U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lung cancer

MedGen UID:
66885
•Concept ID:
C0242379
•
Neoplastic Process
Synonyms: Lung cancer, somatic; Malignant tumor of lung
SNOMED CT: CA - Lung cancer (363358000); Malignant tumor of lung (363358000)
 
Genes (locations): BRAF (7q34); CASP8 (2q33.1); CYP2A6 (19q13.2); EGFR (7p11.2); ERBB2 (17q12); ERCC6 (10q11.23); FASLG (1q24.3); IRF1 (5q31.1); KRAS (12p12.1); MAP3K8 (10p11.23); PIK3CA (3q26.32); PPP2R1B (11q23.1); PRKN (6q26); SLC22A18 (11p15.4)
 
Monarch Initiative: MONDO:0008903
OMIM®: 211980

Definition

A primary or metastatic malignant neoplasm involving the lung. [from NCI]

Clinical features

From HPO
Alveolar cell carcinoma
MedGen UID:
2871
•Concept ID:
C0007120
•
Neoplastic Process
Adenocarcinoma of the Bronchus.
See: Feature record | Search on this feature
Non-small cell lung carcinoma
MedGen UID:
40104
•Concept ID:
C0007131
•
Neoplastic Process
A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.
See: Feature record | Search on this feature
Lung adenocarcinoma
MedGen UID:
57744
•Concept ID:
C0152013
•
Neoplastic Process
A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology.
Lindeman NI, Cagle PT, Aisner DL, Arcila ME, Beasley MB, Bernicker EH, Colasacco C, Dacic S, Hirsch FR, Kerr K, Kwiatkowski DJ, Ladanyi M, Nowak JA, Sholl L, Temple-Smolkin R, Solomon B, Souter LH, Thunnissen E, Tsao MS, Ventura CB, Wynes MW, Yatabe Y
J Mol Diagn 2018 Mar;20(2):129-159. Epub 2018 Jan 23 doi: 10.1016/j.jmoldx.2017.11.004. PMID: 29398453

Recent clinical studies

Etiology

Neighborhood disadvantage and lung cancer risk in a national cohort of never smoking Black women.
Erhunmwunsee L, Wing SE, Zou X, Coogan P, Palmer JR, Lennie Wong F
Lung Cancer 2022 Nov;173:21-27. Epub 2022 Sep 8 doi: 10.1016/j.lungcan.2022.08.022. PMID: 36108579Free PMC Article
Development of an updated, standardized, patient-centered outcome set for lung cancer.
de Rooij BH, van den Hurk C, Smaardijk V, Fernandez-Ortega P, Navarro-Martin A, Barberio L, Guckenberger M, Schmid S, Walraven I, Vallow S, Kotsi C, Preusser M, Mosor E, Klok JM, Becker A, Milani A, Ninov L, van de Poll-Franse LV
Lung Cancer 2022 Nov;173:5-13. Epub 2022 Sep 5 doi: 10.1016/j.lungcan.2022.08.021. PMID: 36103777
Risk perception and disease knowledge in attendees of a community-based lung cancer screening programme.
Lebrett MB, Crosbie EJ, Yorke J, Hewitt K, Rowlands A, Badrick E, Gareth Evans D, Balata H, Booton R, Crosbie PAJ
Lung Cancer 2022 Jun;168:1-9. Epub 2022 Apr 6 doi: 10.1016/j.lungcan.2022.04.003. PMID: 35430354
A risk prediction model for selecting high-risk population for computed tomography lung cancer screening in China.
Guo LW, Lyu ZY, Meng QC, Zheng LY, Chen Q, Liu Y, Xu HF, Kang RH, Zhang LY, Cao XQ, Liu SZ, Sun XB, Zhang JG, Zhang SK
Lung Cancer 2022 Jan;163:27-34. Epub 2021 Dec 1 doi: 10.1016/j.lungcan.2021.11.015. PMID: 34894456
Health and economic impact at a population level of both primary and secondary preventive lung cancer interventions: A model-based cost-effectiveness analysis.
Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group.
Lung Cancer 2021 Sep;159:153-161. Epub 2021 Jul 21 doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591

