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ERBB2 erb-b2 receptor tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 2064, updated on 17-Jan-2022

Summary

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Official Symbol
ERBB2provided by HGNC
Official Full Name
erb-b2 receptor tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:3430
See related
Ensembl:ENSG00000141736 MIM:164870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; HER-2/neu
Summary
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 34.7), skin (RPKM 30.2) and 24 other tissues See more
Orthologs
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Genomic context

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See ERBB2 in Genome Data Viewer
Location:
17q12
Exon count:
35
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (39688094..39728660)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37844347..37884911)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1769 Neighboring gene phenylethanolamine N-methyltransferase Neighboring gene post-GPI attachment to proteins phospholipase 3 Neighboring gene microRNA 4728 Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7 Neighboring gene IKAROS family zinc finger 3 Neighboring gene keratin 8 pseudogene 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions. Andersson A, et al. Nat Commun, 2021 Oct 14. PMID 34650042, Free PMC Article
  2. Comparison of hormonal receptor expression and HER2 status between circulating tumor cells and breast cancer metastases. Sanches SM, et al. Clinics (Sao Paulo), 2021. PMID 34644733, Free PMC Article
  3. Comparison of the multigene panel test and OncoScan™ for the determination of HER2 amplification in breast cancer. Akazawa K, et al. Oncol Rep, 2021 Oct. PMID 34396441
  4. Human epidermal growth factor receptor 2 overexpression in gastric and gastroesophageal junction adenocarcinoma in patients seen at the University Teaching Hospital, Lusaka, Zambia. Kasochi C, et al. Afr Health Sci, 2020 Dec. PMID 34394249, Free PMC Article
  5. Clinicopathological Features, Tumor Mutational Burden, and Tumour-Infiltrating Lymphocyte Interplay in ERBB2-Mutated Breast Cancer: In Silico Analysis. Uchida S, et al. Pathol Oncol Res, 2021. PMID 34257600, Free PMC Article

See all (3148) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
    Title: USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
  2. IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors.
    Title: IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors.
  3. Clinicopathological Features, Tumor Mutational Burden, and Tumour-Infiltrating Lymphocyte Interplay in ERBB2-Mutated Breast Cancer: In Silico Analysis.
    Title: Clinicopathological Features, Tumor Mutational Burden, and Tumour-Infiltrating Lymphocyte Interplay in <i>ERBB2</i>-Mutated Breast Cancer: <i>In Silico</i> Analysis.
  4. Assessment of 25-Year Survival of Women With Estrogen Receptor-Positive/ERBB2-Negative Breast Cancer Treated With and Without Tamoxifen Therapy: A Secondary Analysis of Data From the Stockholm Tamoxifen Randomized Clinical Trial.
    Title: Assessment of 25-Year Survival of Women With Estrogen Receptor-Positive/ERBB2-Negative Breast Cancer Treated With and Without Tamoxifen Therapy: A Secondary Analysis of Data From the Stockholm Tamoxifen Randomized Clinical Trial.
  5. Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity.
    Title: Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity.
  6. Induction of EnR stress by Melatonin enhances the cytotoxic effect of Lapatinib in HER2-positive breast cancer.
    Title: Induction of EnR stress by Melatonin enhances the cytotoxic effect of Lapatinib in HER2-positive breast cancer.
  7. Comparison of the multigene panel test and OncoScan for the determination of HER2 amplification in breast cancer.
    Title: Comparison of the multigene panel test and OncoScan™ for the determination of <i>HER2</i> amplification in breast cancer.
  8. Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
    Title: Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
  9. Quantification of EGFR-HER2 Heterodimers in HER2-Overexpressing Breast Cancer Cells Using Liquid-Phase Electron Microscopy.
    Title: Quantification of EGFR-HER2 Heterodimers in HER2-Overexpressing Breast Cancer Cells Using Liquid-Phase Electron Microscopy.
  10. HER2 Mutated and Nonmutated Non-small Cell Lung Carcinomas Can Harbor Heterogeneous HER2 Gene Amplification and HER2 Protein Expression.
    Title: HER2 Mutated and Nonmutated Non-small Cell Lung Carcinomas Can Harbor Heterogeneous HER2 Gene Amplification and HER2 Protein Expression.
Submit: New GeneRIF Correction See all GeneRIFs (2876)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cetuximab response
MedGen: CN077967 GeneReviews: Not available
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Gastric cancer
MedGen: C0024623 OMIM: 613659 GeneReviews: Not available
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Glioma susceptibility 1
MedGen: C2750850 OMIM: 137800 GeneReviews: Not available
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Lung cancer
MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
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Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
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Panitumumab response
MedGen: CN077999 GeneReviews: Not available
Compare labs
Pertuzumab response
MedGen: CN233145 GeneReviews: Not available
not available
Trastuzumab response
MedGen: CN078025 GeneReviews: Not available
Compare labs
VISCERAL NEUROPATHY, FAMILIAL, 2, AUTOSOMAL RECESSIVE
MedGen: CN300314 OMIM: 619465 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ErbB-3 class receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA polymerase I core binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to growth factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in enzyme linked receptor protein signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of immature T cell proliferation in thymus IEA
Inferred from Electronic Annotation
more info
  
involved_in neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peripheral nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of angiogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of microtubule-based process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of ERBB3:ERBB2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in myelin sheath IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
receptor tyrosine-protein kinase erbB-2
Names
c-erb B2/neu protein
herstatin
human epidermal growth factor receptor 2
metastatic lymph node gene 19 protein
neuro/glioblastoma derived oncogene homolog
neuroblastoma/glioblastoma derived oncogene homolog
proto-oncogene Neu
proto-oncogene c-ErbB-2
tyrosine kinase-type cell surface receptor HER2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
NP_001005862.1
NP_001276865.1
NP_001276866.1
NP_001276867.1
NP_001369711.1
NP_001369712.1
NP_001369713.1
NP_001369714.1
NP_001369715.1
NP_001369716.1
NP_001369717.1
NP_001369718.1
NP_001369719.1
NP_001369720.1
NP_001369721.1
NP_001369722.1
NP_001369723.1
NP_001369724.1
NP_001369725.1
NP_001369726.1
NP_001369727.1
NP_001369728.1
NP_001369729.1
NP_001369730.1
NP_001369731.1
NP_001369732.1
NP_001369733.1
NP_001369734.1
NP_001369735.1
NP_004439.2
XP_024306409.1
XP_024306410.1
XP_024306411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007503.1 RefSeqGene

    Range
    4945..45523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_724

mRNA and Protein(s)

  1. NM_001005862.3 → NP_001005862.1  receptor tyrosine-protein kinase erbB-2 isoform b

    See identical proteins and their annotated locations for NP_001005862.1

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Consensus CDS
    CCDS45667.1
    UniProtKB/Swiss-Prot
    P04626
    Related
    ENSP00000462438.1, ENST00000584601.5
    Conserved Domains (5) summary
    cd12094
    Location:611 → 654
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:682 → 960
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:159 → 308
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22 → 143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:481 → 613
    GF_recep_IV; Growth factor receptor domain IV

  2. NM_001289936.2 → NP_001276865.1  receptor tyrosine-protein kinase erbB-2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Consensus CDS
    CCDS74052.1
    UniProtKB/Swiss-Prot
    P04626
    Related
    ENSP00000446466.1, ENST00000541774.5
    Conserved Domains (8) summary
    cd12094
    Location:626 → 669
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    smart00261
    Location:542 → 588
    FU; Furin-like repeats
    cd00064
    Location:220 → 265
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:697 → 975
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:174 → 323
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:37 → 158
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:705 → 961
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:496 → 628
    GF_recep_IV; Growth factor receptor domain IV

  3. NM_001289937.2 → NP_001276866.1  receptor tyrosine-protein kinase erbB-2 isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Consensus CDS
    CCDS77016.1
    UniProtKB/TrEMBL
    J3QLU9
    Related
    ENSP00000463714.1, ENST00000584450.5
    Conserved Domains (8) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    smart00261
    Location:557 → 603
    FU; Furin-like repeats
    cd00064
    Location:235 → 280
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:712 → 990
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:720 → 976
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV

  4. NM_001289938.2 → NP_001276867.1  receptor tyrosine-protein kinase erbB-2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC087491
    Consensus CDS
    CCDS77017.1
    UniProtKB/Swiss-Prot
    P04626
    UniProtKB/TrEMBL
    F5H1T4
    Related
    ENSP00000462808.1, ENST00000578199.5
    Conserved Domains (5) summary
    smart00261
    Location:527 → 573
    FU; Furin-like repeats
    cd00064
    Location:205 → 250
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:159 → 308
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22 → 143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:481 → 603
    GF_recep_IV; Growth factor receptor domain IV

  5. NM_001382782.1 → NP_001369711.1  receptor tyrosine-protein kinase erbB-2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:611 → 654
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:682 → 960
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:159 → 308
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22 → 143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:481 → 613
    GF_recep_IV; Growth factor receptor domain IV

  6. NM_001382783.1 → NP_001369712.1  receptor tyrosine-protein kinase erbB-2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:611 → 654
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:682 → 960
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:159 → 308
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22 → 143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:481 → 613
    GF_recep_IV; Growth factor receptor domain IV

  7. NM_001382784.1 → NP_001369713.1  receptor tyrosine-protein kinase erbB-2 isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:680 → 723
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:751 → 1029
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:550 → 682
    GF_recep_IV; Growth factor receptor domain IV

  8. NM_001382785.1 → NP_001369714.1  receptor tyrosine-protein kinase erbB-2 isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:675 → 718
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:746 → 1024
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 677
    GF_recep_IV; Growth factor receptor domain IV

  9. NM_001382786.1 → NP_001369715.1  receptor tyrosine-protein kinase erbB-2 isoform h precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:680 → 723
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:1090 → 1219
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:550 → 682
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:751 → 1017
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001382787.1 → NP_001369716.1  receptor tyrosine-protein kinase erbB-2 isoform i precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:666 → 709
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:737 → 1015
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:214 → 363
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 198
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:536 → 668
    GF_recep_IV; Growth factor receptor domain IV

  11. NM_001382788.1 → NP_001369717.1  receptor tyrosine-protein kinase erbB-2 isoform j precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:651 → 694
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:722 → 1000
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:521 → 653
    GF_recep_IV; Growth factor receptor domain IV

  12. NM_001382789.1 → NP_001369718.1  receptor tyrosine-protein kinase erbB-2 isoform k precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:648 → 691
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:719 → 997
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:518 → 650
    GF_recep_IV; Growth factor receptor domain IV

  13. NM_001382790.1 → NP_001369719.1  receptor tyrosine-protein kinase erbB-2 isoform l precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:640 → 683
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:711 → 989
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 642
    GF_recep_IV; Growth factor receptor domain IV

  14. NM_001382791.1 → NP_001369720.1  receptor tyrosine-protein kinase erbB-2 isoform m precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:638 → 681
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:709 → 987
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:186 → 335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 170
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:508 → 640
    GF_recep_IV; Growth factor receptor domain IV

  15. NM_001382792.1 → NP_001369721.1  receptor tyrosine-protein kinase erbB-2 isoform n precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:1051 → 1180
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712 → 978
    PKc_like; Protein Kinases, catalytic domain

  16. NM_001382793.1 → NP_001369722.1  receptor tyrosine-protein kinase erbB-2 isoform o precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:1049 → 1178
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712 → 976
    PKc_like; Protein Kinases, catalytic domain

  17. NM_001382794.1 → NP_001369723.1  receptor tyrosine-protein kinase erbB-2 isoform p precorsor precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:698 → 976
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV

  18. NM_001382795.1 → NP_001369724.1  receptor tyrosine-protein kinase erbB-2 isoform q precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (4) summary
    cd05109
    Location:696 → 974
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 633
    GF_recep_IV; Growth factor receptor domain IV

  19. NM_001382796.1 → NP_001369725.1  receptor tyrosine-protein kinase erbB-2 isoform r precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:712 → 990
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV

  20. NM_001382797.1 → NP_001369726.1  receptor tyrosine-protein kinase erbB-2 isoform s precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:1030 → 1159
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712 → 957
    PKc_like; Protein Kinases, catalytic domain

  21. NM_001382798.1 → NP_001369727.1  receptor tyrosine-protein kinase erbB-2 isoform t precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:1011 → 1140
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712 → 938
    PKc_like; Protein Kinases, catalytic domain

  22. NM_001382799.1 → NP_001369728.1  receptor tyrosine-protein kinase erbB-2 isoform u precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:581 → 624
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:652 → 930
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:148 → 278
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 147
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:451 → 583
    GF_recep_IV; Growth factor receptor domain IV

  23. NM_001382800.1 → NP_001369729.1  receptor tyrosine-protein kinase erbB-2 isoform v precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:1001 → 1130
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712 → 928
    PKc_like; Protein Kinases, catalytic domain

  24. NM_001382801.1 → NP_001369730.1  receptor tyrosine-protein kinase erbB-2 isoform w precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    COG3170
    Location:995 → 1124
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 633
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:696 → 922
    PKc_like; Protein Kinases, catalytic domain

  25. NM_001382802.1 → NP_001369731.1  receptor tyrosine-protein kinase erbB-2 isoform x precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:555 → 598
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:626 → 904
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:201 → 252
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:425 → 557
    GF_recep_IV; Growth factor receptor domain IV

  26. NM_001382803.1 → NP_001369732.1  receptor tyrosine-protein kinase erbB-2 isoform y precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (5) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712 → 976
    PKc_like; Protein Kinases, catalytic domain

  27. NM_001382804.1 → NP_001369733.1  receptor tyrosine-protein kinase erbB-2 isoform z precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Related
    ENSP00000404047.2, ENST00000445658.6
    Conserved Domains (5) summary
    cd12094
    Location:365 → 408
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:436 → 714
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:25 → 62
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:90 → 206
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:235 → 367
    GF_recep_IV; Growth factor receptor domain IV

  28. NM_001382805.1 → NP_001369734.1  receptor tyrosine-protein kinase erbB-2 isoform aa precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (6) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    COG3170
    Location:746 → 875
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:712 → 736
    PKc_like; Protein Kinases, catalytic domain

  29. NM_001382806.1 → NP_001369735.1  receptor tyrosine-protein kinase erbB-2 isoform bb precursor

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Conserved Domains (4) summary
    COG3170
    Location:717 → 846
    FimV; Tfp pilus assembly protein FimV [Cell motility, Extracellular structures]
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    cl21453
    Location:406 → 644
    PKc_like; Protein Kinases, catalytic domain

  30. NM_004448.4 → NP_004439.2  receptor tyrosine-protein kinase erbB-2 isoform a precursor

    See identical proteins and their annotated locations for NP_004439.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC079199, AC087491, BC167147
    Consensus CDS
    CCDS32642.1
    UniProtKB/Swiss-Prot
    P04626
    UniProtKB/TrEMBL
    X5DNK3
    Related
    ENSP00000269571.4, ENST00000269571.10
    Conserved Domains (8) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    smart00261
    Location:557 → 603
    FU; Furin-like repeats
    cd00064
    Location:235 → 280
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:712 → 990
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:720 → 976
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV

RNA

  1. NR_110535.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079199, AC087491
    Related
    ENST00000578373.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    39688094..39728660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450643.1 → XP_024306411.1  receptor tyrosine-protein kinase erbB-2 isoform X3

    Conserved Domains (5) summary
    cd12094
    Location:657 → 700
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:728 → 1006
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:159 → 354
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:22 → 143
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:527 → 659
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_024450642.1 → XP_024306410.1  receptor tyrosine-protein kinase erbB-2 isoform X2

    Conserved Domains (5) summary
    cd12094
    Location:672 → 715
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:743 → 1021
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:174 → 369
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:37 → 158
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:542 → 674
    GF_recep_IV; Growth factor receptor domain IV

  3. XM_024450641.1 → XP_024306409.1  receptor tyrosine-protein kinase erbB-2 isoform X1

    Conserved Domains (5) summary
    cd12094
    Location:687 → 730
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd05109
    Location:758 → 1036
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 384
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52 → 173
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:557 → 689
    GF_recep_IV; Growth factor receptor domain IV
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04626.1 GenPept UniProtKB/Swiss-Prot:P04626

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