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CASP8 caspase 8 [ Homo sapiens (human) ]

Gene ID: 841, updated on 13-Feb-2019

Summary

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Official Symbol
CASP8provided by HGNC
Official Full Name
caspase 8provided by HGNC
Primary source
HGNC:HGNC:1509
See related
Ensembl:ENSG00000064012 MIM:601763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 26.3), lymph node (RPKM 15.2) and 21 other tissues See more
Orthologs
mouse all

Genomic context

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See CASP8 in Genome Data Viewer
Location:
2q33.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (201233443..201287711)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202098166..202152434)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene caspase 10 Neighboring gene MT-ND4L pseudogene 13 Neighboring gene MT-ND5 pseudogene 25 Neighboring gene MT-ND4 pseudogene 23 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene trafficking kinesin protein 2 Neighboring gene SCY1 like pseudokinase 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages. Yoshino H, et al. Int J Mol Sci, 2018 Oct 13. PMID 30322167, Free PMC Article
  2. Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency. Lehle AS, et al. Gastroenterology, 2019 Jan. PMID 30267714
  3. Plasma Concentration of Caspase-8 Is Associated With Short Sleep Duration and the Risk of Incident Diabetes Mellitus. Svensson T, et al. J Clin Endocrinol Metab, 2018 Apr 1. PMID 29409058
  4. Downregulation of Caspase 8 in a group of Iranian breast cancer patients - A pilot study. Aghababazadeh M, et al. J Egypt Natl Canc Inst, 2017 Dec. PMID 29233452
  5. Q482H mutation of procaspase-8 in acute myeloid leukemia abolishes caspase-8-mediated apoptosis by impairing procaspase-8 dimerization. Li M, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29191655

