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PPP2R1B protein phosphatase 2 scaffold subunit Abeta [ Homo sapiens (human) ]

Gene ID: 5519, updated on 24-Nov-2020

Summary

Official Symbol
PPP2R1Bprovided by HGNC
Official Full Name
protein phosphatase 2 scaffold subunit Abetaprovided by HGNC
Primary source
HGNC:HGNC:9303
See related
Ensembl:ENSG00000137713 MIM:603113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR65B; PP2A-Abeta
Summary
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 13.7), fat (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R1B in Genome Data Viewer
Location:
11q23.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (111690273..111766389, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111597632..111637169, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene layilin Neighboring gene salt inducible kinase 2 Neighboring gene RN7SK pseudogene 273 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene G protein subunit gamma 5 pseudogene 3 Neighboring gene ferredoxin-fold anticodon binding domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serine/threonine protein phosphatase 2A (65 kDa regulatory subunit A) in T-cell lines PubMed
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat HIV-1 Tat associates with the promoters of both PPP2R1B and PPP2R5E to increase PPP2R1B and PPP2R5E RNA and protein levels as well as PP2A activity in Jurkat T cells PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26454

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Names
protein phosphatase 2, regulatory subunit A, beta
protein phosphatase 2, structural/regulatory subunit A, beta
NP_001171033.1
NP_001171034.1
NP_002707.3
NP_859050.1
NP_859051.1
XP_016873449.1
XP_016873450.1
XP_024304366.1
XP_024304367.1
XP_024304368.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012117.2 RefSeqGene

    Range
    5057..44533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177562.2NP_001171033.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region compared to variant 1. The resulting isoform (d) is shorter than isoform a.
    Source sequence(s)
    AF163473, AK294716, AP000925, AP001781, DC402587
    Consensus CDS
    CCDS53708.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000343317.6, ENST00000341980.10
    Conserved Domains (3) summary
    pfam13646
    Location:217315
    HEAT_2; HEAT repeats
    sd00044
    Location:257281
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:363421
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001177563.2NP_001171034.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the 5' coding region compared to variant 1. The resulting isoform (e) is shorter than isoform a.
    Source sequence(s)
    AF163473, AK296455, AP000925, DC402587
    Consensus CDS
    CCDS53707.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000376775.2, ENST00000393055.6
    Conserved Domains (4) summary
    COG1413
    Location:115347
    HEAT; HEAT repeat [General function prediction only]
    pfam13646
    Location:374469
    HEAT_2; HEAT repeats
    sd00044
    Location:130154
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:281339
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_002716.5NP_002707.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a

    See identical proteins and their annotated locations for NP_002707.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AF163473, AP000925, BC027596
    Consensus CDS
    CCDS8349.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000437193.1, ENST00000527614.6
    Conserved Domains (3) summary
    pfam13646
    Location:217315
    HEAT_2; HEAT repeats
    sd00044
    Location:257281
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:408466
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_181699.3NP_859050.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b

    See identical proteins and their annotated locations for NP_859050.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF087438, AP001781, BC027596, DB527885
    Consensus CDS
    CCDS8348.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000311344.5, ENST00000311129.9
    Conserved Domains (4) summary
    pfam13513
    Location:191240
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:217316
    HEAT_2; HEAT repeats
    sd00044
    Location:257281
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:408466
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_181700.2NP_859051.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

    See identical proteins and their annotated locations for NP_859051.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region and differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (c) contains a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK301705, DB527885, DC402587
    Consensus CDS
    CCDS53706.1
    UniProtKB/Swiss-Prot
    P30154
    Related
    ENSP00000410671.2, ENST00000426998.6
    Conserved Domains (5) summary
    pfam02985
    Location:231261
    HEAT; HEAT repeat
    pfam13513
    Location:127176
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:153252
    HEAT_2; HEAT repeats
    sd00044
    Location:193217
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:344402
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    111690273..111766389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448599.1XP_024304367.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    Conserved Domains (3) summary
    COG1413
    Location:212474
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:257281
    HEAT; HEAT repeat [structural motif]
    cl26104
    Location:33315
    HEAT_2; HEAT repeats
  2. XM_024448598.1XP_024304366.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    Conserved Domains (3) summary
    COG1413
    Location:212474
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:257281
    HEAT; HEAT repeat [structural motif]
    cl26104
    Location:102315
    HEAT_2; HEAT repeats
  3. XM_024448600.1XP_024304368.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X5

    Conserved Domains (2) summary
    COG1413
    Location:177392
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:257281
    HEAT; HEAT repeat [structural motif]
  4. XM_017017960.2XP_016873449.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3

  5. XM_017017961.1XP_016873450.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4

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