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Lung cancer

MedGen UID:
66885
•Concept ID:
C0242379
•
Neoplastic Process
Synonym: Malignant tumor of lung
SNOMED CT: CA - Lung cancer (363358000); Malignant tumor of lung (363358000)
 
Genes (locations): BRAF (7q34); CASP8 (2q33.1); CYP2A6 (19q13.2); EGFR (7p11.2); ERBB2 (17q12); ERCC6 (10q11.23); FASLG (1q24.3); IRF1 (5q31.1); KRAS (12p12.1); MAP3K8 (10p11.23); PIK3CA (3q26.32); PPP2R1B (11q23.1); PRKN (6q26); SLC22A18 (11p15.4)
 
Monarch Initiative: MONDO:0008903
OMIM®: 211980

Definition

A primary or metastatic malignant neoplasm involving the lung. [from NCI]

Clinical features

From HPO
Alveolar cell carcinoma
MedGen UID:
2871
•Concept ID:
C0007120
•
Neoplastic Process
Adenocarcinoma of the Bronchus.
See: Feature record | Search on this feature
Non-small cell lung carcinoma
MedGen UID:
40104
•Concept ID:
C0007131
•
Neoplastic Process
A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.
See: Feature record | Search on this feature
Lung adenocarcinoma
MedGen UID:
57744
•Concept ID:
C0152013
•
Neoplastic Process
A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Recent clinical studies

Etiology

Health and economic impact at a population level of both primary and secondary preventive lung cancer interventions: A model-based cost-effectiveness analysis.
Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group.
Lung Cancer 2021 Sep;159:153-161. Epub 2021 Jul 21 doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591
Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort.
Borg M, Wen SWC, Nederby L, Hansen TF, Jakobsen A, Andersen RF, Weinreich UM, Hilberg O
Lung Cancer 2021 Aug;158:85-90. Epub 2021 Jun 10 doi: 10.1016/j.lungcan.2021.06.010. PMID: 34130044
Higher mortality in lung cancer patients with COVID-19? A systematic review and meta-analysis.
Lei H, Yang Y, Zhou W, Zhang M, Shen Y, Tao D, Wang L, Lei Q, Wang Y, Wu Y
Lung Cancer 2021 Jul;157:60-65. Epub 2021 May 5 doi: 10.1016/j.lungcan.2021.05.002. PMID: 33985850Free PMC Article
Role of dietary carbohydrates on risk of lung cancer.
Tao J, Jatoi A, Crawford J, Lam WWT, Ho JC, Wang X, Pang H
Lung Cancer 2021 May;155:87-93. Epub 2021 Mar 17 doi: 10.1016/j.lungcan.2021.03.009. PMID: 33756357
Hyponatremia in lung cancer: Incidence and prognostic value in a Danish population-based cohort study.
Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A
Lung Cancer 2021 Mar;153:42-48. Epub 2021 Jan 9 doi: 10.1016/j.lungcan.2020.12.038. PMID: 33454516

Diagnosis

Health and economic impact at a population level of both primary and secondary preventive lung cancer interventions: A model-based cost-effectiveness analysis.
Diaz M, Garcia M, Vidal C, Santiago A, Gnutti G, Gómez D, Trapero-Bertran M, Fu M; Lung Cancer Prevention LUCAPREV research group.
Lung Cancer 2021 Sep;159:153-161. Epub 2021 Jul 21 doi: 10.1016/j.lungcan.2021.06.027. PMID: 34352591
Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort.
Borg M, Wen SWC, Nederby L, Hansen TF, Jakobsen A, Andersen RF, Weinreich UM, Hilberg O
Lung Cancer 2021 Aug;158:85-90. Epub 2021 Jun 10 doi: 10.1016/j.lungcan.2021.06.010. PMID: 34130044
Age disparities in lung cancer survival in New Zealand: The role of patient and clinical factors.
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378
Role of dietary carbohydrates on risk of lung cancer.
Tao J, Jatoi A, Crawford J, Lam WWT, Ho JC, Wang X, Pang H
Lung Cancer 2021 May;155:87-93. Epub 2021 Mar 17 doi: 10.1016/j.lungcan.2021.03.009. PMID: 33756357
Hyponatremia in lung cancer: Incidence and prognostic value in a Danish population-based cohort study.
Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A
Lung Cancer 2021 Mar;153:42-48. Epub 2021 Jan 9 doi: 10.1016/j.lungcan.2020.12.038. PMID: 33454516

Therapy

Analysis of the baseline performance of five UK lung cancer screening programmes.
Balata H, Ruparel M, O'Dowd E, Ledson M, Field JK, Duffy SW, Quaife SL, Sharman A, Janes S, Baldwin D, Booton R, Crosbie PAJ
Lung Cancer 2021 Nov;161:136-140. Epub 2021 Sep 20 doi: 10.1016/j.lungcan.2021.09.012. PMID: 34583222
Role of dietary carbohydrates on risk of lung cancer.
Tao J, Jatoi A, Crawford J, Lam WWT, Ho JC, Wang X, Pang H
Lung Cancer 2021 May;155:87-93. Epub 2021 Mar 17 doi: 10.1016/j.lungcan.2021.03.009. PMID: 33756357
Temporal trends of the lung cancer mortality attributable to smoking from 1990 to 2017: A global, regional and national analysis.
Yang X, Man J, Chen H, Zhang T, Yin X, He Q, Lu M
Lung Cancer 2021 Feb;152:49-57. Epub 2020 Dec 9 doi: 10.1016/j.lungcan.2020.12.007. PMID: 33348250
Characteristics and outcomes of lung cancer in solid organ transplant recipients.
Chen LN, Spivack J, Cao T, Saqi A, Benvenuto LJ, Bulman WA, Mathew M, Stoopler MB, Arcasoy SM, Stanifer BP, Rizvi NA, Shu CA
Lung Cancer 2020 Aug;146:297-302. Epub 2020 Jun 20 doi: 10.1016/j.lungcan.2020.06.018. PMID: 32619780
Covid-19 and lung cancer: A greater fatality rate?
Rogado J, Pangua C, Serrano-Montero G, Obispo B, Marino AM, Pérez-Pérez M, López-Alfonso A, Gullón P, Lara MÁ
Lung Cancer 2020 Aug;146:19-22. Epub 2020 May 30 doi: 10.1016/j.lungcan.2020.05.034. PMID: 32505076Free PMC Article

Prognosis

Performance of the EarlyCDT® Lung test in detection of lung cancer and pulmonary metastases in a high-risk cohort.
Borg M, Wen SWC, Nederby L, Hansen TF, Jakobsen A, Andersen RF, Weinreich UM, Hilberg O
Lung Cancer 2021 Aug;158:85-90. Epub 2021 Jun 10 doi: 10.1016/j.lungcan.2021.06.010. PMID: 34130044
Age disparities in lung cancer survival in New Zealand: The role of patient and clinical factors.
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378
Hyponatremia in lung cancer: Incidence and prognostic value in a Danish population-based cohort study.
Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A
Lung Cancer 2021 Mar;153:42-48. Epub 2021 Jan 9 doi: 10.1016/j.lungcan.2020.12.038. PMID: 33454516
Temporal trends of the lung cancer mortality attributable to smoking from 1990 to 2017: A global, regional and national analysis.
Yang X, Man J, Chen H, Zhang T, Yin X, He Q, Lu M
Lung Cancer 2021 Feb;152:49-57. Epub 2020 Dec 9 doi: 10.1016/j.lungcan.2020.12.007. PMID: 33348250
Optimizing lung cancer radiation treatment worldwide in COVID-19 outbreak.
Liao Z, Rivin Del Campo E, Salem A, Pang Q, Liu H, Lopez Guerra JL
Lung Cancer 2020 Aug;146:230-235. Epub 2020 May 26 doi: 10.1016/j.lungcan.2020.05.029. PMID: 32585497Free PMC Article

