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Casp8 caspase 8 [ Mus musculus (house mouse) ]

Gene ID: 12370, updated on 21-Feb-2024

Summary

Official Symbol
Casp8provided by MGI
Official Full Name
caspase 8provided by MGI
Primary source
MGI:MGI:1261423
See related
Ensembl:ENSMUSG00000026029 AllianceGenome:MGI:1261423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MACH; Mch5; FLICE; CASP-8
Summary
This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]
Expression
Ubiquitous expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.8) and 24 other tissues See more
Orthologs
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Genomic context

See Casp8 in Genome Data Viewer
Location:
1 C1.3; 1 29.19 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58834553..58886663)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58795233..58847503)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E790 Neighboring gene STARR-positive B cell enhancer ABC_E5758 Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene STARR-seq mESC enhancer starr_01021 Neighboring gene STARR-seq mESC enhancer starr_01022 Neighboring gene STARR-positive B cell enhancer ABC_E1220 Neighboring gene STARR-seq mESC enhancer starr_01023 Neighboring gene predicted gene, 39646 Neighboring gene STARR-positive B cell enhancer mm9_chr1:58854474-58854775 Neighboring gene predicted gene 28802 Neighboring gene STARR-seq mESC enhancer starr_01024 Neighboring gene STARR-seq mESC enhancer starr_01025 Neighboring gene trafficking protein, kinesin binding 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59013204-59013435 Neighboring gene STARR-seq mESC enhancer starr_01027 Neighboring gene STARR-positive B cell enhancer ABC_E982 Neighboring gene STE20-related kinase adaptor beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables death effector domain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables death effector domain binding ISO
Inferred from Sequence Orthology
more info
 
enables death receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
involved_in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis involved in protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of thymocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in self proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of CD95 death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
part_of Noc1p-Noc2p complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ripoptosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
caspase-8
Names
Fas-linked ICE-like protease
NP_001073595.1
NP_001264855.2
NP_001406970.1
NP_001406971.1
NP_001406972.1
NP_001406973.1
NP_001406974.1
NP_001406975.1
NP_001406976.1
NP_001406978.1
NP_001406979.1
NP_033942.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080126.2NP_001073595.1  caspase-8 isoform 1

    See identical proteins and their annotated locations for NP_001073595.1

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    Consensus CDS
    CCDS14979.1
    UniProtKB/Swiss-Prot
    O35669, O89110
    UniProtKB/TrEMBL
    Q3U607, Q4FK85
    Related
    ENSMUSP00000127375.2, ENSMUST00000165549.8
    Conserved Domains (3) summary
    cd00032
    Location:227479
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_001277926.2NP_001264855.2  caspase-8 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    Consensus CDS
    CCDS78590.1
    UniProtKB/Swiss-Prot
    O35669, O89110
    UniProtKB/TrEMBL
    Q3U607, Q4FK85
    Related
    ENSMUSP00000140335.2, ENSMUST00000190213.2
  3. NM_001420041.1NP_001406970.1  caspase-8 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    UniProtKB/Swiss-Prot
    O35669, O89110
    UniProtKB/TrEMBL
    Q3U607, Q4FK85
  4. NM_001420042.1NP_001406971.1  caspase-8 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    UniProtKB/Swiss-Prot
    O35669, O89110
    UniProtKB/TrEMBL
    Q3U607, Q4FK85
  5. NM_001420043.1NP_001406972.1  caspase-8 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    UniProtKB/Swiss-Prot
    O35669, O89110
    UniProtKB/TrEMBL
    Q3U607, Q4FK85
  6. NM_001420044.1NP_001406973.1  caspase-8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    UniProtKB/TrEMBL
    Q4FK85
  7. NM_001420045.1NP_001406974.1  caspase-8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    UniProtKB/TrEMBL
    Q4FK85
  8. NM_001420046.1NP_001406975.1  caspase-8 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    UniProtKB/TrEMBL
    Q4FK85
  9. NM_001420047.1NP_001406976.1  caspase-8 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    UniProtKB/TrEMBL
    Q4FK85
  10. NM_001420049.1NP_001406978.1  caspase-8 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    UniProtKB/TrEMBL
    Q4FK85
  11. NM_001420050.1NP_001406979.1  caspase-8 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
  12. NM_009812.3NP_033942.1  caspase-8 isoform 1

    See identical proteins and their annotated locations for NP_033942.1

    Status: REVIEWED

    Source sequence(s)
    AC112968, AC120554
    Consensus CDS
    CCDS14979.1
    UniProtKB/Swiss-Prot
    O35669, O89110
    UniProtKB/TrEMBL
    Q3U607, Q4FK85
    Related
    ENSMUSP00000027189.9, ENSMUST00000027189.15
    Conserved Domains (3) summary
    cd00032
    Location:227479
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:384
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98179
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58834553..58886663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)