich repeat and IQ domain-containing protein 1
Names
IQ domain-containing protein LRRIQ1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163559.2NP_001157031.1  leucine-rich repeat and IQ domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001157031.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122850, AC162918
    Consensus CDS
    CCDS48687.1
    UniProtKB/Swiss-Prot
    Q0P5X1, Q3TYL6, Q9CUK8
    Related
    ENSMUSP00000131419.2, ENSMUST00000166240.8
    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  2. NM_001361058.1NP_001347987.1  leucine-rich repeat and IQ domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122850, AK015687, AK158531, BC051400
    Consensus CDS
    CCDS48686.1
    Conserved Domains (1) summary
    cl26511
    Location:173534
    Neuromodulin_N; Gap junction protein N-terminal region
  3. NM_029134.2NP_083410.1  leucine-rich repeat and IQ domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_083410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a distinct 3' CDS and UTR and lacks many 3' coding exons, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK015687, BC051400
    Consensus CDS
    CCDS48686.1
    UniProtKB/Swiss-Prot
    Q0P5X1
    Related
    ENSMUSP00000020043.6, ENSMUST00000020043.12
    Conserved Domains (1) summary
    cl26511
    Location:173534
    Neuromodulin_N; Gap junction protein N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    102880238..103072236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243593.2XP_011241895.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011241895.1

    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  2. XM_030245337.1XP_030101197.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X6

    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  3. XM_030245336.1XP_030101196.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X5

    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  4. XM_011243594.2XP_011241896.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  5. XM_011243595.2XP_011241897.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X4

    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  6. XM_006514256.2XP_006514319.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  7. XM_011243592.2XP_011241894.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011241894.1

    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  8. XM_011243596.1XP_011241898.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X11

    Conserved Domains (3) summary
    PTZ00121
    Location:73557
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:733754
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:708956
    internalin_A; class 1 internalin InlA
  9. XM_036156065.1XP_036011958.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X12

    Conserved Domains (4) summary
    PTZ00121
    Location:1439
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:615636
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:482836
    internalin_A; class 1 internalin InlA
    cd21340
    Location:618872
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  10. XM_030245338.2XP_030101198.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X8

    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA
  11. XM_036156063.1XP_036011956.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X7

    Conserved Domains (4) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:7001054
    internalin_A; class 1 internalin InlA
    cd21340
    Location:8361090
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  12. XM_036156064.1XP_036011957.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X10

    Conserved Domains (4) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:7001054
    internalin_A; class 1 internalin InlA
    cd21340
    Location:8361090
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  13. XM_006514259.3XP_006514322.1  leucine-rich repeat and IQ domain-containing protein 1 isoform X9

    See identical proteins and their annotated locations for XP_006514322.1

    UniProtKB/Swiss-Prot
    Q0P5X1, Q3TYL6, Q9CUK8
    Conserved Domains (3) summary
    PTZ00121
    Location:173657
    PTZ00121; MAEBL; Provisional
    sd00033
    Location:833854
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:8081056
    internalin_A; class 1 internalin InlA

RNA

  1. XR_871734.2 RNA Sequence