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CASP8 caspase 8 [ Homo sapiens (human) ]

Gene ID: 841, updated on 22-May-2022

Summary

Official Symbol
CASP8provided by HGNC
Official Full Name
caspase 8provided by HGNC
Primary source
HGNC:HGNC:1509
See related
Ensembl:ENSG00000064012 MIM:601763; AllianceGenome:HGNC:1509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 26.3), lymph node (RPKM 15.2) and 21 other tissues See more
Orthologs
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Genomic context

See CASP8 in Genome Data Viewer
Location:
2q33.1
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (201233443..201287711)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201716894..201768369)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202098166..202152434)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene caspase 10 Neighboring gene MT-ND4L pseudogene 13 Neighboring gene MT-ND5 pseudogene 25 Neighboring gene MT-ND4 pseudogene 23 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene trafficking kinesin protein 2 Neighboring gene SCYL2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Autoimmune lymphoproliferative syndrome type 2B
MedGen: C1846545 OMIM: 607271 GeneReviews: Not available
Compare labs
Familial cancer of breast Compare labs
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs
Lung cancer
MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide association study identifies three new melanoma susceptibility loci.
EBI GWAS Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show downregulation of caspase 8 (CASP8, apoptosis-related cysteine peptidase) expression as compared to untreated control PubMed
env Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9 PubMed
env HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8 PubMed
env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
Envelope transmembrane glycoprotein gp41 env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
Nef nef Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8 PubMed
Tat tat FasL-induced activation of caspase-3 and -8 proteins is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of caspase 8, apoptosis-related cysteine protease (CASP8) in U-937 macrophages PubMed
tat HIV-1 Tat induces apoptosis and increases sensitivity to apoptotic signals by upregulating FLICE/Caspase-8 PubMed
Vpr vpr HIV-1 Vpr-mediated apoptosis and mitochondrial depolarization are dependent on CASP8 (caspase 8) activation in THP-1 and monocytes PubMed
vpr HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation PubMed
vpr HIV-1 Vpr induces apoptosis through caspase activation and caspase 8 has been specifically demonstrated in one study to be activated during this process, however in other studies it was not activated PubMed
Vpu vpu Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage PubMed
retropepsin gag-pol HIV-1 Protease cleaves procaspase 8 between amino acids 355 and 356 and generates casp8p41 protein in cells. Casp8p41 is produced in HIV-1-infected cells and colocalizes with dying cells PubMed
gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17672, MGC78473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables death effector domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables death effector domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables death receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in TRAIL-activated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in macrophage differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in natural killer cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis involved in protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pyroptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cobalt ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in self proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in syncytiotrophoblast cell differentiation involved in labyrinthine layer development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ripoptosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase-8
Names
FADD-homologous ICE/CED-3-like protease
FADD-like ICE
ICE-like apoptotic protease 5
MACH-alpha-1/2/3 protein
MACH-beta-1/2/3/4 protein
MORT1-associated ced-3 homolog
apoptotic cysteine protease
apoptotic protease Mch-5
caspase 8, apoptosis-related cysteine peptidase
caspase 8, apoptosis-related cysteine protease
NP_001073593.1
NP_001073594.1
NP_001219.2
NP_001358980.1
NP_001387571.1
NP_001387574.1
NP_001387577.1
NP_001387580.1
NP_001387582.1
NP_001387583.1
NP_001387584.1
NP_001387585.1
NP_001387586.1
NP_001387587.1
NP_001387588.1
NP_001387589.1
NP_001387590.1
NP_001387591.1
NP_001387592.1
NP_001387593.1
NP_001387594.1
NP_001387595.1
NP_001387596.1
NP_001387597.1
NP_001387598.1
NP_001387599.1
NP_001387600.1
NP_001387601.1
NP_001387602.1
NP_001387603.1
NP_001387604.1
NP_001387605.1
NP_001387606.1
NP_001387607.1
NP_001387608.1
NP_001387609.1
NP_001387679.1
NP_001387680.1
NP_203519.1
NP_203520.1
XP_005246950.1
XP_011510271.1
XP_047301915.1
XP_047301916.1
XP_047301917.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007497.1 RefSeqGene