See all (825) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. CASP8 deficiency is a novel cause of very early onset-inflammatory bowel disease associated with lymphocyte dysfunction, impaired inflammasome activation, and defec- tive epithelial cell death responses.
    Title: Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.
  2. Data show that ionizing radiation (IR) induces apoptosis in THP-1 cells through cas-8-mediated pathways, whereas THP-1-derived macrophages (THP-1-M) are resistant to IR due to impaired casp-8-mediated apoptosis during differentiation and not to a capacity for DSB repair suggesting that the regulation of casp-8-mediated apoptosis during differentiation plays a role in the p53-independent radio-resistance of THP-1-M.
    Title: Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages.
  3. The apoptosis was partially dependent upon caspase-8 concomitant with attenuated NF-kappa B survival signal due to stimulus of TNF-alpha. It suggests that PAK4 as target is a switch between caspase-8 apoptosis and NF-kappa B survival signals induced by TNF-alpha in hepatocarcinoma cells.
    Title: p21-activated kinase 4 as a switch between caspase-8 apoptosis and NF-κB survival signals in response to TNF-α in hepatocarcinoma cells.
  4. The caspase 8 mediated RIPK1 cleavage product has a pro-apoptotic function, and further cleavage of this pro-apoptotic cleavage product by human rhinovirus 3C protease may provide a mechanism by which human rhinovirus limits apoptosis.
    Title: Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation.
  5. results suggest that miR-21 regulates the apoptosis of keloid fibroblasts via targeting FasL, and caspase-8 and the mitochondria-mediated apoptotic signaling pathway is involved in this process.
    Title: MiR-21 regulates the apoptosis of keloid fibroblasts by caspase-8 and the mitochondria-mediated apoptotic signaling pathway via targeting FasL.
  6. Caspase-3 and -8 and annexin V may serve as diagnostic markers in Ovarian cancer , also explained that the decrement in control of the S phase in the cell cycle may considered one of the significant factors in the development of ovarian tumors
    Title: Comparative expression of caspases and annexin V in benign and malignant ovarian tumors.
  7. neither rs13416436 nor rs2037815 associated with pre-eclampsia
    Title: CASPASE-8 gene polymorphisms (rs13416436 and rs2037815) are not associated with preeclampsia development in Brazilian women.
  8. High CASP8 expression is associated with Colorectal Cancer.
    Title: Expression Level of Caspase Genes in Colorectal Cancer
  9. Sleep duration is associated with plasma caspase-8. Caspase-8 independently predicts diabetes mellitus years before disease onset and modifies the effect of sleep duration on incident diabetes mellitus.
    Title: Plasma Concentration of Caspase-8 Is Associated With Short Sleep Duration and the Risk of Incident Diabetes Mellitus.
  10. Caspase-8 and Caspase-3 expressions in tumor tissues are novel candidate prognostic markers for colorectal cancer patients
    Title: Synergistic role of Caspase-8 and Caspase-3 expressions: Prognostic and predictive biomarkers in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (518)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Caspase-8 deficiency
MedGen: C1846545 OMIM: 607271 GeneReviews: Not available
Compare labs
Familial cancer of breast
MedGen: C0006142 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer
Compare labs
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs
Lung cancer
MedGen: C0684249 OMIM: 211980 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide association study identifies three new melanoma susceptibility loci.
NHGRI GWA Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show downregulation of caspase 8 (CASP8, apoptosis-related cysteine peptidase) expression as compared to untreated control PubMed
env Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9 PubMed
env HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8 PubMed
env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
Envelope transmembrane glycoprotein gp41 env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
Nef nef Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8 PubMed
Tat tat FasL-induced activation of caspase-3 and -8 proteins is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of caspase 8, apoptosis-related cysteine protease (CASP8) in U-937 macrophages PubMed
tat HIV-1 Tat induces apoptosis and increases sensitivity to apoptotic signals by upregulating FLICE/Caspase-8 PubMed
Vpr vpr HIV-1 Vpr-mediated apoptosis and mitochondrial depolarization are dependent on CASP8 (caspase 8) activation in THP-1 and monocytes PubMed
vpr HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation PubMed
vpr HIV-1 Vpr induces apoptosis through caspase activation and caspase 8 has been specifically demonstrated in one study to be activated during this process, however in other studies it was not activated PubMed
Vpu vpu Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage PubMed
retropepsin gag-pol HIV-1 Protease cleaves procaspase 8 between amino acids 355 and 356 and generates casp8p41 protein in cells. Casp8p41 is produced in HIV-1-infected cells and colocalizes with dying cells PubMed
gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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  • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
    AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
  • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
    Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
  • Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem (from REACTOME)
    Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystemBID may promote cell death by activating BAX and BAK while inactivating anti-apoptotic proteins. The engagement of cell surface receptors activates the caspase-8, a heterodimer, that cleaves BID in i...
  • Allograft Rejection, organism-specific biosystem (from WikiPathways)
    Allograft Rejection, organism-specific biosystemThis pathway illustrates molecular interactions involved in the fundamental adaptive immune response for allograft destruction. This pathway was adapted in large part from the KEGG pathway http://www...
  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
    Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
    Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis - multiple species, conserved biosystem (from KEGG)
    Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation by HSP70, organism-specific biosystem
    Apoptosis Modulation by HSP70
  • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
    Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
  • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
    Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
  • C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
    C-type lectin receptors (CLRs), organism-specific biosystemPathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised ...
  • CASP8 activity is inhibited, organism-specific biosystem (from REACTOME)
    CASP8 activity is inhibited, organism-specific biosystemCell death triggered by extrinsic stimuli via death receptors or toll-like receptors (e.g., TLR3, TLR4) may result in either apoptosis or regulated necrosis (necroptosis) (Holler N et al. 2000; Kalai...
  • CLEC7A (Dectin-1) signaling, organism-specific biosystem (from REACTOME)
    CLEC7A (Dectin-1) signaling, organism-specific biosystemCLEC7A (also known as Dectin-1) is a pattern-recognition receptor (PRR) expressed by myeloid cells (macrophages, dendritic cells and neutrophils) that detects pathogens by binding to beta-1,3-glucans...
  • CLEC7A/inflammasome pathway, organism-specific biosystem (from REACTOME)
    CLEC7A/inflammasome pathway, organism-specific biosystemAntifungal immunity through the induction of T-helper 17 cells (TH17) responses requires the production of mature, active interleukin-1beta (IL1B). CLEC7A (dectin-1) through the SYK route induces act...
  • Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystem (from REACTOME)
    Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
  • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
    Caspase cascade in apoptosis, organism-specific biosystem
    Caspase cascade in apoptosis
  • Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
    Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemCaspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and ...
  • Ceramide signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Ceramide signaling pathway, organism-specific biosystem
    Ceramide signaling pathway
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Coregulation of Androgen receptor activity, organism-specific biosystem
    Coregulation of Androgen receptor activity
  • DNA Damage Response, organism-specific biosystem (from WikiPathways)
    DNA Damage Response, organism-specific biosystemThis is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two ...
  • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
    Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
  • Dimerization of procaspase-8, organism-specific biosystem (from REACTOME)
    Dimerization of procaspase-8, organism-specific biosystemProcaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become acc...
  • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    FAS (CD95) signaling pathway, organism-specific biosystem
    FAS (CD95) signaling pathway
  • Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystem (from WikiPathways)
    Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
  • FasL/ CD95L signaling, organism-specific biosystem (from REACTOME)
    FasL/ CD95L signaling, organism-specific biosystemThe Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the t...
  • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
    HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
    HIV-1 Nef: Negative effector of Fas and TNF-alpha
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
    IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL-17 signaling pathway, conserved biosystem (from KEGG)
    IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Integrated Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Cancer Pathway, organism-specific biosystem
    Integrated Cancer Pathway
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
    Integrins in angiogenesis, organism-specific biosystem
    Integrins in angiogenesis
  • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
    Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Ligand-dependent caspase activation, organism-specific biosystem (from REACTOME)
    Ligand-dependent caspase activation, organism-specific biosystemCaspase-8 is synthesized as zymogen (procaspase-8) and is formed from procaspase-8 as a cleavage product. However, the cleavage itself appears not to be sufficient for the formation of an active casp...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
    MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
  • NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem (from REACTOME)
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystemFas-AssociatedDeathDomain (FADD) and receptor interacting protein 1 (RIP1) are death domain containing molecules that interact with the C-terminal portion of IPS-1 and induce NF-kB through interactio...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
    NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
  • Nanomaterial induced apoptosis, organism-specific biosystem (from WikiPathways)
    Nanomaterial induced apoptosis, organism-specific biosystemApotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been fou...
  • Nanoparticle triggered regulated necrosis, organism-specific biosystem (from WikiPathways)
    Nanoparticle triggered regulated necrosis, organism-specific biosystemProgrammed cell death: regulated necrosis. During regulated necrosis, different stimuli are recognized or sensed by specific receptors on the cell surface or inside cells. The activation of the necro...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
    Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...
  • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
  • Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystem (from WikiPathways)
    Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystemThis pathway describes the Parkin-Ubiquitin proteasome degradation system.
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platinum drug resistance, organism-specific biosystem (from KEGG)
    Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • Platinum drug resistance, conserved biosystem (from KEGG)
    Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
  • RIG-I-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
    RIG-I-like Receptor Signaling, organism-specific biosystemViral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initia...
  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
  • RIPK1-mediated regulated necrosis, organism-specific biosystem (from REACTOME)
    RIPK1-mediated regulated necrosis, organism-specific biosystemReceptor-interacting kinase protein 1 (RIPK1) and RIPK3-dependent necrosis is called necroptosis or programmed necrosis. The kinase activities of RIPK1 and RIPK3 are essential for the necroptotic cel...
  • Regulated Necrosis, organism-specific biosystem (from REACTOME)
    Regulated Necrosis, organism-specific biosystemNecrosis has traditionally been considered as a passive, unregulated cell death. However, accumulating evidence suggests that necrosis, like apoptosis, can be executed by genetically controlled and h...
  • Regulation by c-FLIP, organism-specific biosystem (from REACTOME)
    Regulation by c-FLIP, organism-specific biosystemc-FLIP proteins (CASP8 and FADD-like apoptosis regulators or c-FLICE inhibitory proteins) are death effector domain (DED)-containing proteins that are recruited to the death-inducing signaling comple...
  • Regulation of TNFR1 signaling, organism-specific biosystem (from REACTOME)
    Regulation of TNFR1 signaling, organism-specific biosystemTumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). ...
  • Regulation of necroptotic cell death, organism-specific biosystem (from REACTOME)
    Regulation of necroptotic cell death, organism-specific biosystemA regulated balance between cell survival and cell death is essential for normal development and homeostasis of multicellular organisms. Defects in control of this balance may contribute to autoimmu...
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
  • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TNF receptor signaling pathway, organism-specific biosystem
    TNF receptor signaling pathway
  • TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, organism-specific biosystemTNF related weak inducer of apoptosis (TWEAK) is a small pleiotropic cytokine of the TNF super family and its gene is located at chromosome 17p13.1. TWEAK has been reported to be expressed in tissues...
  • TNF signaling, organism-specific biosystem (from REACTOME)
    TNF signaling, organism-specific biosystemThe inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) is expressed in immune and nonimmune cell types including macrophages, T cells, mast cells, granulocytes, natural killer (NK) cells, ...
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNFR1-induced proapoptotic signaling, organism-specific biosystem (from REACTOME)
    TNFR1-induced proapoptotic signaling, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce cell survival or cell death (Ward C et al. 1999; Micheau O and Tschopp J 2003; Wider...
  • TRAIL signaling, organism-specific biosystem (from REACTOME)
    TRAIL signaling, organism-specific biosystemTumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work throug...
  • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TRAIL signaling pathway, organism-specific biosystem
    TRAIL signaling pathway
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • TRIF-mediated programmed cell death, organism-specific biosystem (from REACTOME)
    TRIF-mediated programmed cell death, organism-specific biosystemTLR3 and -4 trigger TRIF-dependent programmed cell death in various human and mouse cells (Kalai M et al. 2002; Han KJ et al. 2004; Kaiser WJ and Offermann MK 2005; Estornes Y et al. 2012; He S et al...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Toll-like Receptor Signaling Pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral myocarditis, organism-specific biosystem (from KEGG)
    Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
  • miRNA Regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
    miRNA Regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ17672, MGC78473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
  
cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cysteine-type peptidase activity TAS
Traceable Author Statement
more info
 PubMed 
death effector domain binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
death effector domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
death receptor binding IEA
Inferred from Electronic Annotation
more info
  
identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
B cell activation TAS
Traceable Author Statement
more info
 PubMed 
T cell activation TAS
Traceable Author Statement
more info
 PubMed 
TRAIL-activated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
  
activation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
  
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
  
apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
apoptotic signaling pathway TAS
Traceable Author Statement
more info
  
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
  
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
death-inducing signaling complex assembly TAS
Traceable Author Statement
more info
  
execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
execution phase of apoptosis TAS
Traceable Author Statement
more info
  
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
macrophage differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
macrophage differentiation TAS
Traceable Author Statement
more info
 PubMed 
natural killer cell activation TAS
Traceable Author Statement
more info
 PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
  
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
  
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
 PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
  
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
  
positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
proteolysis involved in cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
  
regulation of necroptotic process TAS
Traceable Author Statement
more info
  
regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
  
response to cobalt ion IEA
Inferred from Electronic Annotation
more info
  
response to cold IEA
Inferred from Electronic Annotation
more info
  
response to estradiol IEA
Inferred from Electronic Annotation
more info
  
response to ethanol IEA
Inferred from Electronic Annotation
more info
  
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
response to tumor necrosis factor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
  
syncytiotrophoblast cell differentiation involved in labyrinthine layer development TAS
Traceable Author Statement
more info
 PubMed 
toll-like receptor 3 signaling pathway TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
CD95 death-inducing signaling complex IDA
Inferred from Direct Assay
more info
 PubMed 
cell body IEA
Inferred from Electronic Annotation
more info
  
