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Ppara peroxisome proliferator activated receptor alpha [ Mus musculus (house mouse) ]

Gene ID: 19013, updated on 1-Mar-2024

Summary

Official Symbol
Pparaprovided by MGI
Official Full Name
peroxisome proliferator activated receptor alphaprovided by MGI
Primary source
MGI:MGI:104740
See related
Ensembl:ENSMUSG00000022383 AllianceGenome:MGI:104740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppar; Nr1c1; PPARalpha; PPAR-alpha; 4933429D07Rik
Summary
Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and lipid binding activity. Involved in several processes, including negative regulation of appetite; positive regulation of fatty acid oxidation; and regulation of gene expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of cellular biosynthetic process; and wound healing. Predicted to be located in nucleoplasm. Is expressed in several structures, including adipose tissue; early conceptus; heart; liver; and oocyte. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 11.2), kidney adult (RPKM 8.7) and 15 other tissues See more
Orthologs
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Genomic context

See Ppara in Genome Data Viewer
Location:
15 E2; 15 40.42 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85619112..85691052)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85734910..85806851)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34622 Neighboring gene predicted gene, 46529 Neighboring gene STARR-positive B cell enhancer ABC_E10873 Neighboring gene STARR-seq mESC enhancer starr_39399 Neighboring gene STARR-positive B cell enhancer ABC_E5505 Neighboring gene cysteine rich, DPF motif domain containing 1 Neighboring gene polycystin (PKD) family receptor for egg jelly

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear steroid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear steroid receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within enamel mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transformation of host cell by virus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cellular ketone metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
peroxisome proliferator-activated receptor alpha
Names
nuclear receptor subfamily 1 group C member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113418.1NP_001106889.1  peroxisome proliferator-activated receptor alpha

    See identical proteins and their annotated locations for NP_001106889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117784, AI118064, AK081709
    Consensus CDS
    CCDS27721.1
    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Related
    ENSMUSP00000105050.2, ENSMUST00000109423.8
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  2. NM_011144.6NP_035274.2  peroxisome proliferator-activated receptor alpha

    See identical proteins and their annotated locations for NP_035274.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117784, AI118064, AK035676
    Consensus CDS
    CCDS27721.1
    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Related
    ENSMUSP00000105049.2, ENSMUST00000109422.8
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    85619112..85691052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245517.4XP_011243819.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011243819.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  2. XM_030248422.2XP_030104282.1  peroxisome proliferator-activated receptor alpha isoform X3

    Conserved Domains (2) summary
    cd06932
    Location:36302
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cl02596
    Location:119
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  3. XM_030248424.2XP_030104284.1  peroxisome proliferator-activated receptor alpha isoform X3

    Conserved Domains (2) summary
    cd06932
    Location:36302
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cl02596
    Location:119
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  4. XM_030248421.2XP_030104281.1  peroxisome proliferator-activated receptor alpha isoform X2

    Conserved Domains (2) summary
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    cl11397
    Location:201386
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  5. XM_011245516.4XP_011243818.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011243818.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  6. XM_006520619.3XP_006520682.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006520682.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Related
    ENSMUSP00000059719.6, ENSMUST00000057979.6
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  7. XM_030248423.2XP_030104283.1  peroxisome proliferator-activated receptor alpha isoform X3

    Conserved Domains (2) summary
    cd06932
    Location:36302
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cl02596
    Location:119
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  8. XM_011245519.4XP_011243821.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011243821.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  9. XM_006520623.5XP_006520686.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006520686.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  10. XM_006520621.5XP_006520684.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006520684.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  11. XM_006520620.5XP_006520683.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006520683.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
  12. XM_006520622.5XP_006520685.1  peroxisome proliferator-activated receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006520685.1

    UniProtKB/Swiss-Prot
    P23204
    UniProtKB/TrEMBL
    Q542P9
    Conserved Domains (2) summary
    cd06932
    Location:201467
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:101184
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers