CASP8 caspase 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CASP8provided by HGNC
Official Full Name: caspase 8provided by HGNC
Primary source: HGNC:HGNC:1509
See related: Ensembl:ENSG00000064012 MIM:601763
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Expression: Broad expression in bone marrow (RPKM 26.3), lymph node (RPKM 15.2) and 21 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 2q33.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	2	NC_000002.12 (201233443..201287711)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (202098166..202152434)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human adult ventricular cardiomyocyte line (AC16 cells) exposed to high levels of palmitic acid (PA) shows enhanced transcription of caspase 8. When AC16 cells are transfected with small interfering RNA specific against p38alpha MAPK (si-p38alpha), procaspase 8 is dose-dependently reduced. Induction of apoptosis in cardiomyocytes exposed to high saturated fatty acid by a novel pathway requiring activation of caspase 8.
Title: Activator protein-1 and caspase 8 mediate p38α MAPK-dependent cardiomyocyte apoptosis induced by palmitic acid.
Data suggest that inherited abnormalities related to CASP8 rs3834129 could influence the tumor progression of oropharynx squamous cell carcinoma.
Title: CASP8 (rs3834129) and CASP3 (rs4647601) polymorphisms in oropharynx cancer risk, tumor cell differentiation, and prognosis in a cohort of the Brazilian population.
Silencing of ST3Gal3 by small interfering RNA reversed these effects and increased the protein levels of caspase8/3, which may contribute to paclitaxelinduced apoptosis. The results of the present study suggested that ST3Gal3 was a target for paclitaxel-related resistance during ovarian cancer chemotherapy.
Title: ST3Gal3 confers paclitaxel‑mediated chemoresistance in ovarian cancer cells by attenuating caspase‑8/3 signaling.
Results provide evidence that hypomethylation of Casp8 promoter is associated with the formation of neural tube defects, probably induced by oxidative stress that resulted from exposure to polycyclic aromatic hydrocarbons.
Title: Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure.
CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants.
Title: CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants.
CUL7 prevents Caspase-8 activation by promoting Caspase-8 modification with non-degradative polyubiquitin chains at K215. CUL7 knockdown sensitized cancer cells to TRAIL-induced apoptosis in vitro and in nude mice.
Title: CUL7 promotes cancer cell survival through promoting Caspase-8 ubiquitination.
Activation of CASP8 is associated with advanced primary biliary cholangitis.
Title: Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis.
Our results indicate that the caspase-8 genotype does not appear to play a direct role in personal susceptibility to oral cancer in Taiwan.
Title: Association of Caspase-8 Genotypes With Oral Cancer Risk in Taiwan.
Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing the enzyme dimerization.
Title: Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization.
Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8
Title: Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8.

Submit: New GeneRIF Correction See all GeneRIFs (538)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autoimmune lymphoproliferative syndrome type 2B MedGen: C1846545 OMIM: 607271 GeneReviews: Not available	Compare labs
Familial cancer of breast MedGen: C0006142 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	Compare labs
Hepatocellular carcinoma MedGen: C2239176 OMIM: 114550 GeneReviews: Not available	Compare labs
Lung cancer MedGen: C0684249 OMIM: 211980 GeneReviews: Not available	Compare labs

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies three new melanoma susceptibility loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-treated vaginal epithelial cells show downregulation of caspase 8 (CASP8, apoptosis-related cysteine peptidase) expression as compared to untreated control	PubMed
	env	Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9	PubMed
	env	HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8	PubMed
	env	Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons	PubMed
	env	HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53	PubMed
	env	Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9	PubMed
Envelope transmembrane glycoprotein gp41	env	Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9	PubMed
Nef	nef	Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8	PubMed
Tat	tat	FasL-induced activation of caspase-3 and -8 proteins is inhibited in HIV-1 Tat101-expressing Jurkat cells	PubMed
	tat	Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of caspase 8, apoptosis-related cysteine protease (CASP8) in U-937 macrophages	PubMed
	tat	HIV-1 Tat induces apoptosis and increases sensitivity to apoptotic signals by upregulating FLICE/Caspase-8	PubMed
Vpr	vpr	HIV-1 Vpr-mediated apoptosis and mitochondrial depolarization are dependent on CASP8 (caspase 8) activation in THP-1 and monocytes	PubMed
	vpr	HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation	PubMed
	vpr	HIV-1 Vpr induces apoptosis through caspase activation and caspase 8 has been specifically demonstrated in one study to be activated during this process, however in other studies it was not activated	PubMed
Vpu	vpu	Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage	PubMed
retropepsin	gag-pol	HIV-1 Protease cleaves procaspase 8 between amino acids 355 and 356 and generates casp8p41 protein in cells. Casp8p41 is produced in HIV-1-infected cells and colocalizes with dying cells	PubMed
	gag-pol	HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH70951 (e-PCR)
- UniSTS:19740

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2278 (e-PCR)
- UniSTS:473906

PMC230316P2 (e-PCR)
- UniSTS:272180

RH70497 (e-PCR)
- UniSTS:83037

D2S1853 (e-PCR)
- UniSTS:4703

G29514 (e-PCR)
- UniSTS:75140

RH15884 (e-PCR)
- UniSTS:1671

A008P44 (e-PCR)
- UniSTS:14752

RH36454 (e-PCR)
- UniSTS:49624

GDB:631813 (e-PCR)
- UniSTS:158430

RH78960 (e-PCR)
- UniSTS:4072

Homology

Homologs of the CASP8 gene: The CASP8 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 188 organisms have orthologs with human gene CASP8
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
cysteine-type endopeptidase activity	TAS Traceable Author Statement more info
cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
cysteine-type peptidase activity	TAS Traceable Author Statement more info	PubMed
death effector domain binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
death effector domain binding	IPI Inferred from Physical Interaction more info	PubMed
death receptor binding	IEA Inferred from Electronic Annotation more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
peptidase activity	IDA Inferred from Direct Assay more info	PubMed
peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein-containing complex binding	IEA Inferred from Electronic Annotation more info
scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
B cell activation	TAS Traceable Author Statement more info	PubMed
T cell activation	TAS Traceable Author Statement more info	PubMed
TRAIL-activated apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
TRIF-dependent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
activation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS Traceable Author Statement more info
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	TAS Traceable Author Statement more info
apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic signaling pathway	TAS Traceable Author Statement more info
cell surface receptor signaling pathway	TAS Traceable Author Statement more info
cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
death-inducing signaling complex assembly	TAS Traceable Author Statement more info
execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
execution phase of apoptosis	TAS Traceable Author Statement more info
extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info	PubMed
macrophage differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
macrophage differentiation	TAS Traceable Author Statement more info	PubMed
natural killer cell activation	TAS Traceable Author Statement more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS Traceable Author Statement more info
negative regulation of necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
nucleotide-binding oligomerization domain containing signaling pathway	TAS Traceable Author Statement more info
positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron death	IEA Inferred from Electronic Annotation more info
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	TAS Traceable Author Statement more info
positive regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
proteolysis	IDA Inferred from Direct Assay more info	PubMed
proteolysis involved in cellular protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS Traceable Author Statement more info
regulation of necroptotic process	TAS Traceable Author Statement more info
regulation of tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info
response to cobalt ion	IEA Inferred from Electronic Annotation more info
response to cold	IEA Inferred from Electronic Annotation more info
response to estradiol	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to tumor necrosis factor	IMP Inferred from Mutant Phenotype more info	PubMed
self proteolysis	ISS Inferred from Sequence or Structural Similarity more info
suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process	TAS Traceable Author Statement more info
syncytiotrophoblast cell differentiation involved in labyrinthine layer development	TAS Traceable Author Statement more info	PubMed
toll-like receptor 3 signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
CD95 death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
cell body	IEA Inferred from Electronic Annotation more info
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoskeleton	TAS Traceable Author Statement more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
membrane raft	IEA Inferred from Electronic Annotation more info
mitochondrial outer membrane	TAS Traceable Author Statement more info
mitochondrion	TAS Traceable Author Statement more info	PubMed
neuron projection	IEA Inferred from Electronic Annotation more info
nucleoplasm	IDA Inferred from Direct Assay more info
protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
ripoptosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: caspase-8

Names: FADD-homologous ICE/CED-3-like protease; FADD-like ICE; ICE-like apoptotic protease 5; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MORT1-associated ced-3 homolog; apoptotic cysteine protease; apoptotic protease Mch-5; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease

NP_001073593.1

EC 3.4.22.61

NP_001073594.1

EC 3.4.22.61

NP_001219.2

EC 3.4.22.61

NP_001358980.1

EC 3.4.22.61

NP_203519.1

EC 3.4.22.61

NP_203520.1

EC 3.4.22.61

NP_203522.1

EC 3.4.22.61

XP_005246942.1

EC 3.4.22.61

XP_005246944.1

EC 3.4.22.61

XP_005246945.1

EC 3.4.22.61

XP_005246946.1

EC 3.4.22.61

XP_005246947.1

EC 3.4.22.61

XP_005246948.1

EC 3.4.22.61

XP_005246949.1

EC 3.4.22.61

XP_005246950.1

EC 3.4.22.61

XP_005246951.1

EC 3.4.22.61

XP_005246952.1

EC 3.4.22.61

XP_006712852.1

EC 3.4.22.61

XP_006712853.1

EC 3.4.22.61

XP_006712856.1

EC 3.4.22.61

XP_011510271.1

EC 3.4.22.61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007497.1 RefSeqGene

Range

4986..59254

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_34

mRNA and Protein(s)

NM_001080124.2 → NP_001073593.1 caspase-8 isoform C precursor

See identical proteins and their annotated locations for NP_001073593.1

Status: REVIEWED

Description

Transcript Variant: This variant (F) includes different segments in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.

Source sequence(s)

AC007256, AF422927, AI351872

Consensus CDS

CCDS2343.1

UniProtKB/Swiss-Prot

Q14790

UniProtKB/TrEMBL

A0A024R3Z8

Related

ENSP00000376091.2, ENST00000392263.6

Conserved Domains (3) summary

cd00032
Location:210 → 462

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001080125.2 → NP_001073594.1 caspase-8 isoform G precursor

Status: REVIEWED

Description

Transcript Variant: This variant (G), also known as procaspase-8L or 8L, encodes the longest protein (isoform G).

Source sequence(s)

AC007256, AF422927, AI351872, X98172

Consensus CDS

CCDS42798.1

UniProtKB/Swiss-Prot

Q14790

Related

ENSP00000351273.4, ENST00000358485.8

Conserved Domains (3) summary

cd00032
Location:284 → 536

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001228.4 → NP_001219.2 caspase-8 isoform A precursor

See identical proteins and their annotated locations for NP_001219.2

Status: REVIEWED

Description

Transcript Variant: This variant (A), also known as Alpha-4, has multiple differences in the 5' UTR and coding region, compared to variant G. It encodes isoform A which is shorter than isoform G.

Source sequence(s)

AC007256, AI351872, BC028223, DA420056, U60520

Consensus CDS

CCDS42799.1

UniProtKB/Swiss-Prot

Q14790

Related

ENSP00000264275.5, ENST00000264275.9

Conserved Domains (3) summary

cd00032
Location:242 → 494

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:134 → 212

DD; Death Domain Superfamily of protein-protein interaction domains
NM_001372051.1 → NP_001358980.1 caspase-8 isoform B

Status: REVIEWED

Source sequence(s)

AC007256

Related

ENSP00000501268.1, ENST00000673742.1
NM_033355.3 → NP_203519.1 caspase-8 isoform B precursor

See identical proteins and their annotated locations for NP_203519.1

Status: REVIEWED

Description

Transcript Variant: This variant (B) includes different segments in its 5' UTR and lacks a 5' coding region segment, compared to variant G. This results in translation at a downstream start codon, and the encoded protein (isoform B) has a shorter N-terminus when it is compared to isoform G.

Source sequence(s)

AC007256, AF422928, AI351872, DA420056

Consensus CDS

CCDS2342.1

UniProtKB/Swiss-Prot

Q14790

Related

ENSP00000412523.2, ENST00000432109.6

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
NM_033356.4 → NP_203520.1 caspase-8 isoform C precursor

See identical proteins and their annotated locations for NP_203520.1

Status: REVIEWED

Description

Transcript Variant: This variant (C) includes a different segment in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.

