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Gastric cancer

MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
Synonyms: Malignant tumor of stomach; Stomach cancer
SNOMED CT: Cancer of stomach (363349007); Gastric cancer (363349007); CA - Cancer of stomach (363349007); Malignant tumor of stomach (363349007)
 
Genes (locations): APC (5q22.2); CASP10 (2q33.1); ERBB2 (17q12); FGFR2 (10q26.13); IL1B (2q14.1); IL1RN (2q14.1); IRF1 (5q31.1); KLF6 (10p15.2); KRAS (12p12.1); MUTYH (1p34.1); PIK3CA (3q26.32)
 
HPO: HP:0012126
Monarch Initiative: MONDO:0001056
OMIM®: 613659

Definition

In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), the Li-Fraumeni syndrome (151623), and diffuse gastric and lobular breast cancer syndrome (DGLBC; 137215). Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263). [from OMIM]

Clinical features

From HPO
Gastric cancer
MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), the Li-Fraumeni syndrome (151623), and diffuse gastric and lobular breast cancer syndrome (DGLBC; 137215). Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263).
Increased level of L-fucose in urine
MedGen UID:
1646743
Concept ID:
C4703633
Finding
An increase in the level of L-fucose in the urine.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Conditions with this feature

Gastric cancer
MedGen UID:
44264
Concept ID:
C0024623
Neoplastic Process
In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), the Li-Fraumeni syndrome (151623), and diffuse gastric and lobular breast cancer syndrome (DGLBC; 137215). Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263).
Hereditary diffuse gastric adenocarcinoma
MedGen UID:
310839
Concept ID:
C1708349
Neoplastic Process
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant susceptibility for diffuse gastric cancer, a poorly differentiated adenocarcinoma that infiltrates into the stomach wall causing thickening of the wall (linitis plastica) without forming a distinct mass. Diffuse gastric cancer is also referred to as signet ring carcinoma or isolated cell-type carcinoma. The average age of onset of HDGC is 38 years (range: 14-69 years). The majority of the cancers in individuals with a CDH1 pathogenic variant occur before age 40 years. The estimated cumulative risk of gastric cancer by age 80 years is 70% for men and 56% for women. Women are also at a 42% risk for lobular breast cancer.
Li-Fraumeni syndrome 2
MedGen UID:
322930
Concept ID:
C1836482
Disease or Syndrome
An autosomal dominant cancer predisposition syndrome caused by germline mutations of the CHEK2 gene. It is associated with breast carcinoma, gastric carcinoma, colorectal carcinoma, thyroid gland carcinoma, kidney carcinoma, prostate carcinoma, soft tissue sarcoma, and non-Hodgkin lymphoma.
Familial adenomatous polyposis 4
MedGen UID:
934686
Concept ID:
C4310719
Disease or Syndrome
Familial adenomatous polyposis-4 is an autosomal recessive tumor predisposition syndrome characterized by the development of multiple colonic adenomas in adulthood, often with progression to colorectal cancer. Proliferative lesions in other tissues may also occur (summary by Adam et al., 2016). For a discussion of genetic heterogeneity of familial adenomatous polyposis, see FAP1 (175100).

Recent clinical studies

Etiology

Kojima T, Yao K, Ohtsu K, Kuan C, Tanabe H, Imamura K, Kanemitsu T, Miyaoka M, Nagahama T, Ueki T, Iwashita A
Gastric Cancer 2022 Jul;25(4):761-769. Epub 2022 May 6 doi: 10.1007/s10120-022-01299-5. PMID: 35523984
Takahashi Y, Yamamichi N, Kubota D, Shimamoto T, Nagao S, Sakuma N, Sakaguchi Y, Yakabi S, Tsuji Y, Wada R, Mitsushima T, Ichinose M, Fujishiro M
Gastric Cancer 2022 May;25(3):481-489. Epub 2022 Jan 24 doi: 10.1007/s10120-021-01273-7. PMID: 35067826
Lim JH, Shin CM, Han K, Yoo J, Jin EH, Choi YJ, Lee DH
Gastric Cancer 2022 Jan;25(1):11-21. Epub 2021 Sep 1 doi: 10.1007/s10120-021-01241-1. PMID: 34468870
Chang R, Wei JC, Lin MC, Hung YM
Gastric Cancer 2021 Mar;24(2):292-301. Epub 2020 Nov 1 doi: 10.1007/s10120-020-01132-x. PMID: 33130973
Kuroki K, Oka S, Tanaka S, Yorita N, Hata K, Kotachi T, Boda T, Arihiro K, Chayama K
Gastric Cancer 2021 Jan;24(1):145-155. Epub 2020 Jun 22 doi: 10.1007/s10120-020-01100-5. PMID: 32572791

