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Lung cancer

MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
Synonym: Malignant tumor of lung
SNOMED CT: CA - Lung cancer (363358000); Malignant tumor of lung (363358000)
 
Genes (locations): BRAF (7q34); CASP8 (2q33.1); CYP2A6 (19q13.2); EGFR (7p11.2); ERBB2 (17q12); ERCC6 (10q11.23); FASLG (1q24.3); IRF1 (5q31.1); KRAS (12p12.1); MAP3K8 (10p11.23); PIK3CA (3q26.32); PPP2R1B (11q23.1); PRKN (6q26); SLC22A18 (11p15.4)
 
Monarch Initiative: MONDO:0008903
OMIM®: 211980

Definition

A primary or metastatic malignant neoplasm involving the lung. [from NCI]

Clinical features

From HPO
Alveolar cell carcinoma
MedGen UID:
2871
Concept ID:
C0007120
Neoplastic Process
Adenocarcinoma of the Bronchus.
Non-small cell lung carcinoma
MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.
Lung adenocarcinoma
MedGen UID:
57744
Concept ID:
C0152013
Neoplastic Process
A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Recent clinical studies

Etiology

Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group.
Lung Cancer 2021 Sep;159:153-161. Epub 2021 Jul 21 doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591
Borg M, Wen SWC, Nederby L, Hansen TF, Jakobsen A, Andersen RF, Weinreich UM, Hilberg O
Lung Cancer 2021 Aug;158:85-90. Epub 2021 Jun 10 doi: 10.1016/j.lungcan.2021.06.010. PMID: 34130044
Lei H, Yang Y, Zhou W, Zhang M, Shen Y, Tao D, Wang L, Lei Q, Wang Y, Wu Y
Lung Cancer 2021 Jul;157:60-65. Epub 2021 May 5 doi: 10.1016/j.lungcan.2021.05.002. PMID: 33985850Free PMC Article
Tao J, Jatoi A, Crawford J, Lam WWT, Ho JC, Wang X, Pang H
Lung Cancer 2021 May;155:87-93. Epub 2021 Mar 17 doi: 10.1016/j.lungcan.2021.03.009. PMID: 33756357
Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A
Lung Cancer 2021 Mar;153:42-48. Epub 2021 Jan 9 doi: 10.1016/j.lungcan.2020.12.038. PMID: 33454516

Diagnosis

Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group.
Lung Cancer 2021 Sep;159:153-161. Epub 2021 Jul 21 doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591
Borg M, Wen SWC, Nederby L, Hansen TF, Jakobsen A, Andersen RF, Weinreich UM, Hilberg O
Lung Cancer 2021 Aug;158:85-90. Epub 2021 Jun 10 doi: 10.1016/j.lungcan.2021.06.010. PMID: 34130044
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378
Tao J, Jatoi A, Crawford J, Lam WWT, Ho JC, Wang X, Pang H
Lung Cancer 2021 May;155:87-93. Epub 2021 Mar 17 doi: 10.1016/j.lungcan.2021.03.009. PMID: 33756357
Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A
Lung Cancer 2021 Mar;153:42-48. Epub 2021 Jan 9 doi: 10.1016/j.lungcan.2020.12.038. PMID: 33454516

Therapy

Balata H, Ruparel M, O'Dowd E, Ledson M, Field JK, Duffy SW, Quaife SL, Sharman A, Janes S, Baldwin D, Booton R, Crosbie PAJ
Lung Cancer 2021 Nov;161:136-140. Epub 2021 Sep 20 doi: 10.1016/j.lungcan.2021.09.012. PMID: 34583222
Tao J, Jatoi A, Crawford J, Lam WWT, Ho JC, Wang X, Pang H
Lung Cancer 2021 May;155:87-93. Epub 2021 Mar 17 doi: 10.1016/j.lungcan.2021.03.009. PMID: 33756357
Yang X, Man J, Chen H, Zhang T, Yin X, He Q, Lu M
Lung Cancer 2021 Feb;152:49-57. Epub 2020 Dec 9 doi: 10.1016/j.lungcan.2020.12.007. PMID: 33348250
Chen LN, Spivack J, Cao T, Saqi A, Benvenuto LJ, Bulman WA, Mathew M, Stoopler MB, Arcasoy SM, Stanifer BP, Rizvi NA, Shu CA
Lung Cancer 2020 Aug;146:297-302. Epub 2020 Jun 20 doi: 10.1016/j.lungcan.2020.06.018. PMID: 32619780
Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, López-Alfonso A, Gullón P, Lara MÁ
Lung Cancer 2020 Aug;146:19-22. Epub 2020 May 30 doi: 10.1016/j.lungcan.2020.05.034. PMID: 32505076Free PMC Article

