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CIT citron rho-interacting serine/threonine kinase [ Homo sapiens (human) ]

Gene ID: 11113, updated on 4-Nov-2018

Summary

Official Symbol
CITprovided by HGNC
Official Full Name
citron rho-interacting serine/threonine kinaseprovided by HGNC
Primary source
HGNC:HGNC:1985
See related
Ensembl:ENSG00000122966 MIM:605629; Vega:OTTHUMG00000134325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CITK; CRIK; STK21; MCPH17
Summary
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in brain (RPKM 9.1), testis (RPKM 3.2) and 18 other tissues See more
Orthologs

Genomic context

See CIT in Genome Data Viewer
Location:
12q24.23
Exon count:
50
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (119685790..119877318, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120123595..120315095, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370027 Neighboring gene GATA motif-containing MPRA enhancer 88 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 1 Neighboring gene microRNA 1178 Neighboring gene uncharacterized LOC112268087 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene BICD family like cargo adaptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication is enhanced by CIT expression, which is dependent on NEDD4L expression as shown through siRNA knockdown of NEDD4L PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag polyubiquitination is enhanced by CIT (citron kinase) PubMed
gag HIV-1 Gag interacts with the zinc finger, RhoA-binding, and leucine zipper domains of CIT (citron kinase) in HEK293T cells PubMed
gag Ectopic expression of citron kinase leads to the formation of cytoplasmic structures containing citron kinase and HIV-1 Gag proteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases activate CIT, organism-specific biosystem (from REACTOME)
    RHO GTPases activate CIT, organism-specific biosystemCitron kinase (CIT) or citron RHO-interacting kinase (CRIK) shares similarities with ROCK kinases. Like ROCK, it consists of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding doma...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
Rho GTPase binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
scaffold protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Golgi organization IEA
Inferred from Electronic Annotation
more info
 
generation of neurons ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of actin polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi cisterna IEA
Inferred from Electronic Annotation
more info
 
cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
midbody IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
citron Rho-interacting kinase
Names
citron (rho-interacting, serine/threonine kinase 21)
serine/threonine kinase 21
serine/threonine-protein kinase 21
NP_001193928.1
NP_009105.1
XP_006719269.1
XP_011536085.1
XP_011536086.1
XP_011536087.1
XP_011536089.1
XP_011536090.1
XP_011536091.1
XP_011536092.1
XP_011536093.1
XP_011536094.1
XP_016874224.1
XP_016874225.1
XP_016874226.1
XP_016874227.1
XP_016874228.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029792.1 RefSeqGene

    Range
    5001..196501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206999.1NP_001193928.1  citron Rho-interacting kinase isoform 1

    See identical proteins and their annotated locations for NP_001193928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY257469, AY681966
    Consensus CDS
    CCDS55891.1
    UniProtKB/Swiss-Prot
    O14578
    Related
    ENSP00000376306.2, OTTHUMP00000239872, ENST00000392521.6, OTTHUMT00000401847
    Conserved Domains (6) summary
    smart00036
    Location:16351931
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:4741335
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:14051453
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:14861605
    PH; PH domain
  2. NM_007174.2NP_009105.1  citron Rho-interacting kinase isoform 2

    See identical proteins and their annotated locations for NP_009105.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AY257469, AY681966
    Consensus CDS
    CCDS9192.1
    UniProtKB/Swiss-Prot
    O14578
    Related
    ENSP00000261833.7, OTTHUMP00000166060, ENST00000261833.11, OTTHUMT00000259410
    Conserved Domains (7) summary
    smart00036
    Location:15931889
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:558844
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG4942
    Location:10831365
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:13631411
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:14441563
    PH; PH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    119685790..119877318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537788.1XP_011536090.1  citron Rho-interacting kinase isoform X9

    Conserved Domains (7) summary
    smart00036
    Location:15781874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:558844
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG4942
    Location:10831350
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:13481396
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:14291548
    PH; PH domain
  2. XM_011537787.1XP_011536089.1  citron Rho-interacting kinase isoform X8

    See identical proteins and their annotated locations for XP_011536089.1

    Conserved Domains (7) summary
    smart00036
    Location:15781874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:558844
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG4942
    Location:10831350
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:13481396
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:14291548
    PH; PH domain
  3. XM_017018737.1XP_016874226.1  citron Rho-interacting kinase isoform X7

