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Erbb2 erb-b2 receptor tyrosine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 13866, updated on 6-Sep-2021

Summary

Official Symbol
Erbb2provided by MGI
Official Full Name
erb-b2 receptor tyrosine kinase 2provided by MGI
Primary source
MGI:MGI:95410
See related
Ensembl:ENSMUSG00000062312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ne; HER; Neu; HER-; HER2; c-ne; ErbB-; HER-2; c-neu; l11Ju; Erbb-2; c-erbB; c-erbB2; l11Jus8; mKIAA3023
Expression
Broad expression in colon adult (RPKM 50.3), duodenum adult (RPKM 35.2) and 17 other tissues See more
Orthologs
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Genomic context

See Erbb2 in Genome Data Viewer
Location:
11 61.75 cM; 11 D
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98303310..98328542)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98412484..98437716)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98273798..98299030)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phenylethanolamine-N-methyltransferase Neighboring gene post-GPI attachment to proteins 3 Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7 Neighboring gene IKAROS family zinc finger 3 Neighboring gene predicted gene, 25106

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ErbB-3 class receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase I core binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in estrous cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in sympathetic nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ERBB3:ERBB2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lateral loop ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
receptor tyrosine-protein kinase erbB-2
Names
Neu oncogene
avian erythroblastosis oncogene B 2
c-erbB-2
p185erbB2
proto-oncogene NEU
proto-oncogene c-ErbB-2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
NP_001003817.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003817.1NP_001003817.1  receptor tyrosine-protein kinase erbB-2 precursor

    See identical proteins and their annotated locations for NP_001003817.1

    Status: VALIDATED

    Source sequence(s)
    AK031099, AK129487, AL591390, BB648397
    Consensus CDS
    CCDS25349.1
    UniProtKB/Swiss-Prot
    P70424
    Related
    ENSMUSP00000053897.6, ENSMUST00000058295.6
    Conserved Domains (8) summary
    cd12094
    Location:642685
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    smart00261
    Location:558604
    FU; Furin-like repeats
    cd00064
    Location:236281
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05109
    Location:713991
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:190339
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:52174
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:721977
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:511644
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98303310..98328542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010152.2: Suppressed sequence

    Description
    NM_010152.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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