U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Apc APC, WNT signaling pathway regulator [ Mus musculus (house mouse) ]

Gene ID: 11789, updated on 20-Feb-2024

Summary

Official Symbol
Apcprovided by MGI
Official Full Name
APC, WNT signaling pathway regulatorprovided by MGI
Primary source
MGI:MGI:88039
See related
Ensembl:ENSMUSG00000005871 AllianceGenome:MGI:88039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CC1; Min; mAPC
Summary
Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Apc in Genome Data Viewer
Location:
18 B1; 18 18.53 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34353350..34455243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34220297..34322190)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41686 Neighboring gene predicted gene, 23411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34380446-34380555 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44199 Neighboring gene predicted gene, 54017 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (27)  1 citation
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables gamma-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of acinar cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of acinar cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytoplasmic microtubule organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of acinar cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of acinar cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of Scrib-APC-beta-catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
part_of beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catenin complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell body fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenomatous polyposis coli protein
Names
adenomatosis polyposis coli
multiple intestinal neoplasia

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360979.1NP_001347908.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:588628
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:404447
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:630668
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15761599
    APC_r; APC repeat
    pfam05924
    Location:19731992
    SAMP; SAMP Motif
    pfam05937
    Location:26112783
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21642509
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:671958
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9751074
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12221308
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16011654
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16851778
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18121886
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332405
    APC_rep; Adenomatous polyposis coli (APC) repeat
  2. NM_001360980.1NP_001347909.1  adenomatous polyposis coli protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (16) summary
    smart00185
    Location:665705
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:579611
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:707745
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:16531676
    APC_r; APC repeat
    pfam05924
    Location:20502069
    SAMP; SAMP Motif
    pfam05937
    Location:26882860
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22412586
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7481035
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10521151
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12991385
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16781731
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17621855
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18891963
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam18797
    Location:391464
    APC_rep; Adenomatous polyposis coli (APC) repeat
  3. NM_001402727.1NP_001389656.1  adenomatous polyposis coli protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  4. NM_001402728.1NP_001389657.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  5. NM_001402729.1NP_001389658.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  6. NM_001402730.1NP_001389659.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  7. NM_001402731.1NP_001389660.1  adenomatous polyposis coli protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
    UniProtKB/TrEMBL
    B2RUG9
  8. NM_001402732.1NP_001389661.1  adenomatous polyposis coli protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/TrEMBL
    E9QLQ9
  9. NM_001402733.1NP_001389662.1  adenomatous polyposis coli protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  10. NM_001402734.1NP_001389663.1  adenomatous polyposis coli protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  11. NM_001402735.1NP_001389664.1  adenomatous polyposis coli protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  12. NM_001402736.1NP_001389665.1  adenomatous polyposis coli protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/TrEMBL
    E9QLQ9
  13. NM_001402737.1NP_001389666.1  adenomatous polyposis coli protein isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  14. NM_001402738.1NP_001389667.1  adenomatous polyposis coli protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/TrEMBL
    E9QLQ9
  15. NM_001402739.1NP_001389668.1  adenomatous polyposis coli protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/TrEMBL
    E9QLQ9
    Related
    ENSMUSP00000111447.4, ENSMUST00000115781.10
  16. NM_001402740.1NP_001389669.1  adenomatous polyposis coli protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
  17. NM_007462.4NP_031488.2  adenomatous polyposis coli protein isoform 3

    See identical proteins and their annotated locations for NP_031488.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC090534, AC114003, AL591373
    Consensus CDS
    CCDS29125.1
    UniProtKB/Swiss-Prot
    Q61315, Q62044
    UniProtKB/TrEMBL
    B2RUG9
    Related
    ENSMUSP00000078337.6, ENSMUST00000079362.13
    Conserved Domains (16) summary
    smart00185
    Location:647687
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:463506
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:689727
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:16351658
    APC_r; APC repeat
    pfam05924
    Location:20322051
    SAMP; SAMP Motif
    pfam05937
    Location:26702842
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22232568
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7301017
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10341133
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12811367
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16601713
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17441837
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18711945
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam18797
    Location:391464
    APC_rep; Adenomatous polyposis coli (APC) repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34353350..34455243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525529.4XP_006525592.1  adenomatous polyposis coli protein isoform X1

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:675715
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:589621
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:717755
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:16631686
    APC_r; APC repeat
    pfam05924
    Location:20602079
    SAMP; SAMP Motif
    pfam05937
    Location:26982870
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22512596
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7581045
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10621161
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:13091395
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16881741
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17721865
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18991973
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:401474
    APC_rep; Adenomatous polyposis coli (APC) repeat
  2. XM_006525538.4XP_006525601.1  adenomatous polyposis coli protein isoform X15

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:574614
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:488520
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:616654
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15621585
    APC_r; APC repeat
    pfam05924
    Location:19591978
    SAMP; SAMP Motif
    pfam05937
    Location:25972769
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21502495
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:657944
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9611060
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12081294
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15871640
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16711764
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17981872
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:315373
    APC_rep; Adenomatous polyposis coli (APC) repeat
  3. XM_006525534.4XP_006525597.1  adenomatous polyposis coli protein isoform X6

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:640680
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:554586
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:682720
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:16281651
    APC_r; APC repeat
    pfam05924
    Location:20252044
    SAMP; SAMP Motif
    pfam05937
    Location:26632835
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22162561
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7231010
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10271126
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12741360
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16531706
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17371830
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18641938
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:366439
    APC_rep; Adenomatous polyposis coli (APC) repeat
  4. XM_036160948.1XP_036016841.1  adenomatous polyposis coli protein isoform X21

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:539579
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:453485
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:581621
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15271550
    APC_r; APC repeat
    pfam05924
    Location:19241943
    SAMP; SAMP Motif
    pfam05937
    Location:25622734
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21152460
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:622909
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9261025
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11731259
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15521605
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16361729
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17631837
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:280338
    APC_rep; Adenomatous polyposis coli (APC) repeat
  5. XM_036160950.1XP_036016843.1  adenomatous polyposis coli protein isoform X24

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:521561
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:337380
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:563603
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15091532
    APC_r; APC repeat
    pfam05924
    Location:19061925
    SAMP; SAMP Motif
    pfam05937
    Location:25442716
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:20972442
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:604891
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9081007
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11551241
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15341587
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16181711
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17451819
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:280338
    APC_rep; Adenomatous polyposis coli (APC) repeat
  6. XM_030250280.1XP_030106140.1  adenomatous polyposis coli protein isoform X9

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:622662
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:438481
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:664702
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:16101633
    APC_r; APC repeat
    pfam05924
    Location:20072026
    SAMP; SAMP Motif
    pfam05937
    Location:26452817
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21982543
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:705992
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10091108
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12561342
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16351688
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17191812
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18461920
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:366439
    APC_rep; Adenomatous polyposis coli (APC) repeat
  7. XM_036160951.1XP_036016844.1  adenomatous polyposis coli protein isoform X25

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (16) summary
    smart00185
    Location:511551
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:327370
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:553593
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:14991522
    APC_r; APC repeat
    pfam05924
    Location:18961915
    SAMP; SAMP Motif
    pfam05937
    Location:25342706
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:20872432
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:594881
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:898997
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11451231
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15241577
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16081701
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17351809
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:270328
    APC_rep; Adenomatous polyposis coli (APC) repeat
  8. XM_006525539.4XP_006525602.1  adenomatous polyposis coli protein isoform X20

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (16) summary
    smart00185
    Location:546586
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:362405
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:588628
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15341557
    APC_r; APC repeat
    pfam05924
    Location:19311950
    SAMP; SAMP Motif
    pfam05937
    Location:25692741
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21222467
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:629916
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9331032
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11801266
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15591612
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16431736
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17701844
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:305363
    APC_rep; Adenomatous polyposis coli (APC) repeat
  9. XM_030250281.2XP_030106141.1  adenomatous polyposis coli protein isoform X10

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (16) summary
    smart00185
    Location:612652
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:428471
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:654694
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:16001623
    APC_r; APC repeat
    pfam05924
    Location:19972016
    SAMP; SAMP Motif
    pfam05937
    Location:26352807
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21882533
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:695982
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9991098
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12461332
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16251678
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17091802
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18361910
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:356429
    APC_rep; Adenomatous polyposis coli (APC) repeat
  10. XM_030250288.1XP_030106148.1  adenomatous polyposis coli protein isoform X16

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:571611
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:485517
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:613651
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15591582
    APC_r; APC repeat
    pfam05924
    Location:19561975
    SAMP; SAMP Motif
    pfam05937
    Location:25942766
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21472492
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:654941
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9581057
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12051291
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15841637
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16681761
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17951869
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:297370
    APC_rep; Adenomatous polyposis coli (APC) repeat
  11. XM_030250283.1XP_030106143.1  adenomatous polyposis coli protein isoform X12

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:606646
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:520552
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:648688
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15941617
    APC_r; APC repeat
    pfam05924
    Location:19912010
    SAMP; SAMP Motif
    pfam05937
    Location:26292801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21822527
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:689976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9931092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12401326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16191672
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17031796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18301904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332405
    APC_rep; Adenomatous polyposis coli (APC) repeat
  12. XM_036160952.1XP_036016845.1  adenomatous polyposis coli protein isoform X26

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:487527
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:303346
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:529569
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:14751498
    APC_r; APC repeat
    pfam05924
    Location:18721891
    SAMP; SAMP Motif
    pfam05937
    Location:25102682
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:20632408
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:570857
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:874973
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11211207
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15001553
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:15841677
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17111785
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:246304
    APC_rep; Adenomatous polyposis coli (APC) repeat
  13. XM_030250278.2XP_030106138.1  adenomatous polyposis coli protein isoform X7

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (16) summary
    smart00185
    Location:630670
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:544576
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:672712
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:16181641
    APC_r; APC repeat
    pfam05924
    Location:20152034
    SAMP; SAMP Motif
    pfam05937
    Location:26532825
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22062551
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7131000
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10171116
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12641350
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16431696
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17271820
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18541928
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:356429
    APC_rep; Adenomatous polyposis coli (APC) repeat
  14. XM_030250291.1XP_030106151.1  adenomatous polyposis coli protein isoform X18

