4UQ6,4UQQ,4PE5,4PE5


Conserved Protein Domain Family
Lig_chan

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pfam00060: Lig_chan (this model, PSSM-Id:278489 is obsolete and has been replaced by 395014)
Click on image for an interactive view with Cn3D
Ligand-gated ion channel
This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
Statistics
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PSSM-Id: 278489
View PSSM: pfam00060
Aligned: 48 rows
Threshold Bit Score: 183.593
Threshold Setting Gi: 74869226
Created: 10-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4UQ6_A 524 EIWMCIVFAYIGVSVVLFLVSRFSPYEWHteefedgretQSsestNEFGIFNSLWFSLGAFMQQgCDISPRSLSGRIVGG 603  Norway rat
Q9M8W7 542 SLWLASGAFFVLTGIVVWLVERSVNPEFQ----------GS----WGQQLSMMLWFGFSTIVFA-HREKLQKMSSRFLVI 606  thale cress
Q8LGN1 570 SLWLTIASFFILTGAIVWLIERHDNADFQ----------GS----CFQQIGTLLCFGFSTLVFA-HRERLQHNMSRFVVI 634  thale cress
Q9SDQ4 580 RLWCVVLVSFLVIAVVIWILEHRINEDFR----------GP----PRRQLSTMLLFSFSTLFKR-NQEDTISNLARLVMI 644  thale cress
Q53YX3 615 EMWAVTGGFFLFVGAMVWILEHRFNQEFR----------GP----PRRQLITIFWFSFSTMFFS-HRENTVSSLGRFVLI 679  thale cress
Q7XJL2 589 PMWAVTASFFVIVGAAIWILEHRINDEFR----------GP----PRRQIITILWFTFSTMFFS-HRETTVSTLGRMVLL 653  thale cress
Q8LGN0 584 DLWVTTACFFVFIGFIVWILEHRVNTDFR----------GP----PHHQIGTSFWFAFSTMNFA-HREKVVSNLARFVVL 648  thale cress
O81078 568 ELWVTTGCFFVFIGFVVWLFEHRVNTDFR----------GP----PQYQIGTSLWFSFSTMVFA-HRENVVSNLARFVVV 632  thale cress
Q9C5V5 579 DLWVTTACFFVLIGFVVWLFEHRVNTDFR----------GP----PHHQIGTSFWFSFSTMVFA-HREKVVSNLARFVVV 643  thale cress
O04660 576 ALWLISLLSFFIIGLVVWVLEHRVNPDFD----------GP----GQYQLSTIFWFSFSIMVFA-PRERVLSFWARVVVI 640  thale cress
4UQ6_A 604 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS-KQTEIAYGTLDSGSTKEFFRRskIAVFDKMWTYMrSAEPSVF 682  Norway rat
Q9M8W7 607 VWVFVVLILTSSYSANLTSTKTISRMQ---------------LNHQMVFGGSTTSMTAK------------------LGS 653  thale cress
Q8LGN1 635 VWIFAVLILTSNYTATLTSVMTVQQIRG-LKSNEN---------IGFFSASIAANVVND--NPTFQ--------GPRYKG 694  thale cress
Q9SDQ4 645 VWLFLLMVLTASYTANLTSILTVQQLPSAITGIDSLRaSEVP--IGYQAGTFTLEYLTY-------SLGMARsRLVPLDS 715  thale cress
Q53YX3 680 IWLFVVLIINSSYTASLTSILTIRQLTSRIEGIDSLVtSNEP--IGVQDGTFARNYLIN-------ELNILPsRIVPLKD 750  thale cress
Q7XJL2 654 IWLFVVLIITSSYTASLTSILTVQQLNSPIKGVDTLIsSTGR--IGFQVGSFAENYMTD-------ELNIASsRLVPLAS 724  thale cress