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
cytosol TAS
Traceable Author Statement
more info
  
death-inducing signaling complex IDA
Inferred from Direct Assay
more info
 PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
  
mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
mitochondrion TAS
Traceable Author Statement
more info
 PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
  
nucleoplasm IDA
Inferred from Direct Assay
more info
  
ripoptosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
caspase-8
Names
FADD-homologous ICE/CED-3-like protease
FADD-like ICE
ICE-like apoptotic protease 5
MACH-alpha-1/2/3 protein
MACH-beta-1/2/3/4 protein
MORT1-associated ced-3 homolog
apoptotic cysteine protease
apoptotic protease Mch-5
caspase 8, apoptosis-related cysteine peptidase
caspase 8, apoptosis-related cysteine protease
NP_001073593.1
NP_001073594.1
NP_001219.2
NP_203519.1
NP_203520.1
NP_203522.1
XP_005246942.1
XP_005246943.1
XP_005246944.1
XP_005246945.1
XP_005246946.1
XP_005246947.1
XP_005246948.1
XP_005246949.1
XP_005246950.1
XP_005246951.1
XP_005246952.1
XP_006712852.1
XP_006712853.1
XP_006712856.1
XP_011510271.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007497.1 RefSeqGene

    Range
    4986..59254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_34

mRNA and Protein(s)

  1. NM_001080124.1 → NP_001073593.1  caspase-8 isoform C precursor

    See identical proteins and their annotated locations for NP_001073593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (F) includes different segments in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.
    Source sequence(s)
    AC007256, AF422927, AI351872, DA420056
    Consensus CDS
    CCDS2343.1
    UniProtKB/Swiss-Prot
    Q14790
    UniProtKB/TrEMBL
    A0A024R3Z8
    Related
    ENSP00000376091.2, ENST00000392263.6
    Conserved Domains (3) summary
    cd00032
    Location:210 → 462
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. NM_001080125.1 → NP_001073594.1  caspase-8 isoform G precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (G), also known as procaspase-8L or 8L, encodes the longest protein (isoform G).
    Source sequence(s)
    AC007256, AF422927, AI351872, X98172
    Consensus CDS
    CCDS42798.1
    UniProtKB/Swiss-Prot
    Q14790
    Related
    ENSP00000351273.4, ENST00000358485.8
    Conserved Domains (3) summary
    cd00032
    Location:284 → 536
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. NM_001228.4 → NP_001219.2  caspase-8 isoform A precursor

    See identical proteins and their annotated locations for NP_001219.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A), also known as Alpha-4, has multiple differences in the 5' UTR and coding region, compared to variant G. It encodes isoform A which is shorter than isoform G.
    Source sequence(s)
    AC007256, AI351872, BC028223, DA420056, U60520
    Consensus CDS
    CCDS42799.1
    UniProtKB/Swiss-Prot
    Q14790
    Related
    ENSP00000264275.5, ENST00000264275.9
    Conserved Domains (3) summary
    cd00032
    Location:242 → 494
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:134 → 212
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. NM_033355.3 → NP_203519.1  caspase-8 isoform B precursor

    See identical proteins and their annotated locations for NP_203519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) includes different segments in its 5' UTR and lacks a 5' coding region segment, compared to variant G. This results in translation at a downstream start codon, and the encoded protein (isoform B) has a shorter N-terminus when it is compared to isoform G.
    Source sequence(s)
    AC007256, AF422928, AI351872, DA420056
    Consensus CDS
    CCDS2342.1
    UniProtKB/Swiss-Prot
    Q14790
    Related
    ENSP00000412523.2, ENST00000432109.6
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  5. NM_033356.3 → NP_203520.1  caspase-8 isoform C precursor