    Range
    4986..59254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_34

mRNA and Protein(s)

  1. NM_001080124.2NP_001073593.1  caspase-8 isoform 3

    See identical proteins and their annotated locations for NP_001073593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes different segments in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant 7. Variants 3 and 7 both encode isoform 3, which is shorter than isoform 7. Isoform 3 has also been labelled as Alpha-2 or MCH5-beta.
    Source sequence(s)
    AC007256, AF422927, AI351872
    Consensus CDS
    CCDS2343.1
    UniProtKB/Swiss-Prot
    Q14790
    UniProtKB/TrEMBL
    A0A024R3Z8
    Related
    ENSP00000376091.2, ENST00000392263.6
    Conserved Domains (3) summary
    cd00032
    Location:210462
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98180
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_001080125.2NP_001073594.1  caspase-8 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as procaspase-8L or 8L, encodes the longest protein (isoform 7).
    Source sequence(s)
    AC007256, AF422927, AI351872, X98172
    Consensus CDS
    CCDS42798.1
    UniProtKB/Swiss-Prot
    Q14790
    Related
    ENSP00000351273.4, ENST00000358485.8
    Conserved Domains (3) summary
    cd00032
    Location:284536
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157239
    DD; Death Domain Superfamily of protein-protein interaction domains
  3. NM_001228.4NP_001219.2  caspase-8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001219.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as Alpha-4, has multiple differences in the 5' UTR and coding region, compared to variant 7. It encodes isoform 1 which is shorter than isoform 7.
    Source sequence(s)
    AC007256, AI351872, BC028223, DA420056, U60520
    Consensus CDS
    CCDS42799.1
    UniProtKB/Swiss-Prot
    Q14790
    Related
    ENSP00000264275.5, ENST00000264275.9
    Conserved Domains (3) summary
    cd00032
    Location:242494
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:134212
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. NM_001372051.1NP_001358980.1  caspase-8 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007256
    Related
    ENSP00000501268.1, ENST00000673742.1
    Conserved Domains (3) summary
    cd00032
    Location:225477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98180
    DD; Death Domain Superfamily of protein-protein interaction domains
  5. NM_001400642.1NP_001387571.1  caspase-8 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC007256
    Related
    ENSP00000512381.1, ENST00000696085.1
  6. NM_001400645.1NP_001387574.1  caspase-8 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC007256
  7. NM_001400648.1NP_001387577.1  caspase-8 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  8. NM_001400651.1NP_001387580.1  caspase-8 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
    Related
    ENSP00000512369.1, ENST00000696067.1
  9. NM_001400653.1NP_001387582.1  caspase-8 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007256
  10. NM_001400654.1NP_001387583.1  caspase-8 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007256
  11. NM_001400655.1NP_001387584.1  caspase-8 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007256
  12. NM_001400656.1NP_001387585.1  caspase-8 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007256
    Related
    ENSP00000397528.2, ENST00000413726.6
  13. NM_001400657.1NP_001387586.1  caspase-8 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
    Related
    ENSP00000396869.2, ENST00000440732.6
  14. NM_001400658.1NP_001387587.1  caspase-8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007256
    Related
    ENSP00000512382.1, ENST00000696087.1
  15. NM_001400659.1NP_001387588.1  caspase-8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007256
    Related
    ENSP00000512371.1, ENST00000696069.1
  16. NM_001400660.1NP_001387589.1  caspase-8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  17. NM_001400661.1NP_001387590.1  caspase-8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  18. NM_001400662.1NP_001387591.1  caspase-8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007256
  19. NM_001400663.1NP_001387592.1  caspase-8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  20. NM_001400664.1NP_001387593.1  caspase-8 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC007256
  21. NM_001400665.1NP_001387594.1  caspase-8 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC007256
  22. NM_001400666.1NP_001387595.1  caspase-8 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC007256
  23. NM_001400667.1NP_001387596.1  caspase-8 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC007256
    Related
    ENSP00000394434.3, ENST00000444430.3
  24. NM_001400668.1NP_001387597.1  caspase-8 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC007256
  25. NM_001400669.1NP_001387598.1  caspase-8 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
    Related
    ENSP00000391709.2, ENST00000450491.6
  26. NM_001400670.1NP_001387599.1  caspase-8 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC007256
  27. NM_001400671.1NP_001387600.1  caspase-8 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC007256
  28. NM_001400672.1NP_001387601.1  caspase-8 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC007256
  29. NM_001400673.1NP_001387602.1  caspase-8 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC007256
  30. NM_001400674.1NP_001387603.1  caspase-8 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC007256
  31. NM_001400675.1NP_001387604.1  caspase-8 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC007256
  32. NM_001400676.1NP_001387605.1  caspase-8 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC007256
  33. NM_001400677.1NP_001387606.1  caspase-8 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  34. NM_001400678.1NP_001387607.1  caspase-8 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC007256
  35. NM_001400679.1NP_001387608.1  caspase-8 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
    Consensus CDS
    CCDS2345.1
    Related
    ENSP00000376087.3, ENST00000392258.7
  36. NM_001400680.1NP_001387609.1  caspase-8 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  37. NM_001400750.1NP_001387679.1  caspase-8 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC007256
  38. NM_001400751.1NP_001387680.1  caspase-8 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC007256
  39. NM_033355.3NP_203519.1  caspase-8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_203519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes different segments in its 5' UTR and lacks a 5' coding region segment, compared to variant G. This results in translation at a downstream start codon, and the encoded protein (isoform 2) has a shorter N-terminus when it is compared to isoform 7.
    Source sequence(s)
    AC007256, AF422928, AI351872, DA420056
    Consensus CDS
    CCDS2342.1
    UniProtKB/Swiss-Prot
    Q14790
    Related
    ENSP00000412523.2, ENST00000432109.6
    Conserved Domains (3) summary
    cd00032
    Location:225477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98180
    DD; Death Domain Superfamily of protein-protein interaction domains
  40. NM_033356.4NP_203520.1  caspase-8 isoform 3

    See identical proteins and their annotated locations for NP_203520.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes a different segment in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant 7. Variants 3 and 6 both encode isoform 3, which is shorter than isoform 7. Isoform 3 has also been labelled as Alpha-2 or MCH5-beta.
    Source sequence(s)
    AC007256, AI351872, AL601594, BC028223, X98173
    Consensus CDS
    CCDS2343.1
    UniProtKB/Swiss-Prot
    Q14790
    UniProtKB/TrEMBL
    A0A024R3Z8
    Related
    ENSP00000325722.7, ENST00000323492.11
    Conserved Domains (3) summary
    cd00032
    Location:210462
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98180
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. NR_111983.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has an alternate splice site in the central region, compared to variant 7. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant 7, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007256, AF380342, BG236020, U60520
  2. NR_174564.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  3. NR_174565.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  4. NR_174581.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  5. NR_174582.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
    Related
    ENST00000490682.6
  6. NR_174583.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  7. NR_174584.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  8. NR_174585.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  9. NR_174586.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  10. NR_174588.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  11. NR_174589.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  12. NR_174590.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  13. NR_174591.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  14. NR_174592.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  15. NR_174593.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  16. NR_174594.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  17. NR_174595.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  18. NR_174596.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  19. NR_174598.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256, AC007283
  20. NR_174599.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  21. NR_174600.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  22. NR_174601.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256
  23. NR_174602.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007256

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    201233443..201287711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445961.1XP_047301917.1  caspase-8 isoform X5

  2. XM_047445959.1XP_047301915.1  caspase-8 isoform X1

  3. XM_005246893.4XP_005246950.1  caspase-8 isoform X4

    See identical proteins and their annotated locations for XP_005246950.1

    Conserved Domains (2) summary
    cd08333
    Location:62143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157239
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. XM_047445960.1XP_047301916.1  caspase-8 isoform X2

  5. XM_011511969.3XP_011510271.1  caspase-8 isoform X3

    Conserved Domains (2) summary
    cd00032
    Location:80332
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:135
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. XR_007082538.1 RNA Sequence

  2. XR_007082539.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    201716894..201768369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033357.2: Suppressed sequence

    Description
    NM_033357.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_033358.4: Suppressed sequence

    Description
    NM_033358.4: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.