Format

Send to:

Choose Destination

PPARA peroxisome proliferator activated receptor alpha [ Homo sapiens (human) ]

Gene ID: 5465, updated on 28-Jun-2020

Summary

Official Symbol
PPARAprovided by HGNC
Official Full Name
peroxisome proliferator activated receptor alphaprovided by HGNC
Primary source
HGNC:HGNC:9232
See related
Ensembl:ENSG00000186951 MIM:170998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPAR; NR1C1; hPPAR; PPARalpha
Summary
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 12.0), heart (RPKM 8.1) and 24 other tissues See more
Orthologs

Genomic context

See PPARA in Genome Data Viewer
Location:
22q13.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (46150526..46243756)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46546458..46639653)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MIRLET7B host gene Neighboring gene microRNA let-7b Neighboring gene microRNA 4763 Neighboring gene uncharacterized LOC105373074 Neighboring gene cysteine rich DPF motif domain containing 1 Neighboring gene polycystin family receptor for egg jelly

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB PubMed
tat Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2237, MGC2452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
MDM2/MDM4 family protein binding IEA
Inferred from Electronic Annotation
more info
 
NFAT protein binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
behavioral response to nicotine IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
enamel mineralization IEA
Inferred from Electronic Annotation
more info
 
epidermis development IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid transport TAS
Traceable Author Statement
more info
PubMed 
heart development IEA
Inferred from Electronic Annotation
more info
 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cholesterol storage IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
negative regulation of macrophage derived foam cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of receptor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sequestering of triglyceride IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular ketone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to lipid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
peroxisome proliferator-activated receptor alpha
Names
PPAR-alpha
nuclear receptor subfamily 1 group C member 1
peroxisome proliferative activated receptor, alpha
peroxisome proliferator-activated nuclear receptor alpha variant 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012204.2 RefSeqGene

    Range
    5262..98223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001928.3NP_001001928.1  peroxisome proliferator-activated receptor alpha

    See identical proteins and their annotated locations for NP_001001928.1

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
    Consensus CDS
    CCDS33669.1
    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Related
    ENSP00000262735.5, ENST00000262735.9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  2. NM_001362872.2NP_001349801.1  peroxisome proliferator-activated receptor alpha

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
    Consensus CDS
    CCDS33669.1
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  3. NM_001362873.1NP_001349802.1  peroxisome proliferator-activated receptor alpha

    Status: REVIEWED

    Source sequence(s)
    AK289821, AL078611, BP253825, HY113201
    Consensus CDS
    CCDS33669.1
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  4. NM_005036.6NP_005027.2  peroxisome proliferator-activated receptor alpha

    See identical proteins and their annotated locations for NP_005027.2

    Status: REVIEWED

    Source sequence(s)
    AL078611, FP325332
    Consensus CDS
    CCDS33669.1
    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Related
    ENSP00000385523.1, ENST00000407236.5
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    46150526..46243756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530244.2XP_011528546.1  peroxisome proliferator-activated receptor alpha isoform X2

    See identical proteins and their annotated locations for XP_011528546.1

    Conserved Domains (1) summary
    cd06932
    Location:67333
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  2. XM_011530240.2XP_011528542.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011528542.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  3. XM_017028839.1XP_016884328.1  peroxisome proliferator-activated receptor alpha isoform X2

    Conserved Domains (1) summary
    cd06932
    Location:67333
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  4. XM_024452252.1XP_024308020.1  peroxisome proliferator-activated receptor alpha isoform X2

    Conserved Domains (1) summary
    cd06932
    Location:67333
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  5. XM_011530239.2XP_011528541.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011528541.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  6. XM_011530245.2XP_011528547.1  peroxisome proliferator-activated receptor alpha isoform X2

    See identical proteins and their annotated locations for XP_011528547.1

    Conserved Domains (1) summary
    cd06932
    Location:67333
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  7. XM_006724270.3XP_006724333.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006724333.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  8. XM_024452253.1XP_024308021.1  peroxisome proliferator-activated receptor alpha isoform X3

    Conserved Domains (1) summary
    cd06932
    Location:32264
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  9. XM_011530241.2XP_011528543.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011528543.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  10. XM_005261656.3XP_005261713.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_005261713.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  11. XM_011530243.2XP_011528545.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011528545.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  12. XM_011530242.2XP_011528544.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011528544.1

    UniProtKB/Swiss-Prot
    Q07869
    UniProtKB/TrEMBL
    F1D8S4
    Related
    ENSP00000385246.1, ENST00000402126.1
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RNA

  1. XR_001755253.1 RNA Sequence

  2. XR_937869.2 RNA Sequence

  3. XR_937870.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001929.2: Suppressed sequence

    Description
    NM_001001929.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  2. NM_001001930.2: Suppressed sequence

    Description
    NM_001001930.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
  3. NM_032644.3: Suppressed sequence

    Description
    NM_032644.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Support Center