Grin3b glutamate receptor, ionotropic, NMDA3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grin3bprovided by MGI
Official Full Name: glutamate receptor, ionotropic, NMDA3Bprovided by MGI
Primary source: MGI:MGI:2150393
See related: Ensembl:ENSMUSG00000035745 AllianceGenome:MGI:2150393
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR3B; GluN3B
Summary: Contributes to calcium channel activity. Involved in protein insertion into membrane; regulation of calcium ion transport; and regulation of synaptic plasticity. Located in neuronal cell body. Part of NMDA selective glutamate receptor complex. Is expressed in central nervous system; gut gland; retina; and testis. Orthologous to human GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in testis adult (RPKM 4.1), ovary adult (RPKM 2.3) and 27 other tissues See more
Orthologs: all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79806227..79813024)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79970397..79977190)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NR3B(-/-) mice showed a highly increased social interaction with their familiar cage mates in their home cage
Title: Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes.
NR3B may modulate the function of NMDA receptors in somatic motor neurons during adulthood by controlling membrane trafficking and by reducing Ca2+ permeability
Title: Specific assembly with the NMDA receptor 3B subunit controls surface expression and calcium permeability of NMDA receptors.
The major regulatory subunit of NMDA receptors is likely to switch from NR2 to NR3B in somatic motoneurons during the early postnatal period.
Title: NR2 to NR3B subunit switchover of NMDA receptors in early postnatal motoneurons.
Assembling NMDA receptor subunit NR1 with NR3A or NR3B forms glycine-gated cation channels.
Title: Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Markers

AU044733 (e-PCR)
- UniSTS:160007

Grin3b (e-PCR), detects polymorphism
- UniSTS:527371

AW122032 (e-PCR)
- UniSTS:180073

RH130604 (e-PCR)
- UniSTS:213888

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to NMDA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glycine	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of NMDA selective glutamate receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IMP Inferred from Mutant Phenotype more info	PubMed
part_of neurotransmitter receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in plasma membrane	EXP Inferred from Experiment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	EXP Inferred from Experiment more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 3B

Names: N-methyl-D-aspartate receptor subunit NR3B; NMDA receptor 4; NMDAR3B; glutamate [NMDA] receptor subunit 3B; nr4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130455.2 → NP_569722.1 glutamate receptor ionotropic, NMDA 3B precursor

See identical proteins and their annotated locations for NP_569722.1

Status: VALIDATED

Source sequence(s)

AF396649, AY062435

Consensus CDS

CCDS24001.1

UniProtKB/Swiss-Prot

Q8VHV0, Q91ZU9

Related

ENSMUSP00000048576.2, ENSMUST00000045085.8

Conserved Domains (3) summary

cd13720
Location:414 → 808

PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:576 → 842

Lig_chan; Ligand-gated ion channel

cl10011
Location:21 → 405

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79806227..79813024

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513287.5 → XP_006513350.1 glutamate receptor ionotropic, NMDA 3B isoform X1

Conserved Domains (3) summary

cd13720
Location:494 → 888

PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:656 → 922

Lig_chan; Ligand-gated ion channel

cd06377
Location:141 → 481

PBP1_iGluR_NMDA_NR3; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
XM_030244924.2 → XP_030100784.1 glutamate receptor ionotropic, NMDA 3B isoform X2

Conserved Domains (2) summary

cd13720
Location:494 → 873

PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06377
Location:141 → 481

PBP1_iGluR_NMDA_NR3; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
XM_006513289.3 → XP_006513352.1 glutamate receptor ionotropic, NMDA 3B isoform X3

Conserved Domains (3) summary

pfam00060
Location:656 → 762

Lig_chan; Ligand-gated ion channel

cd06377
Location:141 → 481

PBP1_iGluR_NMDA_NR3; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family

cl21456
Location:494 → 646

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily