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EPB41 erythrocyte membrane protein band 4.1 [ Homo sapiens (human) ]

Gene ID: 2035, updated on 4-Nov-2018

Summary

Official Symbol
EPB41provided by HGNC
Official Full Name
erythrocyte membrane protein band 4.1provided by HGNC
Primary source
HGNC:HGNC:3377
See related
Ensembl:ENSG00000159023 MIM:130500; Vega:OTTHUMG00000003644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HE; EL1; 4.1R
Summary
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 9.2), lymph node (RPKM 8.5) and 25 other tissues See more
Orthologs

Genomic context

See EPB41 in Genome Data Viewer
Location:
1p35.3
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (28887091..29120046)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (29213603..29446558)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376898 Neighboring gene GATA motif-containing MPRA enhancer 282 Neighboring gene ribosomal protein L27 pseudogene 4 Neighboring gene transmembrane protein 200B Neighboring gene serine and arginine rich splicing factor 4 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Elliptocytosis 1
MedGen: C2678497 OMIM: 611804 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) (EPB41) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated erythrocyte membrane protein band 4.1 (EPB41) protein is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein C-terminus binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-terminus binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
spectrin binding TAS
Traceable Author Statement
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell cortex region IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
spectrin-associated cytoskeleton TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein 4.1
Names
EPB4.1
P4.1
band 4.1
elliptocytosis 1, RH-linked
erythrocyte surface protein band 4.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013344.1 RefSeqGene

    Range
    5001..237956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166005.1NP_001159477.1  protein 4.1 isoform 1

    See identical proteins and their annotated locations for NP_001159477.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB209649, AF156225, AI076831, BC039079, BC114450
    Consensus CDS
    CCDS53288.1
    UniProtKB/Swiss-Prot
    P11171
    UniProtKB/TrEMBL
    Q1WWM3, Q59F12
    Related
    ENSP00000345259.4, ENST00000343067.8
    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:754860
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  2. NM_001166006.1NP_001159478.1  protein 4.1 isoform 3

    See identical proteins and their annotated locations for NP_001159478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs at the 5' and 3' ends, and is missing an internal, in-frame coding exon compared to variant 1, resulting in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC039079, DA480006
    Consensus CDS
    CCDS53289.1
    UniProtKB/Swiss-Prot
    P11171
    Related
    ENSP00000362903.1, OTTHUMP00000003771, ENST00000373797.2, OTTHUMT00000010313
    Conserved Domains (6) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:653699
    SAB; SAB domain
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  3. NM_001166007.1NP_001159479.1  protein 4.1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate acceptor splice site at an exon at the 5' end, and is missing three short, internal, in-frame coding exons compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (5) compared to isoform 1.
    Source sequence(s)
    AB209649, AI076831, BC113841
    Consensus CDS
    CCDS85947.1
    UniProtKB/TrEMBL
    Q29RX4, Q59F12
    Related
    ENSP00000496326.1, ENST00000647103.1
    Conserved Domains (7) summary
    smart00295
    Location:2192
    B41; Band 4.1 homologues
    cd13184
    Location:187280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:87192
    FERM_M; FERM central domain
    pfam04382
    Location:406450
    SAB; SAB domain
    pfam05902
    Location:491597
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290332
    FA; FERM adjacent (FA)
    pfam09379
    Location:565
    FERM_N; FERM N-terminal domain
  4. NM_004437.3NP_004428.1  protein 4.1 isoform 6

    See identical proteins and their annotated locations for NP_004428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate acceptor splice site at an exon at the 5' end, and is missing several short, internal, in-frame coding exons compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (6) compared to isoform 1.
    Source sequence(s)
    AB209649, AI076831, AL138785, BC039079, M14993
    Consensus CDS
    CCDS331.1
    UniProtKB/Swiss-Prot
    P11171
    UniProtKB/TrEMBL
    Q59F12
    Related
    ENSP00000362906.3, OTTHUMP00000003772, ENST00000373800.7, OTTHUMT00000010314
    Conserved Domains (7) summary
    smart00295
    Location:2192
    B41; Band 4.1 homologues
    cd13184
    Location:187280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:87192
    FERM_M; FERM central domain
    pfam04382
    Location:425471
    SAB; SAB domain
    pfam05902
    Location:512584
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290332
    FA; FERM adjacent (FA)
    pfam09379
    Location:565
    FERM_N; FERM N-terminal domain
  5. NM_203342.2NP_976217.1  protein 4.1 isoform 4

