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GRIN3B glutamate ionotropic receptor NMDA type subunit 3B [ Homo sapiens (human) ]

Gene ID: 116444, updated on 4-Jun-2020

Summary

Official Symbol
GRIN3Bprovided by HGNC
Official Full Name
glutamate ionotropic receptor NMDA type subunit 3Bprovided by HGNC
Primary source
HGNC:HGNC:16768
See related
Ensembl:ENSG00000116032 MIM:606651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NR3B; GluN3B
Summary
The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in spleen (RPKM 1.5), fat (RPKM 1.0) and 21 other tissues See more
Orthologs

Genomic context

See GRIN3B in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1000419..1009748)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1000437..1009723)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 174 Neighboring gene WD repeat domain 18 Neighboring gene uncharacterized LOC105372235 Neighboring gene transmembrane protein 259 Neighboring gene RNA, U6 small nuclear 2 Neighboring gene calponin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
env HIV-1 clade B gp120 significantly downregulates NMDA receptor gene and protein expression and levels of glutamine compared to clade C gp120 PubMed
env HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects PubMed
Tat tat HIV-1 Tat upregulates the expression of NMDARs for the apoptosis of retinal pigmen epithelium (RPE) cells. Silencing of NMDARs by siRNA abolishes Tat-induced RPE apoptosis PubMed
tat HIV-1 Tat interacts with NMDA receptors in primary neuronal-glial cultures and in hippocampal slice cultures PubMed
tat HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death PubMed
tat HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to NMDA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glycine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neurotransmitter receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
protein insertion into membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NMDA selective glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NMDA selective glutamate receptor complex NAS
Non-traceable Author Statement
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 3B
Names
N-methyl-D-aspartate receptor subtype 3B
NMDA receptor subunit 3B
NMDA type glutamate receptor subunit NR3B
NMDAR3B
glutamate [NMDA] receptor subunit 3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138690.3NP_619635.1  glutamate receptor ionotropic, NMDA 3B precursor

    See identical proteins and their annotated locations for NP_619635.1

    Status: REVIEWED

    Source sequence(s)
    AY507106, BK004079, BM977634
    Consensus CDS
    CCDS32861.1
    UniProtKB/Swiss-Prot
    O60391
    UniProtKB/TrEMBL
    Q5F0I5
    Related
    ENSP00000234389.3, ENST00000234389.3
    Conserved Domains (3) summary
    cd06377
    Location:19405
    PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
    cd13720
    Location:415808
    PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:576842
    Lig_chan; Ligand-gated ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    1000419..1009748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026243.2XP_016881732.1  glutamate receptor ionotropic, NMDA 3B isoform X1

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