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MECP2 methyl-CpG binding protein 2 [ Homo sapiens (human) ]

Gene ID: 4204, updated on 6-Jul-2025
Official Symbol
MECP2provided by HGNC
Official Full Name
methyl-CpG binding protein 2provided by HGNC
Primary source
HGNC:HGNC:6990
See related
Ensembl:ENSG00000169057 MIM:300005; AllianceGenome:HGNC:6990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13
Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in ovary (RPKM 10.4), brain (RPKM 8.2) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See MECP2 in Genome Data Viewer
Location:
Xq28
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154021573..154097717, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152295254..152371375, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153287024..153363174, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153277410-153278394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153278395-153279378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153285318-153286287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30052 Neighboring gene interleukin 1 receptor associated kinase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153297889-153298431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153298432-153298975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153298976-153299518 Neighboring gene microRNA 718 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chrX:153301355-153301920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153306499-153306999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21083 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:153362776-153363014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21085 Neighboring gene Sharpr-MPRA regulatory region 3572 Neighboring gene opsin locus control region Neighboring gene opsin 1, long wave sensitive Neighboring gene TEX28 pseudogene 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Spatio-temporal dynamics and localization of MeCP2 and pathological mutants in living cells. Marchi M, et al. Epigenetics, 2007 Sep. PMID 17965612
  2. Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons. Williams EC, et al. Hum Mol Genet, 2014 Jun 1. PMID 24419315, Free PMC Article
  3. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Zhubi A, et al. Transl Psychiatry, 2014 Jan 21. PMID 24448211, Free PMC Article
  4. MECP2 duplication: possible cause of severe phenotype in females. Scott Schwoerer J, et al. Am J Med Genet A, 2014 Apr. PMID 24458799
  5. Clinical characterization and identification of duplication breakpoints in a Japanese family with Xq28 duplication syndrome including MECP2. Fukushi D, et al. Am J Med Genet A, 2014 Apr. PMID 24478188

See all (736) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons.
    Title: Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons.
  2. Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis.
    Title: Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis.
  3. MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.
    Title: MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.
  4. Methyl-CpG-binding protein 2 regulates CYP27A1-induced myometrial contraction during preterm labor.
    Title: Methyl-CpG-binding protein 2 regulates CYP27A1-induced myometrial contraction during preterm labor.
  5. CRL4[DCAF13] E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes.
    Title: CRL4(DCAF13) E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes.
  6. [Genetic analysis and prenatal diagnosis for a Chinese pedigree affected with co-morbid Ornithine carbamoyl transferase deficiency and MECP2 duplication syndrome].
    Title: [Genetic analysis and prenatal diagnosis for a Chinese pedigree affected with co-morbid Ornithine carbamoyl transferase deficiency and MECP2 duplication syndrome].
  7. Genetic analysis of a pedigree with MECP2 duplication syndrome in China.
    Title: Genetic analysis of a pedigree with MECP2 duplication syndrome in China.
  8. A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways.
    Title: A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways.
  9. Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.
    Title: Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.
  10. Analysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells.
    Title: Analysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells.
Submit: New GeneRIF Correction See all GeneRIFs (549)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-22)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-02-22)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Nef nef MECP2 mRNA is selectively retained in HIV-1 Nef-expressing cellular exosomes, and eight miRNAs (miR-19a, miR-29b, miR-34a*, miR-146b, miR-181a, miR181c, miR-195, and let-7c) which target MECP2 mRNA are selectively secreted in exosomes from these cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686A24160

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables RNA binding HDA PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded methylated DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded methylated DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded methylated DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone reader activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyl-CpG binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables molecular condensate scaffold activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleic acid binding EXP
Inferred from Experiment
more info
 PubMed 
enables promoter-specific chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables siRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in associative learning IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within behavioral fear response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within biogenic amine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within brain development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cardiolipin metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of catecholamine secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellum development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendrite development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epigenetic regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within genomic imprinting IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within genomic imprinting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucocorticoid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heterochromatin formation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within learning IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-term memory IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within memory IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organismal response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuromuscular process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuromuscular process controlling posture IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron maturation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron projection development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylcholine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proprioception IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organismal development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to other organism IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of pain IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within social behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within startle response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within synapse assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of trans-synaptic signaling by BDNF IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ventricular system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual learning IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in heterochromatin IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
methyl-CpG-binding protein 2
Names
meCp-2 protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007107.3 RefSeqGene

    Range
    44387..120531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_764

mRNA and Protein(s)

  1. NM_001110792.2 → NP_001104262.1  methyl-CpG-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001104262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as MECP2B, lacks exon 2. Translation is reported to initiate in the first exon resulting in a protein isoform (2) with a distinct N-terminus. This transcript is reported to be abundant in the central nervous system (PMID: 15034579, 17171659).
    Source sequence(s)
    AF030876, BC011612, BX538060, U52112
    Consensus CDS
    CCDS48193.1
    UniProtKB/TrEMBL
    A0A140VKC4, C6KG45, D0UU70, D5L9I5, D9ZNA4, E9LUH3
    Related
    ENSP00000395535.2, ENST00000453960.7
    Conserved Domains (1) summary
    smart00391
    Location:104 → 181
    MBD; Methyl-CpG binding domain