Source sequence(s)

AC007256, AI351872, AL601594, BC028223, X98173

Consensus CDS

CCDS2343.1

UniProtKB/Swiss-Prot

Q14790

UniProtKB/TrEMBL

A0A024R3Z8

Related

ENSP00000325722.7, ENST00000323492.11

Conserved Domains (3) summary

cd00032
Location:210 → 462

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
NM_033358.4 → NP_203522.1 caspase-8 isoform E

See identical proteins and their annotated locations for NP_203522.1

Status: REVIEWED

Description

Transcript Variant: This variant (E), also known as Beta-1, has multiple differences, one of which causes a frameshift, compared to variant G. It encodes isoform E, which is shorter than isoform G.

Source sequence(s)

AC007256, DA420056, DB157537, X98176

Consensus CDS

CCDS2345.1

UniProtKB/Swiss-Prot

Q14790

Related

ENSP00000376087.3, ENST00000392258.7

Conserved Domains (2) summary

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains

RNA

NR_111983.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (H) has an alternate splice site in the central region, compared to variant G. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant G, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC007256, AF380342, BG236020, U60520

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p13 Primary Assembly

Range

201233443..201287711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006712789.2 → XP_006712852.1 caspase-8 isoform X2

See identical proteins and their annotated locations for XP_006712852.1

UniProtKB/Swiss-Prot

Q14790

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246887.2 → XP_005246944.1 caspase-8 isoform X2

See identical proteins and their annotated locations for XP_005246944.1

UniProtKB/Swiss-Prot

Q14790

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006712793.3 → XP_006712856.1 caspase-8 isoform X8

See identical proteins and their annotated locations for XP_006712856.1

UniProtKB/Swiss-Prot

Q14790

Related

ENSP00000397528.1, ENST00000413726.5

Conserved Domains (2) summary

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246888.2 → XP_005246945.1 caspase-8 isoform X2

See identical proteins and their annotated locations for XP_005246945.1

UniProtKB/Swiss-Prot

Q14790

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246894.4 → XP_005246951.1 caspase-8 isoform X6

Conserved Domains (1) summary

cd00032
Location:26 → 278

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
XM_005246891.5 → XP_005246948.1 caspase-8 isoform X2

See identical proteins and their annotated locations for XP_005246948.1

UniProtKB/Swiss-Prot

Q14790

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_006712790.4 → XP_006712853.1 caspase-8 isoform X2

See identical proteins and their annotated locations for XP_006712853.1

UniProtKB/Swiss-Prot

Q14790

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246889.2 → XP_005246946.1 caspase-8 isoform X2

See identical proteins and their annotated locations for XP_005246946.1

UniProtKB/Swiss-Prot

Q14790

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246892.2 → XP_005246949.1 caspase-8 isoform X3

See identical proteins and their annotated locations for XP_005246949.1

UniProtKB/Swiss-Prot

Q14790

UniProtKB/TrEMBL

A0A024R3Z8

Conserved Domains (3) summary

cd00032
Location:210 → 462

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246885.2 → XP_005246942.1 caspase-8 isoform X1

Conserved Domains (3) summary

cd00032
Location:269 → 521

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246893.3 → XP_005246950.1 caspase-8 isoform X5

See identical proteins and their annotated locations for XP_005246950.1

Conserved Domains (2) summary

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246895.3 → XP_005246952.1 caspase-8 isoform X7

Conserved Domains (2) summary

cd08333
Location:62 → 143

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:157 → 239

DD; Death Domain Superfamily of protein-protein interaction domains
XM_005246890.4 → XP_005246947.1 caspase-8 isoform X2

See identical proteins and their annotated locations for XP_005246947.1

UniProtKB/Swiss-Prot

Q14790

Conserved Domains (3) summary

cd00032
Location:225 → 477

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cd08333
Location:3 → 84

DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8

cl14633
Location:98 → 180

DD; Death Domain Superfamily of protein-protein interaction domains
XM_011511969.2 → XP_011510271.1 caspase-8 isoform X4

Conserved Domains (2) summary

cd00032
Location:80 → 332

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cl14633
Location:1 → 35

DD; Death Domain Superfamily of protein-protein interaction domains

RNA

XR_001738971.1 RNA Sequence
XR_923035.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033357.2: Suppressed sequence

Description

NM_033357.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.