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Gastric cancer

MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
Synonyms: Malignant tumor of stomach; Stomach cancer
SNOMED CT: Cancer of stomach (363349007); Gastric cancer (363349007); CA - Cancer of stomach (363349007); Malignant tumor of stomach (363349007)
 
Genes (locations): APC (5q22.2); CASP10 (2q33.1); ERBB2 (17q12); FGFR2 (10q26.13); IL1B (2q14.1); IL1RN (2q14.1); IRF1 (5q31.1); KLF6 (10p15.2); KRAS (12p12.1); MUTYH (1p34.1); PIK3CA (3q26.32)
 
HPO: HP:0012126
Monarch Initiative: MONDO:0001056
OMIM®: 613659

Definition

In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), the Li-Fraumeni syndrome (151623), and diffuse gastric and lobular breast cancer syndrome (DGLBC; 137215). Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263). [from OMIM]

Clinical features

From HPO
Increased level of L-fucose in urine
MedGen UID:
1646743
Concept ID:
C4703633
Finding
An increase in the level of L-fucose in the urine.
Gastric cancer
MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), the Li-Fraumeni syndrome (151623), and diffuse gastric and lobular breast cancer syndrome (DGLBC; 137215). Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263).

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Conditions with this feature

Gastric cancer
MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), the Li-Fraumeni syndrome (151623), and diffuse gastric and lobular breast cancer syndrome (DGLBC; 137215). Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263).
Hereditary diffuse gastric adenocarcinoma
MedGen UID:
310839
Concept ID:
C1708349
Neoplastic Process
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant susceptibility for diffuse gastric cancer, a poorly differentiated adenocarcinoma that infiltrates into the stomach wall causing thickening of the wall (linitis plastica) without forming a distinct mass. Diffuse gastric cancer is also referred to as signet ring carcinoma or isolated cell-type carcinoma. The average age of onset of HDGC is 38 years (range: 14-69 years). The majority of the cancers in individuals with a CDH1 pathogenic variant occur before age 40 years. The estimated cumulative risk of gastric cancer by age 80 years is 70% for men and 56% for women. Women are also at a 42% risk for lobular breast cancer.
Li-Fraumeni syndrome 2
MedGen UID:
1849727
Concept ID:
C5882668
Disease or Syndrome
Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults.\n\nA very similar condition called Li-Fraumeni-like syndrome shares many of the features of classic Li-Fraumeni syndrome. Both conditions significantly increase the chances of developing multiple cancers beginning in childhood; however, the pattern of specific cancers seen in affected family members is different.\n\nThe cancers most often associated with Li-Fraumeni syndrome include breast cancer, a form of bone cancer called osteosarcoma, and cancers of soft tissues (such as muscle) called soft tissue sarcomas. Other cancers commonly seen in this syndrome include brain tumors, cancers of blood-forming tissues (leukemias), and a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands (small hormone-producing glands on top of each kidney). Several other types of cancer also occur more frequently in people with Li-Fraumeni syndrome.

Professional guidelines

PubMed

Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Moayyedi P, Lacy BE, Andrews CN, Enns RA, Howden CW, Vakil N
Am J Gastroenterol 2017 Jul;112(7):988-1013. Epub 2017 Jun 20 doi: 10.1038/ajg.2017.154. PMID: 28631728
Chey WD, Leontiadis GI, Howden CW, Moss SF
Am J Gastroenterol 2017 Feb;112(2):212-239. Epub 2017 Jan 10 doi: 10.1038/ajg.2016.563. PMID: 28071659

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer, 2023

UK NICE Guideline (NG83), Oesophago-gastric cancer: assessment and management in adults, 2023

