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COX8A cytochrome c oxidase subunit 8A [ Homo sapiens (human) ]

Gene ID: 1351, updated on 7-Jun-2020

Summary

Official Symbol
COX8Aprovided by HGNC
Official Full Name
cytochrome c oxidase subunit 8Aprovided by HGNC
Primary source
HGNC:HGNC:2294
See related
Ensembl:ENSG00000176340 MIM:123870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COX; COX8; VIII; COX8L; COX8-2; VIII-L
Summary
The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 159.8), colon (RPKM 143.7) and 25 other tissues See more
Orthologs

Genomic context

See COX8A in Genome Data Viewer
Location:
11q13.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (63974620..63976543)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63742079..63744015)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene N-alpha-acetyltransferase 40, NatD catalytic subunit Neighboring gene RNA, U6 small nuclear 45, pseudogene Neighboring gene uncharacterized LOC101927673 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1 Neighboring gene mono-ADP ribosylhydrolase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: OTUB1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
generation of precursor metabolites and energy TAS
Traceable Author Statement
more info
PubMed 
mitochondrial electron transport, cytochrome c to oxygen TAS
Traceable Author Statement
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase subunit 8A, mitochondrial
Names
cytochrome c oxidase polypeptide VIII-liver/heart
cytochrome c oxidase subunit 8-2
cytochrome c oxidase subunit 8A (ubiquitous)
cytochrome c oxidase subunit VIII
cytochrome c oxidase subunit VIIIA (ubiquitous)
NP_004065.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046750.1 RefSeqGene

    Range
    5014..6937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004074.3NP_004065.1  cytochrome c oxidase subunit 8A, mitochondrial

    See identical proteins and their annotated locations for NP_004065.1

    Status: REVIEWED

    Source sequence(s)
    BC063025
    Consensus CDS
    CCDS8054.1
    UniProtKB/Swiss-Prot
    P10176
    UniProtKB/TrEMBL
    Q53XN1
    Related
    ENSP00000321260.3, ENST00000314133.4
    Conserved Domains (1) summary
    cd00930
    Location:2668
    Cyt_c_Oxidase_VIII; Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    63974620..63976543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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