ERBB2 erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ERBB2provided by HGNC
Official Full Name: erb-b2 receptor tyrosine kinase 2provided by HGNC
Primary source: HGNC:HGNC:3430
See related: Ensembl:ENSG00000141736 MIM:164870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in kidney (RPKM 34.7), skin (RPKM 30.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
109.20201120	current	GRCh38.p13 (GCF_000001405.39)	17	NC_000017.11 (39688094..39728660)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (37844167..37884915)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prevalence of germline BRCA mutations in HER2-negative metastatic breast cancer: global results from the real-world, observational BREAKOUT study.
Title: Prevalence of germline BRCA mutations in HER2-negative metastatic breast cancer: global results from the real-world, observational BREAKOUT study.
Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr(701) phosphorylation.
Title: Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr<sup>701</sup> phosphorylation.
Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth.
Title: Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth.
Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.
Title: Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets.
Human Epidermal Growth Factor Receptor-2 gene polymorphism and breast cancer risk in women from the Northeastern region of Brazil.
Title: Human Epidermal Growth Factor Receptor-2 gene polymorphism and breast cancer risk in women from the Northeastern region of Brazil.
Differential prognostic value of positive HER2 status determined by immunohistochemistry or fluorescence in situ hybridization in breast cancer.
Title: Differential prognostic value of positive HER2 status determined by immunohistochemistry or fluorescence in situ hybridization in breast cancer.
Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy.
Title: Genetic mutation profile of Chinese HER2-positive breast cancers and genetic predictors of responses to Neoadjuvant anti-HER2 therapy.
CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression.
Title: CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression.
Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer.
Title: Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer.
Long-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial.
Title: Long-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial.

Submit: New GeneRIF Correction See all GeneRIFs (2718)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cetuximab response MedGen: CN077967 GeneReviews: Not available	Compare labs
Glioma susceptibility 1 MedGen: C2750850 OMIM: 137800 GeneReviews: Not available	Compare labs
Panitumumab response MedGen: CN077999 GeneReviews: Not available	Compare labs
Pertuzumab response MedGen: CN233145 GeneReviews: Not available	not available
Trastuzumab response MedGen: CN078025 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:180968 (e-PCR)
- UniSTS:155147

GDB:181407 (e-PCR)
- UniSTS:155240

D15S1477 (e-PCR)
- UniSTS:474482

SHGC-67307 (e-PCR)
- UniSTS:89991

D11S3114 (e-PCR)
- UniSTS:152207

RH75810 (e-PCR)
- UniSTS:86180

RH69066 (e-PCR)
- UniSTS:71382

ERBB2_331 (e-PCR)
- UniSTS:277215

GDB:285022 (e-PCR)
- UniSTS:156385

Homology

Homologs of the ERBB2 gene: The ERBB2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 310 organisms have orthologs with human gene ERBB2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
ErbB-3 class receptor binding	IPI Inferred from Physical Interaction more info	PubMed
RNA polymerase I core binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to growth factor binding	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein C-terminus binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
protein tyrosine kinase activity	TAS Traceable Author Statement more info
transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
ERBB2 signaling pathway	TAS Traceable Author Statement more info
MAPK cascade	TAS Traceable Author Statement more info
cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
cellular response to epidermal growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
enzyme linked receptor protein signaling pathway	TAS Traceable Author Statement more info	PubMed
heart development	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
motor neuron axon guidance	IEA Inferred from Electronic Annotation more info
multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
myelination	IEA Inferred from Electronic Annotation more info
negative regulation of ERBB signaling pathway	TAS Traceable Author Statement more info
negative regulation of immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info
neuromuscular junction development	IEA Inferred from Electronic Annotation more info
neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
peripheral nervous system development	IEA Inferred from Electronic Annotation more info
phosphatidylinositol 3-kinase signaling	IDA Inferred from Direct Assay more info	PubMed
positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of protein kinase B signaling	TAS Traceable Author Statement more info
positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of angiogenesis	NAS Non-traceable Author Statement more info	PubMed
regulation of cell motility	TAS Traceable Author Statement more info
regulation of microtubule-based process	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info
signal transduction	IDA Inferred from Direct Assay more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
ERBB3:ERBB2 complex	IDA Inferred from Direct Assay more info	PubMed
apical plasma membrane	IEA Inferred from Electronic Annotation more info
basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info
early endosome	IEA Inferred from Electronic Annotation more info
endosome membrane	IDA Inferred from Direct Assay more info	PubMed
integral component of membrane	NAS Non-traceable Author Statement more info	PubMed
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
myelin sheath	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	NAS Non-traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
receptor complex	IDA Inferred from Direct Assay more info	PubMed
receptor complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: receptor tyrosine-protein kinase erbB-2