Recent clinical studies

Etiology

Thrift AP, Wenker TN, El-Serag HB
Nat Rev Clin Oncol 2023 May;20(5):338-349. Epub 2023 Mar 23 doi: 10.1038/s41571-023-00747-0. PMID: 36959359
López MJ, Carbajal J, Alfaro AL, Saravia LG, Zanabria D, Araujo JM, Quispe L, Zevallos A, Buleje JL, Cho CE, Sarmiento M, Pinto JA, Fajardo W
Crit Rev Oncol Hematol 2023 Jan;181:103841. Epub 2022 Oct 11 doi: 10.1016/j.critrevonc.2022.103841. PMID: 36240980
Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F
Lancet 2020 Aug 29;396(10251):635-648. doi: 10.1016/S0140-6736(20)31288-5. PMID: 32861308
Thrift AP, El-Serag HB
Clin Gastroenterol Hepatol 2020 Mar;18(3):534-542. Epub 2019 Jul 27 doi: 10.1016/j.cgh.2019.07.045. PMID: 31362118Free PMC Article
Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F
Cancer Epidemiol Biomarkers Prev 2014 May;23(5):700-13. Epub 2014 Mar 11 doi: 10.1158/1055-9965.EPI-13-1057. PMID: 24618998Free PMC Article

Diagnosis

López MJ, Carbajal J, Alfaro AL, Saravia LG, Zanabria D, Araujo JM, Quispe L, Zevallos A, Buleje JL, Cho CE, Sarmiento M, Pinto JA, Fajardo W
Crit Rev Oncol Hematol 2023 Jan;181:103841. Epub 2022 Oct 11 doi: 10.1016/j.critrevonc.2022.103841. PMID: 36240980
Xia JY, Aadam AA
J Surg Oncol 2022 Jun;125(7):1104-1109. doi: 10.1002/jso.26844. PMID: 35481909Free PMC Article
Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F
Lancet 2020 Aug 29;396(10251):635-648. doi: 10.1016/S0140-6736(20)31288-5. PMID: 32861308
Thrift AP, El-Serag HB
Clin Gastroenterol Hepatol 2020 Mar;18(3):534-542. Epub 2019 Jul 27 doi: 10.1016/j.cgh.2019.07.045. PMID: 31362118Free PMC Article
Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F
Cancer Epidemiol Biomarkers Prev 2014 May;23(5):700-13. Epub 2014 Mar 11 doi: 10.1158/1055-9965.EPI-13-1057. PMID: 24618998Free PMC Article

Therapy

Koga Y
World J Gastroenterol 2022 Dec 21;28(47):6702-6715. doi: 10.3748/wjg.v28.i47.6702. PMID: 36620346Free PMC Article
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Chung HC, Bang YJ, S Fuchs C, Qin SK, Satoh T, Shitara K, Tabernero J, Van Cutsem E, Alsina M, Cao ZA, Lu J, Bhagia P, Shih CS, Janjigian YY
Future Oncol 2021 Feb;17(5):491-501. Epub 2020 Nov 10 doi: 10.2217/fon-2020-0737. PMID: 33167735Free PMC Article
Sexton RE, Al Hallak MN, Diab M, Azmi AS
Cancer Metastasis Rev 2020 Dec;39(4):1179-1203. Epub 2020 Sep 7 doi: 10.1007/s10555-020-09925-3. PMID: 32894370Free PMC Article
Bang YJ, Van Cutsem E, Fuchs CS, Ohtsu A, Tabernero J, Ilson DH, Hyung WJ, Strong VE, Goetze TO, Yoshikawa T, Tang LH, Hwang PMT, Webb N, Adelberg D, Shitara K
Future Oncol 2019 Mar;15(9):943-952. Epub 2019 Feb 19 doi: 10.2217/fon-2018-0581. PMID: 30777447