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:556596
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:372415
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:598636
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15441567
    APC_r; APC repeat
    pfam05924
    Location:19411960
    SAMP; SAMP Motif
    pfam05937
    Location:25792751
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21322477
    APC_basic; APC basic domain
    pfam11414
    Location:135215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:639926
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9431042
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11901276
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15691622
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16531746
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17801854
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:315373
    APC_rep; Adenomatous polyposis coli (APC) repeat
  15. XM_036160946.1XP_036016839.1  adenomatous polyposis coli protein isoform X12

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:606646
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:520552
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:648688
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15941617
    APC_r; APC repeat
    pfam05924
    Location:19912010
    SAMP; SAMP Motif
    pfam05937
    Location:26292801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21822527
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:689976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9931092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12401326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16191672
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17031796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18301904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332405
    APC_rep; Adenomatous polyposis coli (APC) repeat
  16. XM_030250293.2XP_030106153.1  adenomatous polyposis coli protein isoform X22

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (17) summary
    smart00185
    Location:529569
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:443475
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:571609
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15171540
    APC_r; APC repeat
    pfam05924
    Location:19141933
    SAMP; SAMP Motif
    pfam05937
    Location:25522724
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21052450
    APC_basic; APC basic domain
    pfam11414
    Location:125205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:612899
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9161015
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11631249
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15421595
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16261719
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17531827
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:455
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam18797
    Location:270328
    APC_rep; Adenomatous polyposis coli (APC) repeat
    cl00755
    Location:172296
    zf-dskA_traR; Prokaryotic dksA/traR C4-type zinc finger
  17. XM_030250282.2XP_030106142.1  adenomatous polyposis coli protein isoform X11

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:610650
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:524556
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:652690
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15981621
    APC_r; APC repeat
    pfam05924
    Location:19952014
    SAMP; SAMP Motif
    pfam05937
    Location:26332805
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21862531
    APC_basic; APC basic domain
    pfam11414
    Location:105185
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:693980
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9971096
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12441330
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16231676
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17071800
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18341908
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:336409
    APC_rep; Adenomatous polyposis coli (APC) repeat
  18. XM_006525533.4XP_006525596.1  adenomatous polyposis coli protein isoform X5

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:645685
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:559591
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:687725
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:16331656
    APC_r; APC repeat
    pfam05924
    Location:20302049
    SAMP; SAMP Motif
    pfam05937
    Location:26682840
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:22212566
    APC_basic; APC basic domain
    pfam11414
    Location:105185
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:7281015
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:10321131
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12791365
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16581711
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17421835
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18691943
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:371444
    APC_rep; Adenomatous polyposis coli (APC) repeat
  19. XM_030250289.2XP_030106149.1  adenomatous polyposis coli protein isoform X16

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:571611
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:485517
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:613651
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15591582
    APC_r; APC repeat
    pfam05924
    Location:19561975
    SAMP; SAMP Motif
    pfam05937
    Location:25942766
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21472492
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:654941
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9581057
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12051291
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15841637
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16681761
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17951869
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:297370
    APC_rep; Adenomatous polyposis coli (APC) repeat
  20. XM_006525536.5XP_006525599.1  adenomatous polyposis coli protein isoform X12

    See identical proteins and their annotated locations for XP_006525599.1

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:606646
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:520552
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:648688
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15941617
    APC_r; APC repeat
    pfam05924
    Location:19912010
    SAMP; SAMP Motif
    pfam05937
    Location:26292801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21822527
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:689976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9931092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12401326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16191672
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17031796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18301904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332405
    APC_rep; Adenomatous polyposis coli (APC) repeat
  21. XM_030250292.2XP_030106152.1  adenomatous polyposis coli protein isoform X19

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:553593
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:369412
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:595633
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15411564
    APC_r; APC repeat
    pfam05924
    Location:19381957
    SAMP; SAMP Motif
    pfam05937
    Location:25762748
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21292474
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:636923
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9401039
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11871273
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15661619
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:16501743
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17771851
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:297370
    APC_rep; Adenomatous polyposis coli (APC) repeat
  22. XM_030250284.2XP_030106144.1  adenomatous polyposis coli protein isoform X12

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:606646
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:520552
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:648688
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:15941617
    APC_r; APC repeat
    pfam05924
    Location:19912010
    SAMP; SAMP Motif
    pfam05937
    Location:26292801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:21822527
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:689976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:9931092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:12401326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:16191672
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:17031796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:18301904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332405
    APC_rep; Adenomatous polyposis coli (APC) repeat
  23. XM_030250295.2XP_030106155.1  adenomatous polyposis coli protein isoform X26

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:487527
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:303346
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:529569
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:14751498
    APC_r; APC repeat
    pfam05924
    Location:18721891
    SAMP; SAMP Motif
    pfam05937
    Location:25102682
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:20632408
    APC_basic; APC basic domain
    pfam11414
    Location:66146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:570857
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:874973
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:11211207
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:15001553
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:15841677
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:17111785
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:246304
    APC_rep; Adenomatous polyposis coli (APC) repeat