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APC APC regulator of WNT signaling pathway [ Homo sapiens (human) ]

Gene ID: 324, updated on 5-Jul-2020

Summary

Official Symbol
APCprovided by HGNC
Official Full Name
APC regulator of WNT signaling pathwayprovided by HGNC
Primary source
HGNC:HGNC:583
See related
Ensembl:ENSG00000134982 MIM:611731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GS; DP2; DP3; BTPS2; DESMD; DP2.5; PPP1R46
Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019]
Annotation information
Note: PROC (Gene ID: 5624) and APC (Gene ID: 324) loci share the APC symbol/alias in common. [08 Feb 2019]
Expression
Ubiquitous expression in brain (RPKM 25.7), colon (RPKM 4.5) and 23 other tissues See more
Orthologs

Genomic context

See APC in Genome Data Viewer
Location:
5q22.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (112707498..112846239)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112043202..112181936)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2200 Neighboring gene uncharacterized LOC102467216 Neighboring gene RNA, U6 small nuclear 482, pseudogene Neighboring gene chromobox 3 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 9882 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5 Neighboring gene X-box binding protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in APC that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Colorectal cancer
MedGen: C1527249 OMIM: 114500 GeneReviews: Lynch Syndrome
Compare labs
Desmoid disease, hereditary
MedGen: C1851124 OMIM: 135290 GeneReviews: Not available
Compare labs
Familial adenomatous polyposis
MedGen: CN240755 GeneReviews: Not available
Compare labs
Familial adenomatous polyposis 1 Compare labs
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs
Neoplasm of stomach
MedGen: C0038356 OMIM: 613659 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2012-07-06)

ClinGen Genome Curation PagePubMed

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SRP19

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT cadherin binding IDA
Inferred from Direct Assay
more info
PubMed 
dynein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
gamma-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
beta-catenin destruction complex assembly TAS
Traceable Author Statement
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
bicellular tight junction assembly NAS
Non-traceable Author Statement
more info
PubMed 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process IC
Inferred by Curator
more info
PubMed 
positive regulation of protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pseudopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of attachment of spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Wnt signalosome NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenomatous polyposis coli protein
Names
APC, WNT signaling pathway regulator
WNT signaling pathway regulator
adenomatosis polyposis coli tumor suppressor
adenomatous polyposis coli (APC)
deleted in polyposis 2.5
epididymis secretory sperm binding protein
protein phosphatase 1, regulatory subunit 46
truncated adenomatosis polyposis coli

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008481.4 RefSeqGene

    Range
    19985..158719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_130

mRNA and Protein(s)

  1. NM_000038.6NP_000029.2  adenomatous polyposis coli protein isoform b

    See identical proteins and their annotated locations for NP_000029.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AB210001, CA313732, DA795663, M73548
    Consensus CDS
    CCDS4107.1
    UniProtKB/Swiss-Prot
    P25054
    UniProtKB/TrEMBL
    Q4LE70
    Related
    ENSP00000257430.4, ENST00000257430.9
    Conserved Domains (17) summary
    smart00185
    Location:649689
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:465508
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16371660
    APC_r; APC repeat
    pfam05924
    Location:20332052
    SAMP; SAMP Motif
    pfam05937
    Location:26702843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22232568
    APC_basic; APC basic domain
    pfam11414
    Location:127207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7321018
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10361135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12831368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16621715
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17461839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18731947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:533734
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    cl25732
    Location:4272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:12911701
    DUF4045; Domain of unknown function (DUF4045)
  2. NM_001127510.3NP_001120982.1  adenomatous polyposis coli protein isoform b

