U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ipo5 importin 5 [ Mus musculus (house mouse) ]

Gene ID: 70572, updated on 10-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Ipo5provided by MGI
Official Full Name
importin 5provided by MGI
Primary source
MGI:MGI:1917822
See related
Ensembl:ENSMUSG00000030662 AllianceGenome:MGI:1917822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IMB3; imp5; Kpnb3; Ranbp5; 1110011C18Rik; 5730478E03Rik
Summary
Enables nuclear import signal receptor activity. Involved in NLS-bearing protein import into nucleus; cellular response to amino acid stimulus; and positive regulation of protein import into nucleus. Located in cytoplasm and nucleus. Is expressed in germ cell of testis; gonad; ovary; spermatid; and testis. Orthologous to human IPO5 (importin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 96.4), CNS E11.5 (RPKM 33.8) and 20 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ipo5 in Genome Data Viewer
Location:
14; 14 E4- E5
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (121134255..121185458)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (120896840..120948046)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33173 Neighboring gene predicted gene, 52124 Neighboring gene FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived) Neighboring gene RIKEN cDNA B930095G15 gene Neighboring gene serine/threonine kinase 24

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway. Li M, et al. Oxid Med Cell Longev, 2022. PMID 36120598, Free PMC Article
  2. RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus. Sutherland JM, et al. FASEB J, 2015 Jul. PMID 25782991
  3. Subcellular distribution of importins correlates with germ cell maturation. Hogarth CA, et al. Dev Dyn, 2007 Aug. PMID 17654710
  4. Expression of testicular germ cell genes identified by differential display analysis. Anway MD, et al. J Androl, 2003 Mar-Apr. PMID 12634303
  5. Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. Miriyala S, et al. Free Radic Biol Med, 2016 Feb. PMID 26689472, Free PMC Article

See all (42) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway.
    Title: IPO5 Mediates EMT and Promotes Esophageal Cancer Development through the RAS-ERK Pathway.
  2. nuclear import protein IPO5 facilitates the nuclear translocation of MSI1 to the transcriptionally silenced XY chromatin domain in meiotic pachytene spermatocytes, resulting in the release of MSI1 RNA-binding targets
    Title: RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.
  3. RanBP5 exhibits age- and gender-specific subcellular localization within fetal gonads. At E12.5, RanBP5 protein is cytoplasmic in gonocytes but predominantly nuclear in oogonia, but by E14.5 RanBP5 appears nuclear in gonocytes and cytoplasmic in oogonia
    Title: Subcellular distribution of importins correlates with germ cell maturation.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear import signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytosolic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
importin-5
Names
RAN binding protein 5
importin beta 3
importin subunit beta-3
karyopherin (importin) beta 3
karyopherin beta-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416269.1 → NP_001403198.1  importin-5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154283

  2. NM_001416270.1 → NP_001403199.1  importin-5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154283

  3. NM_001416271.1 → NP_001403200.1  importin-5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154283
    UniProtKB/Swiss-Prot
    Q9EQ30

  4. NM_001416272.1 → NP_001403201.1  importin-5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154283
    UniProtKB/Swiss-Prot
    Q9EQ30

  5. NM_001416274.1 → NP_001403203.1  importin-5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154283

  6. NM_023579.5 → NP_076068.1  importin-5 isoform 1

    See identical proteins and their annotated locations for NP_076068.1

    Status: VALIDATED

    Source sequence(s)
    AC154283
    Consensus CDS
    CCDS37014.1
    UniProtKB/Swiss-Prot
    Q8BKC5, Q9EQ30
    Related
    ENSMUSP00000032898.8, ENSMUST00000032898.9
    Conserved Domains (6) summary
    COG5215
    Location:13 → 634
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:355 → 387
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:921 → 966
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:268 → 357
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1005 → 1051
    Importin_rep_5; Importin repeat
    pfam18829
    Location:765 → 874
    Importin_rep_6; Importin repeat 6

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    121134255..121185458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248018.2 → XP_030103878.1  importin-5 isoform X1

    Conserved Domains (6) summary
    COG5215
    Location:13 → 634
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:355 → 387
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:921 → 966
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:268 → 357
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1005 → 1051
    Importin_rep_5; Importin repeat
    pfam18829
    Location:765 → 874
    Importin_rep_6; Importin repeat 6

  2. XM_030248019.2 → XP_030103879.1  importin-5 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQ30
    Conserved Domains (6) summary
    COG5215
    Location:13 → 634
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:355 → 387
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:921 → 966
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:268 → 357
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1005 → 1051
    Importin_rep_5; Importin repeat
    pfam18829
    Location:765 → 874
    Importin_rep_6; Importin repeat 6

  3. XM_036158847.1 → XP_036014740.1  importin-5 isoform X1

    Conserved Domains (6) summary
    COG5215
    Location:13 → 634
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:355 → 387
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:921 → 966
    HEAT_EZ; HEAT-like repeat
    pfam18808
    Location:268 → 357
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1005 → 1051
    Importin_rep_5; Importin repeat
    pfam18829
    Location:765 → 874
    Importin_rep_6; Importin repeat 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKC5.3 GenPept UniProtKB/Swiss-Prot:Q8BKC5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous