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Ttn titin [ Mus musculus (house mouse) ]

Gene ID: 22138, updated on 11-Apr-2024

Summary

Official Symbol
Ttnprovided by MGI
Official Full Name
titinprovided by MGI
Primary source
MGI:MGI:98864
See related
Ensembl:ENSMUSG00000051747 AllianceGenome:MGI:98864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L56; mdm; shru; 1100001C23Rik; 2310036G12Rik; 2310057K23Rik; 2310074I15Rik; D330041I19Rik; D830007G01Rik
Summary
Enables ankyrin binding activity. Involved in regulation of relaxation of cardiac muscle. Acts upstream of or within several processes, including chordate embryonic development; forward locomotion; and heart development. Located in M band and Z disc. Is expressed in several structures, including diaphragm; embryo mesenchyme; heart; musculature; and tarsus. Used to study autosomal recessive limb-girdle muscular dystrophy type 2J; dilated cardiomyopathy 1G; and tibial muscular dystrophy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 23.7), mammary gland adult (RPKM 4.5) and 1 other tissue See more
Orthologs
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Genomic context

Location:
2 C3; 2 45.13 cM
Exon count:
350
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76534324..76812901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76703980..76982557, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04894 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 Neighboring gene predicted gene, 39860 Neighboring gene predicted gene, 57692 Neighboring gene STARR-seq mESC enhancer starr_04895 Neighboring gene coiled-coil domain containing 141 Neighboring gene STARR-seq mESC enhancer starr_04897 Neighboring gene STARR-seq mESC enhancer starr_04899 Neighboring gene STARR-seq mESC enhancer starr_04900 Neighboring gene STARR-seq mESC enhancer starr_04901 Neighboring gene predicted gene, 39861 Neighboring gene SEC14 and spectrin domains 1 Neighboring gene nucleophosmin 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (14)  1 citation
  • Chemically induced (ENU) (3) 
  • Endonuclease-mediated (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables muscle alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity conferring elasticity ISO
Inferred from Sequence Orthology
more info
 
enables telethonin binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adult heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac myofibril assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within detection of muscle stretch ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forward locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within heart growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of relaxation of cardiac muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sarcomere organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sarcomere organization TAS
Traceable Author Statement
more info
PubMed 
involved_in sarcomerogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle myosin thick filament assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle thin filament assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in somitogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within striated muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
PubMed 
located_in I band IDA
Inferred from Direct Assay
more info
PubMed 
located_in I band ISO
Inferred from Sequence Orthology
more info
 
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in M band IDA
Inferred from Direct Assay
more info
PubMed 
located_in M band ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of muscle myosin complex TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
located_in striated muscle thin filament ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
titin
Names
connectin
NP_001372637.1
NP_035782.3
NP_082280.2
XP_036016413.1
XP_036016417.1
XP_036016420.1
XP_036016421.1
XP_036016422.1
XP_036016427.1
XP_036016428.1
XP_036016429.1
XP_036016430.1
XP_036016431.1
XP_036016433.1
XP_036016436.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385708.1NP_001372637.1  titin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928681, AL928721, AL928789
    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Related
    ENSMUSP00000097561.4, ENSMUST00000099981.10
    Conserved Domains (22) summary
    cd05747
    Location:3454534636
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:1020810736
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:1155011841
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00060
    Location:1748517569
    FN3; Fibronectin type 3 domain
    smart00410
    Location:1445814522
    IG_like; Immunoglobulin like
    PHA03247
    Location:1170212305
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:253346
    PRK12323; DNA polymerase III subunit gamma/tau
    cd00063
    Location:2688926981
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3323733513
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1106211086
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1320713275
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:2018820190
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2414324224
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3355633645
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    NF033839
    Location:1214912512
    PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
    cl11960
    Location:2018820281
    Ig; Immunoglobulin domain
  2. NM_011652.3NP_035782.3  titin isoform N2-A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (N2-A) represents the longer transcript and encodes the longer isoform (N2-A).
    Source sequence(s)
    AK029024, AK081896, AK084709, AK084780, AK085832, AK132562, AK139762, AK157782, AL928721, AL928789, BB532149, BG795347
    Consensus CDS
    CCDS38154.1
    UniProtKB/TrEMBL
    E9Q8K5, E9Q8N1
    Related
    ENSMUSP00000107477.3, ENSMUST00000111846.9
    Conserved Domains (13) summary
    cd00096
    Location:48864954
    Ig; Immunoglobulin domain
    cd05747
    Location:3260132692
    Ig5_Titin_like; M5, fifth immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins
    cd05748
    Location:2004220115
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00408
    Location:37573823
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:1554115625
    FN3; Fibronectin type 3 domain
    smart00220
    Location:3129431548
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00409
    Location:3058430663
    IG; Immunoglobulin
    smart00410
    Location:2732327405
    IG_like; Immunoglobulin like
    cd00063
    Location:2494525037
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:62656354
    I-set; Immunoglobulin I-set domain
    cd14104
    Location:3129331569
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam00047
    Location:1251312579
    ig; Immunoglobulin domain
    cl11960
    Location:2368523758
    Ig; Immunoglobulin domain
  3. NM_028004.2NP_082280.2  titin isoform N2-B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (N2-B) has multiple differences in the coding region compared to variant N2-A. The resulting isoform (N2-B) has the same N- and C-termini but is shorter compared to isoform N2-A.
    Source sequence(s)
    AK029024, AK081896, AK084709, AK084780, AK132562, AK157782, AL928721, AL928789, BB662000
    UniProtKB/TrEMBL
    A0A5K1VVQ1
    Conserved Domains (13) summary
    cd00096
    Location:2401224079
    Ig; Immunoglobulin domain
    cd05747
    Location:2602026111
    Ig5_Titin_like; M5, fifth immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins
    cd05748
    Location:1346113534
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00408
    Location:913979
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:89609044
    FN3; Fibronectin type 3 domain
    smart00220
    Location:2471324967
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00409
    Location:2074220824
    IG; Immunoglobulin
    smart00410
    Location:2400324082
    IG_like; Immunoglobulin like
    cd00063
    Location:1836418456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:2602426112
    I-set; Immunoglobulin I-set domain
    cd14104
    Location:2471224988
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam00047
    Location:59325998
    ig; Immunoglobulin domain
    cl11960
    Location:1710417177
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    76534324..76812901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160538.1XP_036016431.1  titin isoform X10