Clinical prediction guides

Age disparities in lung cancer survival in New Zealand: The role of patient and clinical factors.
Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D
Lung Cancer 2021 Jul;157:92-99. Epub 2021 May 13 doi: 10.1016/j.lungcan.2021.05.015. PMID: 34006378
Hyponatremia in lung cancer: Incidence and prognostic value in a Danish population-based cohort study.
Sandfeld-Paulsen B, Aggerholm-Pedersen N, Winther-Larsen A
Lung Cancer 2021 Mar;153:42-48. Epub 2021 Jan 9 doi: 10.1016/j.lungcan.2020.12.038. PMID: 33454516
The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients.
Jiang M, Fares AF, Shepshelovich D, Yang P, Christiani D, Zhang J, Shiraishi K, Ryan BM, Chen C, Schwartz AG, Tardon A, Shete S, Schabath MB, Teare MD, Le Marchand L, Zhang ZF, Field JK, Brenner H, Diao N, Xie J, Kohno T, Harris CC, Wenzlaff AS, Fernandez-Tardon G, Ye Y, Taylor F, Wilkens LR, Davies M, Liu Y, Barnett MJ, Goodman GE, Morgenstern H, Holleczek B, Thomas S, Brown MC, Hung RJ, Xu W, Liu G
Lung Cancer 2021 Feb;152:58-65. Epub 2020 Dec 4 doi: 10.1016/j.lungcan.2020.11.029. PMID: 33352384Free PMC Article
Characteristics and outcomes of lung cancer in solid organ transplant recipients.
Chen LN, Spivack J, Cao T, Saqi A, Benvenuto LJ, Bulman WA, Mathew M, Stoopler MB, Arcasoy SM, Stanifer BP, Rizvi NA, Shu CA
Lung Cancer 2020 Aug;146:297-302. Epub 2020 Jun 20 doi: 10.1016/j.lungcan.2020.06.018. PMID: 32619780
COPD and lung cancer incidence in the Women's Health Initiative Observational Study: A brief report.
Nagasaka M, Lehman A, Chlebowski R, Haynes BM, Ho G, Patel M, Sakoda LC, Schwartz AG, Simon MS, Cote ML
Lung Cancer 2020 Mar;141:78-81. Epub 2020 Jan 7 doi: 10.1016/j.lungcan.2020.01.006. PMID: 31958598

Recent systematic reviews

Higher mortality in lung cancer patients with COVID-19? A systematic review and meta-analysis.
Lei H, Yang Y, Zhou W, Zhang M, Shen Y, Tao D, Wang L, Lei Q, Wang Y, Wu Y
Lung Cancer 2021 Jul;157:60-65. Epub 2021 May 5 doi: 10.1016/j.lungcan.2021.05.002. PMID: 33985850Free PMC Article
Platinum-doublet chemotherapy as second-line treatment for relapsed patients with small-cell lung cancer: A systematic review and meta-analysis.
Horiuchi K, Sato T, Kuno T, Takagi H, Hirsch FR, Powell CA, Fukunaga K
Lung Cancer 2021 Jun;156:59-67. Epub 2021 Apr 19 doi: 10.1016/j.lungcan.2021.04.013. PMID: 33894495
Association between family history of lung cancer and lung cancer risk: a systematic review and meta-analysis.
Ang L, Chan CPY, Yau WP, Seow WJ
Lung Cancer 2020 Oct;148:129-137. Epub 2020 Aug 20 doi: 10.1016/j.lungcan.2020.08.012. PMID: 32892102
Risk-Based lung cancer screening: A systematic review.
Toumazis I, Bastani M, Han SS, Plevritis SK
Lung Cancer 2020 Sep;147:154-186. Epub 2020 Jul 12 doi: 10.1016/j.lungcan.2020.07.007. PMID: 32721652
Airflow limitation and survival after surgery for non-small cell lung cancer: Results from a systematic review and lung cancer screening trial (NLST-ACRIN sub-study).
Hopkins RJ, Ko J, Gamble GD, Young RP
Lung Cancer 2019 Sep;135:80-87. Epub 2019 Jul 18 doi: 10.1016/j.lungcan.2019.07.015. PMID: 31447006

Supplemental Content

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      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
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      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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      Pathways, annotations and biological systems (BioSystems) that cite genes for the current record.
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      Related information in PubMed Central Links
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