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Lung cancer

MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
Synonyms: Lung cancer, somatic; Malignant tumor of lung
SNOMED CT: CA - Lung cancer (363358000); Malignant tumor of lung (363358000)
 
Genes (locations): BRAF (7q34); CASP8 (2q33.1); CYP2A6 (19q13.2); EGFR (7p11.2); ERBB2 (17q12); ERCC6 (10q11.23); FASLG (1q24.3); IRF1 (5q31.1); KRAS (12p12.1); MAP3K8 (10p11.23); PIK3CA (3q26.32); PPP2R1B (11q23.1); PRKN (6q26); SLC22A18 (11p15.4)
 
Monarch Initiative: MONDO:0008903
OMIM®: 211980

Definition

A primary or metastatic malignant neoplasm involving the lung. [from NCI]

Clinical features

From HPO
Alveolar cell carcinoma
MedGen UID:
2871
Concept ID:
C0007120
Neoplastic Process
Adenocarcinoma of the Bronchus.
Non-small cell lung carcinoma
MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.
Lung adenocarcinoma
MedGen UID:
57744
Concept ID:
C0152013
Neoplastic Process
A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Lindeman NI, Cagle PT, Aisner DL, Arcila ME, Beasley MB, Bernicker EH, Colasacco C, Dacic S, Hirsch FR, Kerr K, Kwiatkowski DJ, Ladanyi M, Nowak JA, Sholl L, Temple-Smolkin R, Solomon B, Souter LH, Thunnissen E, Tsao MS, Ventura CB, Wynes MW, Yatabe Y
J Mol Diagn 2018 Mar;20(2):129-159. Epub 2018 Jan 23 doi: 10.1016/j.jmoldx.2017.11.004. PMID: 29398453

Recent clinical studies

Etiology

Erhunmwunsee L, Wing SE, Zou X, Coogan P, Palmer JR, Lennie Wong F
Lung Cancer 2022 Nov;173:21-27. Epub 2022 Sep 8 doi: 10.1016/j.lungcan.2022.08.022. PMID: 36108579Free PMC Article
de Rooij BH, van den Hurk C, Smaardijk V, Fernandez-Ortega P, Navarro-Martin A, Barberio L, Guckenberger M, Schmid S, Walraven I, Vallow S, Kotsi C, Preusser M, Mosor E, Klok JM, Becker A, Milani A, Ninov L, van de Poll-Franse LV
Lung Cancer 2022 Nov;173:5-13. Epub 2022 Sep 5 doi: 10.1016/j.lungcan.2022.08.021. PMID: 36103777
Lebrett MB, Crosbie EJ, Yorke J, Hewitt K, Rowlands A, Badrick E, Gareth Evans D, Balata H, Booton R, Crosbie PAJ
Lung Cancer 2022 Jun;168:1-9. Epub 2022 Apr 6 doi: 10.1016/j.lungcan.2022.04.003. PMID: 35430354
Guo LW, Lyu ZY, Meng QC, Zheng LY, Chen Q, Liu Y, Xu HF, Kang RH, Zhang LY, Cao XQ, Liu SZ, Sun XB, Zhang JG, Zhang SK
Lung Cancer 2022 Jan;163:27-34. Epub 2021 Dec 1 doi: 10.1016/j.lungcan.2021.11.015. PMID: 34894456
Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group.
Lung Cancer 2021 Sep;159:153-161. Epub 2021 Jul 21 doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591

Diagnosis

Erhunmwunsee L, Wing SE, Zou X, Coogan P, Palmer JR, Lennie Wong F
Lung Cancer 2022 Nov;173:21-27. Epub 2022 Sep 8 doi: 10.1016/j.lungcan.2022.08.022. PMID: 36108579Free PMC Article
Williams RM, Kareff SA, Sackstein P, Roy T, Luta G, Kim C, Taylor KL, Tammemägi MC
Lung Cancer 2022 Jul;169:55-60. Epub 2022 May 17 doi: 10.1016/j.lungcan.2022.05.008. PMID: 35644087Free PMC Article
Lebrett MB, Crosbie EJ, Yorke J, Hewitt K, Rowlands A, Badrick E, Gareth Evans D, Balata H, Booton R, Crosbie PAJ
Lung Cancer 2022 Jun;168:1-9. Epub 2022 Apr 6 doi: 10.1016/j.lungcan.2022.04.003. PMID: 35430354
Li M, Zhang C, Deng S, Li L, Liu S, Bai J, Xu Y, Guan Y, Xia X, Sun L, Carbone DP, Hu C
Lung Cancer 2021 Dec;162:16-22. Epub 2021 Sep 28 doi: 10.1016/j.lungcan.2021.09.017. PMID: 34649105
Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group.
Lung Cancer 2021 Sep;159:153-161. Epub 2021 Jul 21 doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591

