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Ehmt2 euchromatic histone lysine N-methyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 110147, updated on 8-Dec-2022

Summary

Official Symbol
Ehmt2provided by MGI
Official Full Name
euchromatic histone lysine N-methyltransferase 2provided by MGI
Primary source
MGI:MGI:2148922
See related
Ensembl:ENSMUSG00000013787 AllianceGenome:MGI:2148922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G9a; Bat8; NG36; KMT1C; D17Ertd710e
Summary
Enables several functions, including C2H2 zinc finger domain binding activity; histone-lysine N-methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation; histone methylation; and regulation of DNA replication. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of autophagosome assembly; and response to cocaine. Located in nucleus. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 86.7), testis adult (RPKM 83.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ehmt2 in Genome Data Viewer
Location:
17 B1; 17 18.45 cM
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35117426..35133049)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34898463..34914073)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene complement component 2 (within H-2S) Neighboring gene predicted gene, 40706 Neighboring gene zinc finger and BTB domain containing 12 Neighboring gene solute carrier family 44, member 4 Neighboring gene neuraminidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K27 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K9 methyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
enables histone H3K9 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone H3K9 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K9 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K9 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone lysine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within DNA methylation on cytosine within a CG sequence IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to cocaine IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H3-K9 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone lysine methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine dimethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine dimethylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phenotypic switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of histone H3-K9 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of histone methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase EHMT2
Names
H3-K9-HMTase 3
HLA-B associated transcript 8
histone H3-K9 methyltransferase 3
histone-lysine N-methyltransferase, H3 lysine-9 specific 3
protein G9a
NP_001273502.1
NP_001273504.1
NP_665829.1
NP_671493.1
XP_006523545.1
XP_011244550.2
XP_011244551.2
XP_030105308.1
XP_036016153.1
XP_036016154.1
XP_036016155.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286573.2NP_001273502.1  histone-lysine N-methyltransferase EHMT2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame internal coding exon, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    CT025759
    Consensus CDS
    CCDS70798.1
    UniProtKB/Swiss-Prot
    Q9Z148
    UniProtKB/TrEMBL
    A2CG76
    Related
    ENSMUSP00000094955.4, ENSMUST00000097342.10
    Conserved Domains (9) summary
    smart00468
    Location:9421041
    PreSET; N-terminal to some SET domains
    smart00317
    Location:10571179
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:9561197
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00204
    Location:705824
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:741834
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:804834
    ANK; ANK repeat [structural motif]
    cl02529
    Location:673724
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cl09938
    Location:46226
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
    cl18951
    Location:573608
    Amidase; Amidase
  2. NM_001286575.2NP_001273504.1  histone-lysine N-methyltransferase EHMT2 isoform d

    See identical proteins and their annotated locations for NP_001273504.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' terminal exon, which includes the 5' coding sequence, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    CT025759
    Consensus CDS
    CCDS70797.1
    UniProtKB/Swiss-Prot
    Q9Z148
    Related
    ENSMUSP00000109667.3, ENSMUST00000114033.9
    Conserved Domains (7) summary
    smart00468
    Location:9191018
    PreSET; N-terminal to some SET domains
    smart00317
    Location:10341156
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00204
    Location:682801
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:718811
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:781811
    ANK; ANK repeat [structural motif]
    cl02529
    Location:650701
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cl18951
    Location:550585
    Amidase; Amidase
  3. NM_001403867.1NP_001390796.1  histone-lysine N-methyltransferase EHMT2 isoform e

    Status: VALIDATED

    Source sequence(s)
    CT025759
  4. NM_001403869.1NP_001390798.1  histone-lysine N-methyltransferase EHMT2 isoform f

    Status: VALIDATED

    Source sequence(s)
    CT025759
  5. NM_001403870.1NP_001390799.1  histone-lysine N-methyltransferase EHMT2 isoform g

    Status: VALIDATED

    Source sequence(s)
    CT025759
  6. NM_145830.3NP_665829.1  histone-lysine N-methyltransferase EHMT2 isoform a

