Format

Send to:

Choose Destination

KRAS KRAS proto-oncogene, GTPase [ Homo sapiens (human) ]

Gene ID: 3845, updated on 20-Sep-2020

Summary

Official Symbol
KRASprovided by HGNC
Official Full Name
KRAS proto-oncogene, GTPaseprovided by HGNC
Primary source
HGNC:HGNC:6407
See related
Ensembl:ENSG00000133703 MIM:190070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NS; NS3; OES; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; K-Ras 2; 'C-K-RAS; c-Ki-ras; c-Ki-ras2
Summary
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in colon (RPKM 7.8), brain (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See KRAS in Genome Data Viewer
Location:
12p12.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (25205246..25250929, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (25358180..25403870, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene cilia and flagella associated protein 94 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene NFE2L2 motif-containing MPRA enhancer 301/302 Neighboring gene uncharacterized LOC105369701

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Acute myeloid leukemia Compare labs
Carcinoma of pancreas
MedGen: C0235974 OMIM: 260350 GeneReviews: Not available
Compare labs
Cardiofaciocutaneous syndrome 2
MedGen: C3809005 OMIM: 615278 GeneReviews: Cardiofaciocutaneous Syndrome
Compare labs
Cerebral arteriovenous malformation
MedGen: C0917804 OMIM: 108010 GeneReviews: Not available
Compare labs
Epidermal nevus syndrome
MedGen: C0265318 OMIM: 163200 GeneReviews: Not available
Compare labs
Familial cancer of breast Compare labs
Hereditary diffuse gastric cancer Compare labs
Lung cancer
MedGen: C0684249 OMIM: 211980 GeneReviews: Not available
Compare labs
Noonan syndrome 3
MedGen: C1860991 OMIM: 609942 GeneReviews: Noonan Syndrome
Compare labs
RAS-associated autoimmune leukoproliferative disorder
MedGen: C2674723 OMIM: 614470 GeneReviews: Not available
Compare labs
Toriello-Lacassie-Droste syndrome
MedGen: C1838329 OMIM: 600268 GeneReviews: Not available
Compare labs
Urinary bladder cancer
MedGen: C0005684 OMIM: 109800 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2015-10-08)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2015-10-08)

ClinGen Genome Curation Page

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of Kirsten rat sarcoma viral oncogene homolog (KRAS) in human B cells PubMed
Envelope surface glycoprotein gp160, precursor env Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells PubMed
env HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation PubMed
Tat tat Treatment with HIV-1 Tat and cocaine activates Ras/Erk pathway in human pulmonary artery endothelial cells PubMed
tat NOX4-mediated K-Ras activation on the ER endomembrane results in Tat-induced unfolded-protein response PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GMP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
LRR domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ras protein signal transduction TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
endocrine signaling IEA
Inferred from Electronic Annotation
more info
 
epithelial tube branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
forebrain astrocyte development IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to isolation stress IEA
Inferred from Electronic Annotation
more info
 
response to mineralocorticoid IEA
Inferred from Electronic Annotation
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
GTPase KRas
Names
K-ras p21 protein
Kirsten rat sarcoma viral oncogene homolog
Kirsten rat sarcoma viral proto-oncogene
PR310 c-K-ras oncogene
c-Kirsten-ras protein
cellular c-Ki-ras2 proto-oncogene
cellular transforming proto-oncogene
oncogene KRAS2
transforming protein p21
v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
NP_001356715.1
NP_001356716.1
NP_004976.2
NP_203524.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007524.2 RefSeqGene

    Range
    5075..50758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_344

mRNA and Protein(s)

  1. NM_001369786.1NP_001356715.1  GTPase KRas isoform a

    Status: REVIEWED

    Source sequence(s)
    AC087239, AC092794, KF459678
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
  2. NM_001369787.1NP_001356716.1  GTPase KRas isoform b

    Status: REVIEWED

    Source sequence(s)
    AC087239, AC092794
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
  3. NM_004985.5NP_004976.2  GTPase KRas isoform b

    See identical proteins and their annotated locations for NP_004976.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) is composed of five exons and lacks exon 4a which the longer transcript variant (a) includes. This predominant variant (b) has a cds that terminates in exon 4b and encodes isoform b.
    Source sequence(s)
    AC092794, AK292510, M54968
    Consensus CDS
    CCDS8702.1
    UniProtKB/Swiss-Prot
    P01116
    UniProtKB/TrEMBL
    A0A024RAV5
    Related
    ENSP00000308495.3, ENST00000311936.8
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
  4. NM_033360.4NP_203524.1  GTPase KRas isoform a

    See identical proteins and their annotated locations for NP_203524.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) is composed of six exons, including exon 4a, which the shorter transcript variant (b) lacks. This rare variant (a) has a cds that terminates in exon 4a and encodes a unique C-terminus, compared to isoform a.
    Source sequence(s)
    AC087239, AC092794, KF459678
    Consensus CDS
    CCDS8703.1
    UniProtKB/Swiss-Prot
    P01116
    UniProtKB/TrEMBL
    I1SRC5, L7RSL8
    Related
    ENSP00000256078.4, ENST00000256078.9
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    25205246..25250929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center