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Kras Kirsten rat sarcoma viral oncogene homolog [ Mus musculus (house mouse) ]

Gene ID: 16653, updated on 11-Sep-2019

Summary

Official Symbol
Krasprovided by MGI
Official Full Name
Kirsten rat sarcoma viral oncogene homologprovided by MGI
Primary source
MGI:MGI:96680
See related
Ensembl:ENSMUSG00000030265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; AI929937; c-Ki-ras
Expression
Ubiquitous expression in CNS E18 (RPKM 17.0), whole brain E14.5 (RPKM 16.2) and 26 other tissues See more
Orthologs

Genomic context

See Kras in Genome Data Viewer
Location:
6 G3; 6 77.37 cM
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145216699..145250420, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (145165219..145198751, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene lymphoid-restricted membrane protein Neighboring gene cancer susceptibility candidate 1 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding ISO
Inferred from Sequence Orthology
more info
 
GMP binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
LRR domain binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
endocrine signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial tube branching involved in lung morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
epithelial tube branching involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
forebrain astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
homeostasis of number of cells within a tissue IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
visual learning IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GTPase KRas
Names
Kirsten rat sarcoma oncogene 2, expressed
p21 protein
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021284.6NP_067259.4  GTPase KRas

    See identical proteins and their annotated locations for NP_067259.4

    Status: VALIDATED

    Source sequence(s)
    AC157091, AK164065
    Consensus CDS
    CCDS20693.1
    UniProtKB/Swiss-Prot
    P32883
    UniProtKB/TrEMBL
    Q5J7N1
    Related
    ENSMUSP00000032399.5, ENSMUST00000032399.11
    Conserved Domains (2) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00010
    Location:16166
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

    Range
    145216699..145250420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506918.4XP_006506981.1  GTPase KRas isoform X1

    See identical proteins and their annotated locations for XP_006506981.1

    UniProtKB/Swiss-Prot
    P32883
    UniProtKB/TrEMBL
    Q0VDV7
    Related
    ENSMUSP00000107339.1, ENSMUST00000111710.7
    Conserved Domains (1) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
  2. XM_006506919.4XP_006506982.1  GTPase KRas isoform X2

    See identical proteins and their annotated locations for XP_006506982.1

    Conserved Domains (2) summary
    cd04138
    Location:3164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00173
    Location:16166
    RAS; Ras subfamily of RAS small GTPases

Reference GRCm38.p6 NOD/ShiLtJ

Genomic

  1. NT_166305.2 Reference GRCm38.p6 NOD/ShiLtJ

    Range
    1734813..1768417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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