    See identical proteins and their annotated locations for NP_665829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also known as G9a long).
    Source sequence(s)
    CT025759
    Consensus CDS
    CCDS28667.1
    UniProtKB/Swiss-Prot
    Q9Z148, Q9Z149
    Related
    ENSMUSP00000013931.6, ENSMUST00000013931.12
    Conserved Domains (8) summary
    smart00468
    Location:9761075
    PreSET; N-terminal to some SET domains
    smart00317
    Location:10911213
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:9901231
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00204
    Location:739858
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:775868
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:838868
    ANK; ANK repeat [structural motif]
    cl02529
    Location:707758
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cl18951
    Location:607642
    Amidase; Amidase
  7. NM_147151.3NP_671493.1  histone-lysine N-methyltransferase EHMT2 isoform b

    See identical proteins and their annotated locations for NP_671493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' terminal exon which includes the 5' coding sequence, and lacks an in-frame internal coding exon, compared to variant 1. The resulting isoform (b, also known as G9a short) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform a.
    Source sequence(s)
    CT025759
    Consensus CDS
    CCDS28666.1
    UniProtKB/Swiss-Prot
    Q9Z148
    Related
    ENSMUSP00000077208.7, ENSMUST00000078061.13
    Conserved Domains (7) summary
    smart00468
    Location:885984
    PreSET; N-terminal to some SET domains
    smart00317
    Location:10001122
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00204
    Location:648767
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:684777
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:747777
    ANK; ANK repeat [structural motif]
    cl02529
    Location:616667
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cl18951
    Location:516551
    Amidase; Amidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35117426..35133049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523482.5XP_006523545.1  histone-lysine N-methyltransferase EHMT2 isoform X3

    Conserved Domains (5) summary
    PHA03247
    Location:23201
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:662827
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:791821
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:795887
    Ank_2; Ankyrin repeats (3 copies)
    cd10533
    Location:9541192
    SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
  2. XM_030249448.2XP_030105308.1  histone-lysine N-methyltransferase EHMT2 isoform X4

    Conserved Domains (5) summary
    PHA03247
    Location:23201
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:628793
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:757787
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:761853
    Ank_2; Ankyrin repeats (3 copies)
    cd10533
    Location:9201158
    SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
  3. XM_036160261.1XP_036016154.1  histone-lysine N-methyltransferase EHMT2 isoform X5

    Conserved Domains (5) summary
    sd00045
    Location:585615
    ANK; ANK repeat [structural motif]
    cd10533
    Location:748986
    SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
    pfam12796
    Location:522615
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:210339
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
    cl18951
    Location:344379
    Amidase
  4. XM_011246248.2XP_011244550.2  histone-lysine N-methyltransferase EHMT2 isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:126379
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:969999
    ANK; ANK repeat [structural motif]
    cd10533
    Location:11321370
    SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
    pfam12796
    Location:906999
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:594723
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
  5. XM_011246249.2XP_011244551.2  histone-lysine N-methyltransferase EHMT2 isoform X2

    Conserved Domains (5) summary
    PHA03247
    Location:126379
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:935965
    ANK; ANK repeat [structural motif]
    cd10533
    Location:10981336
    SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
    pfam12796
    Location:872965
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:560689
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
  6. XM_036160260.1XP_036016153.1  histone-lysine N-methyltransferase EHMT2 isoform X5

    Conserved Domains (5) summary
    sd00045
    Location:585615
    ANK; ANK repeat [structural motif]
    cd10533
    Location:748986
    SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
    pfam12796
    Location:522615
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:210339
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
    cl18951
    Location:344379
    Amidase
  7. XM_036160262.1XP_036016155.1  histone-lysine N-methyltransferase EHMT2 isoform X6

    Conserved Domains (6) summary
    COG0666
    Location:419611
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:575605
    ANK; ANK repeat [structural motif]
    cd10533
    Location:738976
    SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
    pfam12796
    Location:512605
    Ank_2; Ankyrin repeats (3 copies)
    cd20905
    Location:210339
    EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
    cl18951
    Location:344379
    Amidase

RNA

  1. XR_876459.2 RNA Sequence

  2. XR_001782028.2 RNA Sequence

  3. XR_003952076.2 RNA Sequence