Akt2 thymoma viral proto-oncogene 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akt2provided by MGI
Official Full Name: thymoma viral proto-oncogene 2provided by MGI
Primary source: MGI:MGI:104874
See related: Ensembl:ENSMUSG00000004056 AllianceGenome:MGI:104874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PKB; PKBbeta; 2410016A19Rik
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to insulin stimulus; intracellular protein transmembrane transport; and positive regulation of transport. Acts upstream of or within with a negative effect on protein localization to nucleus. Acts upstream of or within several processes, including activation of GTPase activity; cellular response to high light intensity; and peripheral nervous system myelin maintenance. Located in cell cortex and ruffle membrane. Is expressed in several structures, including brown fat; central nervous system; genitourinary system; retina; and spleen. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; hypoinsulinemic hypoglycemia with hemihypertrophy; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 40.3), mammary gland adult (RPKM 35.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 15.94 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (27290977..27340251)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (27591552..27640826)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.
Title: Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
Title: Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis.
Title: Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis.
AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology.
Title: AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology.
Protein Kinase B2 (PKB2/AKT2) Is Essential for Host Protection in CVB3-Induced Acute Viral Myocarditis.
Title: Protein Kinase B2 (PKB2/AKT2) Is Essential for Host Protection in CVB3-Induced Acute Viral Myocarditis.
Cardiac metallothionein overexpression rescues diabetic cardiomyopathy in Akt2-knockout mice.
Title: Cardiac metallothionein overexpression rescues diabetic cardiomyopathy in Akt2-knockout mice.
Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
Title: Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis.
Title: High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis.
AKT2 deficiency impairs formation of the BCR signalosome.
Title: AKT2 deficiency impairs formation of the BCR signalosome.
PKBbeta/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors.
Title: PKBβ/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors.

Submit: New GeneRIF Correction See all GeneRIFs (162)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94820 (e-PCR)
- UniSTS:120066

Akt2 (e-PCR), detects polymorphism
- UniSTS:532507

SGC30851 (e-PCR)
- UniSTS:8286

AW554154 (e-PCR)
- UniSTS:185701

Akt2 (e-PCR), detects polymorphism
- UniSTS:527245

AKT2 (e-PCR)
- UniSTS:277960

Akt2 (e-PCR), detects polymorphism
- UniSTS:546521

D7Mit77 (e-PCR), detects polymorphism
- UniSTS:116707

Homology

Homologs of the Akt2 gene: The Akt2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 401 organisms have orthologs with human gene Akt2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carbohydrate transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to high light intensity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within peripheral nervous system myelin maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glucose import	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase B signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal rod cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RAC-beta serine/threonine-protein kinase

Names: PKB beta; RAC-PK-beta; protein kinase Akt-2; protein kinase B, beta

NP_001103678.1

EC 2.7.11.1

NP_001318037.1

EC 2.7.11.1

NP_001318038.1

EC 2.7.11.1

NP_031460.1

EC 2.7.11.1

XP_006539544.1

EC 2.7.11.1

XP_006539545.1

EC 2.7.11.1

XP_006539546.1

EC 2.7.11.1

XP_030097857.1

EC 2.7.11.1

XP_030097858.1

EC 2.7.11.1

XP_030097859.1

EC 2.7.11.1

XP_030097860.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110208.2 → NP_001103678.1 RAC-beta serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_001103678.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.

Source sequence(s)

AK028871, AK158792, BM899551, CJ159088

Consensus CDS

CCDS21027.1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95, Q8CE74

Related

ENSMUSP00000103981.3, ENSMUST00000108344.9

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
NM_001331108.1 → NP_001318037.1 RAC-beta serine/threonine-protein kinase

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.

Source sequence(s)

AC074312, BM899551

Consensus CDS

CCDS21027.1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
NM_001331109.1 → NP_001318038.1 RAC-beta serine/threonine-protein kinase

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.

Source sequence(s)

AK028871, BC040377, BM899551

Consensus CDS

CCDS21027.1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95, Q8CE74

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
NM_007434.4 → NP_031460.1 RAC-beta serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_031460.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.

Source sequence(s)

AK028871, AK158792, BM899551, CJ152468

Consensus CDS

CCDS21027.1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95, Q8CE74

Related

ENSMUSP00000052103.6, ENSMUST00000051356.12

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

27290977..27340251

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539482.3 → XP_006539545.1 RAC-beta serine/threonine-protein kinase isoform X2

See identical proteins and their annotated locations for XP_006539545.1

Conserved Domains (2) summary

cd05595
Location:113 → 435

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cl17171
Location:4 → 68

PH-like; Pleckstrin homology-like domain
XM_030241998.1 → XP_030097858.1 RAC-beta serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
XM_030241997.2 → XP_030097857.1 RAC-beta serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
XM_006539483.2 → XP_006539546.1 RAC-beta serine/threonine-protein kinase isoform X2

See identical proteins and their annotated locations for XP_006539546.1

Conserved Domains (2) summary

cd05595
Location:113 → 435

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cl17171
Location:4 → 68

PH-like; Pleckstrin homology-like domain
XM_030241999.1 → XP_030097859.1 RAC-beta serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95

Related

ENSMUSP00000103980.2, ENSMUST00000108343.8

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
XM_006539481.5 → XP_006539544.1 RAC-beta serine/threonine-protein kinase isoform X1

See identical proteins and their annotated locations for XP_006539544.1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
XM_030242000.2 → XP_030097860.1 RAC-beta serine/threonine-protein kinase isoform X1

UniProtKB/Swiss-Prot

Q60823

UniProtKB/TrEMBL

A0A6P5PYA4, A0A8C6I7P6, Q3TY95

Related

ENSMUSP00000132141.2, ENSMUST00000167435.8

Conserved Domains (2) summary

cd05595
Location:156 → 478

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain