A recently-discovered NMDA receptor gene, GRIN3B, is associated with duration mismatch negativity

Psychiatry Res. 2014 Aug 30;218(3):356-8. doi: 10.1016/j.psychres.2014.04.032. Epub 2014 Apr 28.

Abstract

The study explored associations between mismatch negativity and N-methyl-d-aspartic acid receptor subunit genes, GRIN1, GRIN2B and GRIN3B in healthy subjects and schizophrenia. Nineteen single-nucleotide polymorphisms were genotyped in 138 schizophrenia patients and 103 healthy subjects. Rs2240158 of GRIN3B was significantly associated with mismatch negativity in healthy subjects.

Keywords: Glutamate; Mismatch negativity; Schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide
  • Receptors, N-Methyl-D-Aspartate / genetics*
  • Reference Values
  • Schizophrenia / genetics*

Substances

  • Nerve Tissue Proteins
  • Receptors, N-Methyl-D-Aspartate