1X05,3NSU,3BJI,1QQG,1V89,1U2B,1U5D,1WJM,1PLS,1U5F,3FEH,1PMS,2DN6,1P6S,3PSC,1V5U,1DRO,1WI1,3HK0,1RJ2,2D9Z,1B55,2ROV,1V5M,1KI1,2DTC,1DYN


Conserved Protein Domain Family
PH

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smart00233: PH 
Click on image for an interactive view with Cn3D
Pleckstrin homology domain.
Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.
Statistics
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PSSM-Id: 214574
View PSSM: smart00233
Aligned: 336 rows
Threshold Bit Score: 30.5945
Threshold Setting Gi: 193209463
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1X05_A         18 IIKQGCLLKQG-H-------------------------------------RRKNWKVRKFILRE-DpaYLHYYDpagAE- 57   human
AAM97343       20 YDLSGTATVCY----------------------------------------KSKTYSAKILLHG-N--VLCVEEsggAvt 56   nematode
XP_713060     480 TGKQGPVHIGGtAkaqgwrvgh--------------------fkvndlkgIYERRVEKWMLVRN-S--YITYVSdinSTt 536  Candida albic...
EDN64742       14 ILIASNLIKKPsTsqnktptaqsssgnngaadgapqgyhhhhhhhrhlwwPRTTDHQYWCVLRK-N--QFAYYKtrdERe 90   Saccharomyces...
NP_001129699  310 PTASGALRVQQaG-------------------------------------ELQNGTLVHGVLKGtN--LFCYWRsedADt 350  house mouse
NP_012956     496 QGKQGYLVIRStAkaqgwrvsh--------------------fgkhafkdMIDRHTTKWFLVRN-S--YLTYVSdls--- 549  Saccharomyces...
XP_508625     441 PDRAGSLELRG------------------------------------------FKNKLYVAVVG-D--KVQLYKnleEy- 474  chimpanzee
NP_594936     682 YIKQGILKFQSkEshk--------------------------------frKKEVWSTVLAVLQR-D--VFTLYNlntPNl 726  Schizosacchar...
EEU06208      716 LVLSGTVYKKRd--------------------------------------LWLDPTPVYIALLD-N--CLLITEeisKGe 754  Saccharomyces...
EDV08524      239 VKMSGNLNIRTk---------------------------------------LIRSTRYWCVLKN-H--LFSMYTsstEl- 275  Saccharomyces...
1X05_A         58 ---------DPLGAIHLRGC-VVTSVESNsng------------------------------------------------ 79   human
AAM97343       57 --------sACVPLIFLLER-VVLKKLEEns------------------------------------------------- 78   nematode
XP_713060     537 pld--vflvDSDFKISARNL-EIANRDDDdslfdnssvaq---------------------------------------q 574  Candida albic...
EDN64742       91 a-------iSVIPRFDILNF-KISELD----------------------------------------------------- 109  Saccharomyces...
NP_001129699  351 g-------qEPLFTIVINKEtRVRAGELEq-------------------------------------------------- 373  house mouse
NP_012956     550 -------stTPLDVFLIDWKfKVRFSGNKnnildneneinwiihdpnleindelee------fgiendannildkngksk 616  Saccharomyces...
XP_508625     475 --------hLGIGITFIDMS-VGNVKEV---------------------------------------------------- 493  chimpanzee
NP_594936     727 sydpkdldiSKVGKPVIKTT-IIASLAKPfpssed--------------------------------------------- 760  Schizosacchar...
EEU06208      755 tq----kykLIERPIPIDYL-SLEKRKIPgtskqplrnysqkehkspmhnfstpinsmrpllkssgnhmstaygdrktsn 829  Saccharomyces...
EDV08524      276 --------yFPVLTIDLREVqKIETQKHTln------------------------------------------------- 298  Saccharomyces...
1X05_A         80 ------rksEEENLFEIITADE-----VHYFLQAA-------TPKERTEWIKAIQMASR 120  human
AAM97343       79 --------dTAKFTFLLTFTDPa----ENLEISVE-------SEELREQWMIKLATCSH 118  nematode
XP_713060     575 qmhenenkfFPHLKITLENRER------KLVMSPK-------SQREHSLWIDSLRTMQN 620  Candida albicans SC5314
EDN64742      110 ------------GILTVYTPSK------DLIFKFPrgqnekvGMELMHNWKIALEKFLS 150  Saccharomyces cerevisiae YJM789
NP_001129699  374 ---------APEWPFTLSISNKygddeVTNTLQLE-------SREALQNWMEALWQLFF 416  house mouse
NP_012956     617 thqkksnisSKLLLLTLENSER------KLKIICK-------SESSLKQWMSSIIKMST 662  Saccharomyces cerevisiae S288c
XP_508625     494 ----------DRRSFDLTTPYR------IFSFSAD-------SELEKEQWLEAMQGAIA 529  chimpanzee
NP_594936     761 ---avvlksTNSLYFDLETSSQ-----LKLRFAGP-------SPKDAQGWIDALNYWAA 804  Schizosaccharomyces pombe 972h-
EEU06208      830 teisnanpnTDEFSFKIRNTATg----ESFKFFTE-------SAEVLNQWIDAIMESFK 877  Saccharomyces cerevisiae JAY291
EDV08524      299 --------gSATKTFKLYTDES------TFKFNAD-------SEFSAKSWVNALKKEQF 336  Saccharomyces cerevisiae RM11-1a
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