2NYL,2OT8,4JLQ,4I5L,1OYZ,2NYL,4HMY,2IE3,4ADY,4I5L,2BPT,3W3V,1W63,3W3T,2XA7,4HMY,3W3V,2QNA


Conserved Protein Domain Family
HEAT

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sd00044: HEAT 
Click on image for an interactive view with Cn3D
HEAT repeats
The canonical HEAT repeat consists of two helices forming a helical hairpin. HEAT repeats are found in a diverse family of proteins, including the four proteins from which its name is based: Huntingtin, Elongation factor 3, the PR65/A subunit of protein phosphatase 2A (PP2A), and the lipid kinase TOR (target of rapamycin). The HEAT repeat family is related to armadillo (ARM)/beta-catenin-like repeats.
Statistics
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PSSM-Id: 293787
View PSSM: sd00044
Aligned: 99 rows
Threshold Bit Score: 34.3903
Threshold Setting Gi: 501925200
Created: 30-May-2013
Updated: 6-Nov-2015
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        ##  #  ##                                 ##  # 
2NYL_A         6 IAVLIDELRNed----------------vqLRLNSIKKLSTialalgv--ertrseLLPFLTDTIYDed--eVLLALAEQ 65
2OT8_A       361 LPLLKELLFHhe----------------wvVKESGILVLGAiaegcmqgmipylpeLIPHLIQCLSDkk-alVRSITCWT 423
gi 502776990  96 VAFLTSIMDHen----------------keVRKLILDSLVAtss----------kySIPALRAALRDka-pnVMITAIEY 148
gi 500017023 104 VDVLMELAALtrs---------------elVMRNCYHALAAigg----------erPGQFLLAAYDKtprqdIRADLIDL 158
gi 503814328 474 LAGLTALRAGgatpevlrvlrgapeyrgewLRTAALRALDAfgpa--------areAVPELRALIRRpg--tAATEAAEA 543
gi 502692428  90 IALLLIGFAGgllythwr-----sadastqLANSTASATPEv--------------AIKKVLAFESN-----PKTSASER 145
gi 501925200  34 ISTNTSAAETsgmlnaeye--kafkygtptQKIATIAKIKRtkn----------eaDIAMLANHYPEeknnrVKSEIINF 101
gi 32172448   15 IAVLIDELRNed----------------vtLRLNSIRKLSTialalgv--ertrneLIQFLTDTIYDed--eVLLVLAEQ 74
gi 159107641   9 IAVLIDDLKNed----------------anARLSAVKRIDQiavalgp--krtrdeFIPFLCECVDDdd--eILIELAQK 68
gi 82209565  115 LPIVVRYLADqn----------------nlVRKTSQAALLVlleqelmeradvetlVCPVLVDLTAPdsnddVKTEAMAI 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         ##  #                               ##  #  ##  #                              #
2NYL_A        66 LGTFTTlvggp---eyvhCLLPPLESLATVEet-vVRDKAVESLRAISHEhsps--dleaHFVPLVKRLAGGdw-ftSRT 138
2OT8_A       424 LSRYAHwvvsqppdtylkPLMTELLKRILDSnk-rVQEAACSAFATLEEEactelvpylaYILDTLVFAFSKyq-hkNLL 501
gi 502776990 149 LGKIYDe-----------ESLNDVMEIFETStepmVRSACLETLTIMGSPdn------vdRVLAVLGAGGMDs---fYKP 208
gi 500017023 159 LCQMGYe-----------AALPRTEGILKKD----FDEYYYESVFAFGKMg--------dKATPFLLGKIEDpd-rnVRM 214
gi 503814328 544 LWSVEGda---------gAVLPVLLEGLGAErv-hDCRAAAVALGRLGGEa--------aVAVPRLRALLAHde-lwLRV 604
gi 502692428 146 IQAINQsfelt---qadrDITQLLINTLNFDpnvnVRLAACQALVRFENEp---------VVRNALIQSLQIqtdpnVQI 213
gi 501925200 102 FKQNKNd-----------NAKAIIEYAIKDEnd-sVRKDAYYLCSIYPDIq---------YEVPIMSEITNAtg--lVLD 158
gi 32172448   75 LGNFTPlvggp---dhvhCLLLPLENLATVEet-vVRDKAVESLRKIADKhssa--sleeHFVPMLRRLATGdw-ftSRT 147
gi 159107641  69 LGKFVDpvggp---nyapTLLNPLRLLACADsk-lVRDEAIASAVRVGSKltdk--dfatSFVPMVEALIKGew-ynHRT 141
gi 82209565  179 ICKMAPmvgkd---iterLFLPRFCEMCCDCrmfhVRKVCAANFGDICSVvggd--ateeLLLPRFFQLCSDnv-wgVRK 252
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1        #  #  ##                                      ##  #  ## 
2NYL_A       139 SACGLFSVcyprv-----ssavKAELRQYFRNLCSDdt----pxVRRAAASKLGEF 185
2OT8_A       502 ILYDAIGTladsvghhlnkpeyIQMLMPPLIQKWNMlkd--edkDLFPLLECLSSV 555
gi 502776990 209 SVIRLAGEk------------gGSRHLEFLLSFLNNkntmyfreISNGILKIISRE 252
gi 500017023 215 HSIHVLGLwl----------mpLEAAQPLRDHYWKEpd----peLRSLVLSSLERV 256
gi 503814328 605 DAAVALWEis----------grTGESVPVLLAAWEQnr-----hVRVRVAQCLVRM 645
gi 502692428 214 TLIDVLVAi------------kEKRAVTEIQRLAQNqqv--leaVRIKAAEGITRL 255
gi 501925200 159 SMVNALGAi------------kSEMAADYLLEIYTNntv--gssTKVEILRYFSET 200
gi 32172448  148 SACGLFSVvyprv-----spaiKSELKSMFRTLCRDdt----pmVRRAAAAKLGEF 194
gi 159107641 142 SGVGLAHLvfkrc----ttstiRNDLLEAIQRLAQDtl----pmVRRTVAECLSQI 189
gi 82209565  253 ACAECFMSvssas----spevrRSKLSAVFISLISDps----rwVRQAAFQSLGQF 300

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