Diagnosis

Kojima T, Yao K, Ohtsu K, Kuan C, Tanabe H, Imamura K, Kanemitsu T, Miyaoka M, Nagahama T, Ueki T, Iwashita A
Gastric Cancer 2022 Jul;25(4):761-769. Epub 2022 May 6 doi: 10.1007/s10120-022-01299-5. PMID: 35523984
Takahashi Y, Yamamichi N, Kubota D, Shimamoto T, Nagao S, Sakuma N, Sakaguchi Y, Yakabi S, Tsuji Y, Wada R, Mitsushima T, Ichinose M, Fujishiro M
Gastric Cancer 2022 May;25(3):481-489. Epub 2022 Jan 24 doi: 10.1007/s10120-021-01273-7. PMID: 35067826
Ascherman B, Oh A, Hur C
Gastric Cancer 2021 Jul;24(4):878-887. Epub 2021 Feb 17 doi: 10.1007/s10120-021-01162-z. PMID: 33595744
Chang R, Wei JC, Lin MC, Hung YM
Gastric Cancer 2021 Mar;24(2):292-301. Epub 2020 Nov 1 doi: 10.1007/s10120-020-01132-x. PMID: 33130973
Kuroki K, Oka S, Tanaka S, Yorita N, Hata K, Kotachi T, Boda T, Arihiro K, Chayama K
Gastric Cancer 2021 Jan;24(1):145-155. Epub 2020 Jun 22 doi: 10.1007/s10120-020-01100-5. PMID: 32572791

Therapy

Misawa K, Kurokawa Y, Mizusawa J, Takiguchi S, Doki Y, Makino S, Choda Y, Takeno A, Tokunaga M, Sano T, Sasako M, Yoshikawa T, Terashima M; Stomach Cancer Study Group of the Japan Clinical Oncology Group.
Gastric Cancer 2022 Mar;25(2):459-467. Epub 2021 Nov 19 doi: 10.1007/s10120-021-01266-6. PMID: 34797440
Kim HD, Ryu MH, Park YS, Lee SY, Moon M, Kang YK
Gastric Cancer 2022 Jan;25(1):226-234. Epub 2021 Sep 1 doi: 10.1007/s10120-021-01233-1. PMID: 34468871
Kakeji Y, Yoshida K, Kodera Y, Kochi M, Sano T, Ichikawa W, Lee SW, Shibahara K, Shikano T, Kataoka M, Ishiguro A, Ojima H, Sakai Y, Musha N, Takase T, Kimura T, Takeuchi M, Fujii M
Gastric Cancer 2022 Jan;25(1):188-196. Epub 2021 Aug 5 doi: 10.1007/s10120-021-01224-2. PMID: 34351555
Chen Y, Katayose T, Nagaoka S, Piao Y, Yamaguchi K, Asou H
Gastric Cancer 2021 Nov;24(6):1320-1329. Epub 2021 May 28 doi: 10.1007/s10120-021-01199-0. PMID: 34050432Free PMC Article
Abe S, Takizawa K, Oda I, Mizusawa J, Kadota T, Ono H, Hasuike N, Yano T, Yamamoto Y, Horiuchi Y, Nagata S, Yoshikawa T, Terashima M, Muto M
Gastric Cancer 2021 Sep;24(5):1123-1130. Epub 2021 Mar 31 doi: 10.1007/s10120-021-01183-8. PMID: 33788066

