EHMT2 euchromatic histone lysine methyltransferase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EHMT2provided by HGNC
Official Full Name: euchromatic histone lysine methyltransferase 2provided by HGNC
Primary source: HGNC:HGNC:14129
See related: Ensembl:ENSG00000204371 MIM:604599; AllianceGenome:HGNC:14129
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: G9A; BAT8; GAT8; NG36; KMT1C; C6orf30
Summary: This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression: Ubiquitous expression in ovary (RPKM 14.8), testis (RPKM 14.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.33

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (31879759..31897698, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (31732994..31750940, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (31847536..31865475, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
Title: Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer.
Inhibition of the Tumor Suppressor Gene SPINK5 via EHMT2 Induces the Oral Squamous Cell Carcinoma Development.
Title: Inhibition of the Tumor Suppressor Gene SPINK5 via EHMT2 Induces the Oral Squamous Cell Carcinoma Development.
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
Title: Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease.
Title: G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer's Disease.
Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma.
Title: Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma.
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-kappaB signaling in keratinocyte.
Title: Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.
G9a and DNMT1 inhibition modulates CDKN1A promoter methylation and the cell cycle leading to improvement in kidney fibrosis.
Title: G9a and DNMT1 inhibition modulates CDKN1A promoter methylation and the cell cycle leading to improvement in kidney fibrosis.
Euchromatic histone lysine methyltransferase 2 facilitates radioresistance in prostate cancer by repressing endoplasmic reticulum protein 29 transcription.
Title: Euchromatic histone lysine methyltransferase 2 facilitates radioresistance in prostate cancer by repressing endoplasmic reticulum protein 29 transcription.
Low G9a expression is a tumor progression factor of colorectal cancer via IL-8 promotion.
Title: Low G9a expression is a tumor progression factor of colorectal cancer via IL-8 promotion.
EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS (G12D) tumor development and propagation.
Title: EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS (G12D) tumor development and propagation.

Submit: New GeneRIF Correction See all GeneRIFs (157)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). EBI GWAS Catalog EBI GWAS CatalogPubMed
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. EBI GWAS Catalog EBI GWAS CatalogPubMed
The genetic architecture of economic and political preferences. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Tat	tat	Histone H3 Lysine9 (H3K9) methyltransferase G9a significantly inhibits basal and the TNF-alpha- or HIV-1 Tat- induced HIV-1 gene expression for the maintenance of HIV-1 latency	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46780 (e-PCR)
- UniSTS:22049

WI-19170 (e-PCR)
- UniSTS:22050

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

NoName (e-PCR)
- UniSTS:237636

D15S948E (e-PCR)
- UniSTS:153949

D11S3114 (e-PCR)
- UniSTS:152207

D6S2052 (e-PCR)
- UniSTS:37014

STS-X69838 (e-PCR)
- UniSTS:23983

L17971 (e-PCR)
- UniSTS:43966

ksks210 (e-PCR)
- UniSTS:514243

MARC_12895-12896:999881472:3 (e-PCR)
- UniSTS:267471

RH70238 (e-PCR)
- UniSTS:16894

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	IEA Inferred from Electronic Annotation more info
enables C2H2 zinc finger domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables H1-4K26 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables histone H3 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K56 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K9 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K9 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K9 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-lysine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-lysine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA methylation-dependent constitutive heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in DNA methylation-dependent constitutive heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within behavioral response to cocaine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to cocaine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome condensation	IDA Inferred from Direct Assay more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within germ cell development	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of autophagosome assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression via chromosomal CpG island methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organ growth	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine dimethylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phenotypic switching	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatid development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptonemal complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase EHMT2

Names: G9A histone methyltransferase; H3-K9-HMTase 3; HLA-B associated transcript 8; ankyrin repeat-containing protein; euchromatic histone-lysine N-methyltransferase 2; histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase, H3 lysine-9 specific 3; lysine N-methyltransferase 1C

