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AKT2 AKT serine/threonine kinase 2 [ Homo sapiens (human) ]

Gene ID: 208, updated on 7-Jun-2020

Summary

Official Symbol
AKT2provided by HGNC
Official Full Name
AKT serine/threonine kinase 2provided by HGNC
Primary source
HGNC:HGNC:392
See related
Ensembl:ENSG00000105221 MIM:164731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA
Summary
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]
Expression
Ubiquitous expression in thyroid (RPKM 30.9), fat (RPKM 28.8) and 25 other tissues See more
Orthologs

Genomic context

See AKT2 in Genome Data Viewer
Location:
19q13.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (40230317..40285531, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40736224..40791443, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 9B Neighboring gene cyclin P Neighboring gene uncharacterized LOC107985289 Neighboring gene microRNA 641 Neighboring gene chromosome 19 open reading frame 47 Neighboring gene RNA, U6 small nuclear 945, pseudogene Neighboring gene phospholipase D family member 3 Neighboring gene microRNA 6796

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diabetes mellitus type 2
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
Compare labs
Hypoglycemia, neonatal, simulating foetopathia diabetica
MedGen: C1855860 OMIM: 240900 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2015-05-07)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2015-05-07)

ClinGen Genome Curation Page

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
env HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38 PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env Gp120-mediated activation of caspase-3 is significantly reduced in cells pretreated with PDGF-B. PDGF-mediated protection against gp120 involves the phosphoinositide (PI)3-kinase/Akt pathway PubMed
env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
env HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env Fractalkine (CX3CL1) protects hippocampal neurons from the neurotoxicity induced by the HIV-1 envelope protein gp120, and neuronal CX(3)CR1 receptors and Akt activation are responsible for the neuroprotective effects of fractalkine PubMed
env HIV-1 gp120 downregulates expression of c-Myc, Max, and 14-3-3epsilon proteins, and decreases phosphorylation of ATP-dependent tyrosine kinases (Akt) at Ser-473 in human mesangial cells (HMC) PubMed
Nef nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
nef Knockdown of AKT2 and AKT3 by siRNA shows significant reduction of CCL5 levels, suggesting that AKT2 and AKT3 proteins are involved in Nef-mediated upregulation of CCL5 PubMed
nef HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity PubMed
nef HIV-1 Nef synergizes with IL-6 to activate the AKT pathway promoting angiogenesis and tumorigenesis in a chicken chorioallantoic membrane model and nude mice PubMed
nef HIV-1 Nef synergizes with IL-6 to enhance vascular tube formation, cell proliferation, VEGF expression, and phosphorylated AKT activation in human umbilical vein endothelial cells PubMed
nef Incubation of human macrophages with exogenous HIV-1 Nef protein induces phosphorylation of Akt and GSK-3ss, and promotes IL-10 release PubMed
nef HIV-1 Nef decreases levels of AKT phosphorylation in insulin-stimulated adipocytes PubMed
Tat tat HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins PubMed
tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
tat PI3K/Akt, TRPC, and GSK3beta signaling pathways are all involved in PDGF-C mediated neuroprotection against HIV-1 Tat in human neuroblastoma cells PubMed
tat HIV-1 Tat activates AKT kinase through activation of PI3 kinase, resulting in the protection of cells from apoptosis PubMed
tat Lancemaside A1 inhibits the movement of Akt to the plasma membrane, a critical step for Akt activation, and Compound K inhibits Akt phosphorylation in Tat-expressing CHME5 cells PubMed
tat PDGF-BB-mediated protection against HIV-1 Tat and morphine-induced neuron apoptosis involves Akt activation PubMed
tat HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling PubMed
tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
tat A Coumarin derivative BPRHIV001 modulates Tat function through a reduction of the p300 protein level and a concordant reduction of phosphorylated Akt PubMed
tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
tat HIV-1 Tat downregulates CREB transcription factor expression in PC12 neuronal cells through activation of a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway PubMed
tat HIV-1 Tat upregulates several anti-apoptotic genes, including AKT-1, AKT-2, BCL2, BCL-XL, and insulin-like growth factor I in vincristine-treated Kaposi's sarcoma cells PubMed
Vpr vpr HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NFKB1 (NF-kappa-B), p38delta MAPK, Akt-2 and Akt-3, and AP-1 transcription factor in HIV-1 Vpr transfected astrocytes PubMed
vpr PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of CXCL8 (IL8) in astrocytes PubMed
vpr PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) is involved in HIV-1 Vpr induced upregulation of IL6 in astrocytes PubMed
vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
vpr HIV-1 Vpr inhibits Akt-induced cytoplasmic translocation of Foxo3a, a subtype of the forkhead transcription factors PubMed
matrix gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed
gag HIV-1 p17 and its C-terminal truncated form of p17 (p17delta36) differentially regulate Akt phosphorylation by reducing and increasing phosphorylation levels of PTEN, respectively PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
cellular response to high light intensity IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
fat cell differentiation TAS
Traceable Author Statement
more info
PubMed 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
intracellular protein transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mammary gland epithelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of plasma membrane long-chain fatty acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peripheral nervous system myelin maintenance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vesicle fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
retinal rod cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
RAC-beta serine/threonine-protein kinase
Names
PKB beta
RAC-PK-beta
murine thymoma viral (v-akt) homolog-2
protein kinase Akt-2
protein kinase B beta
putative v-akt murine thymoma viral oncoprotein 2
rac protein kinase beta
v-akt murine thymoma viral oncogene homolog 2
NP_001229956.1
NP_001229957.1
NP_001317440.1
NP_001617.1
XP_011524916.1
XP_011524917.1
XP_011524918.1
XP_011524920.1
XP_011524921.1
XP_011524922.1
XP_011524924.1
XP_016881959.1
XP_024307184.1
XP_024307185.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012038.2 RefSeqGene

    Range
    5014..60042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1391

mRNA and Protein(s)

  1. NM_001243027.3NP_001229956.1  RAC-beta serine/threonine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001229956.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, contains an alternate splice site in the 5' coding region, and initiates translation at a downstream AUG. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AC118344, AK122839, AK294453, BM675176, CN351354, KC877734
    UniProtKB/TrEMBL
    B4DG79
    Conserved Domains (3) summary
    cd05595
    Location:94416
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    smart00220
    Location:90347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl17171
    Location:149
    PH-like; Pleckstrin homology-like domain
  2. NM_001243028.3NP_001229957.1  RAC-beta serine/threonine-protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001229957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate exon in the 5' coding region, and initiates translation at a downstream AUG. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AC118344, AK122839, AK308006, BM675176, CN351354, KC877734
    UniProtKB/TrEMBL
    B4DG79
    Related
    ENSP00000471369.1, ENST00000579047.5
    Conserved Domains (3) summary
    cd05595
    Location:94416
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    smart00220
    Location:90347
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl17171
    Location:149
    PH-like; Pleckstrin homology-like domain
  3. NM_001330511.1NP_001317440.1  RAC-beta serine/threonine-protein kinase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC118344, BC120995, KC877734
    Consensus CDS
    CCDS82350.1
    UniProtKB/Swiss-Prot
    P31751
    Related
    ENSP00000309428.6, ENST00000311278.10
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:156435
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001626.6NP_001617.1  RAC-beta serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC118344, AK122839, BC040028, BC120994, BM675176, KC877734
    Consensus CDS
    CCDS12552.1
    UniProtKB/Swiss-Prot
    P31751
    Related
    ENSP00000375892.2, ENST00000392038.7
    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    40230317..40285531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526620.1XP_011524922.1  RAC-beta serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011524922.1

    UniProtKB/Swiss-Prot
    P31751
    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
  2. XM_024451417.1XP_024307185.1  RAC-beta serine/threonine-protein kinase isoform X2

    Related
    ENSP00000399532.2, ENST00000424901.5
    Conserved Domains (2) summary
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cl21453
    Location:156435
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011526618.1XP_011524920.1  RAC-beta serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011524920.1

    UniProtKB/Swiss-Prot
    P31751
    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
  4. XM_017026470.2XP_016881959.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    P31751
    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
  5. XM_024451416.1XP_024307184.1  RAC-beta serine/threonine-protein kinase isoform X1

    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
  6. XM_011526614.1XP_011524916.1  RAC-beta serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011524916.1

    UniProtKB/Swiss-Prot
    P31751
    Related
    ENSP00000463262.2, ENST00000578615.6
    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
  7. XM_011526615.1XP_011524917.1  RAC-beta serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011524917.1

    UniProtKB/Swiss-Prot
    P31751
    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
  8. XM_011526619.1XP_011524921.1  RAC-beta serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011524921.1

    UniProtKB/Swiss-Prot
    P31751
    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
  9. XM_011526616.1XP_011524918.1  RAC-beta serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_011524918.1

    UniProtKB/Swiss-Prot
    P31751
    Conserved Domains (2) summary
    cd05595
    Location:156478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
  10. XM_011526622.2XP_011524924.1  RAC-beta serine/threonine-protein kinase isoform X3

    Conserved Domains (4) summary
    smart00220
    Location:152391
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01241
    Location:4111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    pfam00169
    Location:6106
    PH; PH domain
    cl21453
    Location:156391
    PKc_like; Protein Kinases, catalytic domain
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