Prognosis

Tian H, Wang F, Deng Y, Ying L, Fang W, Chen D, Miao C, Li H, Sun S, Ma Y, Cai H, Guo T
Gastric Cancer 2022 Sep;25(5):879-895. Epub 2022 Jun 17 doi: 10.1007/s10120-022-01311-y. PMID: 35715658
Shibamoto J, Arita T, Konishi H, Kataoka S, Furuke H, Takaki W, Takabatake K, Kiuchi J, Ohashi T, Shimizu H, Yamamoto Y, Komatsu S, Shiozaki A, Kubota T, Okamoto K, Otsuji E
Gastric Cancer 2022 Jul;25(4):712-725. Epub 2022 Apr 4 doi: 10.1007/s10120-022-01293-x. PMID: 35368210
Chang R, Wei JC, Lin MC, Hung YM
Gastric Cancer 2021 Mar;24(2):292-301. Epub 2020 Nov 1 doi: 10.1007/s10120-020-01132-x. PMID: 33130973
Kuroki K, Oka S, Tanaka S, Yorita N, Hata K, Kotachi T, Boda T, Arihiro K, Chayama K
Gastric Cancer 2021 Jan;24(1):145-155. Epub 2020 Jun 22 doi: 10.1007/s10120-020-01100-5. PMID: 32572791
Yang HJ, Kang D, Chang Y, Ahn J, Ryu S, Cho J, Guallar E, Sohn CI
Gastric Cancer 2020 May;23(3):382-390. Epub 2019 Dec 18 doi: 10.1007/s10120-019-01033-8. PMID: 31853749

Clinical prediction guides

Kojima T, Yao K, Ohtsu K, Kuan C, Tanabe H, Imamura K, Kanemitsu T, Miyaoka M, Nagahama T, Ueki T, Iwashita A
Gastric Cancer 2022 Jul;25(4):761-769. Epub 2022 May 6 doi: 10.1007/s10120-022-01299-5. PMID: 35523984
Takahashi Y, Yamamichi N, Kubota D, Shimamoto T, Nagao S, Sakuma N, Sakaguchi Y, Yakabi S, Tsuji Y, Wada R, Mitsushima T, Ichinose M, Fujishiro M
Gastric Cancer 2022 May;25(3):481-489. Epub 2022 Jan 24 doi: 10.1007/s10120-021-01273-7. PMID: 35067826
Chang R, Wei JC, Lin MC, Hung YM
Gastric Cancer 2021 Mar;24(2):292-301. Epub 2020 Nov 1 doi: 10.1007/s10120-020-01132-x. PMID: 33130973
Kuroki K, Oka S, Tanaka S, Yorita N, Hata K, Kotachi T, Boda T, Arihiro K, Chayama K
Gastric Cancer 2021 Jan;24(1):145-155. Epub 2020 Jun 22 doi: 10.1007/s10120-020-01100-5. PMID: 32572791
Nunobe S, Oda I, Ishikawa T, Akazawa K, Katai H, Isobe Y, Miyashiro I, Tsujitani S, Ono H, Tanabe S, Fukagawa T, Suzuki S, Kakeji Y; Registration Committee of the Japanese Gastric Cancer.
Gastric Cancer 2020 Mar;23(2):328-338. Epub 2019 Aug 26 doi: 10.1007/s10120-019-01000-3. PMID: 31451990

Recent systematic reviews

Rowsell A, Sodergren SC, Vassiliou V, Darlington AS, Guren MG, Alkhaffaf B, Moorbey C, Dennis K, Terada M
Gastric Cancer 2022 Jul;25(4):665-677. Epub 2022 Jun 11 doi: 10.1007/s10120-022-01309-6. PMID: 35689705Free PMC Article
Kamarajah SK, Bundred J, Tan BHL
Gastric Cancer 2019 Jan;22(1):10-22. Epub 2018 Oct 1 doi: 10.1007/s10120-018-0882-2. PMID: 30276574
Sugano K
Gastric Cancer 2019 May;22(3):435-445. Epub 2018 Sep 11 doi: 10.1007/s10120-018-0876-0. PMID: 30206731
Yue H, Shan L, Bin L
Gastric Cancer 2018 Jul;21(4):579-587. Epub 2018 Feb 19 doi: 10.1007/s10120-018-0812-3. PMID: 29460004
Shimada H, Fukagawa T, Haga Y, Oba K
Gastric Cancer 2016 Apr;19(2):339-349. Epub 2015 Dec 14 doi: 10.1007/s10120-015-0582-0. PMID: 26667370

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