    UniProtKB/TrEMBL
    A0A5K1VVQ1
    Related
    ENSMUSP00000011934.7, ENSMUST00000011934.13
    Conserved Domains (16) summary
    cd05747
    Location:2606626157
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:2597626710
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:90069090
    FN3; Fibronectin type 3 domain
    smart00410
    Location:59796043
    IG_like; Immunoglobulin like
    cd00063
    Location:1841018502
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:2475825034
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam07679
    Location:9461035
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:47284796
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1170911711
    Ig; Ig strand A [structural motif]
    cd05748
    Location:1566415745
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:2507725166
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1170911802
    Ig; Immunoglobulin domain
  2. XM_036160537.1XP_036016430.1  titin isoform X9

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (19) summary
    cd05747
    Location:3237232463
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:3228233016
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1531215396
    FN3; Fibronectin type 3 domain
    smart00409
    Location:1228512349
    IG; Immunoglobulin
    smart00410
    Location:1112711191
    IG_like; Immunoglobulin like
    cd00063
    Location:2471624808
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3106431340
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1053510559
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1103411102
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1801518017
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2197022051
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3138331472
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1801518108
    Ig; Immunoglobulin domain
  3. XM_036160536.1XP_036016429.1  titin isoform X8

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (18) summary
    cd05747
    Location:3284332934
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:3275333487
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1578315867
    FN3; Fibronectin type 3 domain
    smart00410
    Location:1275612820
    IG_like; Immunoglobulin like
    cd00063
    Location:2518725279
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3153531811
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1100611030
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1150511573
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1848618488
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2107021149
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3185431943
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1848618579
    Ig; Immunoglobulin domain
  4. XM_036160535.1XP_036016428.1  titin isoform X7

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (18) summary
    cd05747
    Location:3287332964
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:1020810736
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1581315897
    FN3; Fibronectin type 3 domain
    smart00410
    Location:1278612850
    IG_like; Immunoglobulin like
    cd00063
    Location:2521725309
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3156531841
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1103611060
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1153511603
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1851618518
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2110021179
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3188431973
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1851618609
    Ig; Immunoglobulin domain
  5. XM_036160534.1XP_036016427.1  titin isoform X6

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (19) summary
    cd05747
    Location:3289932990
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:1020810736
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1583915923
    FN3; Fibronectin type 3 domain
    smart00409
    Location:1281212876
    IG; Immunoglobulin
    smart00410
    Location:1165411718
    IG_like; Immunoglobulin like
    cd00063
    Location:2524325335
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3159131867
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1106211086
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1156111629
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1854218544
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2112621205
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3191031999
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1854218635
    Ig; Immunoglobulin domain
  6. XM_036160529.1XP_036016422.1  titin isoform X5

