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CAMK2G calcium/calmodulin dependent protein kinase II gamma [ Homo sapiens (human) ]

Gene ID: 818, updated on 6-May-2021

Summary

Official Symbol
CAMK2Gprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II gammaprovided by HGNC
Primary source
HGNC:HGNC:1463
See related
Ensembl:ENSG00000148660 MIM:602123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMK; CAMKG; MRD59; CAMK-II
Summary
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in brain (RPKM 28.7), prostate (RPKM 10.9) and 24 other tissues See more
Orthologs
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Genomic context

See CAMK2G in Genome Data Viewer
Location:
10q22.2
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (73812501..73874582, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75572259..75634313, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene chromosome 10 putative open reading frame 55 Neighboring gene plasminogen activator, urokinase Neighboring gene VISTA enhancer hs2142

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of calcium/calmodulin-dependent protein kinase II gamma is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
tat HIV-1 Tat activates a CaMKII pathway at inhibitory synapses that leads to structural changes in GABARAP, resulting in increased membrane insertion of the gamma 2 subunit of GABAR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16043, MGC26678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of calcium- and calmodulin-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit gamma
Names
caMK-II subunit gamma
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
NP_001191421.1
NP_001213.2
NP_001307827.1
NP_001354443.1
NP_001354445.1
NP_001354446.1
NP_001354447.1
NP_001354448.1
NP_001354449.1
NP_001354450.1
NP_001354451.1
NP_001354452.1
NP_001354453.1
NP_001354454.1
NP_001354455.1
NP_001354456.1
NP_001354457.1
NP_001354458.1
NP_001354459.1
NP_001354460.1
NP_001354461.1
NP_001354462.1
NP_001354463.1
NP_001354464.1
NP_001354465.1
NP_001354466.1
NP_001354467.1
NP_001354468.1
NP_001354469.1
NP_001354470.1
NP_001354471.1
NP_001354472.1
NP_001354473.1
NP_001354474.1
NP_001354475.1
NP_001354476.1
NP_001354477.1
NP_751909.1
NP_751910.1
NP_751911.1
NP_751913.1
XP_005270255.1
XP_005270262.1
XP_006718059.1
XP_006718061.1
XP_016872205.1
XP_016872206.1
XP_016872207.1
XP_016872208.1
XP_016872209.1
XP_016872211.1
XP_016872212.1
XP_016872213.1
XP_016872219.1
XP_016872226.1
XP_024303982.1
XP_024303984.1
XP_024303985.1
XP_024303986.1
XP_024303987.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029408.2 RefSeqGene

    Range
    5001..67091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204492.2NP_001191421.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7

    See identical proteins and their annotated locations for NP_001191421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate in-frame exon and lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 7) is shorter and lacks two internal segments compared to isoform 1.
    Source sequence(s)
    AC022400, AL596247, AL713896
    Consensus CDS
    CCDS73153.1
    UniProtKB/TrEMBL
    A0A0A0MS52
    Related
    ENSP00000505103.1, ENST00000680035.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:407534
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001222.4NP_001213.2  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4

