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Ppp2r1b protein phosphatase 2, regulatory subunit A, beta [ Mus musculus (house mouse) ]

Gene ID: 73699, updated on 2-Nov-2024

Summary

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Official Symbol
Ppp2r1bprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit A, betaprovided by MGI
Primary source
MGI:MGI:1920949
See related
Ensembl:ENSMUSG00000032058 AllianceGenome:MGI:1920949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410091N08Rik
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in apoptotic process involved in morphogenesis; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and protein dephosphorylation. Is active in glutamatergic synapse. Is expressed in several structures, including cerebral cortex; eye; genitourinary system; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 19.8), genital fat pad adult (RPKM 16.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp2r1b in Genome Data Viewer
Location:
9 A5.3; 9 27.75 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50767946..50810625)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50856896..50899325)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3828 Neighboring gene STARR-positive B cell enhancer ABC_E9760 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene predicted gene, 57547 Neighboring gene STARR-seq mESC enhancer starr_24122 Neighboring gene STARR-positive B cell enhancer mm9_chr9:50664895-50665195 Neighboring gene predicted gene, 25558 Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The PP2A-Aβ gene is regulated by multiple transcriptional factors including Ets-1, SP1/SP3, and RXRα/β. Liu J, et al. Curr Mol Med, 2012 Sep. PMID 22827437
  2. PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis. Du M, et al. FASEB J, 2021 May. PMID 33913576
  3. A Chromatin Accessibility Atlas of the Developing Human Telencephalon. Markenscoff-Papadimitriou E, et al. Cell, 2020 Aug 6. PMID 32610082, Free PMC Article
  4. Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Liu WB, et al. Mol Vis, 2008 Apr 21. PMID 18432318, Free PMC Article
  5. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, et al. Mol Cell, 2010 Dec 22. PMID 21172653

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
    Title: PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
  2. Multiple transcription factors regulate the PP2A-Abeta gene.
    Title: The PP2A-Aβ gene is regulated by multiple transcriptional factors including Ets-1, SP1/SP3, and RXRα/β.
  3. PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
    Title: Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process involved in morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
NP_001029257.1
NP_001273482.1
NP_082890.2
XP_006510704.3
XP_006510705.3
XP_036011230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034085.2 → NP_001029257.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a

    See identical proteins and their annotated locations for NP_001029257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 3. It encodes isoform a, which has a shorter and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AC123614, AK161392
    Consensus CDS
    CCDS40625.1
    UniProtKB/TrEMBL
    H3BKU1, Q3TTF6
    Related
    ENSMUSP00000034560.8, ENSMUST00000034560.14
    Conserved Domains (2) summary
    COG1413
    Location:227 → 474
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:257 → 281
    HEAT; HEAT repeat [structural motif]

  2. NM_001286553.1 → NP_001273482.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (c).
    Source sequence(s)
    AC123614, AK077158, AK136106, AK161392
    Consensus CDS
    CCDS72232.1
    UniProtKB/TrEMBL
    G3UWS4, Q8BIX1
    Related
    ENSMUSP00000133404.2, ENSMUST00000174628.8
    Conserved Domains (4) summary
    pfam02985
    Location:295 → 325
    HEAT; HEAT repeat
    pfam13513
    Location:191 → 240
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:217 → 315
    HEAT_2; HEAT repeats
    sd00044
    Location:257 → 281
    HEAT; HEAT repeat [structural motif]

  3. NM_028614.3 → NP_082890.2  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b

    See identical proteins and their annotated locations for NP_082890.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' structure and contains a 3' terminal exon which extends past a splice site that is used in variant 3. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AC123614, AK010754, AK077158, AK136106, BC056218, BM932667, BY687256, CX566645
    Consensus CDS
    CCDS40626.1
    UniProtKB/Swiss-Prot
    E9QNJ1, Q7TNP2
    UniProtKB/TrEMBL
    H3BKU1
    Related
    ENSMUSP00000110080.3, ENSMUST00000114437.9
    Conserved Domains (2) summary
    sd00044
    Location:257 → 281
    HEAT; HEAT repeat [structural motif]
    cl26104
    Location:227 → 474
    HEAT_2; HEAT repeats

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50767946..50810625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510641.5 → XP_006510704.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    UniProtKB/TrEMBL
    H3BKU1
    Related
    ENSMUSP00000135525.2, ENSMUST00000176798.8
    Conserved Domains (3) summary
    COG1413
    Location:325 → 572
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:355 → 379
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:276 → 306
    HEAT; HEAT repeat

  2. XM_006510642.5 → XP_006510705.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    UniProtKB/TrEMBL
    H3BKU1
    Conserved Domains (3) summary
    COG1413
    Location:325 → 572
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:355 → 379
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:276 → 306
    HEAT; HEAT repeat

  3. XM_036155337.1 → XP_036011230.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3

    UniProtKB/TrEMBL
    H3BIV7
    Conserved Domains (2) summary
    COG1413
    Location:2 → 246
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:66 → 90
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_001779023.3 RNA Sequence

  2. XR_001779024.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNP2.2 GenPept UniProtKB/Swiss-Prot:Q7TNP2

Gene LinkOut

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