    See identical proteins and their annotated locations for NP_001120982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also contains an alternate in-frame exon compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AB210001, CA313732, DA795663
    Consensus CDS
    CCDS4107.1
    UniProtKB/Swiss-Prot
    P25054
    UniProtKB/TrEMBL
    Q4LE70
    Related
    ENSP00000427089.2, ENST00000508376.6
    Conserved Domains (17) summary
    smart00185
    Location:649689
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:465508
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16371660
    APC_r; APC repeat
    pfam05924
    Location:20332052
    SAMP; SAMP Motif
    pfam05937
    Location:26702843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22232568
    APC_basic; APC basic domain
    pfam11414
    Location:127207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7321018
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10361135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12831368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16621715
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17461839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18731947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:533734
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    cl25732
    Location:4272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:12911701
    DUF4045; Domain of unknown function (DUF4045)
  3. NM_001127511.3NP_001120983.2  adenomatous polyposis coli protein isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (a).
    Source sequence(s)
    AB210001, AC136500, AK294544, BP230350, CA313732
    UniProtKB/Swiss-Prot
    P25054
    UniProtKB/TrEMBL
    Q4LE70
    Conserved Domains (13) summary
    cd00020
    Location:593713
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:16191643
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20162035
    SAMP; SAMP Motif
    pfam05937
    Location:26522825
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22052550
    APC_basic; APC basic domain
    pfam11414
    Location:137217
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:7141001
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10181117
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12651350
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16441700
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17211821
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18581929
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:447490
    ARM; armadillo repeat [structural motif]
  4. NM_001354895.2NP_001341824.1  adenomatous polyposis coli protein isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
    Source sequence(s)
    AC008575, AC136500
    Consensus CDS
    CCDS4107.1
    Conserved Domains (17) summary
    smart00185
    Location:649689
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:465508
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16371660
    APC_r; APC repeat
    pfam05924
    Location:20332052
    SAMP; SAMP Motif
    pfam05937
    Location:26702843
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22232568
    APC_basic; APC basic domain
    pfam11414
    Location:127207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7321018
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10361135
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12831368
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16621715
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17461839
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18731947
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:533734
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    cl25732
    Location:4272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:12911701
    DUF4045; Domain of unknown function (DUF4045)
  5. NM_001354896.2NP_001341825.1  adenomatous polyposis coli protein isoform c

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (17) summary
    smart00185
    Location:667707
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:709749
    Arm; Armadillo/beta-catenin-like repeat
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:581613
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16551678
    APC_r; APC repeat
    pfam05924
    Location:20512070
    SAMP; SAMP Motif
    pfam05937
    Location:26882861
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22412586
    APC_basic; APC basic domain
    pfam11414
    Location:127207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7501036
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10541153
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:13011386
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16801733
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17641857
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18911965
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25732
    Location:4272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:13091719
    DUF4045; Domain of unknown function (DUF4045)
  6. NM_001354897.2NP_001341826.1  adenomatous polyposis coli protein isoform d

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (15) summary
    smart00185
    Location:659699
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:701741
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:475518
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16471670
    APC_r; APC repeat
    pfam05924
    Location:20432062
    SAMP; SAMP Motif
    pfam05937
    Location:26802853
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22332578
    APC_basic; APC basic domain
    pfam11414
    Location:137217
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7421028
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10461145
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12931378
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16721725
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17561849
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18831957
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:13011711
    DUF4045; Domain of unknown function (DUF4045)
  7. NM_001354898.2NP_001341827.1  adenomatous polyposis coli protein isoform e

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (15) summary
    smart00185
    Location:624664
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:666706
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:440483
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16121635
    APC_r; APC repeat
    pfam05924
    Location:20082027
    SAMP; SAMP Motif
    pfam05937
    Location:26452818
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21982543
    APC_basic; APC basic domain
    pfam11414
    Location:102182
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:707993
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10111110
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12581343
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16371690
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17211814
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18481922
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:12661676
    DUF4045; Domain of unknown function (DUF4045)
  8. NM_001354899.2NP_001341828.1  adenomatous polyposis coli protein isoform f

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (16) summary
    smart00185
    Location:621661
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:663703
    Arm; Armadillo/beta-catenin-like repeat
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:437480
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16091632
    APC_r; APC repeat
    pfam05924
    Location:20052024
    SAMP; SAMP Motif
    pfam05937
    Location:26422815
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21952540
    APC_basic; APC basic domain
    pfam11414
    Location:127207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:704990
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10081107
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12551340
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16341687
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17181811
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18451919
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:12631673
    DUF4045; Domain of unknown function (DUF4045)
  9. NM_001354900.2NP_001341829.1  adenomatous polyposis coli protein isoform g