Names: c-erb B2/neu protein; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; proto-oncogene Neu; proto-oncogene c-ErbB-2; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

NP_001005862.1

EC 2.7.10.1

NP_001276865.1

EC 2.7.10.1

NP_001276866.1

EC 2.7.10.1

NP_001276867.1

EC 2.7.10.1

NP_001369711.1

EC 2.7.10.1

NP_001369712.1

EC 2.7.10.1

NP_001369713.1

EC 2.7.10.1

NP_001369714.1

EC 2.7.10.1

NP_001369715.1

EC 2.7.10.1

NP_001369716.1

EC 2.7.10.1

NP_001369717.1

EC 2.7.10.1

NP_001369718.1

EC 2.7.10.1

NP_001369719.1

EC 2.7.10.1

NP_001369720.1

EC 2.7.10.1

NP_001369721.1

EC 2.7.10.1

NP_001369722.1

EC 2.7.10.1

NP_001369723.1

EC 2.7.10.1

NP_001369724.1

EC 2.7.10.1

NP_001369725.1

EC 2.7.10.1

NP_001369726.1

EC 2.7.10.1

NP_001369727.1

EC 2.7.10.1

NP_001369728.1

EC 2.7.10.1

NP_001369729.1

EC 2.7.10.1

NP_001369730.1

EC 2.7.10.1

NP_001369731.1

EC 2.7.10.1

NP_001369732.1

EC 2.7.10.1

NP_001369733.1

EC 2.7.10.1

NP_001369734.1

EC 2.7.10.1

NP_001369735.1

EC 2.7.10.1

NP_004439.2

EC 2.7.10.1

XP_024306409.1

EC 2.7.10.1

XP_024306410.1

EC 2.7.10.1

XP_024306411.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007503.1 RefSeqGene

Range

4945..45523

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_724

mRNA and Protein(s)

NM_001005862.3 → NP_001005862.1 receptor tyrosine-protein kinase erbB-2 isoform b

See identical proteins and their annotated locations for NP_001005862.1

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS45667.1

UniProtKB/Swiss-Prot

P04626

Related

ENSP00000462438.1, ENST00000584601.5

Conserved Domains (8) summary

cd12094
Location:611 → 654

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

smart00261
Location:527 → 573

FU; Furin-like repeats

cd00064
Location:205 → 250

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05109
Location:682 → 960

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:159 → 308

Furin-like; Furin-like cysteine rich region

pfam01030
Location:22 → 143

Recep_L_domain; Receptor L domain

pfam07714
Location:690 → 946

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:481 → 613

GF_recep_IV; Growth factor receptor domain IV
NM_001289936.2 → NP_001276865.1 receptor tyrosine-protein kinase erbB-2 isoform c

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS74052.1

UniProtKB/Swiss-Prot

P04626

Related

ENSP00000446466.1, ENST00000541774.5

Conserved Domains (8) summary

cd12094
Location:626 → 669

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

smart00261
Location:542 → 588

FU; Furin-like repeats

cd00064
Location:220 → 265

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05109
Location:697 → 975

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:174 → 323

Furin-like; Furin-like cysteine rich region

pfam01030
Location:37 → 158

Recep_L_domain; Receptor L domain

pfam07714
Location:705 → 961

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:496 → 628

GF_recep_IV; Growth factor receptor domain IV
NM_001289937.2 → NP_001276866.1 receptor tyrosine-protein kinase erbB-2 isoform d precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Consensus CDS

CCDS77016.1

UniProtKB/TrEMBL

J3QLU9

Related

ENSP00000463714.1, ENST00000584450.5

Conserved Domains (8) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

smart00261
Location:557 → 603

FU; Furin-like repeats

cd00064
Location:235 → 280

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05109
Location:712 → 990

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam07714
Location:720 → 976

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV
NM_001289938.2 → NP_001276867.1 receptor tyrosine-protein kinase erbB-2 isoform e

Status: REVIEWED

Source sequence(s)

AC087491

Consensus CDS

CCDS77017.1

UniProtKB/Swiss-Prot

P04626

UniProtKB/TrEMBL

F5H1T4

Related

ENSP00000462808.1, ENST00000578199.5

Conserved Domains (5) summary

smart00261
Location:527 → 573

FU; Furin-like repeats

cd00064
Location:205 → 250

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:159 → 308

Furin-like; Furin-like cysteine rich region

pfam01030
Location:22 → 143

Recep_L_domain; Receptor L domain

pfam14843
Location:481 → 603

GF_recep_IV; Growth factor receptor domain IV
NM_001382782.1 → NP_001369711.1 receptor tyrosine-protein kinase erbB-2 isoform b

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382783.1 → NP_001369712.1 receptor tyrosine-protein kinase erbB-2 isoform b