NP_001276342.1

EC 2.1.1.367

Length

1176

XP_006715037.2

EC 2.1.1.367

XP_006715038.2

EC 2.1.1.367

XP_054184418.1

EC 2.1.1.367

XP_054184419.1

EC 2.1.1.367

XP_054185699.1

EC 2.1.1.367

XP_054185700.1

EC 2.1.1.367

XP_054186196.1

EC 2.1.1.367

XP_054186197.1

EC 2.1.1.367

XP_054186734.1

EC 2.1.1.367

XP_054186735.1

EC 2.1.1.367

XP_054186968.1

EC 2.1.1.367

XP_054186969.1

EC 2.1.1.367

XP_054210059.1

EC 2.1.1.367

XP_054210060.1

EC 2.1.1.367

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289413.2 → NP_001276342.1 histone-lysine N-methyltransferase EHMT2 isoform c

Status: REVIEWED

Source sequence(s)

AL671762

Consensus CDS

CCDS75425.1

UniProtKB/TrEMBL

A0A0G2JIR1, A2ABF8, B7Z852

Related

ENSP00000364678.4, ENST00000375528.8

Conserved Domains (7) summary

smart00468
Location:946 → 1045

PreSET; N-terminal to some SET domains

smart00317
Location:1061 → 1183

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:709 → 828

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:745 → 838

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:808 → 838

ANK; ANK repeat [structural motif]

cl02529
Location:677 → 728

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cl09938
Location:46 → 139

cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
NM_001318833.2 → NP_001305762.1 histone-lysine N-methyltransferase EHMT2 isoform d

Status: REVIEWED

Source sequence(s)

AL671762

UniProtKB/TrEMBL

Q59FM7

Related

ENST00000480912.5

Conserved Domains (7) summary

smart00468
Location:721 → 820

PreSET; N-terminal to some SET domains

smart00317
Location:836 → 958

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:477 → 596

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:513 → 606

Ank_2; Ankyrin repeats (3 copies)

pfam13857
Location:635 → 688

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:477 → 506

ANK; ANK repeat [structural motif]

cl02529
Location:445 → 496

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
NM_001363689.2 → NP_001350618.1 histone-lysine N-methyltransferase EHMT2 isoform e

Status: REVIEWED

Source sequence(s)

AL671762

Consensus CDS

CCDS87384.1

UniProtKB/TrEMBL

A0A0G2JK64, A2ABF9

Related

ENSP00000379078.3, ENST00000395728.7

Conserved Domains (7) summary

smart00468
Location:980 → 1079

PreSET; N-terminal to some SET domains

smart00317
Location:1095 → 1217

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:743 → 862

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:842 → 872

ANK; ANK repeat [structural motif]

pfam12796
Location:711 → 772

Ank_2; Ankyrin repeats (3 copies)

cl26464
Location:5 → 261

Atrophin-1; Atrophin-1 family

cl27511
Location:275 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001395160.1 → NP_001382089.1 histone-lysine N-methyltransferase EHMT2 isoform f

Status: REVIEWED

Source sequence(s)

AL671762

UniProtKB/TrEMBL

A0A1U9X7P8

Related

ENSP00000562754.1, ENST00000892695.1

Conserved Domains (7) summary

PHA03247
Location:42 → 204

PHA03247; large tegument protein UL36; Provisional

COG0666
Location:623 → 819

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

TIGR00927
Location:218 → 326

2A1904; K+-dependent Na+/Ca+ exchanger

sd00045
Location:686 → 715

ANK; ANK repeat [structural motif]

cd10533
Location:955 → 1193

SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins

pfam12796
Location:722 → 815

Ank_2; Ankyrin repeats (3 copies)

cd20905
Location:420 → 549

EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
NM_001395161.1 → NP_001382090.1 histone-lysine N-methyltransferase EHMT2 isoform g

Status: REVIEWED

Source sequence(s)

AL671762

UniProtKB/TrEMBL

A0A0G2JIS2

Conserved Domains (5) summary

PHA03247
Location:42 → 204

PHA03247; large tegument protein UL36; Provisional

TIGR00927
Location:218 → 326

2A1904; K+-dependent Na+/Ca+ exchanger

sd00045
Location:764 → 794

ANK; ANK repeat [structural motif]

cd10533
Location:927 → 1165

SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins

cl39094
Location:620 → 855

Ank_2; Ankyrin repeats (3 copies)
NM_001395162.1 → NP_001382091.1 histone-lysine N-methyltransferase EHMT2 isoform h

Status: REVIEWED

Source sequence(s)

AL671762

UniProtKB/TrEMBL

A0A1U9X7P8

Conserved Domains (6) summary

PLN03192
Location:828 → 889

PLN03192; Voltage-dependent potassium channel; Provisional

PHA03247
Location:42 → 204

PHA03247; large tegument protein UL36; Provisional

COG0666
Location:623 → 821

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

TIGR00927
Location:218 → 326

2A1904; K+-dependent Na+/Ca+ exchanger

sd00045
Location:785 → 815

ANK; ANK repeat [structural motif]

cl40432
Location:948 → 1160

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
NM_001395163.1 → NP_001382092.1 histone-lysine N-methyltransferase EHMT2 isoform i

Status: REVIEWED

Source sequence(s)

AL671762

UniProtKB/TrEMBL

A0A0G2JIS2

Related

ENSP00000562756.1, ENST00000892697.1

Conserved Domains (7) summary

PHA03247
Location:42 → 204

PHA03247; large tegument protein UL36; Provisional

COG0666
Location:589 → 785

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

TIGR00927
Location:218 → 326

2A1904; K+-dependent Na+/Ca+ exchanger

sd00045
Location:652 → 681

ANK; ANK repeat [structural motif]

cd10533
Location:921 → 1159

SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins

pfam12796
Location:688 → 781

Ank_2; Ankyrin repeats (3 copies)

cd20905
Location:386 → 515

EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
NM_001395164.1 → NP_001382093.1 histone-lysine N-methyltransferase EHMT2 isoform j

Status: REVIEWED

Source sequence(s)

AL671762

UniProtKB/TrEMBL

A0A1U9X7P8

Related

ENSP00000562755.1, ENST00000892696.1

Conserved Domains (5) summary

PHA03247
Location:42 → 204

PHA03247; large tegument protein UL36; Provisional

COG0666
Location:661 → 847

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

TIGR00927
Location:218 → 326

2A1904; K+-dependent Na+/Ca+ exchanger

sd00045
Location:686 → 715

ANK; ANK repeat [structural motif]

cd10533
Location:913 → 1151

SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
NM_001395165.1 → NP_001382094.1 histone-lysine N-methyltransferase EHMT2 isoform k

Status: REVIEWED

Source sequence(s)

AL671762

UniProtKB/TrEMBL

A0A0G2JIS2

Conserved Domains (5) summary

PLN03192
Location:742 → 803

PLN03192; Voltage-dependent potassium channel; Provisional

PHA03247
Location:42 → 204

PHA03247; large tegument protein UL36; Provisional

COG0666
Location:537 → 735

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:699 → 729

ANK; ANK repeat [structural motif]

cd10533
Location:862 → 1100

SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
NM_006709.5 → NP_006700.3 histone-lysine N-methyltransferase EHMT2 isoform a

See identical proteins and their annotated locations for NP_006700.3

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as NG36/G9a) uses an alternate 5' UTR and 5' coding region, contains an alternate in-frame exon in the 5' coding region, and lacks an alternate in-frame exon compared to variant 3. It encodes isoform a, which is shorter and has a distinct N-terminus, compared to isoform c.

