Format

Send to:

Choose Destination

Apc APC, WNT signaling pathway regulator [ Mus musculus (house mouse) ]

Gene ID: 11789, updated on 21-May-2019

Summary

Official Symbol
Apcprovided by MGI
Official Full Name
APC, WNT signaling pathway regulatorprovided by MGI
Primary source
MGI:MGI:88039
See related
Ensembl:ENSMUSG00000005871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CC1; Min; mAPC; AI047805; AU020952; AW124434
Expression
Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues See more
Orthologs

Genomic context

See Apc in Genome Data Viewer
Location:
18 B1; 18 18.53 cM
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (34220617..34322190)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (34380638..34481844)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene chr18_319.1 Neighboring gene predicted gene, 41687 Neighboring gene predicted gene, 41686 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
dynein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
gamma-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
chromosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic microtubule organization IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metaphase/anaphase transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of molecular function TAS
Traceable Author Statement
more info
PubMed 
negative regulation of odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
regulation of nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Scrib-APC-beta-catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
catenin complex ISO
Inferred from Sequence Orthology
more info
 
cell body fiber ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cell projection membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
 
kinetochore ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenomatous polyposis coli protein
Names
adenomatosis polyposis coli
multiple intestinal neoplasia

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360979.1NP_001347908.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC090534, AC114003, AL591373
    Conserved Domains (14) summary
    smart00185
    Location:588628
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:404447
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:15761599
    APC_r; APC repeat
    pfam05924
    Location:19731992
    SAMP; SAMP Motif
    pfam05937
    Location:26112783
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21642509
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:671957
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9751074
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12221308
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16011654
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16851778
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18121886
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:472673
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
  2. NM_001360980.1NP_001347909.1  adenomatous polyposis coli protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC090534, AC114003, AL591373
    Conserved Domains (15) summary
    smart00185
    Location:665705
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:579611
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16531676
    APC_r; APC repeat
    pfam05924
    Location:20502069
    SAMP; SAMP Motif
    pfam05937
    Location:26882860
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22412586
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7481034
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10521151
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12991385
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16781731
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17621855
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18891963
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:549750
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
  3. NM_007462.3NP_031488.2  adenomatous polyposis coli protein isoform 3

    See identical proteins and their annotated locations for NP_031488.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC090534, AK080907, AL591373, BE623286
    Consensus CDS
    CCDS29125.1
    UniProtKB/TrEMBL
    B2RUG9, Q8BNP7
    Related
    ENSMUSP00000078337.5, ENSMUST00000079362.12
    Conserved Domains (14) summary
    cd00020
    Location:609729
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:16351659
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20332052
    SAMP; SAMP Motif
    pfam05937
    Location:26702842
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22232568
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:7301017
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10341133
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12811367
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16601716
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17371837
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18741945
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    sd00043
    Location:463506
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    34220617..34322190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525529.3XP_006525592.1  adenomatous polyposis coli protein isoform X1

    Conserved Domains (13) summary
    cd00020
    Location:637757
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:16631687
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20612080
    SAMP; SAMP Motif
    pfam05937
    Location:26982870
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22512596
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:7581045
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10621161
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:13091395
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16881744
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17651865
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:19021973
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:589621
    ARM; armadillo repeat [structural motif]
  2. XM_006525534.3XP_006525597.1  adenomatous polyposis coli protein isoform X5

    Conserved Domains (13) summary
    cd00020
    Location:602722
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:16281652
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20262045
    SAMP; SAMP Motif
    pfam05937
    Location:26632835
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22162561
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:7231010
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10271126
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12741360
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16531709
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17301830
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18671938
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:554586
    ARM; armadillo repeat [structural motif]
  3. XM_006525532.3XP_006525595.1  adenomatous polyposis coli protein isoform X3

    See identical proteins and their annotated locations for XP_006525595.1

    Conserved Domains (13) summary
    cd00020
    Location:619739
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:16451669
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20432062
    SAMP; SAMP Motif
    pfam05937
    Location:26802852
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22332578
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:7401027
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10441143
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12911377
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16701726
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17471847
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18841955
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:473516
    ARM; armadillo repeat [structural motif]
  4. XM_006525538.3XP_006525601.1  adenomatous polyposis coli protein isoform X8

    Conserved Domains (13) summary
    cd00020
    Location:536656
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:15621586
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:19601979
    SAMP; SAMP Motif
    pfam05937
    Location:25972769
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21502495
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:657944
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9611060
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12081294
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15871643
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16641764
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18011872
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:488520
    ARM; armadillo repeat [structural motif]
  5. XM_006525530.1XP_006525593.1  adenomatous polyposis coli protein isoform X2

    See identical proteins and their annotated locations for XP_006525593.1

    Conserved Domains (15) summary
    smart00185
    Location:665705
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:579611
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16531676
    APC_r; APC repeat
    pfam05924
    Location:20502069
    SAMP; SAMP Motif
    pfam05937
    Location:26882860
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22412586
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7481034
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10521151
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12991385
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16781731
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17621855
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18891963
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:549750
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
  6. XM_006525539.2XP_006525602.1  adenomatous polyposis coli protein isoform X9

    Conserved Domains (14) summary
    cd00020
    Location:508628
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:15341558
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:19321951
    SAMP; SAMP Motif
    pfam05937
    Location:25692741
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21222467
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:629916
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9331032
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11801266
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15591615
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16361736
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17731844
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    sd00043
    Location:362405
    ARM; armadillo repeat [structural motif]
  7. XM_006525533.2XP_006525596.1  adenomatous polyposis coli protein isoform X4

    Conserved Domains (13) summary
    cd00020
    Location:607727
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:16331657
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:20312050
    SAMP; SAMP Motif
    pfam05937
    Location:26682840
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22212566
    APC_basic; APC basic domain
    pfam11414
    Location:105185
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:7281015
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10321131
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12791365
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16581714
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17351835
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18721943
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:559591
    ARM; armadillo repeat [structural motif]
  8. XM_006525536.3XP_006525599.1  adenomatous polyposis coli protein isoform X6

    See identical proteins and their annotated locations for XP_006525599.1

    Conserved Domains (13) summary
    cd00020
    Location:568688
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:15941618
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:19922011
    SAMP; SAMP Motif
    pfam05937
    Location:26292801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21822527
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:689976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9931092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12401326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16191675
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16961796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18331904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:520552
    ARM; armadillo repeat [structural motif]
  9. XM_017317804.1XP_017173293.1  adenomatous polyposis coli protein isoform X7

    Conserved Domains (14) summary
    smart00185
    Location:588628
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:404447
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:15761599
    APC_r; APC repeat
    pfam05924
    Location:19731992
    SAMP; SAMP Motif
    pfam05937
    Location:26112783
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21642509
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:671957
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9751074
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12221308
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16011654
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16851778
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18121886
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:472673
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
  10. XM_006525531.1XP_006525594.1  adenomatous polyposis coli protein isoform X2

    Conserved Domains (15) summary
    smart00185
    Location:665705
    ARM; Armadillo/beta-catenin-like repeats
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerisation domain
    sd00043
    Location:579611
    ARM; armadillo repeat [structural motif]
    pfam05923
    Location:16531676
    APC_r; APC repeat
    pfam05924
    Location:20502069
    SAMP; SAMP Motif
    pfam05937
    Location:26882860
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22412586
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7481034
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10521151
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12991385
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16781731
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17621855
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18891963
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    cl21727
    Location:549750
    VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
  11. XM_006525535.1XP_006525598.1  adenomatous polyposis coli protein isoform X6

    See identical proteins and their annotated locations for XP_006525598.1

    Conserved Domains (13) summary
    cd00020
    Location:568688
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05923
    Location:15941618
    APC_crr; APC cysteine-rich region
    pfam05924
    Location:19922011
    SAMP; SAMP Motif
    pfam05937
    Location:26292801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21822527
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
    pfam16629
    Location:689976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9931092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12401326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16191675
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16961796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18331904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    sd00043
    Location:520552
    ARM; armadillo repeat [structural motif]
Support Center