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Stomach cancer

MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
Synonyms: Gastric cancer; Malignant tumor of stomach
SNOMED CT: Cancer of stomach (363349007); Gastric cancer (363349007); CA - Cancer of stomach (363349007); Malignant tumor of stomach (363349007)
Modes of inheritance:
Somatic mutation
MedGen UID:
107465
Concept ID:
C0544886
Cell or Molecular Dysfunction
Sources: HPO, OMIM
A mode of inheritance in which a trait or disorder results from a de novo mutation occurring after conception, rather than being inherited from a preceding generation.
Somatic mutation (HPO, OMIM)
 
HPO: HP:0012126
OMIM®: 613659

Definition

A primary or metastatic malignant neoplasm involving the stomach. [from NCI]

Clinical features

From HPO
Stomach cancer
MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
A primary or metastatic malignant neoplasm involving the stomach.
Increased level of L-fucose in urine
MedGen UID:
1646743
Concept ID:
C4703633
Finding
An increase in the level of L-fucose in the urine.
Stomach cancer
MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
A primary or metastatic malignant neoplasm involving the stomach.
Increased level of L-fucose in urine
MedGen UID:
1646743
Concept ID:
C4703633
Finding
An increase in the level of L-fucose in the urine.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Conditions with this feature

Stomach cancer
MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
A primary or metastatic malignant neoplasm involving the stomach.
Neoplasm of stomach
MedGen UID:
20958
Concept ID:
C0038356
Neoplastic Process
In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), and the Li-Fraumeni syndrome (151623). See also hereditary diffuse gastric cancer (HDGC; 137215). Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263).
Hereditary diffuse gastric cancer
MedGen UID:
310839
Concept ID:
C1708349
Neoplastic Process
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant susceptibility for diffuse gastric cancer, a poorly differentiated adenocarcinoma that infiltrates into the stomach wall causing thickening of the wall (linitis plastica) without forming a distinct mass. Diffuse gastric cancer is also referred to as signet ring carcinoma or isolated cell-type carcinoma. The average age of onset of HDGC is 38 years (range: 14-69 years). The majority of the cancers in individuals with a CDH1 pathogenic variant occur before age 40 years. The estimated cumulative risk of gastric cancer by age 80 years is 70% for men and 56% for women. Women are also at a 42% risk for lobular breast cancer.
Li-Fraumeni syndrome 2
MedGen UID:
322930
Concept ID:
C1836482
Disease or Syndrome
Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults.\n\nA very similar condition called Li-Fraumeni-like syndrome shares many of the features of classic Li-Fraumeni syndrome. Both conditions significantly increase the chances of developing multiple cancers beginning in childhood; however, the pattern of specific cancers seen in affected family members is different.\n\nThe cancers most often associated with Li-Fraumeni syndrome include breast cancer, a form of bone cancer called osteosarcoma, and cancers of soft tissues (such as muscle) called soft tissue sarcomas. Other cancers commonly seen in this syndrome include brain tumors, cancers of blood-forming tissues (leukemias), and a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands (small hormone-producing glands on top of each kidney). Several other types of cancer also occur more frequently in people with Li-Fraumeni syndrome.
Familial adenomatous polyposis 4
MedGen UID:
934686
Concept ID:
C4310719
Disease or Syndrome
Familial adenomatous polyposis-4 is an autosomal recessive tumor predisposition syndrome characterized by the development of multiple colonic adenomas in adulthood, often with progression to colorectal cancer. Proliferative lesions in other tissues may also occur (summary by Adam et al., 2016). For a discussion of genetic heterogeneity of familial adenomatous polyposis, see FAP1 (175100).

Recent clinical studies

Etiology

Stojanovic MM, Rancic NK, Andjelkovic Apostolovic MR, Ignjatovic AM, Ilic MV
Medicina (Kaunas) 2021 Jun 28;57(7) doi: 10.3390/medicina57070665. PMID: 34203145Free PMC Article
Deng W, Jin L, Zhuo H, Vasiliou V, Zhang Y
Chem Biol Interact 2021 Feb 25;336:109365. Epub 2021 Jan 4 doi: 10.1016/j.cbi.2021.109365. PMID: 33412155
Phuoc LH, Sengngam K, Ogawa T, Ngatu NR, Ikeda S, Hoc TH, Phu PV, Minh DT, Ngoan LT
Asian Pac J Cancer Prev 2020 Jul 1;21(7):2109-2115. doi: 10.31557/APJCP.2020.21.7.2109. PMID: 32711439Free PMC Article
Ghasemi-Kebria F, Amiriani T, Fazel A, Naimi-Tabiei M, Norouzi A, Khoshnia M, Seyyedmajidi M, Pooshani A, Mousaviemadi S, Poorkhani H, Sedaghat S, Salamat F, Hasanpour-Heidari S, Jafari-Delouie N, Gholami M, Semnani S, Roshandel G, Weiderpass E, Malekzadeh R
Arch Iran Med 2020 Jun 1;23(6):362-368. doi: 10.34172/aim.2020.28. PMID: 32536172
GBD 2017 Stomach Cancer Collaborators.
Lancet Gastroenterol Hepatol 2020 Jan;5(1):42-54. Epub 2019 Oct 21 doi: 10.1016/S2468-1253(19)30328-0. PMID: 31648970Free PMC Article

Diagnosis

Zhang K, Yin J, Huang H, Wang L, Guo L, Shi J, Dai M
Front Public Health 2020;8:310. Epub 2020 Aug 7 doi: 10.3389/fpubh.2020.00310. PMID: 32850573Free PMC Article
Zhuntova GV, Azizova TV, Grigoryeva ES
PLoS One 2020;15(4):e0231531. Epub 2020 Apr 15 doi: 10.1371/journal.pone.0231531. PMID: 32294114Free PMC Article
Chang CJ, Yang YH, Chen PC, Peng HY, Lu YC, Song SR, Yang HY
Int J Environ Res Public Health 2019 Feb 28;16(5) doi: 10.3390/ijerph16050717. PMID: 30823367Free PMC Article
Minami Y, Kanemura S, Oikawa T, Suzuki S, Hasegawa Y, Miura K, Nishino Y, Kakugawa Y, Fujiya T
Int J Cancer 2018 Sep 1;143(5):1072-1085. Epub 2018 Apr 17 doi: 10.1002/ijc.31408. PMID: 29603213
Jim MA, Pinheiro PS, Carreira H, Espey DK, Wiggins CL, Weir HK
Cancer 2017 Dec 15;123 Suppl 24:4994-5013. doi: 10.1002/cncr.30881. PMID: 29205310Free PMC Article

Therapy

Deng W, Jin L, Zhuo H, Vasiliou V, Zhang Y
Chem Biol Interact 2021 Feb 25;336:109365. Epub 2021 Jan 4 doi: 10.1016/j.cbi.2021.109365. PMID: 33412155
Phuoc LH, Sengngam K, Ogawa T, Ngatu NR, Ikeda S, Hoc TH, Phu PV, Minh DT, Ngoan LT
Asian Pac J Cancer Prev 2020 Jul 1;21(7):2109-2115. doi: 10.31557/APJCP.2020.21.7.2109. PMID: 32711439Free PMC Article
Zhuntova GV, Azizova TV, Grigoryeva ES
PLoS One 2020;15(4):e0231531. Epub 2020 Apr 15 doi: 10.1371/journal.pone.0231531. PMID: 32294114Free PMC Article
Minami Y, Kanemura S, Oikawa T, Suzuki S, Hasegawa Y, Miura K, Nishino Y, Kakugawa Y, Fujiya T
Int J Cancer 2018 Sep 1;143(5):1072-1085. Epub 2018 Apr 17 doi: 10.1002/ijc.31408. PMID: 29603213
Putthanachote N, Promthet S, Hurst C, Suwanrungruang K, Chopjitt P, Wiangnon S, Chen SL, Yen AM, Chen TH
BMC Cancer 2017 Oct 11;17(1):680. doi: 10.1186/s12885-017-3675-9. PMID: 29020930Free PMC Article