Diagnosis

Neighborhood disadvantage and lung cancer risk in a national cohort of never smoking Black women.
Erhunmwunsee L, Wing SE, Zou X, Coogan P, Palmer JR, Lennie Wong F
Lung Cancer 2022 Nov;173:21-27. Epub 2022 Sep 8 doi: 10.1016/j.lungcan.2022.08.022. PMID: 36108579Free PMC Article
Race & sex disparities related to low-dose computed tomography lung cancer screening eligibility criteria: A lung cancer cases review.
Williams RM, Kareff SA, Sackstein P, Roy T, Luta G, Kim C, Taylor KL, Tammemägi MC
Lung Cancer 2022 Jul;169:55-60. Epub 2022 May 17 doi: 10.1016/j.lungcan.2022.05.008. PMID: 35644087Free PMC Article
Risk perception and disease knowledge in attendees of a community-based lung cancer screening programme.
Lebrett MB, Crosbie EJ, Yorke J, Hewitt K, Rowlands A, Badrick E, Gareth Evans D, Balata H, Booton R, Crosbie PAJ
Lung Cancer 2022 Jun;168:1-9. Epub 2022 Apr 6 doi: 10.1016/j.lungcan.2022.04.003. PMID: 35430354
Lung cancer-associated T cell repertoire as potential biomarker for early detection of stage I lung cancer.
Li M, Zhang C, Deng S, Li L, Liu S, Bai J, Xu Y, Guan Y, Xia X, Sun L, Carbone DP, Hu C
Lung Cancer 2021 Dec;162:16-22. Epub 2021 Sep 28 doi: 10.1016/j.lungcan.2021.09.017. PMID: 34649105
Health and economic impact at a population level of both primary and secondary preventive lung cancer interventions: A model-based cost-effectiveness analysis.
Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group.
Lung Cancer 2021 Sep;159:153-161. Epub 2021 Jul 21 doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591

Therapy

Neighborhood disadvantage and lung cancer risk in a national cohort of never smoking Black women.
Erhunmwunsee L, Wing SE, Zou X, Coogan P, Palmer JR, Lennie Wong F
Lung Cancer 2022 Nov;173:21-27. Epub 2022 Sep 8 doi: 10.1016/j.lungcan.2022.08.022. PMID: 36108579Free PMC Article
A risk prediction model for selecting high-risk population for computed tomography lung cancer screening in China.
Guo LW, Lyu ZY, Meng QC, Zheng LY, Chen Q, Liu Y, Xu HF, Kang RH, Zhang LY, Cao XQ, Liu SZ, Sun XB, Zhang JG, Zhang SK
Lung Cancer 2022 Jan;163:27-34. Epub 2021 Dec 1 doi: 10.1016/j.lungcan.2021.11.015. PMID: 34894456
Analysis of the baseline performance of five UK lung cancer screening programmes.
Balata H, Ruparel M, O'Dowd E, Ledson M, Field JK, Duffy SW, Quaife SL, Sharman A, Janes S, Baldwin D, Booton R, Crosbie PAJ
Lung Cancer 2021 Nov;161:136-140. Epub 2021 Sep 20 doi: 10.1016/j.lungcan.2021.09.012. PMID: 34583222
Role of dietary carbohydrates on risk of lung cancer.
Tao J, Jatoi A, Crawford J, Lam WWT, Ho JC, Wang X, Pang H
Lung Cancer 2021 May;155:87-93. Epub 2021 Mar 17 doi: 10.1016/j.lungcan.2021.03.009. PMID: 33756357
Temporal trends of the lung cancer mortality attributable to smoking from 1990 to 2017: A global, regional and national analysis.
Yang X, Man J, Chen H, Zhang T, Yin X, He Q, Lu M
Lung Cancer 2021 Feb;152:49-57. Epub 2020 Dec 9 doi: 10.1016/j.lungcan.2020.12.007. PMID: 33348250

Prognosis

Hospital case-volume and mortality after lung cancer surgery: A population-based retrospective cohort study.
Kim BR, Sohn JY, Jang EJ, Jo J, Lee H, Ryu HG
Lung Cancer 2022 Jul;169:61-66. Epub 2022 May 27 doi: 10.1016/j.lungcan.2022.05.016. PMID: 35660970
Race & sex disparities related to low-dose computed tomography lung cancer screening eligibility criteria: A lung cancer cases review.
Williams RM, Kareff SA, Sackstein P, Roy T, Luta G, Kim C, Taylor KL, Tammemägi MC
Lung Cancer 2022 Jul;169:55-60. Epub 2022 May 17 doi: 10.1016/j.lungcan.2022.05.008. PMID: 35644087Free PMC Article
A risk prediction model for selecting high-risk population for computed tomography lung cancer screening in China.
Guo LW, Lyu ZY, Meng QC, Zheng LY, Chen Q, Liu Y, Xu HF, Kang RH, Zhang LY, Cao XQ, Liu SZ, Sun XB, Zhang JG, Zhang SK
Lung Cancer 2022 Jan;163:27-34. Epub 2021 Dec 1 doi: 10.1016/j.lungcan.2021.11.015. PMID: 34894456
Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort.
Borg M, Wen SWC, Nederby L, Hansen TF, Jakobsen A, Andersen RF, Weinreich UM, Hilberg O
Lung Cancer 2021 Aug;158:85-90. Epub 2021 Jun 10 doi: 10.1016/j.lungcan.2021.06.010. PMID: 34130044
Age disparities in lung cancer survival in New Zealand: The role of patient and clinical factors.
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378