Therapy

Erhunmwunsee L, Wing SE, Zou X, Coogan P, Palmer JR, Lennie Wong F
Lung Cancer 2022 Nov;173:21-27. Epub 2022 Sep 8 doi: 10.1016/j.lungcan.2022.08.022. PMID: 36108579Free PMC Article
Guo LW, Lyu ZY, Meng QC, Zheng LY, Chen Q, Liu Y, Xu HF, Kang RH, Zhang LY, Cao XQ, Liu SZ, Sun XB, Zhang JG, Zhang SK
Lung Cancer 2022 Jan;163:27-34. Epub 2021 Dec 1 doi: 10.1016/j.lungcan.2021.11.015. PMID: 34894456
Balata H, Ruparel M, O'Dowd E, Ledson M, Field JK, Duffy SW, Quaife SL, Sharman A, Janes S, Baldwin D, Booton R, Crosbie PAJ
Lung Cancer 2021 Nov;161:136-140. Epub 2021 Sep 20 doi: 10.1016/j.lungcan.2021.09.012. PMID: 34583222
Tao J, Jatoi A, Crawford J, Lam WWT, Ho JC, Wang X, Pang H
Lung Cancer 2021 May;155:87-93. Epub 2021 Mar 17 doi: 10.1016/j.lungcan.2021.03.009. PMID: 33756357
Yang X, Man J, Chen H, Zhang T, Yin X, He Q, Lu M
Lung Cancer 2021 Feb;152:49-57. Epub 2020 Dec 9 doi: 10.1016/j.lungcan.2020.12.007. PMID: 33348250

Prognosis

Kim BR, Sohn JY, Jang EJ, Jo J, Lee H, Ryu HG
Lung Cancer 2022 Jul;169:61-66. Epub 2022 May 27 doi: 10.1016/j.lungcan.2022.05.016. PMID: 35660970
Williams RM, Kareff SA, Sackstein P, Roy T, Luta G, Kim C, Taylor KL, Tammemägi MC
Lung Cancer 2022 Jul;169:55-60. Epub 2022 May 17 doi: 10.1016/j.lungcan.2022.05.008. PMID: 35644087Free PMC Article
Guo LW, Lyu ZY, Meng QC, Zheng LY, Chen Q, Liu Y, Xu HF, Kang RH, Zhang LY, Cao XQ, Liu SZ, Sun XB, Zhang JG, Zhang SK
Lung Cancer 2022 Jan;163:27-34. Epub 2021 Dec 1 doi: 10.1016/j.lungcan.2021.11.015. PMID: 34894456
Borg M, Wen SWC, Nederby L, Hansen TF, Jakobsen A, Andersen RF, Weinreich UM, Hilberg O
Lung Cancer 2021 Aug;158:85-90. Epub 2021 Jun 10 doi: 10.1016/j.lungcan.2021.06.010. PMID: 34130044
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378

Clinical prediction guides

de Rooij BH, van den Hurk C, Smaardijk V, Fernandez-Ortega P, Navarro-Martin A, Barberio L, Guckenberger M, Schmid S, Walraven I, Vallow S, Kotsi C, Preusser M, Mosor E, Klok JM, Becker A, Milani A, Ninov L, van de Poll-Franse LV
Lung Cancer 2022 Nov;173:5-13. Epub 2022 Sep 5 doi: 10.1016/j.lungcan.2022.08.021. PMID: 36103777
Williams RM, Kareff SA, Sackstein P, Roy T, Luta G, Kim C, Taylor KL, Tammemägi MC
Lung Cancer 2022 Jul;169:55-60. Epub 2022 May 17 doi: 10.1016/j.lungcan.2022.05.008. PMID: 35644087Free PMC Article
Lebrett MB, Crosbie EJ, Yorke J, Hewitt K, Rowlands A, Badrick E, Gareth Evans D, Balata H, Booton R, Crosbie PAJ
Lung Cancer 2022 Jun;168:1-9. Epub 2022 Apr 6 doi: 10.1016/j.lungcan.2022.04.003. PMID: 35430354
Guo LW, Lyu ZY, Meng QC, Zheng LY, Chen Q, Liu Y, Xu HF, Kang RH, Zhang LY, Cao XQ, Liu SZ, Sun XB, Zhang JG, Zhang SK
Lung Cancer 2022 Jan;163:27-34. Epub 2021 Dec 1 doi: 10.1016/j.lungcan.2021.11.015. PMID: 34894456
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378

Recent systematic reviews

Lei H, Yang Y, Zhou W, Zhang M, Shen Y, Tao D, Wang L, Lei Q, Wang Y, Wu Y
Lung Cancer 2021 Jul;157:60-65. Epub 2021 May 5 doi: 10.1016/j.lungcan.2021.05.002. PMID: 33985850Free PMC Article
Horiuchi K, Sato T, Kuno T, Takagi H, Hirsch FR, Powell CA, Fukunaga K
Lung Cancer 2021 Jun;156:59-67. Epub 2021 Apr 19 doi: 10.1016/j.lungcan.2021.04.013. PMID: 33894495
Ang L, Chan CPY, Yau WP, Seow WJ
Lung Cancer 2020 Oct;148:129-137. Epub 2020 Aug 20 doi: 10.1016/j.lungcan.2020.08.012. PMID: 32892102
Toumazis I, Bastani M, Han SS, Plevritis SK
Lung Cancer 2020 Sep;147:154-186. Epub 2020 Jul 12 doi: 10.1016/j.lungcan.2020.07.007. PMID: 32721652
Hopkins RJ, Ko J, Gamble GD, Young RP
Lung Cancer 2019 Sep;135:80-87. Epub 2019 Jul 18 doi: 10.1016/j.lungcan.2019.07.015. PMID: 31447006

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