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OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 [ Homo sapiens (human) ]

Gene ID: 55611, updated on 3-May-2020

Summary

Official Symbol
OTUB1provided by HGNC
Official Full Name
OTU deubiquitinase, ubiquitin aldehyde binding 1provided by HGNC
Primary source
HGNC:HGNC:23077
See related
Ensembl:ENSG00000167770 MIM:608337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTB1; OTU1; HSPC263
Summary
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 29.9), placenta (RPKM 22.0) and 25 other tissues See more
Orthologs

Genomic context

See OTUB1 in Genome Data Viewer
Location:
11q13.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (63985853..63998420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63753325..63765892)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 45, pseudogene Neighboring gene cytochrome c oxidase subunit 8A Neighboring gene uncharacterized LOC101927673 Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene fibronectin leucine rich transmembrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the expression of ubiquitin thioesterase (OTUB1) protein in Nef-transfected SupT1 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: COX8A

Homology

Clone Names

  • MGC4584, FLJ20113, FLJ40710, MGC111158

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NEDD8-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NEDD8-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
negative regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone H2A K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of histone H2A K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin thioesterase OTUB1
Names
OTU domain, ubiquitin aldehyde binding 1
OTU domain-containing ubiquitin aldehyde-binding protein 1
OTU-domain Ubal-binding 1
deubiquitinating enzyme OTUB1
otubain-1
ubiquitin-specific protease otubain 1
ubiquitin-specific-processing protease OTUB1
NP_060140.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017670.2NP_060140.2  ubiquitin thioesterase OTUB1

    See identical proteins and their annotated locations for NP_060140.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript.
    Source sequence(s)
    AK098029, AP000721, BC007519, CK906312
    Consensus CDS
    CCDS8055.1
    UniProtKB/Swiss-Prot
    Q96FW1
    UniProtKB/TrEMBL
    B3KUV5
    Related
    ENSP00000444357.1, ENST00000538426.5
    Conserved Domains (1) summary
    pfam10275
    Location:40271
    Peptidase_C65; Peptidase C65 Otubain

RNA

  1. NR_003089.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as alternative reading frame 1 or ARF-1, includes an alternate segment in the 3' coding region, compared to variant 1, resulting in a frameshift. The nature of the polypeptide, if any, expressed from this transcript has not been experimentally confirmed. This variant is predominantly found in lymphoid tissues.
    Source sequence(s)
    AK098029, AL096714, CK906312
    Related
    ENST00000301453.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    63985853..63998420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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