Prognosis

Charvat H, Fukui K, Matsuda T, Katanoda K, Ito Y
Int J Cancer 2023 Sep 15;153(6):1162-1171. Epub 2023 Jun 6 doi: 10.1002/ijc.34610. PMID: 37278616
Libânio D, Rodrigues JR, Bento MJ, Ebigbo A, Messman H, Verhoeven RHA, Van Damme N, Bisschops R, Spaander MCW, Dinis-Ribeiro M
Endoscopy 2022 Jul;54(7):644-652. Epub 2021 Dec 16 doi: 10.1055/a-1673-1118. [Epub ahead of print] PMID: 34666399
Wong MCS, Huang J, Chan PSF, Choi P, Lao XQ, Chan SM, Teoh A, Liang P
JAMA Netw Open 2021 Jul 1;4(7):e2118457. doi: 10.1001/jamanetworkopen.2021.18457. PMID: 34309666Free PMC Article
Miao ZF, Xu H, Xu YY, Wang ZN, Zhao TT, Song YX, Xu HM
Oncotarget 2017 Jul 4;8(27):44881-44892. doi: 10.18632/oncotarget.16487. PMID: 28415651Free PMC Article
D'Ugo D, Biondi A, Tufo A, Persiani R
Dig Surg 2013;30(2):159-68. Epub 2013 Jul 18 doi: 10.1159/000350878. PMID: 23867593

Clinical prediction guides

Jiang Y, Zhang Z, Yuan Q, Wang W, Wang H, Li T, Huang W, Xie J, Chen C, Sun Z, Yu J, Xu Y, Poultsides GA, Xing L, Zhou Z, Li G, Li R
Lancet Digit Health 2022 May;4(5):e340-e350. doi: 10.1016/S2589-7500(22)00040-1. PMID: 35461691
Shah SC, Piazuelo MB, Kuipers EJ, Li D
Gastroenterology 2021 Oct;161(4):1325-1332.e7. Epub 2021 Aug 26 doi: 10.1053/j.gastro.2021.06.078. PMID: 34454714Free PMC Article
Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Koike T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribasyashi S, Kiyotoki S, Mabe K, Nakamura T, Nakaya N, Fujishiro M, Masamune A
Gut 2021 Mar;70(3):476-484. Epub 2020 Jun 4 doi: 10.1136/gutjnl-2019-319926. PMID: 32499390Free PMC Article
Arnold M, Park JY, Camargo MC, Lunet N, Forman D, Soerjomataram I
Gut 2020 May;69(5):823-829. Epub 2020 Jan 30 doi: 10.1136/gutjnl-2019-320234. PMID: 32001553Free PMC Article
Pasechnikov V, Chukov S, Fedorov E, Kikuste I, Leja M
World J Gastroenterol 2014 Oct 14;20(38):13842-62. doi: 10.3748/wjg.v20.i38.13842. PMID: 25320521Free PMC Article

Recent systematic reviews

Chen YC, Malfertheiner P, Yu HT, Kuo CL, Chang YY, Meng FT, Wu YX, Hsiao JL, Chen MJ, Lin KP, Wu CY, Lin JT, O'Morain C, Megraud F, Lee WC, El-Omar EM, Wu MS, Liou JM
Gastroenterology 2024 Apr;166(4):605-619. Epub 2024 Jan 2 doi: 10.1053/j.gastro.2023.12.022. PMID: 38176660
Wu X, Chen L, Cheng J, Qian J, Fang Z, Wu J
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204260. PMID: 36296944Free PMC Article
Ford AC, Yuan Y, Moayyedi P
Gut 2020 Dec;69(12):2113-2121. Epub 2020 Mar 23 doi: 10.1136/gutjnl-2020-320839. PMID: 32205420
Yusefi AR, Bagheri Lankarani K, Bastani P, Radinmanesh M, Kavosi Z
Asian Pac J Cancer Prev 2018 Mar 27;19(3):591-603. doi: 10.22034/APJCP.2018.19.3.591. PMID: 29579788Free PMC Article
Lee YC, Chiang TH, Chou CK, Tu YK, Liao WC, Wu MS, Graham DY
Gastroenterology 2016 May;150(5):1113-1124.e5. Epub 2016 Feb 2 doi: 10.1053/j.gastro.2016.01.028. PMID: 26836587

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer, 2023
    • NICE, 2023
      UK NICE Guideline (NG83), Oesophago-gastric cancer: assessment and management in adults, 2023

    Consumer resources

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