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382784.1 → NP_001369713.1 receptor tyrosine-protein kinase erbB-2 isoform f precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382785.1 → NP_001369714.1 receptor tyrosine-protein kinase erbB-2 isoform g precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382786.1 → NP_001369715.1 receptor tyrosine-protein kinase erbB-2 isoform h precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382787.1 → NP_001369716.1 receptor tyrosine-protein kinase erbB-2 isoform i precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382788.1 → NP_001369717.1 receptor tyrosine-protein kinase erbB-2 isoform j precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382789.1 → NP_001369718.1 receptor tyrosine-protein kinase erbB-2 isoform k precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382790.1 → NP_001369719.1 receptor tyrosine-protein kinase erbB-2 isoform l precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382791.1 → NP_001369720.1 receptor tyrosine-protein kinase erbB-2 isoform m precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382792.1 → NP_001369721.1 receptor tyrosine-protein kinase erbB-2 isoform n precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382793.1 → NP_001369722.1 receptor tyrosine-protein kinase erbB-2 isoform o precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382794.1 → NP_001369723.1 receptor tyrosine-protein kinase erbB-2 isoform p precorsor precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382795.1 → NP_001369724.1 receptor tyrosine-protein kinase erbB-2 isoform q precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382796.1 → NP_001369725.1 receptor tyrosine-protein kinase erbB-2 isoform r precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382797.1 → NP_001369726.1 receptor tyrosine-protein kinase erbB-2 isoform s precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382798.1 → NP_001369727.1 receptor tyrosine-protein kinase erbB-2 isoform t precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382799.1 → NP_001369728.1 receptor tyrosine-protein kinase erbB-2 isoform u precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382800.1 → NP_001369729.1 receptor tyrosine-protein kinase erbB-2 isoform v precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382801.1 → NP_001369730.1 receptor tyrosine-protein kinase erbB-2 isoform w precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382802.1 → NP_001369731.1 receptor tyrosine-protein kinase erbB-2 isoform x precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382803.1 → NP_001369732.1 receptor tyrosine-protein kinase erbB-2 isoform y precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382804.1 → NP_001369733.1 receptor tyrosine-protein kinase erbB-2 isoform z precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Related

ENSP00000404047.2, ENST00000445658.6
NM_001382805.1 → NP_001369734.1 receptor tyrosine-protein kinase erbB-2 isoform aa precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_001382806.1 → NP_001369735.1 receptor tyrosine-protein kinase erbB-2 isoform bb precursor

Status: REVIEWED

Source sequence(s)

AC079199, AC087491
NM_004448.4 → NP_004439.2 receptor tyrosine-protein kinase erbB-2 isoform a precursor

See identical proteins and their annotated locations for NP_004439.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC079199, AC087491, BC167147

Consensus CDS

CCDS32642.1

UniProtKB/Swiss-Prot

P04626

UniProtKB/TrEMBL

X5DNK3

Related

ENSP00000269571.4, ENST00000269571.9

Conserved Domains (8) summary

cd12094
Location:641 → 684

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

smart00261
Location:557 → 603

FU; Furin-like repeats

cd00064
Location:235 → 280

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05109
Location:712 → 990

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 338

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam07714
Location:720 → 976

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:511 → 643

GF_recep_IV; Growth factor receptor domain IV

RNA

NR_110535.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC079199, AC087491

Related

ENST00000578373.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p13 Primary Assembly

Range

39688094..39728660

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024450643.1 → XP_024306411.1 receptor tyrosine-protein kinase erbB-2 isoform X3

Conserved Domains (5) summary

cd12094
Location:657 → 700

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:728 → 1006

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:159 → 354

Furin-like; Furin-like cysteine rich region

pfam01030
Location:22 → 143

Recep_L_domain; Receptor L domain

pfam14843
Location:527 → 659

GF_recep_IV; Growth factor receptor domain IV
XM_024450642.1 → XP_024306410.1 receptor tyrosine-protein kinase erbB-2 isoform X2

Conserved Domains (5) summary

cd12094
Location:672 → 715

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:743 → 1021

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:174 → 369

Furin-like; Furin-like cysteine rich region

pfam01030
Location:37 → 158

Recep_L_domain; Receptor L domain

pfam14843
Location:542 → 674

GF_recep_IV; Growth factor receptor domain IV
XM_024450641.1 → XP_024306409.1 receptor tyrosine-protein kinase erbB-2 isoform X1

Conserved Domains (5) summary

cd12094
Location:687 → 730

TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase

cd05109
Location:758 → 1036

PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

pfam00757
Location:189 → 384

Furin-like; Furin-like cysteine rich region

pfam01030
Location:52 → 173

Recep_L_domain; Receptor L domain

pfam14843
Location:557 → 689

GF_recep_IV; Growth factor receptor domain IV