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PPARA peroxisome proliferator activated receptor alpha [ Homo sapiens (human) ]

Gene ID: 5465, updated on 26-Jul-2021

Summary

Official Symbol
PPARAprovided by HGNC
Official Full Name
peroxisome proliferator activated receptor alphaprovided by HGNC
Primary source
HGNC:HGNC:9232
See related
Ensembl:ENSG00000186951 MIM:170998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPAR; NR1C1; hPPAR; PPARalpha; PPAR-alpha
Summary
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 12.0), heart (RPKM 8.1) and 24 other tissues See more
Orthologs
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Genomic context

See PPARA in Genome Data Viewer
Location:
22q13.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (46150526..46243756)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46546429..46639652)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MIRLET7B host gene Neighboring gene microRNA let-7b Neighboring gene microRNA 4763 Neighboring gene uncharacterized LOC105373074 Neighboring gene cysteine rich DPF motif domain containing 1 Neighboring gene polycystin family receptor for egg jelly

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB PubMed
tat Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2237, MGC2452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables MDM2/MDM4 family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables NFAT protein binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables drug binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables steroid hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in behavioral response to nicotine IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in enamel mineralization IEA
Inferred from Electronic Annotation
more info
 
involved_in epidermis development IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid localization IEA
Inferred from Electronic Annotation
more info
 
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cholesterol storage IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of macrophage derived foam cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sequestering of triglyceride IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular ketone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of fatty acid transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
peroxisome proliferator-activated receptor alpha
Names
nuclear receptor subfamily 1 group C member 1
peroxisome proliferative activated receptor, alpha
peroxisome proliferator-activated nuclear receptor alpha variant 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012204.2 RefSeqGene

    Range
    5262..98223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001928.4NP_001001928.1  peroxisome proliferator-activated receptor alpha isoform 1

    See identical proteins and their annotated locations for NP_001001928.1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
    Consensus CDS
    CCDS33669.1
    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Related
    ENSP00000262735.5, ENST00000262735.9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  2. NM_001001929.3NP_001001929.1  peroxisome proliferator-activated receptor alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
  3. NM_001362872.2NP_001349801.1  peroxisome proliferator-activated receptor alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
    Consensus CDS
    CCDS33669.1
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  4. NM_001362873.3NP_001349802.1  peroxisome proliferator-activated receptor alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
    Consensus CDS
    CCDS33669.1
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  5. NM_001393941.1NP_001380870.1  peroxisome proliferator-activated receptor alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
  6. NM_001393942.1NP_001380871.1  peroxisome proliferator-activated receptor alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
  7. NM_001393943.1NP_001380872.1  peroxisome proliferator-activated receptor alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
  8. NM_001393944.1NP_001380873.1  peroxisome proliferator-activated receptor alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
  9. NM_001393945.1NP_001380874.1  peroxisome proliferator-activated receptor alpha isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
  10. NM_001393946.1NP_001380875.1  peroxisome proliferator-activated receptor alpha isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
  11. NM_001393947.1NP_001380876.1  peroxisome proliferator-activated receptor alpha isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
  12. NM_005036.6NP_005027.2  peroxisome proliferator-activated receptor alpha isoform 1

    See identical proteins and their annotated locations for NP_005027.2

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
    Consensus CDS
    CCDS33669.1
    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Related
    ENSP00000385523.1, ENST00000407236.5
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    46150526..46243756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530244.2XP_011528546.1  peroxisome proliferator-activated receptor alpha isoform X2

    See identical proteins and their annotated locations for XP_011528546.1

    Conserved Domains (1) summary
    cd06932
    Location:67333
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  2. XM_011530240.2XP_011528542.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011528542.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  3. XM_017028839.1XP_016884328.1  peroxisome proliferator-activated receptor alpha isoform X2

    Conserved Domains (1) summary
    cd06932
    Location:67333
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  4. XM_024452252.1XP_024308020.1  peroxisome proliferator-activated receptor alpha isoform X2

    Conserved Domains (1) summary
    cd06932
    Location:67333
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  5. XM_011530239.2XP_011528541.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011528541.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  6. XM_011530245.2XP_011528547.1  peroxisome proliferator-activated receptor alpha isoform X2

    See identical proteins and their annotated locations for XP_011528547.1

    Conserved Domains (1) summary
    cd06932
    Location:67333
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  7. XM_024452253.1XP_024308021.1  peroxisome proliferator-activated receptor alpha isoform X3

    Conserved Domains (1) summary
    cd06932
    Location:32264
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  8. XM_005261656.3XP_005261713.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_005261713.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  9. XM_011530242.2XP_011528544.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011528544.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Related
    ENSP00000385246.1, ENST00000402126.1
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RNA

  1. XR_001755253.1 RNA Sequence

  2. XR_937869.2 RNA Sequence

  3. XR_937870.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001930.2: Suppressed sequence

    Description
    NM_001001930.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  2. NM_032644.3: Suppressed sequence

    Description
    NM_032644.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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