Q8LGN0 649 VWCFVVLVLIQSYTANLTSFFTVKLLQPTVTNWKDLIkFNKN--IGYQRGTFVRELLKS-------QGFDES-QLKPFGS 718  thale cress
O81078 633 VWCFVVLVLTQSYTASLTSFLTVQSLQPTVTNVNDLIkNRDC--VGYQGGAFVKDILLG-------LGFHED-QLKPFDS 702  thale cress
Q9C5V5 644 VWCFVVLVLTQSYTANLTSFLTVQRFQPAAINVKDLIkNGDY--VGYQHGAFVKDFLIK-------EGFNVS-KLKPFGS 713  thale cress
O04660 641 IWYFLVLVLTQSYTASLASLLTTQHLHPTVTNINSLLaKGES--VGYQ-SSFILGRLRD-------SGFSEA-SLVSYGS 709  thale cress
4UQ6_A 683 VRTTAEGVARVRksKGK-YAYLLESTMNEYIEQRKpCD-TMKVGGNLDSKGYGIATPKGSSLGNPVNLAVLKLNEQGLLD 760  Norway rat
Q9M8W7 654 INAVEAYAQLLR--DGTlNHVINEIPYLSILIGNYpND-FVMTDRVTNTNGFGFMFQKGSDLVPKVSREIAKLRSLGMLK 730  thale cress
Q8LGN1 695 LKTADDFTNALR--NGTiSFIVDEVPYVKLFVAKHpSE-FVIVETESVTNGFGFAFQKGSPLVQKVSREIEKLRRTEKLK 771  thale cress
Q9SDQ4 716 TEEYEKALKLGPtnWGGvAAIVDELPYIELFLAER-TG-FKIVGEPFMHRGWGFAFKRDSPLAIDMSTAILKLSETRKLQ 793  thale cress
Q53YX3 751 EEQYLSALQRGPnaGGV-AAIVDELPYIEVLLTNSnCK-FRTVGQEFTRTGWGFAFQRDSPLAVDMSTAILQLSEEGELE 828  thale cress
Q7XJL2 725 PEEYANALQ-----NGTvAAIVDERPYIDLFLSDY-CK-FAIRGQEFTRCGWGFAFPRDSPLAVDMSTAILGLSETGELQ 797  thale cress
Q8LGN0 719 AVECDELFS-----NGTiTASFDEVAYIKVILSQN-SSkYTMVEPSFKTAGFGFVFPKKSPLTDDVSRAILNVTQGEEMQ 792  thale cress
O81078 703 AKDADDLLSKGKs-KGI-AAAFDEVAYLKAILSQS-CSkYVMVEPTFKTGGFGFAFPKNSPLTGEFSRAILNLTQNNVTQ 779  thale cress
Q9C5V5 714 SEECHALLS-----NGSiSAAFDEVAYLRAILSQY-CSkYAIVEPTFKTAGFGFAFPRNSPLTGDVSKAILNVTQGDEMQ 787  thale cress
O04660 710 PEHCDALLSKGQaeGGV-SAVLMEVPYVRIFLGQY-CNkYKMVQTPFKVDGLGFVFPIGSPLVADISRAILKVEESNKAN 787  thale cress
4UQ6_A 761 KLKNKW--WYDKg----eCGAKDSGSKEktSa------LSLSNVAGVFYILVGGL 803  Norway rat
Q9M8W7 731 DMEKKW--FQKLdslnvhSNTEEVASTN--DddeaskrFTFRELRGLFIIAGAAH 781  thale cress
Q8LGN1 772 AIENWW--FQRQ---------TTSATSE--Dtf---hpLTVYTFRGLFMITGVSF 810  thale cress
Q9SDQ4 794 EIRKKW--LCKTn-----CAGKSNWNPE--Pn-----qLHLKSFKGLYLVC-IAI 833  thale cress
Q53YX3 829 KIHRKWlnYKHE------CSMQISNSED--Sq------LSLKSFWGLFLICGITC 869  thale cress
Q7XJL2 798 KIHDRW--LSKSn-----CSSPHGSQSG--Dse----qLNVHSFWGMFLVVGIAC 839  thale cress
Q8LGN0 793 HIENKW--FKKPn----nCPDLNTSLSS--Nh------LSLSSFWGLFLIAGIAS 833  thale cress
O81078 780 QIEDRW--FPKKn----dCPDPMTALSS--Nr------LNLSSFLGLFLIAGTAI 820  thale cress
Q9C5V5 788 HIENKW--FMKQn----dCPDPKTALSS--Nr------LSLRSFWGLFLIAGIAS 828  thale cress
O04660 788 QLENAW--FKPIde---sCPDPLTNPDP--NpsvsfrqLGFDSFWVLFLVAAIVC 835  thale cress
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