Clinical prediction guides

Development of an updated, standardized, patient-centered outcome set for lung cancer.
de Rooij BH, van den Hurk C, Smaardijk V, Fernandez-Ortega P, Navarro-Martin A, Barberio L, Guckenberger M, Schmid S, Walraven I, Vallow S, Kotsi C, Preusser M, Mosor E, Klok JM, Becker A, Milani A, Ninov L, van de Poll-Franse LV
Lung Cancer 2022 Nov;173:5-13. Epub 2022 Sep 5 doi: 10.1016/j.lungcan.2022.08.021. PMID: 36103777
Race & sex disparities related to low-dose computed tomography lung cancer screening eligibility criteria: A lung cancer cases review.
Williams RM, Kareff SA, Sackstein P, Roy T, Luta G, Kim C, Taylor KL, Tammemägi MC
Lung Cancer 2022 Jul;169:55-60. Epub 2022 May 17 doi: 10.1016/j.lungcan.2022.05.008. PMID: 35644087Free PMC Article
Risk perception and disease knowledge in attendees of a community-based lung cancer screening programme.
Lebrett MB, Crosbie EJ, Yorke J, Hewitt K, Rowlands A, Badrick E, Gareth Evans D, Balata H, Booton R, Crosbie PAJ
Lung Cancer 2022 Jun;168:1-9. Epub 2022 Apr 6 doi: 10.1016/j.lungcan.2022.04.003. PMID: 35430354
A risk prediction model for selecting high-risk population for computed tomography lung cancer screening in China.
Guo LW, Lyu ZY, Meng QC, Zheng LY, Chen Q, Liu Y, Xu HF, Kang RH, Zhang LY, Cao XQ, Liu SZ, Sun XB, Zhang JG, Zhang SK
Lung Cancer 2022 Jan;163:27-34. Epub 2021 Dec 1 doi: 10.1016/j.lungcan.2021.11.015. PMID: 34894456
Age disparities in lung cancer survival in New Zealand: The role of patient and clinical factors.
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378

Recent systematic reviews

Higher mortality in lung cancer patients with COVID-19? A systematic review and meta-analysis.
Lei H, Yang Y, Zhou W, Zhang M, Shen Y, Tao D, Wang L, Lei Q, Wang Y, Wu Y
Lung Cancer 2021 Jul;157:60-65. Epub 2021 May 5 doi: 10.1016/j.lungcan.2021.05.002. PMID: 33985850Free PMC Article
Platinum-doublet chemotherapy as second-line treatment for relapsed patients with small-cell lung cancer: A systematic review and meta-analysis.
Horiuchi K, Sato T, Kuno T, Takagi H, Hirsch FR, Powell CA, Fukunaga K
Lung Cancer 2021 Jun;156:59-67. Epub 2021 Apr 19 doi: 10.1016/j.lungcan.2021.04.013. PMID: 33894495
Association between family history of lung cancer and lung cancer risk: a systematic review and meta-analysis.
Ang L, Chan CPY, Yau WP, Seow WJ
Lung Cancer 2020 Oct;148:129-137. Epub 2020 Aug 20 doi: 10.1016/j.lungcan.2020.08.012. PMID: 32892102
Risk-Based lung cancer screening: A systematic review.
Toumazis I, Bastani M, Han SS, Plevritis SK
Lung Cancer 2020 Sep;147:154-186. Epub 2020 Jul 12 doi: 10.1016/j.lungcan.2020.07.007. PMID: 32721652
Airflow limitation and survival after surgery for non-small cell lung cancer: Results from a systematic review and lung cancer screening trial (NLST-ACRIN sub-study).
Hopkins RJ, Ko J, Gamble GD, Young RP
Lung Cancer 2019 Sep;135:80-87. Epub 2019 Jul 18 doi: 10.1016/j.lungcan.2019.07.015. PMID: 31447006

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    You are here: NCBI
    Support Center