Prognosis

Stojanovic MM, Rancic NK, Andjelkovic Apostolovic MR, Ignjatovic AM, Ilic MV
Medicina (Kaunas) 2021 Jun 28;57(7) doi: 10.3390/medicina57070665. PMID: 34203145Free PMC Article
Pham TM, Quy PN, Horimatsu T, Muto M, Shack L, Cheung WY, Kubo T, Fujino Y, Matsuda S
Ann Epidemiol 2020 Jul;47:19-24. Epub 2020 Jun 3 doi: 10.1016/j.annepidem.2020.05.012. PMID: 32713503
Phuoc LH, Sengngam K, Ogawa T, Ngatu NR, Ikeda S, Hoc TH, Phu PV, Minh DT, Ngoan LT
Asian Pac J Cancer Prev 2020 Jul 1;21(7):2109-2115. doi: 10.31557/APJCP.2020.21.7.2109. PMID: 32711439Free PMC Article
Ghasemi-Kebria F, Amiriani T, Fazel A, Naimi-Tabiei M, Norouzi A, Khoshnia M, Seyyedmajidi M, Pooshani A, Mousaviemadi S, Poorkhani H, Sedaghat S, Salamat F, Hasanpour-Heidari S, Jafari-Delouie N, Gholami M, Semnani S, Roshandel G, Weiderpass E, Malekzadeh R
Arch Iran Med 2020 Jun 1;23(6):362-368. doi: 10.34172/aim.2020.28. PMID: 32536172
GBD 2017 Stomach Cancer Collaborators.
Lancet Gastroenterol Hepatol 2020 Jan;5(1):42-54. Epub 2019 Oct 21 doi: 10.1016/S2468-1253(19)30328-0. PMID: 31648970Free PMC Article

Clinical prediction guides

Bryniarski P, Bryniarska M, Jezioro M, Andrysiak D, Filipczak-Bryniarska I
Int J Palliat Nurs 2021 Feb 2;27(1):46-52. doi: 10.12968/ijpn.2021.27.1.46. PMID: 33629907
Xu L, Hu J, Song Y, Bai S, Yi Z
Med Phys 2021 Apr;48(4):1720-1730. Epub 2021 Mar 12 doi: 10.1002/mp.14733. PMID: 33503270
Zhuntova GV, Azizova TV, Grigoryeva ES
PLoS One 2020;15(4):e0231531. Epub 2020 Apr 15 doi: 10.1371/journal.pone.0231531. PMID: 32294114Free PMC Article
Venneman K, Huybrechts I, Gunter MJ, Vandendaele L, Herrero R, Van Herck K
Helicobacter 2018 Jun;23(3):e12483. Epub 2018 Apr 10 doi: 10.1111/hel.12483. PMID: 29635869
Minami Y, Kanemura S, Oikawa T, Suzuki S, Hasegawa Y, Miura K, Nishino Y, Kakugawa Y, Fujiya T
Int J Cancer 2018 Sep 1;143(5):1072-1085. Epub 2018 Apr 17 doi: 10.1002/ijc.31408. PMID: 29603213

Recent systematic reviews

Poorolajal J, Moradi L, Mohammadi Y, Cheraghi Z, Gohari-Ensaf F
Epidemiol Health 2020;42:e2020004. Epub 2020 Feb 2 doi: 10.4178/epih.e2020004. PMID: 32023777Free PMC Article
Chang CJ, Tu YK, Chen PC, Yang HY
J Formos Med Assoc 2020 Apr;119(4):781-792. Epub 2018 Aug 9 doi: 10.1016/j.jfma.2018.07.015. PMID: 30100164
Venneman K, Huybrechts I, Gunter MJ, Vandendaele L, Herrero R, Van Herck K
Helicobacter 2018 Jun;23(3):e12483. Epub 2018 Apr 10 doi: 10.1111/hel.12483. PMID: 29635869
Peng WJ, Jia XJ, Wei BG, Yang LS, Yu Y, Zhang L
J Cancer Res Clin Oncol 2015 Jul;141(7):1141-9. Epub 2014 Aug 13 doi: 10.1007/s00432-014-1791-3. PMID: 25115694
Arnold M, Moore SP, Hassler S, Ellison-Loschmann L, Forman D, Bray F
Gut 2014 Jan;63(1):64-71. Epub 2013 Oct 23 doi: 10.1136/gutjnl-2013-305033. PMID: 24153248

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