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IL1RN interleukin 1 receptor antagonist [ Homo sapiens (human) ]

Gene ID: 3557, updated on 3-Jun-2018
Official Symbol
IL1RNprovided by HGNC
Official Full Name
interleukin 1 receptor antagonistprovided by HGNC
Primary source
HGNC:HGNC:6000
See related
Ensembl:ENSG00000136689 MIM:147679; Vega:OTTHUMG00000131341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
Expression
Biased expression in esophagus (RPKM 367.9), bone marrow (RPKM 53.9) and 2 other tissues See more
Orthologs
See IL1RN in Genome Data Viewer
Location:
2q14.1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (113099365..113134016)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113868693..113891593)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 1 family member 10 Neighboring gene RNA, U6 small nuclear 1180, pseudogene Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene uncharacterized LOC107985935

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
NHGRI GWA Catalog
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
NHGRI GWA Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of interleukin 1 receptor antagonist (IL1RN) in human B cells PubMed
Tat tat HIV-1 Tat upregulates the expression of IL-1 receptor antagonist through binding to and inhibiting CD26 PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL1-mediated signaling events, organism-specific biosystem
    IL1-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
  • Interleukin-10 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-10 signaling, organism-specific biosystemInterleukin-10 (IL10) was originally described as a factor named cytokine synthesis inhibitory factor that inhibited T-helper (Th) 1 activation and Th1 cytokine production (Fiorentino et al. 1989). ...
  • Leptin signaling pathway, organism-specific biosystem (from WikiPathways)
    Leptin signaling pathway, organism-specific biosystemLeptin is a peptide hormone mainly synthesised and secreted from adipocytes. It is also expressed in other tissues including placenta, stomach and skeletal muscle. Leptin mediates its effects by bind...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC10430

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 receptor antagonist activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1 receptor antagonist activity TAS
Traceable Author Statement
more info
PubMed 
interleukin-1 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 type I receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 type I receptor antagonist activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1 type II receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1 type II receptor antagonist activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1, type I receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1, type I receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-1, type II receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1, type II receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
carboxylic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to norepinephrine stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chronic inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fever generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin secretion IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of glutamate secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of heterotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to drug IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to glucocorticoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interleukin-4 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
interleukin-1 receptor antagonist protein
Names
IL1 inhibitor
intracellular IL-1 receptor antagonist type II
intracellular interleukin-1 receptor antagonist (icIL-1ra)
type II interleukin-1 receptor antagonist

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021240.1 RefSeqGene

    Range
    5001..21124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_188

mRNA and Protein(s)

  1. NM_000577.4NP_000568.1  interleukin-1 receptor antagonist protein isoform 3

    See identical proteins and their annotated locations for NP_000568.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an inframe coding segment, as compared to variant 2. The resulting isoform (3) lacks an internal region, as compared to the longest isoform (2).
    Source sequence(s)
    AC024704, AF043143, BC009745, M55646
    Consensus CDS
    CCDS2113.1
    UniProtKB/Swiss-Prot
    P18510
    Related
    ENSP00000329072.3, OTTHUMP00000162023, ENST00000354115.6, OTTHUMT00000254117
    Conserved Domains (1) summary
    smart00125
    Location:16156
    IL1; Interleukin-1 homologues
  2. NM_001318914.1NP_001305843.1  interleukin-1 receptor antagonist protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains two alternate internal exons compared to variant 2. This results in translation from a downstream start codon, and an isoform (4) that has a shorter N-terminus, as compared to the longest isoform (2). Variants 4 and 5 both encode the same isoform (4).
    Source sequence(s)
    AC024704, AF043143, BC009745, DA667440
    Consensus CDS
    CCDS2115.1
    UniProtKB/Swiss-Prot
    P18510
    UniProtKB/TrEMBL
    A0A024R528
    Conserved Domains (1) summary
    smart00125
    Location:1140
    IL1; Interleukin-1 homologues
  3. NM_173841.2NP_776213.1  interleukin-1 receptor antagonist protein isoform 2

    See identical proteins and their annotated locations for NP_776213.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AC024704, AF043143, AK290898, BC009745
    Consensus CDS
    CCDS2114.1
    UniProtKB/Swiss-Prot
    P18510
    Related
    ENSP00000259206.5, OTTHUMP00000162022, ENST00000259206.9, OTTHUMT00000254116
    Conserved Domains (1) summary
    smart00125
    Location:37177
    IL1; Interleukin-1 homologues
  4. NM_173842.2NP_776214.1  interleukin-1 receptor antagonist protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_776214.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' end compared to variant 2, resulting in an isoform (1) that has a distinct and shorter N-terminus, as compared to the longest isoform (2).
    Source sequence(s)
    AC024704, BC009745, BI766516
    Consensus CDS
    CCDS46396.1
    UniProtKB/Swiss-Prot
    P18510
    Related
    ENSP00000387173.3, OTTHUMP00000203731, ENST00000409930.3, OTTHUMT00000330802
    Conserved Domains (1) summary
    smart00125
    Location:34174
    IL1; Interleukin-1 homologues
  5. NM_173843.2NP_776215.1  interleukin-1 receptor antagonist protein isoform 4

    See identical proteins and their annotated locations for NP_776215.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a distinct internal exon compared to variant 2. This results in translation from a downstream start codon, and an isoform (4) that has a shorter N-terminus, as compared to the longest isoform (2). Variants 4 and 5 both encode the same isoform (4).
    Source sequence(s)
    AC024704, AF043143, BC009745
    Consensus CDS
    CCDS2115.1
    UniProtKB/Swiss-Prot
    P18510
    UniProtKB/TrEMBL
    A0A024R528
    Related
    ENSP00000354816.3, OTTHUMP00000162024, ENST00000361779.7, OTTHUMT00000254118
    Conserved Domains (1) summary
    smart00125
    Location:1140
    IL1; Interleukin-1 homologues

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    113099365..113134016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511121.1XP_011509423.1  interleukin-1 receptor antagonist protein isoform X1

    See identical proteins and their annotated locations for XP_011509423.1

    UniProtKB/Swiss-Prot
    P18510
    UniProtKB/TrEMBL
    A0A024R528
    Related
    ENSP00000387210.1, OTTHUMP00000203730, ENST00000409052.5, OTTHUMT00000330801
    Conserved Domains (1) summary
    smart00125
    Location:1140
    IL1; Interleukin-1 homologues
  2. XM_005263661.4XP_005263718.1  interleukin-1 receptor antagonist protein isoform X1

    See identical proteins and their annotated locations for XP_005263718.1

    UniProtKB/Swiss-Prot
    P18510
    UniProtKB/TrEMBL
    A0A024R528
    Conserved Domains (1) summary
    smart00125
    Location:1140
    IL1; Interleukin-1 homologues
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