1CP3,1I4O,1JXQ,1I4E


Conserved Protein Domain Family
CASc

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cd00032: CASc 
Click on image for an interactive view with Cn3D
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologs.
Statistics
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PSSM-Id: 237997
Aligned: 52 rows
Threshold Bit Score: 208.609
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1CP3_A     36 SYKMDYp---EMGLCIIINNKNFHks--------------tgMTSRSGTDVDAANLRETFRN-LKYEVRNKNDLTREEIV 97  human
P42573    234 MYRNFSs---PRGMCLIINNEHFEq-----------------MPTRNGTKADKDNLTNLFRC-MGYTVICKDNLTGRGML 292 Caenorhabditis ele...
AAD41595  165 VYQFTS----PRGYALIISNEHFRt-----------------MPQRRGTKADVIALKNLFISkLGYEVEVHENLTGKELH 223 Pristionchus pacif...
NP_524017 186 TYKMQSr--fNRGVLLMVNIMDYPd----------------qNRRRIGAEKDSKSLIHLFQE-LNFTIFPYGNVNQDQFF 246 fruit fly
NP_500960 580 KYRNNRs---SKCRAIIINNVVFCg-----------------MEKRIGSDKDKKKLSKLFER-LGYQSTSYDNLKSSEIL 638 Caenorhabditis ele...
7510012   362 CYEMNSn---PRGTVLILSNENFKn-----------------MERRVGTKQDEVNLTKLFQK-LQYTVICKRNLEAESML 420 Caenorhabditis ele...
AAF98011   85 DFYYTL----STGFVLIINNEKFVe-----------------EENRDGSEVDVQALNSFFKG-TLGWCVKSCNNLKREDI 142 Hydra vulgaris
O15519    212 RLKEQLgaqqEPVKKSIQESEAFLpqsipeerykmkskplgiCLIIDCIGNETELLRDTFTS-LGYEVQKFLHLSMHGIS 290 human
P31944      4 PRSLEEe---KYDMSGARLALILCv-----------------TKAREGSEEDLDALEHMFRQ-LRFESTMKRDPTAEQFQ 62  human
O89094      8 PQPLQEe---RYDMSGARLALTLCv-----------------TKAREGSEVDMEALERMFRY-LKFESTMKRDPTAQQFL 66  house mouse
Feature 1                               #                                                #    
1CP3_A     98 ELMRDVsk---eDHSKRSSFVCVLLSHGEE----GIIFGTN---GPVDLKKITNFFrgdRCRSLTGKPKLFIIQACRGTE 167 human
P42573    293 LTIRDFa----kHESHGDSAILVILSHGEE----NVIIGVDd--IPISTHEIYDLLnaaNAPRLANKPKIVFVQACRGER 362 Caenorhabditis ele...
AAD41595  224 NNIKSFas--stKHSFTSSAIVCILTHGEH----DVLYGVDd--QVVDVHYLLSSFnthNAPHLAGKPKIILLQACRGER 295 Pristionchus pacif...
NP_524017 247 KLLTMVts--ssYVQNTECFVMVLMTHGNSvegkEKVEFCDg--SVVDMQKIKDHFqtaKCPYLVNKPKVLMFPFCRGDE 322 fruit fly
NP_500960 639 ETVRQFt-----QSNHGDSLIITIMSHGDQ----GLLYGVDg--VPVQMLDIIDLM---CTASLAKKPKWLMCVCCRGDR 704 Caenorhabditis ele...
7510012   421 EAIKEFa-----EMAHTDSIILFLLSHGDGa---GSVFGIDd--MPVNVMEVSTYLa--YHQNLLLKPKWVAVSACRGGE 488 Caenorhabditis ele...
AAF98011  143 INIVYSls--qvKCFPFSALFIVILSHGSE----SGILGIDs-sEEIKINSLLENFkadNAPAFDKKPKVFIVQACRGEK 215 Hydra vulgaris
O15519    291 QILGQFac--mpEHRDYDSFVCVLVSRGGS----QSVYGVDqthSGLPLHHIRRMFmgdSCPYLAGKPKMFFIQNYVVSE 364 human