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (15) summary
    smart00185
    Location:608648
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:650690
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:522554
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:15961619
    APC_r; APC repeat
    pfam05924
    Location:19922011
    SAMP; SAMP Motif
    pfam05937
    Location:26292802
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21822527
    APC_basic; APC basic domain
    pfam11414
    Location:68148
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:691977
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9951094
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12421327
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16211674
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17051798
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18321906
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:12501660
    DUF4045; Domain of unknown function (DUF4045)
  10. NM_001354901.2NP_001341830.1  adenomatous polyposis coli protein isoform h

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (15) summary
    smart00185
    Location:590630
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:632672
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:406449
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:15781601
    APC_r; APC repeat
    pfam05924
    Location:19741993
    SAMP; SAMP Motif
    pfam05937
    Location:26112784
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21642509
    APC_basic; APC basic domain
    pfam11414
    Location:68148
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:673959
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9771076
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12241309
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16031656
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16871780
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18141888
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:12321642
    DUF4045; Domain of unknown function (DUF4045)
  11. NM_001354902.2NP_001341831.1  adenomatous polyposis coli protein isoform i

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (15) summary
    smart00185
    Location:558598
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:600640
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:374417
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:15461569
    APC_r; APC repeat
    pfam05924
    Location:19421961
    SAMP; SAMP Motif
    pfam05937
    Location:25792752
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21322477
    APC_basic; APC basic domain
    pfam11414
    Location:137217
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:641927
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9451044
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11921277
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15711624
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16551748
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17821856
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:12001610
    DUF4045; Domain of unknown function (DUF4045)
  12. NM_001354903.2NP_001341832.1  adenomatous polyposis coli protein isoform j

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (17) summary
    smart00185
    Location:548588
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:590630
    Arm; Armadillo/beta-catenin-like repeat
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:364407
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:15361559
    APC_r; APC repeat
    pfam05924
    Location:19321951
    SAMP; SAMP Motif
    pfam05937
    Location:25692742
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21222467
    APC_basic; APC basic domain
    pfam11414
    Location:127207
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:631917
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9351034
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11821267
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15611614
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16451738
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17721846
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25732
    Location:4272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl25751
    Location:11901600
    DUF4045; Domain of unknown function (DUF4045)
  13. NM_001354904.2NP_001341833.1  adenomatous polyposis coli protein isoform k

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (15) summary
    smart00185
    Location:523563
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:565605
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:339382
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:15111534
    APC_r; APC repeat
    pfam05924
    Location:19071926
    SAMP; SAMP Motif
    pfam05937
    Location:25442717
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:20972442
    APC_basic; APC basic domain
    pfam11414
    Location:102182
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:606892
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9101009
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11571242
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15361589
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16201713
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17471821
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:11651575
    DUF4045; Domain of unknown function (DUF4045)
  14. NM_001354905.2NP_001341834.1  adenomatous polyposis coli protein isoform l

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (15) summary
    smart00185
    Location:489529
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:531571
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:305348
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:14771500
    APC_r; APC repeat
    pfam05924
    Location:18731892
    SAMP; SAMP Motif
    pfam05937
    Location:25102683
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:20632408
    APC_basic; APC basic domain
    pfam11414
    Location:68148
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:572858
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:876975
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11231208
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15021555
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:15861679
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17131787
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:11311541
    DUF4045; Domain of unknown function (DUF4045)
  15. NM_001354906.2NP_001341835.1  adenomatous polyposis coli protein isoform m

    Status: REVIEWED

    Source sequence(s)
    AC008575, AC136500
    Conserved Domains (14) summary
    smart00185
    Location:366406
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:408448
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:182225
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:13541377
    APC_r; APC repeat
    pfam05924
    Location:17501769
    SAMP; SAMP Motif
    pfam05937
    Location:23872560
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:19402285
    APC_basic; APC basic domain
    pfam16629
    Location:449735
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:753852
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:10001085
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:13791432
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:14631556
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:15901664
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl25751
    Location:10081418
    DUF4045; Domain of unknown function (DUF4045)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    112707498..112846239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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