    See identical proteins and their annotated locations for NP_001213.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (4), that is missing internal segments compared to isoform 1.
    Source sequence(s)
    AC022400, AL596247, AL713896, L07043
    Consensus CDS
    CCDS7336.1
    UniProtKB/Swiss-Prot
    Q13555
    Related
    ENSP00000277853.5, ENST00000351293.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:363490
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_001320898.2NP_001307827.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022400, AK131199, AK225771, AW295338, BC034044, DR002605
    UniProtKB/Swiss-Prot
    Q13555
    UniProtKB/TrEMBL
    B3KY86
    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    cl09109
    Location:433488
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
  4. NM_001367514.1NP_001354443.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022400, AK131199, AL596247
  5. NM_001367516.1NP_001354445.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386500
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  6. NM_001367517.1NP_001354446.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (50), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. NM_001367518.1NP_001354447.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:412539
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  8. NM_001367519.1NP_001354448.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  9. NM_001367520.1NP_001354449.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  10. NM_001367521.1NP_001354450.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  11. NM_001367522.1NP_001354451.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  12. NM_001367523.1NP_001354452.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  13. NM_001367524.1NP_001354453.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  14. NM_001367525.1NP_001354454.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12295
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:416543
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  15. NM_001367526.1NP_001354455.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  16. NM_001367527.1NP_001354456.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:422549
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  17. NM_001367528.1NP_001354457.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  18. NM_001367529.1NP_001354458.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  19. NM_001367530.1NP_001354459.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:374501
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  20. NM_001367531.1NP_001354460.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Related
    ENSP00000307082.7, ENST00000305762.11
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:397524
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  21. NM_001367532.1NP_001354461.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12295
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:378505
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  22. NM_001367533.1NP_001354462.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  23. NM_001367534.1NP_001354463.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Related
    ENSP00000410298.3, ENST00000423381.6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:456583
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  24. NM_001367535.1NP_001354464.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (1) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  25. NM_001367536.1NP_001354465.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:403530
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  26. NM_001367537.1NP_001354466.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247
  27. NM_001367538.1NP_001354467.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247
  28. NM_001367539.1NP_001354468.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    pfam08332
    Location:342469
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  29. NM_001367540.1NP_001354469.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  30. NM_001367541.1NP_001354470.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  31. NM_001367542.1NP_001354471.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Related
    ENSP00000378243.4, ENST00000394762.7
    Conserved Domains (2) summary
    pfam08332
    Location:194321
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:152
    PKc_like; Protein Kinases, catalytic domain
  32. NM_001367543.1NP_001354472.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:418545
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  33. NM_001367544.1NP_001354473.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:445572
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  34. NM_001367545.1NP_001354474.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:401528
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  35. NM_001367546.1NP_001354475.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:433560
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  36. NM_001367547.1NP_001354476.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:433560
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  37. NM_001367548.1NP_001354477.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  38. NM_172169.3NP_751909.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_751909.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC022400, AL596247, BC034044
    Consensus CDS
    CCDS7337.1
    UniProtKB/Swiss-Prot
    Q13555
    Related
    ENSP00000315599.3, ENST00000322635.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:395522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  39. NM_172170.5NP_751910.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_751910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1. Variants 3 and 50 both encode the same isoform (3).
    Source sequence(s)
    AC022400, AL596247, AL713896
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  40. NM_172171.3NP_751911.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_751911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC022400, AL596247, AL713896, U66063
    Consensus CDS
    CCDS7338.1
    UniProtKB/TrEMBL
    Q13280
    Related
    ENSP00000319060.3, ENST00000322680.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:424551
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  41. NM_172173.3NP_751913.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 6

    See identical proteins and their annotated locations for NP_751913.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (6), that is missing internal segments compared to isoform 1.
    Source sequence(s)
    AC022400, AL596247, AL713896, U50360
    UniProtKB/Swiss-Prot
    Q13555
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:372499
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RNA

  1. NR_160040.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  2. NR_160041.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  3. NR_160042.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  4. NR_160044.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  5. NR_160045.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  6. NR_160046.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  7. NR_160047.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL596247, AL713896
  8. NR_160263.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400, AK095576, AL596247

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    73812501..73874582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016730.1XP_016872219.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X30

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:383510
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. XM_006717996.1XP_006718059.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X15

    See identical proteins and their annotated locations for XP_006718059.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:435562
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. XM_005270205.1XP_005270262.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X29

    See identical proteins and their annotated locations for XP_005270262.1

    UniProtKB/TrEMBL
    Q5SWX3
    Related
    ENSP00000361851.1, ENST00000372765.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:384511
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. XM_005270198.1XP_005270255.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X17

    See identical proteins and their annotated locations for XP_005270255.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:431558
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. XM_006717998.1XP_006718061.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

    See identical proteins and their annotated locations for XP_006718061.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:404531
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  6. XM_024448218.1XP_024303986.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X28

    Conserved Domains (2) summary
    cd14086
    Location:12295
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:387514
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. XM_024448219.1XP_024303987.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X35

    Related
    ENSP00000393784.1, ENST00000433289.5
    Conserved Domains (2) summary
    pfam08332
    Location:304431
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017016723.1XP_016872212.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X9

  9. XM_017016720.1XP_016872209.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5

  10. XM_017016724.1XP_016872213.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X10

  11. XM_017016722.1XP_016872211.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

  12. XM_017016718.1XP_016872207.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3

  13. XM_017016719.1XP_016872208.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X4

  14. XM_017016716.1XP_016872205.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1

  15. XM_024448214.1XP_024303982.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8

    Conserved Domains (2) summary
    cd14086
    Location:12295
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    cl09109
    Location:427482
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
  16. XM_017016717.1XP_016872206.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2

  17. XM_024448217.1XP_024303985.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X26

    Conserved Domains (2) summary
    cl09109
    Location:374429
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  18. XM_017016737.1XP_016872226.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X34

  19. XM_024448216.1XP_024303984.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X26

    Conserved Domains (2) summary
    cl09109
    Location:374429
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_945824.1 RNA Sequence

  2. XR_001747218.1 RNA Sequence

  3. XR_001747219.1 RNA Sequence

  4. XR_945822.1 RNA Sequence

  5. XR_945821.1 RNA Sequence

  6. XR_945823.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172172.1: Suppressed sequence

    Description
    NM_172172.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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