P31944     63 EELEKFqqaidsREDPVSCAFVVLMAHGRE----GFLKGEDg--EMVKLENLFEALnnkNCQALRAKPKVYIIQACRGEQ 136 human
O89094     67 EELDEFqqtidnWEEPVSCAFVVLMAHGEE----GLLKGEDe--KMVRLEDLFEVLnnkNCKALRGKPKVYIIQACRGEH 140 house mouse
Feature 1                                                                                     
1CP3_A    168 LDCgietdsgvd---------------------------ddmachkiPVDADFLYAYSTAPGYYSWRNSKDGSWFIQSLC 220 human
P42573    363 RDNgfpvldsvdgvpaflrrgwdnrdgplfnflgcvrpqvqqvwrkkPSQADILIRYATTAQYVSWRNSARGSWFIQAVC 442 Caenorhabditis ele...
AAD41595  296 KDIgyeetdsgrpfafle--------------clgmggggmmtrnkrPAESDILVAYATPAHYVSWRNSEKGSWFIQSFV 361 Pristionchus pacif...
NP_524017 323 YDLghpknqgnlmepvytaqe--------ekwpdtqtegipspstnvPSLADTLVCYANTPGYVTHRDLDTGSWYIQKFC 394 fruit fly
NP_500960 705 IDRavrcdgfidnffdrfp------------kffqfmkskfpshqtsSSQADLLVSFSTSPGFLSFRDETKGTWYIQELY 772 Caenorhabditis ele...
7510012   489 IDLiffafq---------------------------------pgtftSLNADVIISFSTTDGFTSYRDEEAGTWYIKSMC 535 Caenorhabditis ele...
AAF98011  216 DDIrkdgikdak--------------------------rtyynestiPMLSDFVVAYPCAAGYTALRSTVKGSWFIQELV 269 Hydra vulgaris
O15519    365 GQLedssllevdgpamk----------------nvefkaqkrglctvHREADFFWSLCTADMSLLEQSHSSPSLYLQCLS 428 human
P31944    137 RDPgetvggdeiv------------------------mvikdspqtiPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLV 192 human
O89094    141 RDPgeelrgneelggdeel-------------ggdevavlknnpqsiPTYTDTLHIYSTVEGYLSYRHDEKGSGFIQTLT 207 house mouse
Feature 1                                                               
1CP3_A    221 AMLKQYad-kLEFMHILTRVNRKVATEfesfsfdatfhakKQIPCI-VSMLTKELYFY 276 human
P42573    443 EVFSTHak-dMDVVELLTEVNKKVACGfqtsq---gsnilKQMPEM-TSRLLKKFYFW 495 Caenorhabditis elegans
AAD41595  362 EVAEKRsh-dSDLLSILTQVNAKVAETykans---stgeyKQISEF-SSKLTKKFFFF 414 Pristionchus pacificus
NP_524017 395 QVMADHah-dTDLEDILKKTSEAVGNKrtk-------kgsMQTGAYdNLGFNKKLYFN 444 fruit fly
NP_500960 773 RVIIENak-dTHLADLLMETNRRVVEKyeadk---vvivcKQAPEF-WSRFTKQLFFD 825 Caenorhabditis elegans
7510012   536 KVFNKHsk-tMHLLDILTETGRNVVTKyenvq---gnvvlKQAPEV-GSPNLKCCLKC 588 Caenorhabditis elegans
AAF98011  270 KCLSIFyd-kEDFLSILNRVNFKVANVtlp-------qglKEQPCF-EVGLRTRCFFQ 318 Hydra vulgaris
O15519    429 QKLRQEr--kRPLLDLHIELNGYMYDWnsrv-----sakeKYYVWL-QHTLRKKLILS 478 human
P31944    193 DVFTKRk---GHILELLTEVTRRMAEAelvqe----gkarKTNPEI-QSTLRKRLYLQ 242 human
O89094    208 DVFIHKkgsiLELTEEITRLMANTEVMqeg-------kprKVNPEV-QSTLRKKLYLQ 257 house mouse

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