    See identical proteins and their annotated locations for NP_203520.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) includes a different segment in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.
    Source sequence(s)
    AC007256, AI351872, AL601594, BC028223, X98173
    Consensus CDS
    CCDS2343.1
    UniProtKB/Swiss-Prot
    Q14790
    UniProtKB/TrEMBL
    A0A024R3Z8
    Related
    ENSP00000325722.7, ENST00000323492.11
    Conserved Domains (3) summary
    cd00032
    Location:210 → 462
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  6. NM_033358.3 → NP_203522.1  caspase-8 isoform E

    See identical proteins and their annotated locations for NP_203522.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E), also known as Beta-1, has multiple differences, one of which causes a frameshift, compared to variant G. It encodes isoform E, which is shorter than isoform G.
    Source sequence(s)
    DA420056, DB157537, X98176
    Consensus CDS
    CCDS2345.1
    UniProtKB/Swiss-Prot
    Q14790
    Related
    ENSP00000376087.3, ENST00000392258.7
    Conserved Domains (2) summary
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. NR_111983.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (H) has an alternate splice site in the central region, compared to variant G. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant G, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007256, AF380342, BG236020, U60520

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    201233443..201287711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712789.2 → XP_006712852.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_006712852.1

    UniProtKB/Swiss-Prot
    Q14790
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_005246887.2 → XP_005246944.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_005246944.1

    UniProtKB/Swiss-Prot
    Q14790
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_006712793.3 → XP_006712856.1  caspase-8 isoform X8

    See identical proteins and their annotated locations for XP_006712856.1

    UniProtKB/Swiss-Prot
    Q14790
    Related
    ENSP00000397528.1, ENST00000413726.5
    Conserved Domains (2) summary
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_005246888.2 → XP_005246945.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_005246945.1

    UniProtKB/Swiss-Prot
    Q14790
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  5. XM_005246894.4 → XP_005246951.1  caspase-8 isoform X6

    Conserved Domains (1) summary
    cd00032
    Location:26 → 278
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  6. XM_005246891.5 → XP_005246948.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_005246948.1

    UniProtKB/Swiss-Prot
    Q14790
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  7. XM_006712790.4 → XP_006712853.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_006712853.1

    UniProtKB/Swiss-Prot
    Q14790
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  8. XM_005246889.2 → XP_005246946.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_005246946.1

    UniProtKB/Swiss-Prot
    Q14790
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  9. XM_005246892.2 → XP_005246949.1  caspase-8 isoform X3

    See identical proteins and their annotated locations for XP_005246949.1

    UniProtKB/Swiss-Prot
    Q14790
    UniProtKB/TrEMBL
    A0A024R3Z8
    Conserved Domains (3) summary
    cd00032
    Location:210 → 462
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  10. XM_005246885.2 → XP_005246942.1  caspase-8 isoform X1

    Conserved Domains (3) summary
    cd00032
    Location:269 → 521
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  11. XM_005246893.3 → XP_005246950.1  caspase-8 isoform X5

    See identical proteins and their annotated locations for XP_005246950.1

    Conserved Domains (2) summary
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  12. XM_005246895.3 → XP_005246952.1  caspase-8 isoform X7

    Conserved Domains (2) summary
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  13. XM_005246890.4 → XP_005246947.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_005246947.1

    UniProtKB/Swiss-Prot
    Q14790
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  14. XM_005246886.2 → XP_005246943.1  caspase-8 isoform X2

    See identical proteins and their annotated locations for XP_005246943.1

    UniProtKB/Swiss-Prot
    Q14790
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  15. XM_011511969.2 → XP_011510271.1  caspase-8 isoform X4

    Conserved Domains (2) summary
    cd00032
    Location:80 → 332
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:1 → 35
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. XR_001738971.1 RNA Sequence

  2. XR_923035.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033357.2: Suppressed sequence

    Description
    NM_033357.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14790.1 GenPept UniProtKB/Swiss-Prot:Q14790

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