    See identical proteins and their annotated locations for NP_976217.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an additional exon at the 5' end, and is missing an internal, in-frame coding exon compared to variant 1. This results in translation start from a downstream AUG and a shorter isoform (4) compared to isoform 1.
    Source sequence(s)
    AB209649, AI076831, AL138785, BC039079, J03796
    Consensus CDS
    CCDS332.1
    UniProtKB/Swiss-Prot
    P11171
    UniProtKB/TrEMBL
    Q59F12
    Related
    ENSP00000495565.1, OTTHUMP00000003773, ENST00000642260.1, OTTHUMT00000010315
    Conserved Domains (7) summary
    smart00295
    Location:2192
    B41; Band 4.1 homologues
    cd13184
    Location:187280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:87192
    FERM_M; FERM central domain
    pfam04382
    Location:444490
    SAB; SAB domain
    pfam05902
    Location:531637
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290332
    FA; FERM adjacent (FA)
    pfam09379
    Location:565
    FERM_N; FERM N-terminal domain
  6. NM_203343.2NP_976218.1  protein 4.1 isoform 2

    See identical proteins and their annotated locations for NP_976218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing several short, internal, in-frame coding exons compared to variant 1, resulting in a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AB209649, AI076831, J03796
    Consensus CDS
    CCDS330.1
    UniProtKB/TrEMBL
    Q59F12
    Related
    ENSP00000290100.6, OTTHUMP00000003774, ENST00000347529.7, OTTHUMT00000010316
    Conserved Domains (6) summary
    smart00295
    Location:211366
    B41; Band 4.1 homologues
    cd13184
    Location:361454
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:261366
    FERM_M; FERM central domain
    pfam04382
    Location:580624
    SAB; SAB domain
    pfam05902
    Location:665771
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:464506
    FA; FERM adjacent (FA)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    28887091..29120046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540964.1XP_011539266.1  protein 4.1 isoform X35

    Conserved Domains (7) summary
    smart00295
    Location:2192
    B41; Band 4.1 homologues
    cd13184
    Location:187280
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:87192
    FERM_M; FERM central domain
    pfam04382
    Location:458504
    SAB; SAB domain
    pfam05902
    Location:712818
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:290332
    FA; FERM adjacent (FA)
    pfam09379
    Location:565
    FERM_N; FERM N-terminal domain
  2. XM_017000595.1XP_016856084.1  protein 4.1 isoform X38

  3. XM_017000594.1XP_016856083.1  protein 4.1 isoform X37

  4. XM_017000596.1XP_016856085.1  protein 4.1 isoform X40

  5. XM_017000593.1XP_016856082.1  protein 4.1 isoform X36

  6. XM_017000597.1XP_016856086.1  protein 4.1 isoform X41

  7. XM_024453880.1XP_024309648.1  protein 4.1 isoform X39

    Conserved Domains (5) summary
    smart00295
    Location:2157
    B41; Band 4.1 homologues
    cd13184
    Location:152245
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam04382
    Location:423469
    SAB; SAB domain
    pfam05902
    Location:677783
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:255297
    FA; FERM adjacent (FA)
  8. XM_017000599.1XP_016856088.1  protein 4.1 isoform X43

  9. XM_017000598.1XP_016856087.1  protein 4.1 isoform X42

    Related
    ENSP00000496138.1, ENST00000646189.1
  10. XM_017000600.1XP_016856089.1  protein 4.1 isoform X44

    Related
    ENSP00000493575.1, ENST00000646800.1
  11. XM_017000603.1XP_016856092.1  protein 4.1 isoform X46

  12. XM_017000602.1XP_016856091.1  protein 4.1 isoform X45

    Related
    ENSP00000495138.1, ENST00000644342.1
  13. XM_017000604.1XP_016856093.1  protein 4.1 isoform X47

  14. XM_017000584.2XP_016856073.1  protein 4.1 isoform X1

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:9211027
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  15. XM_017000585.2XP_016856074.1  protein 4.1 isoform X12

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:615659
    SAB; SAB domain
    pfam05902
    Location:867973
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  16. XM_011540956.1XP_011539258.1  protein 4.1 isoform X1

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:9211027
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  17. XM_011540958.1XP_011539260.1  protein 4.1 isoform X4

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:9081014
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  18. XM_005245760.1XP_005245817.1  protein 4.1 isoform X14

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:771877
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  19. XM_006710434.1XP_006710497.1  protein 4.1 isoform X3

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:9161022
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  20. XM_006710439.1XP_006710502.1  protein 4.1 isoform X15

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:766872
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  21. XM_005245753.1XP_005245810.1  protein 4.1 isoform X6

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:9041010
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  22. XM_005245761.1XP_005245818.1  protein 4.1 isoform X16

    See identical proteins and their annotated locations for XP_005245818.1

    UniProtKB/Swiss-Prot
    P11171
    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:754860
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  23. XM_005245768.1XP_005245825.1  protein 4.1 isoform X22

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam05902
    Location:731817
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  24. XM_011540959.1XP_011539261.1  protein 4.1 isoform X5

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:653699
    SAB; SAB domain
    pfam05902
    Location:9071013
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  25. XM_005245763.1XP_005245820.1  protein 4.1 isoform X17

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:653699
    SAB; SAB domain
    pfam05902
    Location:740846
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  26. XM_011540961.1XP_011539263.1  protein 4.1 isoform X8

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:633678
    SAB; SAB domain
    pfam05902
    Location:886992
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  27. XM_017000586.1XP_016856075.1  protein 4.1 isoform X18

    Related
    ENSP00000317597.8, ENST00000349460.9
  28. XM_005245757.1XP_005245814.1  protein 4.1 isoform X11

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:633678
    SAB; SAB domain
    pfam05902
    Location:869975
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  29. XM_005245765.1XP_005245822.1  protein 4.1 isoform X20

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:633678
    SAB; SAB domain
    pfam05902
    Location:719825
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  30. XM_011540960.1XP_011539262.1  protein 4.1 isoform X7

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:634680
    SAB; SAB domain
    pfam05902
    Location:888994
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  31. XM_005245764.1XP_005245821.1  protein 4.1 isoform X19

    See identical proteins and their annotated locations for XP_005245821.1

    UniProtKB/Swiss-Prot
    P11171
    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:634680
    SAB; SAB domain
    pfam05902
    Location:721827
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  32. XM_011540962.1XP_011539264.1  protein 4.1 isoform X12

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:615659
    SAB; SAB domain
    pfam05902
    Location:867973
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  33. XM_005245769.1XP_005245826.1  protein 4.1 isoform X23

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:615659
    SAB; SAB domain
    pfam05902
    Location:700806
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  34. XM_005245774.1XP_005245831.1  protein 4.1 isoform X32

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:615659
    SAB; SAB domain
    pfam05902
    Location:677763
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  35. XM_011540957.1XP_011539259.1  protein 4.1 isoform X2

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:666712
    SAB; SAB domain
    pfam05902
    Location:9201026
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  36. XM_017000583.1XP_016856072.1  protein 4.1 isoform X13

  37. XM_005245770.1XP_005245827.1  protein 4.1 isoform X24

    Conserved Domains (7) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:614658
    SAB; SAB domain
    pfam05902
    Location:699805
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  38. XM_017000581.1XP_016856070.1  protein 4.1 isoform X9

  39. XM_017000589.1XP_016856078.1  protein 4.1 isoform X29

    UniProtKB/Swiss-Prot
    P11171
    Conserved Domains (6) summary
    smart00295
    Location:211366
    B41; Band 4.1 homologues
    cd13184
    Location:361454
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:261366
    FERM_M; FERM central domain
    pfam04382
    Location:580624
    SAB; SAB domain
    pfam05902
    Location:665771
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:464506
    FA; FERM adjacent (FA)
  40. XM_017000582.1XP_016856071.1  protein 4.1 isoform X10

  41. XM_017000590.1XP_016856079.1  protein 4.1 isoform X30

  42. XM_005245772.4XP_005245829.1  protein 4.1 isoform X25

    Related
    ENSP00000494945.1, ENST00000644600.1
    Conserved Domains (6) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  43. XM_011540963.2XP_011539265.1  protein 4.1 isoform X21

    Related
    ENSP00000498003.1, ENST00000650265.1
    Conserved Domains (6) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  44. XM_011540965.3XP_011539267.1  protein 4.1 isoform X31

    Conserved Domains (6) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  45. XM_005245773.4XP_005245830.1  protein 4.1 isoform X27

    Related
    ENSP00000494435.1, ENST00000643604.1
    Conserved Domains (6) summary
    smart00295
    Location:211401
    B41; Band 4.1 homologues
    cd13184
    Location:396489
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:296401
    FERM_M; FERM central domain
    pfam04382
    Location:667713
    SAB; SAB domain
    pfam08736
    Location:499541
    FA; FERM adjacent (FA)
    pfam09379
    Location:214274
    FERM_N; FERM N-terminal domain
  46. XM_017000591.1XP_016856080.1  protein 4.1 isoform X33

  47. XM_017000587.1XP_016856076.1  protein 4.1 isoform X26

  48. XM_017000588.1XP_016856077.1  protein 4.1 isoform X28

  49. XM_017000592.1XP_016856081.1  protein 4.1 isoform X34

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