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (19) summary
    cd05747
    Location:3301233103
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:1020810736
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1595216036
    FN3; Fibronectin type 3 domain
    smart00409
    Location:1292512989
    IG; Immunoglobulin
    smart00410
    Location:1176711831
    IG_like; Immunoglobulin like
    cd00063
    Location:2535625448
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3170431980
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1106211086
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1167411742
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1865518657
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2261022691
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3202332112
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1865518748
    Ig; Immunoglobulin domain
  7. XM_036160528.1XP_036016421.1  titin isoform X4

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (19) summary
    cd05747
    Location:3321633307
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:1020810736
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1615616240
    FN3; Fibronectin type 3 domain
    smart00410
    Location:1312913193
    IG_like; Immunoglobulin like
    COG0810
    Location:1106511134
    TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
    cd00063
    Location:2556025652
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3190832184
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1106211086
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1187811946
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1885918861
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2281422895
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3222732316
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1885918952
    Ig; Immunoglobulin domain
  8. XM_036160527.1XP_036016420.1  titin isoform X3

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (20) summary
    cd05747
    Location:3337433465
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:1020810736
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1631416398
    FN3; Fibronectin type 3 domain
    smart00409
    Location:1328713351
    IG; Immunoglobulin
    smart00410
    Location:1212912193
    IG_like; Immunoglobulin like
    COG0810
    Location:1106511134
    TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
    cd00063
    Location:2571825810
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3206632342
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1106211086
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1203612104
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1901719019
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2297223053
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3238532474
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1901719110
    Ig; Immunoglobulin domain
  9. XM_036160524.1XP_036016417.1  titin isoform X2

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (19) summary
    cd05747
    Location:3340233493
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:1020810736
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1634216426
    FN3; Fibronectin type 3 domain
    smart00410
    Location:1331513379
    IG_like; Immunoglobulin like
    COG0810
    Location:1106511134
    TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]
    cd00063
    Location:2574625838
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3209432370
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1106211086
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1206412132
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1904519047
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2300023081
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3241332502
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:1904519138
    Ig; Immunoglobulin domain
  10. XM_036160520.1XP_036016413.1  titin isoform X1

    UniProtKB/TrEMBL
    A0A5K1VVQ9
    Conserved Domains (21) summary
    cd05747
    Location:3424934340
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:1020810736
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:1718917273
    FN3; Fibronectin type 3 domain
    smart00410
    Location:1416214226
    IG_like; Immunoglobulin like
    PHA03247
    Location:1178612205
    PHA03247; large tegument protein UL36; Provisional
    PRK12323
    Location:253346
    PRK12323; DNA polymerase III subunit gamma/tau
    cd00063
    Location:2659326685
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:3294133217
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam02818
    Location:1230312329
    PPAK; PPAK motif
    pfam07679
    Location:72847373
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:1291112979
    Ig_3; Immunoglobulin domain
    pfam18362
    Location:95919621
    THB; Tri-helix bundle domain
    cd00096
    Location:1989219894
    Ig; Ig strand A [structural motif]
    cd05748
    Location:2384723928
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:3326033349
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    NF033839
    Location:1157111977
    PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form
    cl11960
    Location:1989219985
    Ig; Immunoglobulin domain
  11. XM_036160540.1XP_036016433.1  titin isoform X11

    UniProtKB/TrEMBL
    A0A5K1VVQ1
    Conserved Domains (12) summary
    cd05747
    Location:2182921920
    IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    PTZ00121
    Location:2173922473
    PTZ00121; MAEBL; Provisional
    smart00060
    Location:47694853
    FN3; Fibronectin type 3 domain
    smart00410
    Location:17421806
    IG_like; Immunoglobulin like
    cd00063
    Location:1417314265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14104
    Location:2052120797
    STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin
    pfam07679
    Location:2245722546
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:491559
    Ig_3; Immunoglobulin domain
    cd00096
    Location:74727474
    Ig; Ig strand A [structural motif]
    cd05748
    Location:1142711508
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd20927
    Location:2084020929
    IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains
    cl11960
    Location:74727565
    Ig; Immunoglobulin domain
  12. XM_036160543.1XP_036016436.1  titin isoform X12

    Related
    ENSMUSP00000097560.4, ENSMUST00000099980.10
    Conserved Domains (9) summary
    PHA03307
    Location:242378
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam07679
    Location:9461035
    I-set; Immunoglobulin I-set domain
    pfam09042
    Location:465504
    Titin_Z; Titin Z
    pfam13927
    Location:35083589
    Ig_3; Immunoglobulin domain
    cd00096
    Location:32453247
    Ig; Ig strand A [structural motif]
    cd20951
    Location:20842175
    IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
    cd20972
    Location:103193
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cd20974
    Location:698
    IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains
    cl11960
    Location:32453335
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027369.1: Suppressed sequence

    Description
    NM_027369.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.