Prognosis

Borg M, Wen SWC, Nederby L, Hansen TF, Jakobsen A, Andersen RF, Weinreich UM, Hilberg O
Lung Cancer 2021 Aug;158:85-90. Epub 2021 Jun 10 doi: 10.1016/j.lungcan.2021.06.010. PMID: 34130044
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378
Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A
Lung Cancer 2021 Mar;153:42-48. Epub 2021 Jan 9 doi: 10.1016/j.lungcan.2020.12.038. PMID: 33454516
Yang X, Man J, Chen H, Zhang T, Yin X, He Q, Lu M
Lung Cancer 2021 Feb;152:49-57. Epub 2020 Dec 9 doi: 10.1016/j.lungcan.2020.12.007. PMID: 33348250
Liao Z, Rivin Del Campo E, Salem A, Pang Q, Liu H, Lopez Guerra JL
Lung Cancer 2020 Aug;146:230-235. Epub 2020 May 26 doi: 10.1016/j.lungcan.2020.05.029. PMID: 32585497Free PMC Article

Clinical prediction guides

Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378
Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A
Lung Cancer 2021 Mar;153:42-48. Epub 2021 Jan 9 doi: 10.1016/j.lungcan.2020.12.038. PMID: 33454516
Jiang M, Fares AF, Shepshelovich D, Yang P, Christiani D, Zhang J, Shiraishi K, Ryan BM, Chen C, Schwartz AG, Tardon A, Shete S, Schabath MB, Teare MD, Le Marchand L, Zhang ZF, Field JK, Brenner H, Diao N, Xie J, Kohno T, Harris CC, Wenzlaff AS, Fernandez-Tardon G, Ye Y, Taylor F, Wilkens LR, Davies M, Liu Y, Barnett MJ, Goodman GE, Morgenstern H, Holleczek B, Thomas S, Brown MC, Hung RJ, Xu W, Liu G
Lung Cancer 2021 Feb;152:58-65. Epub 2020 Dec 4 doi: 10.1016/j.lungcan.2020.11.029. PMID: 33352384Free PMC Article
Chen LN, Spivack J, Cao T, Saqi A, Benvenuto LJ, Bulman WA, Mathew M, Stoopler MB, Arcasoy SM, Stanifer BP, Rizvi NA, Shu CA
Lung Cancer 2020 Aug;146:297-302. Epub 2020 Jun 20 doi: 10.1016/j.lungcan.2020.06.018. PMID: 32619780
Nagasaka M, Lehman A, Chlebowski R, Haynes BM, Ho G, Patel M, Sakoda LC, Schwartz AG, Simon MS, Cote ML
Lung Cancer 2020 Mar;141:78-81. Epub 2020 Jan 7 doi: 10.1016/j.lungcan.2020.01.006. PMID: 31958598

Recent systematic reviews

Lei H, Yang Y, Zhou W, Zhang M, Shen Y, Tao D, Wang L, Lei Q, Wang Y, Wu Y
Lung Cancer 2021 Jul;157:60-65. Epub 2021 May 5 doi: 10.1016/j.lungcan.2021.05.002. PMID: 33985850Free PMC Article
Horiuchi K, Sato T, Kuno T, Takagi H, Hirsch FR, Powell CA, Fukunaga K
Lung Cancer 2021 Jun;156:59-67. Epub 2021 Apr 19 doi: 10.1016/j.lungcan.2021.04.013. PMID: 33894495
Ang L, Chan CPY, Yau WP, Seow WJ
Lung Cancer 2020 Oct;148:129-137. Epub 2020 Aug 20 doi: 10.1016/j.lungcan.2020.08.012. PMID: 32892102
Toumazis I, Bastani M, Han SS, Plevritis SK
Lung Cancer 2020 Sep;147:154-186. Epub 2020 Jul 12 doi: 10.1016/j.lungcan.2020.07.007. PMID: 32721652
Hopkins RJ, Ko J, Gamble GD, Young RP
Lung Cancer 2019 Sep;135:80-87. Epub 2019 Jul 18 doi: 10.1016/j.lungcan.2019.07.015. PMID: 31447006

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