1X05,3NSU,3BJI,1QQG,1V89,1U2B,1U5D,1WJM,1PLS,1U5F,3FEH,1PMS,2DN6,1P6S,3PSC,1V5U,1DRO,1WI1,3HK0,1RJ2,2D9Z,1B55,2ROV,1V5M,1KI1,2DTC,1DYN


Conserved Protein Domain Family
PH

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smart00233: PH 
Click on image for an interactive view with Cn3D
Pleckstrin homology domain.
Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.
Statistics
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PSSM-Id: 214574
View PSSM: smart00233
Aligned: 336 rows
Threshold Bit Score: 29.4389
Threshold Setting Gi: 17507011
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1X05_A         18 IIKQGCLLKQG-H-------------------------------------RRKNWKVRKFILRE-DpaYLHYYDpagAE- 57
gi 22476893    20 YDLSGTATVCY----------------------------------------KSKTYSAKILLHG-N--VLCVEEsggAvt 56
gi 68486087   480 TGKQGPVHIGGtAkaqgwrvgh--------------------fkvndlkgIYERRVEKWMLVRN-S--YITYVSdinSTt 536
gi 151946520   14 ILIASNLIKKPsTsqnktptaqsssgnngaadgapqgyhhhhhhhrhlwwPRTTDHQYWCVLRK-N--QFAYYKtrdERe 90
gi 209977095  310 PTASGALRVQQaG-------------------------------------ELQNGTLVHGVLKGtN--LFCYWRsedADt 350
gi 6322883    496 QGKQGYLVIRStAkaqgwrvsh--------------------fgkhafkdMIDRHTTKWFLVRN-S--YLTYVSdls--- 549
gi 332837406  441 PDRAGSLELRG------------------------------------------FKNKLYVAVVG-D--KVQLYKnleEy- 474
gi 19115848   682 YIKQGILKFQSkEshk--------------------------------frKKEVWSTVLAVLQR-D--VFTLYNlntPNl 726
gi 256271113  716 LVLSGTVYKKRd--------------------------------------LWLDPTPVYIALLD-N--CLLITEeisKGe 754
gi 190405257  239 VKMSGNLNIRTk---------------------------------------LIRSTRYWCVLKN-H--LFSMYTsstEl- 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1X05_A         58 ---------DPLGAIHLRGC-VVTSVESNsng------------------------------------------------ 79
gi 22476893    57 --------sACVPLIFLLER-VVLKKLEEns------------------------------------------------- 78
gi 68486087   537 pld--vflvDSDFKISARNL-EIANRDDDdslfdnssvaq---------------------------------------q 574
gi 151946520   91 a-------iSVIPRFDILNF-KISELD----------------------------------------------------- 109
gi 209977095  351 g-------qEPLFTIVINKEtRVRAGELEq-------------------------------------------------- 373
gi 6322883    550 -------stTPLDVFLIDWKfKVRFSGNKnnildneneinwiihdpnleindelee------fgiendannildkngksk 616
gi 332837406  475 --------hLGIGITFIDMS-VGNVKEV---------------------------------------------------- 493
gi 19115848   727 sydpkdldiSKVGKPVIKTT-IIASLAKPfpssed--------------------------------------------- 760
gi 256271113  755 tq----kykLIERPIPIDYL-SLEKRKIPgtskqplrnysqkehkspmhnfstpinsmrpllkssgnhmstaygdrktsn 829
gi 190405257  276 --------yFPVLTIDLREVqKIETQKHTln------------------------------------------------- 298
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
1X05_A         80 ------rksEEENLFEIITADE-----VHYFLQAA-------TPKERTEWIKAIQMASR 120
gi 22476893    79 --------dTAKFTFLLTFTDPa----ENLEISVE-------SEELREQWMIKLATCSH 118
gi 68486087   575 qmhenenkfFPHLKITLENRER------KLVMSPK-------SQREHSLWIDSLRTMQN 620
gi 151946520  110 ------------GILTVYTPSK------DLIFKFPrgqnekvGMELMHNWKIALEKFLS 150
gi 209977095  374 ---------APEWPFTLSISNKygddeVTNTLQLE-------SREALQNWMEALWQLFF 416
gi 6322883    617 thqkksnisSKLLLLTLENSER------KLKIICK-------SESSLKQWMSSIIKMST 662
gi 332837406  494 ----------DRRSFDLTTPYR------IFSFSAD-------SELEKEQWLEAMQGAIA 529
gi 19115848   761 ---avvlksTNSLYFDLETSSQ-----LKLRFAGP-------SPKDAQGWIDALNYWAA 804
gi 256271113  830 teisnanpnTDEFSFKIRNTATg----ESFKFFTE-------SAEVLNQWIDAIMESFK 877
gi 190405257  299 --------gSATKTFKLYTDES------TFKFNAD-------SEFSAKSWVNALKKEQF 336
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