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Mecp2 methyl CpG binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 17257, updated on 19-Feb-2024

Summary

Official Symbol
Mecp2provided by MGI
Official Full Name
methyl CpG binding protein 2provided by MGI
Primary source
MGI:MGI:99918
See related
Ensembl:ENSMUSG00000031393 AllianceGenome:MGI:99918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mbd5; WBP10; 1500041B07Rik; D630021H01Rik
Summary
Enables several functions, including nucleic acid binding activity; promoter-specific chromatin binding activity; and transcription corepressor activity. Involved in several processes, including negative regulation of smooth muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; and positive regulation of histone H3-K9 trimethylation. Acts upstream of or within several processes, including glycerolipid metabolic process; nervous system development; and regulation of gene expression. Located in cytosol; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; early conceptus; nervous system; paraxial mesenchyme; and sensory organ. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; X-linked intellectual disability-psychosis-macroorchidism syndrome; autistic disorder; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability Lubs type. Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 8.6), CNS E18 (RPKM 7.6) and 26 other tissues See more
Orthologs
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Genomic context

See Mecp2 in Genome Data Viewer
Location:
X A7.3; X 37.63 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73070198..73129296, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74026592..74085690, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene microRNA 5132 Neighboring gene microRNA 718 Neighboring gene green (M) opsin gene upstream regulatory region Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) Neighboring gene testis expressed 28

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded methylated DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded methylated DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded methylated DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone reader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone reader activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables siRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unmethylated CpG binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within biogenic amine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiolipin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of catecholamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to isoquinoline alkaloid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to potassium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epigenetic regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within genomic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within genomic imprinting ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucocorticoid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glutamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inositol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of primary miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of respiratory gaseous exchange ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling posture IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphatidylcholine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of anterograde dense core granule transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of retrograde dense core granule transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within proprioception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of action potential firing threshold ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cocaine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to other organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of trans-synaptic signaling by BDNF IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methyl-CpG-binding protein 2
Names
meCp-2 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081979.2NP_001075448.1  methyl-CpG-binding protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as alpha) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK158664, AL672002, BU700810
    Consensus CDS
    CCDS41016.1
    UniProtKB/Swiss-Prot
    Q9Z2D6
    Related
    ENSMUSP00000033770.7, ENSMUST00000033770.13
    Conserved Domains (1) summary
    smart00391
    Location:109186
    MBD; Methyl-CpG binding domain
  2. NM_010788.4NP_034918.1  methyl-CpG-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_034918.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as beta) has an additional exon in the 5' region, which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL672002, BU700810
    Consensus CDS
    CCDS41017.1
    UniProtKB/Swiss-Prot
    B1AUZ2, B1AUZ3, Q3TYG1, Q9Z2D6
    Related
    ENSMUSP00000098314.4, ENSMUST00000100750.10
    Conserved Domains (1) summary
    smart00391
    Location:92169
    MBD; Methyl-CpG binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73070198..73129296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251240.1XP_030107100.1  methyl-CpG-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B1AUZ2, B1AUZ3, Q3TYG1, Q9Z2D6
    Conserved Domains (1) summary
    smart00391
    Location:92169
    MBD; Methyl-CpG binding domain