  4. XM_006719206.2XP_006719269.1  citron Rho-interacting kinase isoform X6

    Conserved Domains (6) summary
    smart00036
    Location:16201916
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:4741320
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:13901438
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:14711590
    PH; PH domain
  5. XM_017018736.1XP_016874225.1  citron Rho-interacting kinase isoform X5

  6. XM_011537785.1XP_011536087.1  citron Rho-interacting kinase isoform X3

    Conserved Domains (6) summary
    smart00036
    Location:16351931
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:4741320
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:13901438
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:14711590
    PH; PH domain
  7. XM_017018735.1XP_016874224.1  citron Rho-interacting kinase isoform X4

  8. XM_011537784.1XP_011536086.1  citron Rho-interacting kinase isoform X2

    Conserved Domains (6) summary
    smart00036
    Location:16501946
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:14051453
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:14861605
    PH; PH domain
    pfam09730
    Location:4831110
    BicD; Microtubule-associated protein Bicaudal-D
  9. XM_011537783.1XP_011536085.1  citron Rho-interacting kinase isoform X1

    Conserved Domains (6) summary
    smart00036
    Location:16501946
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:4741335
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:14051453
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:14861605
    PH; PH domain
  10. XM_011537790.2XP_011536092.1  citron Rho-interacting kinase isoform X10

    See identical proteins and their annotated locations for XP_011536092.1

    Conserved Domains (9) summary
    smart00036
    Location:12041500
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:10401159
    PH; Pleckstrin homology domain
    COG4942
    Location:679961
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:2641
    PRK03918; chromosome segregation protein; Provisional
    cd00029
    Location:9591007
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:10401159
    PH; PH domain
    pfam00836
    Location:231319
    Stathmin; Stathmin family
    pfam09311
    Location:462743
    Rab5-bind; Rabaptin-like protein
    cl00788
    Location:188253
    MttA_Hcf106; mttA/Hcf106 family
  11. XM_011537789.1XP_011536091.1  citron Rho-interacting kinase isoform X10

    See identical proteins and their annotated locations for XP_011536091.1

    Conserved Domains (9) summary
    smart00036
    Location:12041500
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:10401159
    PH; Pleckstrin homology domain
    COG4942
    Location:679961
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:2641
    PRK03918; chromosome segregation protein; Provisional
    cd00029
    Location:9591007
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:10401159
    PH; PH domain
    pfam00836
    Location:231319
    Stathmin; Stathmin family
    pfam09311
    Location:462743
    Rab5-bind; Rabaptin-like protein
    cl00788
    Location:188253
    MttA_Hcf106; mttA/Hcf106 family
  12. XM_011537792.2XP_011536094.1  citron Rho-interacting kinase isoform X13

    See identical proteins and their annotated locations for XP_011536094.1

    Conserved Domains (8) summary
    smart00036
    Location:11121408
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:9631082
    PH; Pleckstrin homology domain
    COG1340
    Location:92378
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG4942
    Location:617884
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:882930
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:9631082
    PH; PH domain
    pfam09311
    Location:400681
    Rab5-bind; Rabaptin-like protein
    cl00788
    Location:168243
    MttA_Hcf106; mttA/Hcf106 family
  13. XM_017018739.1XP_016874228.1  citron Rho-interacting kinase isoform X13

    Related
    ENSP00000376305.2, OTTHUMP00000239873, ENST00000392520.2, OTTHUMT00000401848
    Conserved Domains (8) summary
    smart00036
    Location:11121408
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:9631082
    PH; Pleckstrin homology domain
    COG1340
    Location:92378
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG4942
    Location:617884
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:882930
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:9631082
    PH; PH domain
    pfam09311
    Location:400681
    Rab5-bind; Rabaptin-like protein
    cl00788
    Location:168243
    MttA_Hcf106; mttA/Hcf106 family
  14. XM_011537791.2XP_011536093.1  citron Rho-interacting kinase isoform X11

    Conserved Domains (9) summary
    smart00036
    Location:11841480
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:10201139
    PH; Pleckstrin homology domain
    COG4942
    Location:659941
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:12578
    PRK03918; chromosome segregation protein; Provisional
    cd00029
    Location:939987
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:10201139
    PH; PH domain
    pfam00836
    Location:211299
    Stathmin; Stathmin family
    pfam09311
    Location:442723
    Rab5-bind; Rabaptin-like protein
    cl00788
    Location:168233
    MttA_Hcf106; mttA/Hcf106 family
  15. XM_017018738.1XP_016874227.1  citron Rho-interacting kinase isoform X12

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