  2. NM_001316337.2 → NP_001303266.1  methyl-CpG-binding protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes exon 2 and an additional exon, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-7 all encode the same isoform (3).
    Source sequence(s)
    AB209464, AF030876, BC011612, BI767019, U52112
    UniProtKB/TrEMBL
    D5L9I5
    Conserved Domains (1) summary
    smart00391
    Location:1 → 76
    MBD; Methyl-CpG binding domain

  3. NM_001369391.2 → NP_001356320.1  methyl-CpG-binding protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes exon 2 and some additional exons, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-7 all encode the same isoform (3).
    Source sequence(s)
    AC244097, AF030876, U52112
    UniProtKB/TrEMBL
    D5L9I5
    Conserved Domains (1) summary
    smart00391
    Location:1 → 76
    MBD; Methyl-CpG binding domain

  4. NM_001369392.2 → NP_001356321.1  methyl-CpG-binding protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) includes exon 2 and an additional exon, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-7 all encode the same isoform (3).
    Source sequence(s)
    AC244097, AF030876, U52112
    UniProtKB/TrEMBL
    D5L9I5
    Conserved Domains (1) summary
    smart00391
    Location:1 → 76
    MBD; Methyl-CpG binding domain

  5. NM_001369393.2 → NP_001356322.1  methyl-CpG-binding protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks exon 2 and contains an additional exon, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-7 all encode the same isoform (3).
    Source sequence(s)
    AC244097, AF030876, U52112
    UniProtKB/TrEMBL
    D5L9I5
    Conserved Domains (1) summary
    smart00391
    Location:1 → 76
    MBD; Methyl-CpG binding domain

  6. NM_001369394.2 → NP_001356323.1  methyl-CpG-binding protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3-7 all encode the same isoform (3).
    Source sequence(s)
    AC244097, AF030876, U52112
    UniProtKB/TrEMBL
    D5L9I5
    Conserved Domains (1) summary
    smart00391
    Location:1 → 76
    MBD; Methyl-CpG binding domain

  7. NM_001386137.1 → NP_001373066.1  methyl-CpG-binding protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC244097, AF030876, U52112

  8. NM_001386138.1 → NP_001373067.1  methyl-CpG-binding protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC244097, AF030876, U52112

  9. NM_001386139.1 → NP_001373068.1  methyl-CpG-binding protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC244097, AF030876, U52112

  10. NM_004992.4 → NP_004983.1  methyl-CpG-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_004983.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as MECP2A, includes exon 2. Translation is reported to initiate in exon 2 resulting in a protein isoform (1) with a distinct N-terminus.
    Source sequence(s)
    AC244097, AF030876, U52112
    Consensus CDS
    CCDS14741.1
    UniProtKB/Swiss-Prot
    O15233, P51608, Q6QHH9, Q7Z384
    UniProtKB/TrEMBL
    C6KG45, D0UU70, D3YJ43, D5L9I5, D9ZNA4, E9LUH3
    Related
    ENSP00000301948.6, ENST00000303391.11
    Conserved Domains (1) summary
    smart00391
    Location:92 → 169
    MBD; Methyl-CpG binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154021573..154097717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442116.1 → XP_047298072.1  methyl-CpG-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O15233, P51608, Q6QHH9, Q7Z384
    UniProtKB/TrEMBL
    C6KG45, D0UU70, D3YJ43, D5L9I5, D9ZNA4, E9LUH3
    Related
    ENSP00000486089.2, ENST00000630151.3

  2. XM_047442115.1 → XP_047298071.1  methyl-CpG-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O15233, P51608, Q6QHH9, Q7Z384
    UniProtKB/TrEMBL
    C6KG45, D0UU70, D3YJ43, D5L9I5, D9ZNA4, E9LUH3

  3. XM_047442120.1 → XP_047298076.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  4. XM_047442119.1 → XP_047298075.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  5. XM_047442118.1 → XP_047298074.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  6. XM_024452383.2 → XP_024308151.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5
    Conserved Domains (1) summary
    smart00391
    Location:1 → 76
    MBD; Methyl-CpG binding domain

  7. XM_047442117.1 → XP_047298073.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  8. XM_047442121.1 → XP_047298077.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  9. XM_047442122.1 → XP_047298078.1  methyl-CpG-binding protein 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152295254..152371375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327092.1 → XP_054183067.1  methyl-CpG-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O15233, P51608, Q6QHH9, Q7Z384
    UniProtKB/TrEMBL
    C6KG45, D0UU70, D3YJ43, D5L9I5, D9ZNA4, E9LUH3

  2. XM_054327091.1 → XP_054183066.1  methyl-CpG-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O15233, P51608, Q6QHH9, Q7Z384
    UniProtKB/TrEMBL
    C6KG45, D0UU70, D3YJ43, D5L9I5, D9ZNA4, E9LUH3

  3. XM_054327097.1 → XP_054183072.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  4. XM_054327096.1 → XP_054183071.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  5. XM_054327095.1 → XP_054183070.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  6. XM_054327093.1 → XP_054183068.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  7. XM_054327094.1 → XP_054183069.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  8. XM_054327098.1 → XP_054183073.1  methyl-CpG-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    D5L9I5

  9. XM_054327099.1 → XP_054183074.1  methyl-CpG-binding protein 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51608.1 GenPept UniProtKB/Swiss-Prot:P51608

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