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IPO5 importin 5 [ Homo sapiens (human) ]

Gene ID: 3843, updated on 2-Mar-2021

Summary

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Official Symbol
IPO5provided by HGNC
Official Full Name
importin 5provided by HGNC
Primary source
HGNC:HGNC:6402
See related
Ensembl:ENSG00000065150 MIM:602008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMB3; Pse1; imp5; KPNB3; RANBP5
Summary
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 84.9), ovary (RPKM 29.9) and 25 other tissues See more
Orthologs
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Genomic context

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See IPO5 in Genome Data Viewer
Location:
13q32.2
Exon count:
31
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (97953641..98024296)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (98605929..98676550)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370324 Neighboring gene uncharacterized LOC105370325 Neighboring gene ribosomal protein L7a pseudogene 61 Neighboring gene uncharacterized LOC105370328 Neighboring gene uncharacterized LOC107984566 Neighboring gene ferritin light chain pseudogene 8 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 1 Neighboring gene ring finger protein 113B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. Swale C, et al. J Mol Biol, 2020 May 1. PMID 32222384
  2. Ebola virus encodes a miR-155 analog to regulate importin-α5 expression. Liu Y, et al. Cell Mol Life Sci, 2016 Oct. PMID 27094387
  3. Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5. Hutchinson EC, et al. J Gen Virol, 2011 Aug. PMID 21562121
  4. Genetic and functional study of the IPO5 gene in schizophrenia. Wang ZQ, et al. Psychiatry Res, 2011 May 30. PMID 20542336
  5. Lack of association of the KPNB3 locus in case-control samples. Wu N, et al. Schizophr Res, 2008 Apr. PMID 18295457

See all (177) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
    Title: X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
  2. DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.
    Title: DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.
  3. IPO5 is an oncogene involved in CRC cell proliferation and migration. This highlights the significance of IPO5 in 5-fluorouracil-resistant CRC cells. The oncogenic function of IPO5 was mediated by promoting RAS signalling by increasing the nuclear translocation of RASAL2
    Title: IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
  4. Results indicate that the interaction between FLIL33 and IPO5 is localized to a specific segment of the FLIL33 protein, is not required for nuclear localization of FLIL33, and protects FLIL33 from proteasome-dependent degradation.
    Title: The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation.
  5. importin-alpha5, which is a key regulator of interferon signaling following Ebola virus infection, as one putative target of miRNA.
    Title: Ebola virus encodes a miR-155 analog to regulate importin-α5 expression.
  6. The nuclear importin IPO5 was identified as a novel interacting protein of SMAD1. Overexpression of IPO5 in various cell lines specifically increases nuclear localization of BMP receptor-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 and BMP but not TGF-beta R-SMADs.
    Title: Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.
  7. Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly.
    Title: Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.
  8. Single nucleotide polymorphism in IPO5 gene is associated with Peripheral Arterial Disease.
    Title: Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population.
  9. IQGAP1 interacts with human importin-beta5 in HEK 293T cells.
    Title: IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling.
  10. In case of L7, importin beta2 or importin beta3 are preferentially used by clusters with a high import efficiency.
    Title: The quantitative assessment of the role played by basic amino acid clusters in the nuclear uptake of human ribosomal protein L7.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of IPO5 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev importin beta specifically binds to the Rev nuclear localization signal (NLS, amino acids 35-50) and mediates the nuclear import of Rev PubMed
rev importin beta can inhibit the interaction of HIV-1 Rev with HIV-1 RRE RNA PubMed
Tat tat The binding of HIV-1 Tat with importin beta is inhibited by RanGTP PubMed
tat Importin beta binds to the HIV-1 Tat protein nuclear localization signal (NLS; amino acids 49-57) and mediates the nuclear import of Tat through a novel import pathway PubMed
Vpr vpr HIV-1 Vpr causes increased levels of CyclinB1, Plk1, and Cdk1 in a complex with the nuclear transport and spindle assembly protein, importin beta PubMed
vpr HIV-1 Vpr co-localizes with karyopherin beta and regulates karyopherin beta-mediated docking of the HIV-1 preintegration complex at the nuclear envelope, however multiple reports indicate the two proteins do not directly interact PubMed
capsid gag The interaction of HIV-1 CA with human cellular importin 5 protein (IPO5) is identified by yeast two-hybrid screen PubMed
integrase gag-pol Some reports indicate a possible role for the interactions between karyopherin alpha and beta with HIV-1 integrase in the nuclear import of HIV-1 preintegration complexes (PIC), while other reports indicate integrase is not involved in PIC nuclear import PubMed
gag-pol Karyopherin beta binds to complexes between HIV-1 integrase (integrase/GST fusion protein) and karyopherin alpha, but not to integrase alone PubMed
gag-pol Karyopherin alpha and beta are reported to interact with HIV-1 integrase (IN) to facilitate nuclear import of IN, however a conflicting report indicates nuclear accumulation of IN does not involve karyopherin alpha, beta 1, or beta 2 mediated pathways PubMed
matrix gag Karyopherin beta mediates the nuclear import of HIV-1 preintegration complexes through karyopherin alpha, which binds directly to nuclear localization signals in HIV-1 Matrix PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2068, FLJ43041, DKFZp686O1576

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
RNA binding HDA PubMed 
nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nuclear import signal receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
small GTPase binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
negative regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
positive regulation of protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
ribosomal protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
membrane HDA PubMed 
nuclear pore TAS
Traceable Author Statement
more info
 PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
importin-5
Names
RAN binding protein 5
Ran_GTP binding protein 5
importin beta-3 subunit
importin subunit beta-3
karyopherin (importin) beta 3
karyopherin beta-3
ran-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002271.6 → NP_002262.4  importin-5

    Status: REVIEWED

    Source sequence(s)
    AF339834, AK125031, AL137120, AL705630, BC000947, BC001497, BC045640, BU618294, Y08890
    Consensus CDS
    CCDS31999.1
    Related
    ENSP00000499125.1, ENST00000651721.2
    Conserved Domains (6) summary
    COG5215
    Location:13 → 634
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:355 → 387
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:921 → 966
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:268 → 357
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1005 → 1051
    Importin_rep_5; Importin repeat
    pfam18829
    Location:765 → 874
    Importin_rep_6; Importin repeat 6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    97953641..98024296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521089.2 → XP_011519391.1  importin-5 isoform X1

    See identical proteins and their annotated locations for XP_011519391.1

    UniProtKB/Swiss-Prot
    O00410
    Conserved Domains (6) summary
    COG5215
    Location:31 → 652
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:373 → 405
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:939 → 984
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:286 → 375
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1023 → 1069
    Importin_rep_5; Importin repeat
    pfam18829
    Location:783 → 892
    Importin_rep_6; Importin repeat 6

  2. XM_011521087.2 → XP_011519389.1  importin-5 isoform X1

    See identical proteins and their annotated locations for XP_011519389.1

    UniProtKB/Swiss-Prot
    O00410
    Conserved Domains (6) summary
    COG5215
    Location:31 → 652
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:373 → 405
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:939 → 984
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:286 → 375
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1023 → 1069
    Importin_rep_5; Importin repeat
    pfam18829
    Location:783 → 892
    Importin_rep_6; Importin repeat 6

  3. XM_011521088.2 → XP_011519390.1  importin-5 isoform X1

    See identical proteins and their annotated locations for XP_011519390.1

    UniProtKB/Swiss-Prot
    O00410
    Conserved Domains (6) summary
    COG5215
    Location:31 → 652
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:373 → 405
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:939 → 984
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:286 → 375
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1023 → 1069
    Importin_rep_5; Importin repeat
    pfam18829
    Location:783 → 892
    Importin_rep_6; Importin repeat 6

  4. XM_017020562.1 → XP_016876051.1  importin-5 isoform X1

    UniProtKB/Swiss-Prot
    O00410
    Conserved Domains (6) summary
    COG5215
    Location:31 → 652
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:373 → 405
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:939 → 984
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:286 → 375
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1023 → 1069
    Importin_rep_5; Importin repeat
    pfam18829
    Location:783 → 892
    Importin_rep_6; Importin repeat 6

  5. XM_024449346.1 → XP_024305114.1  importin-5 isoform X1

    Related
    ENSP00000261574.5, ENST00000261574.10
    Conserved Domains (6) summary
    COG5215
    Location:31 → 652
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:373 → 405
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:939 → 984
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:286 → 375
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1023 → 1069
    Importin_rep_5; Importin repeat
    pfam18829
    Location:783 → 892
    Importin_rep_6; Importin repeat 6

  6. XM_005254052.3 → XP_005254109.1  importin-5 isoform X1

    See identical proteins and their annotated locations for XP_005254109.1

    UniProtKB/Swiss-Prot
    O00410
    Conserved Domains (6) summary
    COG5215
    Location:31 → 652
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:373 → 405
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:939 → 984
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:286 → 375
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1023 → 1069
    Importin_rep_5; Importin repeat
    pfam18829
    Location:783 → 892
    Importin_rep_6; Importin repeat 6

  7. XM_011521090.2 → XP_011519392.1  importin-5 isoform X1

    See identical proteins and their annotated locations for XP_011519392.1

    UniProtKB/Swiss-Prot
    O00410
    Conserved Domains (6) summary
    COG5215
    Location:31 → 652
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:373 → 405
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:939 → 984
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:286 → 375
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1023 → 1069
    Importin_rep_5; Importin repeat
    pfam18829
    Location:783 → 892
    Importin_rep_6; Importin repeat 6

  8. XM_005254053.3 → XP_005254110.1  importin-5 isoform X1

    See identical proteins and their annotated locations for XP_005254110.1

    UniProtKB/Swiss-Prot
    O00410
    Conserved Domains (6) summary
    COG5215
    Location:31 → 652
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:373 → 405
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:939 → 984
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:286 → 375
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1023 → 1069
    Importin_rep_5; Importin repeat
    pfam18829
    Location:783 → 892
    Importin_rep_6; Importin repeat 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00410.4 GenPept UniProtKB/Swiss-Prot:O00410

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