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Kras Kirsten rat sarcoma viral oncogene homolog [ Mus musculus (house mouse) ]

Gene ID: 16653, updated on 29-Nov-2022

Summary

Official Symbol
Krasprovided by MGI
Official Full Name
Kirsten rat sarcoma viral oncogene homologprovided by MGI
Primary source
MGI:MGI:96680
See related
Ensembl:ENSMUSG00000030265 AllianceGenome:MGI:96680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
Summary
Enables GTPase activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 17.0), whole brain E14.5 (RPKM 16.2) and 26 other tissues See more
Orthologs
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Genomic context

See Kras in Genome Data Viewer
Location:
6 G3; 6 77.37 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145162425..145196144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145216699..145250420, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene cancer susceptibility candidate 1 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GMP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables LRR domain binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-membrane adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of type I pneumocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within visual learning IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
GTPase KRas
Names
Kirsten rat sarcoma oncogene 2, expressed
p21 protein
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
NP_067259.4
XP_006506981.1
XP_006506982.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403240.1NP_001390169.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1
  2. NM_001403241.1NP_001390170.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1
  3. NM_001403242.1NP_001390171.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1
  4. NM_001403243.1NP_001390172.1  GTPase KRas isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/Swiss-Prot
    P08643
    UniProtKB/TrEMBL
    A0A6P5PQ68, A0A8C6H981, Q0VDV7
  5. NM_001403244.1NP_001390173.1  GTPase KRas isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157091
  6. NM_001403245.1NP_001390174.1  GTPase KRas isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157091
  7. NM_001403246.1NP_001390175.1  GTPase KRas isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    A0A0N4SVY1
  8. NM_021284.7NP_067259.4  GTPase KRas isoform 1

    See identical proteins and their annotated locations for NP_067259.4

    Status: VALIDATED

    Source sequence(s)
    AC157091
    Consensus CDS
    CCDS20693.1
    UniProtKB/Swiss-Prot
    P32883
    UniProtKB/TrEMBL
    Q5J7N1
    Related
    ENSMUSP00000032399.6, ENSMUST00000032399.12
    Conserved Domains (2) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00010
    Location:16166
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

RNA

  1. NR_175367.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157091
  2. NR_175368.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157091

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    145162425..145196144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506918.5XP_006506981.1  GTPase KRas isoform X1

    UniProtKB/Swiss-Prot
    P32883
    UniProtKB/TrEMBL
    Q0VDV7
    Related
    ENSMUSP00000107339.2, ENSMUST00000111710.8
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
  2. XM_006506919.5XP_006506982.1  GTPase KRas isoform X2

    See identical proteins and their annotated locations for XP_006506982.1

    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B