Source sequence(s)

BC009351, CN397400, HY067184, X69838

Consensus CDS

CCDS4725.1

UniProtKB/Swiss-Prot

B0UZY2, Q14349, Q5JP83, Q5JQ92, Q5JQA1, Q5JQG3, Q6PK06, Q96KQ7, Q96MH5, Q96QD0, Q9UQL8, Q9Y331

UniProtKB/TrEMBL

A0A024RCN9, A0A1U9X7P8

Related

ENSP00000364687.4, ENST00000375537.9

Conserved Domains (7) summary

smart00468
Location:923 → 1022

PreSET; N-terminal to some SET domains

smart00317
Location:1038 → 1160

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:686 → 805

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:785 → 815

ANK; ANK repeat [structural motif]

pfam12796
Location:654 → 715

Ank_2; Ankyrin repeats (3 copies)

cl26464
Location:42 → 204

Atrophin-1; Atrophin-1 family

cl27511
Location:218 → 326

Na_Ca_ex; Sodium/calcium exchanger protein
NM_025256.7 → NP_079532.5 histone-lysine N-methyltransferase EHMT2 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as NG36/G9a-SPI) uses an alternate 5' UTR and 5' coding region and lacks an alternate in-frame exon compared to variant 3. It encodes isoform b, which has a shorter and distinct N-terminus and is shorter compared to isoform c.

Source sequence(s)

BC009351, CN397400, HY067184, X69838

Consensus CDS

CCDS4726.1

UniProtKB/TrEMBL

A0A0G2JIS2

Related

ENSP00000364680.4, ENST00000375530.8

Conserved Domains (6) summary

smart00468
Location:889 → 988

PreSET; N-terminal to some SET domains

smart00317
Location:1004 → 1126

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd00204
Location:652 → 771

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:688 → 781

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:751 → 781

ANK; ANK repeat [structural motif]

cl02529
Location:620 → 671

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

31879759..31897698 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006714975.2 → XP_006715038.2 histone-lysine N-methyltransferase EHMT2 isoform X2

UniProtKB/TrEMBL

A0A0G2JIR1, B7Z852
XM_006714974.2 → XP_006715037.2 histone-lysine N-methyltransferase EHMT2 isoform X1

UniProtKB/TrEMBL

A0A0G2JK64

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

3212374..3230320 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328444.1 → XP_054184419.1 histone-lysine N-methyltransferase EHMT2 isoform X2

UniProtKB/TrEMBL

A0A0G2JIR1
XM_054328443.1 → XP_054184418.1 histone-lysine N-methyltransferase EHMT2 isoform X1

UniProtKB/TrEMBL

A0A0G2JK64

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

3357184..3375123 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329725.1 → XP_054185700.1 histone-lysine N-methyltransferase EHMT2 isoform X2

UniProtKB/TrEMBL

A0A0G2JIR1, B7Z852
XM_054329724.1 → XP_054185699.1 histone-lysine N-methyltransferase EHMT2 isoform X1

UniProtKB/TrEMBL

A0A0G2JK64

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

Range

3127533..3145472 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330222.1 → XP_054186197.1 histone-lysine N-methyltransferase EHMT2 isoform X2

UniProtKB/TrEMBL

A0A0G2JIR1, B7Z852
XM_054330221.1 → XP_054186196.1 histone-lysine N-methyltransferase EHMT2 isoform X1

UniProtKB/TrEMBL

A0A0G2JK64

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

Range

3221824..3239770 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330760.1 → XP_054186735.1 histone-lysine N-methyltransferase EHMT2 isoform X2

UniProtKB/TrEMBL

A0A0G2JIR1
XM_054330759.1 → XP_054186734.1 histone-lysine N-methyltransferase EHMT2 isoform X1

UniProtKB/TrEMBL

A0A0G2JK64

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

Range

3135732..3153670 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330994.1 → XP_054186969.1 histone-lysine N-methyltransferase EHMT2 isoform X2

UniProtKB/TrEMBL

A0A0G2JIR1, B7Z852
XM_054330993.1 → XP_054186968.1 histone-lysine N-methyltransferase EHMT2 isoform X1

UniProtKB/TrEMBL

A0A0G2JK64

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

3180981..3190908 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

31732994..31750940 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054354085.1 → XP_054210060.1 histone-lysine N-methyltransferase EHMT2 isoform X2

UniProtKB/TrEMBL

A0A0G2JIR1
XM_054354084.1 → XP_054210059.1 histone-lysine N-methyltransferase EHMT2 isoform X1

UniProtKB/TrEMBL

A0A0G2JK64